Compounds > 1,3-ditolylguanidine
Page last updated: 2024-08-18

1,3-ditolylguanidine and PB28

1,3-ditolylguanidine has been researched along with PB28 in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's4 (33.33)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berardi, F; Colabufo, NA; Giudice, G; Govoni, S; Lucchi, L; Perrone, R; Tortorella, V1
Abate, C; Berardi, F; Colabufo, NA; Contino, M; Ferorelli, S; Perrone, R; Tortorella, V1
Abate, C; Berardi, F; Colabufo, NA; Contino, M; Ferorelli, S; Inglese, C; Perrone, R1
Abate, C; Berardi, F; Colabufo, NA; de Robertis, AF; Ferorelli, S; Leopoldo, M; Niso, M; Perrone, R1
Abate, C; Berardi, F; Colabufo, NA; Ferorelli, S; Niso, M; Perrone, R; Uricchio, V1
Abate, C; Lacivita, E; Mosier, PD; Niso, M; Perrone, R; Toscano, A1
Abate, C; Berardi, F; Colabufo, NA; Contino, M; Ferorelli, S; Marottoli, R; Perrone, R1
Abate, C; Berardi, F; Hawkins, WG; Hornick, JR; Niso, M; Perrone, R; Spitzer, D1
Abate, C; Berardi, F; Cassano, G; Ferorelli, S; Gasparre, G; Niso, M; Perrone, R1
Abate, C; Berardi, F; Ferorelli, S; Ghigo, D; Lacivita, E; Lamb, DC; Marottoli, R; Niso, M; Ossato, G; Perrone, R; Riganti, C1
Bai, S; Chu, W; Li, S; Mach, RH; Peng, X; Sai, K; Tu, Z; Xu, J; Zeng, C1
Bracher, F; Fanter, L; Müller, C; Schepmann, D; Wünsch, B1

Other Studies

12 other study(ies) available for 1,3-ditolylguanidine and PB28

ArticleYear
New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Analgesics, Opioid; Animals; Binding Sites; Brain; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Pentazocine; Phencyclidine; Piperazines; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Phencyclidine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, sigma; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes

1996
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.
    Journal of medicinal chemistry, 2004, Apr-22, Volume: 47, Issue:9

    Topics: Animals; Antineoplastic Agents; Binding Sites; Brain; Cell Line, Tumor; Drug Screening Assays, Antitumor; Guinea Pigs; Humans; In Vitro Techniques; Ligands; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Radioligand Assay; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Urinary Bladder

2004
Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization.
    Bioorganic & medicinal chemistry letters, 2008, Mar-15, Volume: 18, Issue:6

    Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Liver; Molecular Structure; Piperazines; Radioligand Assay; Rats; Receptors, sigma; RNA, Messenger; Tritium

2008
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
    Journal of medicinal chemistry, 2008, Dec-11, Volume: 51, Issue:23

    Topics: Apoptosis; Binding Sites; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Molecular Structure; Piperazines; Pyridines; Stereoisomerism; Steroid Isomerases; Structure-Activity Relationship; Tumor Cells, Cultured

2008
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Guinea Pigs; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Male; Naphthalenes; Nitrogen; Piperazines; Rats; Receptors, sigma; Steroid Isomerases; Structure-Activity Relationship

2009
Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.
    Journal of medicinal chemistry, 2011, Feb-24, Volume: 54, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Gas Chromatography-Mass Spectrometry; Humans; Ligands; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Optical Rotation; Piperazines; Positron-Emission Tomography; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Surface Properties; Tetrahydronaphthalenes

2011
Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:9

    Topics: Acrylamides; Animals; Cell Line; Dogs; Ligands; Magnetic Resonance Spectroscopy; Positron-Emission Tomography; Radioligand Assay; Receptors, sigma; Structure-Activity Relationship

2011
Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
    Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16

    Topics: Binding, Competitive; Cell Line, Tumor; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescence; Humans; Ligands; Lysosomes; Microscopy, Confocal; Microscopy, Fluorescence; Models, Chemical; Molecular Structure; Pancreatic Neoplasms; Piperazines; Protein Binding; Protein Isoforms; Radioligand Assay; Receptors, sigma

2011
Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Calcium; Cell Line, Tumor; Cell Proliferation; Female; Humans; Methylation; Naphthalenes; Piperidines; Receptors, sigma; Tetrahydronaphthalenes

2013
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
    Journal of medicinal chemistry, 2014, Apr-24, Volume: 57, Issue:8

    Topics: Animals; Flow Cytometry; Fluorescence; Guinea Pigs; Humans; Ligands; Male; MCF-7 Cells; Piperazines; Rats; Receptors, sigma

2014
Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.
    Journal of medicinal chemistry, 2014, May-22, Volume: 57, Issue:10

    Topics: Animals; Benzamides; Cell Line, Tumor; Guinea Pigs; Ligands; Mice; Molecular Conformation; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship; Triazoles

2014
Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel σ
    Bioorganic & medicinal chemistry, 2017, 09-01, Volume: 25, Issue:17

    Topics: Animals; Azepines; Cholesterol; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Kinetics; Ligands; Male; Muscle Contraction; Protein Binding; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Yeasts

2017