Compounds > 1,3-dipropylxanthine

Page last updated: 2024-09-05

1,3-dipropylxanthine and 1,3-dipropyl-8-cyclopentylxanthine

1,3-dipropylxanthine has been researched along with 1,3-dipropyl-8-cyclopentylxanthine in 9 studies

Compound Research Comparison

Studies (1,3-dipropylxanthine)	Trials (1,3-dipropylxanthine)	Recent Studies (post-2010) (1,3-dipropylxanthine)	Studies (1,3-dipropyl-8-cyclopentylxanthine)	Trials (1,3-dipropyl-8-cyclopentylxanthine)	Recent Studies (post-2010) (1,3-dipropyl-8-cyclopentylxanthine)
26	0	0	1,301	1	165

Protein Interaction Comparison

Protein	Taxonomy	1,3-dipropylxanthine (IC50)	1,3-dipropyl-8-cyclopentylxanthine (IC50)
Adenosine receptor A1	Rattus norvegicus (Norway rat)		0.0051
Adenosine receptor A3	Rattus norvegicus (Norway rat)		0.0038
Adenosine receptor A2a	Homo sapiens (human)		0.2033
Adenosine receptor A2b	Homo sapiens (human)		0.0234
Adenosine receptor A1	Homo sapiens (human)		0.0083

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (33.33)	18.7374
1990's	4 (44.44)	18.2507
2000's	1 (11.11)	29.6817
2010's	1 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ishii, A; Nonaka, H; Shimada, J; Suzuki, F	1
Ichikawa, S; Ishii, A; Nonaka, H; Shimada, J; Suzuki, F	1
Ishii, A; Karasawa, A; Kubo, K; Mizumoto, H; Nonaka, H; Ohno, T; Shimada, J; Suzuki, F	1
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D	1
Barone, S; Bradbury, BJ; Campagne, JM; Daly, JW; Jacobson, KA; Kammula, U; Kiriasis, L; Neumeyer, JL; Pfleiderer, W; Secunda, S	1
Daly, JW; Hong, O; Padgett, WL; Shamim, MT; Ukena, D	1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE	1
Baker, SP; Belardinelli, L; Olsson, RA; Scammells, PJ	1
Aurelio, L; Christopoulos, A; Scammells, PJ; Sexton, PM; Urmaliya, VB; Valant, C; White, P	1

Other Studies

9 other study(ies) available for 1,3-dipropylxanthine and 1,3-dipropyl-8-cyclopentylxanthine

Article	Year
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. Journal of medicinal chemistry, 1992, Mar-06, Volume: 35, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Guinea Pigs; Humans; Molecular Conformation; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship; Xanthines	1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Corpus Striatum; Guinea Pigs; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Structure-Activity Relationship; Xanthines	1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Diuretics; Indicators and Reagents; Kidney; Kidney Function Tests; Kinetics; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1991
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines	1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. Journal of medicinal chemistry, 1989, Volume: 32, Issue:8 Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Purinergic; Structure-Activity Relationship; Sulfur; Xanthines	1989
8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Adenylyl Cyclase Inhibitors; Animals; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Solubility; Structure-Activity Relationship; Xanthines	1988
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11 Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines	2002
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors. Journal of medicinal chemistry, 1994, Aug-19, Volume: 37, Issue:17 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Drug Design; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; PC12 Cells; Purinergic P1 Receptor Antagonists; Radioligand Assay; Structure-Activity Relationship; Xanthines	1994
Delineating the mode of action of adenosine A1 receptor allosteric modulators. Molecular pharmacology, 2010, Volume: 78, Issue:3 Topics: Adenosine; Allosteric Site; Ligands; Receptor, Adenosine A1; Receptors, G-Protein-Coupled; Signal Transduction; Xanthines	2010