Page last updated: 2024-09-05

1,3-dipropylxanthine and 8-phenyltheophylline

1,3-dipropylxanthine has been researched along with 8-phenyltheophylline in 8 studies

Compound Research Comparison

Studies
(1,3-dipropylxanthine)
Trials
(1,3-dipropylxanthine)
Recent Studies (post-2010)
(1,3-dipropylxanthine)
Studies
(8-phenyltheophylline)
Trials
(8-phenyltheophylline)
Recent Studies (post-2010) (8-phenyltheophylline)
2600518011

Protein Interaction Comparison

ProteinTaxonomy1,3-dipropylxanthine (IC50)8-phenyltheophylline (IC50)
Adenosine receptor A3Homo sapiens (human)1.25
Adenosine receptor A1Rattus norvegicus (Norway rat)0.2756
Adenosine receptor A1Bos taurus (cattle)0.003
Adenosine receptor A2aHomo sapiens (human)0.454
Adenosine receptor A2bHomo sapiens (human)0.3125
Adenosine receptor A2bRattus norvegicus (Norway rat)1.1
Adenosine receptor A1Homo sapiens (human)1.34

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D1
Barone, S; Bradbury, BJ; Campagne, JM; Daly, JW; Jacobson, KA; Kammula, U; Kiriasis, L; Neumeyer, JL; Pfleiderer, W; Secunda, S1
Bruns, RF; Christ, WJ; Ibay, AC; Schneller, SW1
Butts-Lamb, P; Daly, JW; Padgett, W; Shamim, MT; Waters, J1
Daly, JW; Glennon, RA; Padgett, W; Tejani-Butt, SM1
Grahner, B; Lanzner, W; Müller, CE; Winiwarter, S1
Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Kiriasis, L; Manning, M; Müller, C; Neumeyer, JL; Pfleiderer, W; Shi, D1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE1

Other Studies

8 other study(ies) available for 1,3-dipropylxanthine and 8-phenyltheophylline

ArticleYear
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines

1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Purinergic; Structure-Activity Relationship; Sulfur; Xanthines

1989
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:10

    Topics: Animals; Brain; Cell Membrane; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Receptors, Purinergic; Structure-Activity Relationship; Xanthines

1989
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:4

    Topics: Adenosine; Animals; Cerebral Cortex; In Vitro Techniques; Rats; Receptors, Cell Surface; Receptors, Purinergic; Solubility; Structure-Activity Relationship

1985
Mesoionic xanthine analogues: antagonists of adenosine receptors.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:10

    Topics: Adenosine; Animals; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Rats; Receptors, Cell Surface; Receptors, Purinergic; Spectrophotometry, Infrared; Structure-Activity Relationship; Xanthines

1984
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.
    Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10

    Topics: Animals; Brain; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Xanthines

1994
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
    Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18

    Topics: Acylation; Alkylation; Animals; Brain; Caffeine; Cell Membrane; Cyclization; Molecular Structure; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Trifluoroacetic Acid; Xanthines

1993
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
    Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11

    Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines

2002