Compounds > 1,3-dipropyl-8-cyclopentylxanthine

1,3-dipropyl-8-cyclopentylxanthine and theophylline

1,3-dipropyl-8-cyclopentylxanthine has been researched along with theophylline in 156 studies

Research

Studies (156)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (3.21)	18.7374
1990's	92 (58.97)	18.2507
2000's	45 (28.85)	29.6817
2010's	13 (8.33)	24.3611
2020's	1 (0.64)	2.80

Authors

Authors	Studies
Ishii, A; Karasawa, A; Kawakita, T; Kubo, K; Mizumoto, H; Nonaka, H; Shimada, J; Suzuki, F	1
Ishii, A; Nonaka, H; Shimada, J; Suzuki, F	1
Ichikawa, S; Ishii, A; Nonaka, H; Shimada, J; Suzuki, F	1
Jacobson, KA; van Galen, PJ; Williams, M	1
Ishii, A; Karasawa, A; Kubo, K; Mizumoto, H; Nonaka, H; Ohno, T; Shimada, J; Suzuki, F	1
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D	1
Barone, S; Bradbury, BJ; Campagne, JM; Daly, JW; Jacobson, KA; Kammula, U; Kiriasis, L; Neumeyer, JL; Pfleiderer, W; Secunda, S	1
Jacobson, KA; Ji, XD; Kim, HO; Melman, N; Olah, ME; Stiles, GL	1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Martini, C; Messini, L; Senatore, G	1
Fuse, E; Ichikawa, S; Ishii, A; Kobayashi, H; Nakamura, J; Nonaka, H; Shimada, J; Shiozaki, S; Suzuki, F	1
Arslan, G; Dionisotti, S; Fredholm, BB; Kull, B; Ongini, E; Zocchi, C	1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C	1
Catarzi, D; Cecchi, L; Colotta, V; Filacchioni, G; Lucacchini, A; Martini, C; Trincavelli, L; Varano, F	1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE	1
Calabri, FR; Catarzi, D; Colotta, V; Deflorian, F; Filacchioni, G; Lenzi, O; Martini, C; Moro, S; Trincavelli, L; Varano, F	1
Catarzi, D; Colotta, V; Filacchioni, G; Lenzi, O; Martini, C; Montopoli, C; Moro, S; Trincavelli, L; Varano, F	1
Elzein, E; Gimbel, A; Kalla, RV; Li, X; Maa, T; Palle, V; Perry, T; Varkhedkar, V; Zablocki, J; Zeng, D	1
Catarzi, D; Ciampi, O; Colotta, V; Filacchioni, G; Lenzi, O; Marighetti, F; Martini, C; Morizzo, E; Moro, S; Trincavelli, L; Varani, K; Varano, F	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Capelli, F; Catarzi, D; Ciampi, O; Colotta, V; Filacchioni, G; Lenzi, O; Martini, C; Morizzo, E; Moro, S; Pedata, F; Pugliese, AM; Schiesaro, A; Trincavelli, L; Varano, F	1
Catarzi, D; Ciampi, O; Colotta, V; Filacchioni, G; Lenzi, O; Martini, C; Morizzo, E; Moro, S; Pedata, F; Pugliese, AM; Traini, C; Trincavelli, L; Varano, F	2
Auchampach, JA; Gizewski, E; Kreckler, LM; Maas, GE; Maas, JE; Narayanan, J; van der Hoeven, D; Wan, TC	1
El-Tayeb, A; Inamdar, GS; Li, W; Müller, CE; Scheiff, AB; Sudarsanam, V; Vasu, KK; Yerande, SG	1
Cheng, F; Liu, G; Tang, Y; Xu, Z	1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L	1
Azuaje, J; Carbajales, C; Crespo, A; El Maatougui, A; Escalante, L; García-Mera, X; González-Gómez, M; Gutiérrez-de-Terán, H; Miguez, G; Sotelo, E	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Brink, A; Fuder, H; Meincke, M; Tauber, U	1
Földes, FF; Nagano, O; Nakatsuka, H; Ohta, Y; Reich, D; Sperlagh, B; Vizi, ES	1
Khoo, HE; Tan, CH; Tey, HB	2
Späth, L; Starke, K; von Kügelgen, I	1
Martin, PL	1
Baumgold, J; Jacobson, KA; Nikodijevic, O	1
Collis, MG; Keddie, JR; Shaw, G	1
Ameri, A; Jurna, I	1
Brackett, LE; Daly, JW	1
Fastbom, J; Fredholm, BB	1
Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z	1
Barry, SR	1
Dobson, JG; MacDonald, SG; Romano, FD	1
Lohse, MJ; Schmitz, W; Scholz, H; Scholz, J; Schwabe, U; von der Leyen, H	1
Collis, MG; Martin, FM; Stoggall, SM	1
Armstrong, S; Ganote, CE	2
Black, JW; Prentice, DJ; Shankley, NP	1
Danhof, M; Hartog-Witte, HR; IJzerman, AP; Lidaks, MJ; Mathôt, RA; Pirovano, IM; Roelen, HC; Van Aerschot, A; Van der Wenden, EM; von Frijtag Drabbe Künzel, JK	1
Imaizumi, M; Miyazaki, S; Onodera, K	1
Apaya, RP; IJzerman, AP; Price, SL; Soudijn, W; van der Wenden, EM	1
Jarvis, JE; Reeves, JJ; Sheehan, MJ; Strong, P	1
Forghani, R; Krnjević, K	1
Dawid-Milner, MS; Silva-Carvalho, L; Spyer, KM; St Lambert, JH	1
Hada, J; Hayashi, Y; Kaku, T	1
Abiko, Y; Hara, A	1
Coates, J; Green, MA; Sheehan, MJ; Strong, P	1
Akatsuka, Y; Egashira, K; Katsuda, Y; Narishige, T; Shimokawa, H; Takeshita, A; Ueno, H	1
Martin, PL; Potts, AA	1
Downey, JM; Liu, GS; Mullane, K; Olsson, RA; Richards, SC; Walsh, RS	1
Dawid-Milner, MS; Goldsmith, GR; Silva-Carvalho, L; Spyer, KM	1
Martin, PL; May, JM	1
King, BF	1
Macgregor, DG; Stone, TW	1
Ali, S; Metzger, WJ; Mustafa, SJ	1
Burnstock, G; Ralevic, V; Rubino, A	1
Becker, BF; Gerlach, E; Raschke, P; Schwartz, LM	1
Hershkowitz, N; Katchman, AN	1
Lutz, PL; Pérez-Pinzón, MA; Rosenthal, M; Sick, TJ	1
Lacroix, C; Lynch, AE; McKean, TA; Sterling, H; Streeby, DR; Vestal, RE	1
Burnstock, G; Vials, A	1
Joad, JP; Kott, KS	1
Grover, LM; Teyler, TJ	1
Amerini, S; Filippi, S; Ledda, F; Mantelli, L	1
Bruns, RF; Montamat, SC; Mudumbi, RV; Vestal, RE	1
Belloni, FL; Lee, HT; Linden, J; Thompson, CI	1
Alexander, SP; Cooper, JA; Hill, SJ; Horn, EH; Rubin, PC	1
Hope, W; Rose'Meyer, RB; White, PJ	1
Fernandez, M; Fredholm, BB; Svenningsson, P	1
Croning, MD; Grahame-Smith, DG; Newberry, NR; Zetterström, TS	1
Brownhill, VR; Hourani, SM; Nicholls, J	1
Hettinger-Smith, BD; Leid, M; Murray, TF	1
Kwan, YW; Qi, AD	1
Abe, T; Gutterman, DD; Morgan, DA	1
Bullough, DA; Drake, L; Firestein, GS; Mullane, KM; Sajjadi, F; Wang, J	1
Krnjević, K; Zhu, PJ	1
Eleno, N; Lopez-Novoa, JM; MacLaughlin, M; Martinez-Salgado, C; Olivera, A	1
el-Ani, D; Jacobson, KA; Shainberg, A	1
Jin, J; Keith, IM; Neely, CF	1
Florio, C; Rosati, AM; Traversa, U; Vertua, R	1
Bernardi, G; Calabresi, P; Centonze, D; Pisani, A	2
Chopde, CT; Ghosh, AK; Mandhane, SN	1
Burgert, K; Erley, CM; Heyne, N; Langanke, J; Osswald, H; Risler, T	1
Barr, PM; Cannady, SB; Malinowski, MN; Schmit, KV; Schrock, JW; Wilson, DF	1
Barth, A; Janigro, D; Meno, JR; Newell, DW; Nguyen, LB; Wender, R; Winn, HR	1
Brause, M; Delabar, U; Eckardt, KU; Gleiter, CH; Zebski, H	1
Adén, U; Bona, E; Fredholm, BB; Gilland, E; Hagberg, H	1
Anderson, DR; Chen, Q; Matsugi, T	1
Hettinger, BD; Leid, M; Murray, TF	1
Bockaert, J; Manzoni, O; Pujalte, D; Williams, J	1
Beukers, MW; Dalpiaz, A; IJzerman, AP; Schofield, PR; Townsend-Nicholson, A	1
Almaraz, L; Gonzalez, C; Rocher, A	1
Richardt, G; Schreieck, J	1
Barahona, MV; Bustamante, S; García-Sacristán, A; Hernández, M; Orensanz, LM	1
Gupta, YK; Malhotra, J	1
Brock, JA; Hardy, TA	1
Bordoni, F; Corradetti, R; Latini, S; Pedata, F	1
Fredholm, BB; Johansson, B; Kuzmin, A; Zvartau, EE	1
Gandolfi, O; Lucchi, R; Notari, S; Poli, A; Traversa, U; Zampacavallo, G	1
Schwartz, AD; Whitacre, CL; Wilson, DF	1
Bickford, PC; Dunwiddie, TV; Masino, SA; Mesches, MH	1
Dunwiddie, TV; Thümmler, S	1
Kato, F; Shigetomi, E	1
Burgdorf, C; Jain, D; Katus, HA; Kurz, T; Richardt, D; Richardt, G; Seyfarth, M	1
Chen, S; He, RR	2
Asano, G; Hiraide, T; Katayama, Y; Katsura, K; Muramatsu, H	1
Hamann, M; Richter, A	1
Cheng, JT; Chi, TC; Liu, IM	1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P	1
Crum, AV; Meno, JR; Winn, HR	1
Shimada, H; Sugino, H; Tsuchimoto, K	1
Esselstyn, J; Hertel, C; Lee, R; Lerner, A; Moon, E; Wolda, S	1
Chen, S; He, RR; Li, DP	1
Bhat, SG; Mei, Y; Mishra, S; Nie, Z; Ramkumar, V; Rybak, LP; Whitworth, CA	1
Albasanz, JL; Fernández, M; León, D; Martín, M; Ruíz, MA	1
Andersson, A; Bodin, B; Carlsson, PO; Jansson, L; Källskog, O; Olsson, R	1
Danielyan, L; Kloor, D; Osswald, H	1
Antoniou, K; Ferré, S; Fuxe, K; Goldberg, SR; Justinova, Z; Karcz-Kubicha, M; Müller, CE; Pezzola, A; Popoli, P; Quarta, D; Reggio, R; Solinas, M; Terasmaa, A	1
Blood, AB; Hunter, CJ; Power, GG	1
Furuta, S; Honma, I; Kumagai, M; Miyazaki, S; Onodera, K; Sakurada, S; Sato, T	1
Ishii, K; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Yonoki, Y	1
de Ligt, RA; IJzerman, AP; Leurs, R; Lorenzen, A; Rivkees, SA	1
Kato, M; Mobarakeh, JI; Nishino, S; Sakurada, S; Takahashi, K; Watanabe, H; Yanai, K	1
Amerson, BS; Guyton, RA; Halkos, ME; Headrick, JP; Kerendi, F; Kin, H; Lofye, MT; Vinten-Johansen, J; Zatta, AJ; Zhao, ZQ	1
Cohen, MV; Downey, JM; Solenkova, NV; Solodushko, V	1
Coelho, JE; Cunha, RA; de Mendonça, A; Fragata, I; Rebola, N; Ribeiro, JA	1
Marshall, JM; Walsh, MP	1
Fan, YJ; Lautt, WW; Ming, Z; Yang, X	1
Alexander, SP	1
Ashton, KJ; Blackburn, MR; Headrick, JP; Matherne, GP; Peart, JN; Reichelt, ME; Willems, L	1
Brumand, K; Deemyad, T; Malihi, G; Pousti, A	1
Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G	1
Battastini, AM; Bavaresco, L; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G; Wink, MR	1
Chorostowska-Wynimko, J; Kus, J; Skopińska-Rózewska, E	1
Coskun, C; Mutlu, D; Savci, V; Suzer, O; Yalcin, M; Yilmaz, MS	1
Sheppy, E; Wong, T; Wu, C; Wu, X; Zhang, L	1
Ciocan, D; Constantinescu, AO; Ilie, A; Moldovan, M; Zagrean, AM; Zagrean, L	1
Coney, AM; Marshall, JM	1
Abd-Elfattah, AS; Ding, M; Jessen, ME; Wechsler, AS	1
Searl, TJ; Silinsky, EM	1
Lindquist, BE; Shuttleworth, CW	1
Biesiadecki, BJ; Billman, GE; Carnes, CA; Csepe, TA; Fedorenko, O; Fedorov, VV; Glukhov, AV; Györke, S; Hage, LT; Hansen, BJ; Kalyanasundaram, A; Li, N; Lou, Q; Mohler, PJ; Weiss, R	1
Ballanyi, K; Ciechanski, P; Mosca, EV; Roy, A; Scheibli, EC; Wilson, RJ	1
Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY	1
Madayag, A; Malykhina, AP; McCarthy, KD; Minton, SK; Xie, AX	1

Reviews

2 review(s) available for 1,3-dipropyl-8-cyclopentylxanthine and theophylline

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1 Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1	2013

Other Studies

154 other study(ies) available for 1,3-dipropyl-8-cyclopentylxanthine and theophylline

Article	Year
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16 Topics: Acute Kidney Injury; Adenosine; Animals; Cations, Monovalent; Diuretics; Male; Potassium; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sodium; Structure-Activity Relationship; Xanthines	1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. Journal of medicinal chemistry, 1992, Mar-06, Volume: 35, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Guinea Pigs; Humans; Molecular Conformation; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship; Xanthines	1992
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Corpus Striatum; Guinea Pigs; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Structure-Activity Relationship; Xanthines	1992
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Diuretics; Indicators and Reagents; Kidney; Kidney Function Tests; Kinetics; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1991
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines	1989
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. Journal of medicinal chemistry, 1989, Volume: 32, Issue:8 Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; In Vitro Techniques; Radioligand Assay; Rats; Receptors, Purinergic; Structure-Activity Relationship; Sulfur; Xanthines	1989
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors. Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Brain Chemistry; Caffeine; CHO Cells; Cricetinae; Gene Expression; Iodine Radioisotopes; Molecular Structure; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection; Xanthines	1994
8-Azaxanthine derivatives as antagonists of adenosine receptors. Journal of medicinal chemistry, 1994, Sep-02, Volume: 37, Issue:18 Topics: Animals; Brain; Cattle; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines	1994
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. Journal of medicinal chemistry, 1993, Aug-20, Volume: 36, Issue:17 Topics: Adenosine; Amnesia; Animals; Avoidance Learning; Diuretics; Male; Mice; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Wistar; Receptors, Purinergic; Scopolamine; Structure-Activity Relationship; Xanthines	1993
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Species Specificity; Transfection; Triazoles	1997
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines	1998
Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. Journal of medicinal chemistry, 2000, Aug-10, Volume: 43, Issue:16 Topics: Animals; Binding, Competitive; Cattle; Cerebral Cortex; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Ligands; Purinergic P1 Receptor Antagonists; Quinolines; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Structure-Activity Relationship	2000
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11 Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines	2002
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies. Journal of medicinal chemistry, 2004, Jul-01, Volume: 47, Issue:14 Topics: Adenosine A3 Receptor Antagonists; Animals; Cattle; CHO Cells; Cricetinae; Humans; Ligands; Models, Molecular; Quinoxalines; Radioligand Assay; Receptor, Adenosine A3; Structure-Activity Relationship; Triazoles	2004
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives. Journal of medicinal chemistry, 2005, Dec-15, Volume: 48, Issue:25 Topics: Adenosine A3 Receptor Antagonists; Amino Acid Motifs; Animals; Binding Sites; Cattle; Cerebral Cortex; Corpus Striatum; Drug Design; Humans; In Vitro Techniques; Models, Molecular; Quinoxalines; Radioligand Assay; Receptor, Adenosine A3; Structure-Activity Relationship; Triazoles	2005
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12 Topics: Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Humans; Pyrazoles; Radioligand Assay; Theophylline; Xanthines	2006
4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies. Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; In Vitro Techniques; Ligands; Membranes; Models, Molecular; Quinoxalines; Radioligand Assay; Structure-Activity Relationship; Triazoles	2006
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17 Topics: Adenosine A3 Receptor Antagonists; Animals; Benzamides; Brain Ischemia; Cerebral Cortex; CHO Cells; Corpus Striatum; Cricetinae; Cricetulus; Cyclic AMP; Electrophysiology; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Models, Molecular; Pyrazoles; Quinolines; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Synaptic Transmission; Testis	2007
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Protein Binding; Quinoxalines; Rats; Receptor, Adenosine A3; Rhodopsin; Structural Homology, Protein; Structure-Activity Relationship; Triazoles; Xanthines	2008
Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1 Topics: Acetamides; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amino Acid Sequence; Animals; Brain Chemistry; Calcium; Cell Line; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Dogs; Humans; Ligands; Mice; Molecular Sequence Data; Purines; Rabbits; Radioligand Assay; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity	2009
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8 Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corpus Striatum; Cricetinae; Cricetulus; Cyclic AMP; Heterocyclic Compounds, 3-Ring; Hippocampus; Humans; Hydrogen Bonding; In Vitro Techniques; Ligands; Male; Models, Molecular; Pyrazines; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Synaptic Transmission; Triazoles	2009
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Adenosine A1 Receptor Antagonists; Animals; Drug Design; Humans; Molecular Structure; Rats; Receptor, Adenosine A1; Stereoisomerism; Structure-Activity Relationship; Thiazoles	2010
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. European journal of medicinal chemistry, 2010, Volume: 45, Issue:8 Topics: Adenosine A2 Receptor Antagonists; Amino Acid Sequence; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Receptor, Adenosine A2B; Reproducibility of Results; Sequence Homology, Amino Acid	2010
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. Journal of medicinal chemistry, 2016, Mar-10, Volume: 59, Issue:5 Topics: Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Pyrimidinones; Receptor, Adenosine A2B; Structure-Activity Relationship	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Purinoceptor-mediated modulation by endogenous and exogenous agonists of stimulation-evoked [3H]noradrenaline release on rat iris. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4 Topics: Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Iris; Male; Norepinephrine; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Synaptic Transmission; Theophylline; Xanthines	1992
Presynaptic A1-purinoceptor-mediated inhibitory effects of adenosine and its stable analogues on the mouse hemidiaphragm preparation. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:2 Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Diaphragm; Dipyridamole; Electric Stimulation; In Vitro Techniques; Magnesium; Male; Mice; Muscle Contraction; Neuromuscular Junction; Phrenic Nerve; Purinergic Antagonists; Receptors, Purinergic; Synapses; Synaptic Transmission; Theophylline; Tritium; Tubocurarine; Xanthines	1992
Adenosine modulates cell growth in human epidermoid carcinoma (A431) cells. Biochemical and biophysical research communications, 1992, Sep-30, Volume: 187, Issue:3 Topics: Adenosine; Carcinoma, Squamous Cell; Cell Division; Humans; In Vitro Techniques; Receptors, Purinergic; Theophylline; Tumor Cells, Cultured; Xanthines	1992
Stable adenine nucleotides inhibit [3H]-noradrenaline release in rabbit brain cortex slices by direct action at presynaptic adenosine A1-receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:2 Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cerebral Cortex; Drug Interactions; Drug Stability; Electric Stimulation; Female; Male; Nerve Endings; Norepinephrine; Purinergic Antagonists; Rabbits; Receptors, Purinergic; Suramin; Synapses; Theophylline; Tritium; Xanthines	1992
Evidence that adenosine receptors in the dog left atrium are not of the typical A1 or A2 adenosine receptor subtypes. European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3 Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dogs; Female; Heart Atria; In Vitro Techniques; Male; Myocardium; Norbornanes; Receptors, Purinergic; Theophylline; Vasodilation; Xanthines	1992
Penetration of adenosine antagonists into mouse brain as determined by ex vivo binding. Biochemical pharmacology, 1992, Feb-18, Volume: 43, Issue:4 Topics: Adenosine; Animals; Brain Chemistry; Cerebrovascular Circulation; Injections, Intraperitoneal; Locomotion; Male; Mice; Receptors, Purinergic; Theophylline; Time Factors; Xanthines	1992
Diuretic and saliuretic effects of 1,3-dipropyl-8-cyclopentylxanthine, a selective A1-adenosine receptor antagonist. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:2 Topics: Adenosine; Animals; Blood Pressure; Diuresis; Electrolytes; Heart Rate; Infusions, Intravenous; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Xanthines	1991
Adenosine A1 and non-A1 receptors: intracellular analysis of the actions of adenosine agonists and antagonists in rat hippocampal neurons. Brain research, 1991, Apr-12, Volume: 546, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Electric Stimulation; Electrodes; Hippocampus; Male; Membrane Potentials; Neurons; Phenylisopropyladenosine; Purinergic Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic; Synapses; Theophylline; Xanthines	1991
Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1 Topics: Adenosine; Animals; Carbachol; Deoxyadenosines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Receptors, Purinergic; Theophylline; Thionucleosides; Trachea; Xanthine; Xanthines	1991
Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins. Brain research, 1990, Jan-22, Volume: 507, Issue:2 Topics: Adenosine; Animals; Autoradiography; Brain; GTP-Binding Proteins; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Xanthines	1990
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948. Psychopharmacology, 1990, Volume: 100, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines	1990
Adenosine depresses spontaneous transmitter release from frog motor nerve terminals by acting at an A1-like receptor. Life sciences, 1990, Volume: 46, Issue:19 Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Membrane Potentials; Motor Neurons; Phenylisopropyladenosine; Purinergic Antagonists; Rana pipiens; Receptors, Purinergic; Theophylline; Xanthines	1990
Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membranes. The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2 Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; Colforsin; Guanylyl Imidodiphosphate; Heart Ventricles; Isoproterenol; Kinetics; Male; Myocardium; Peptidyl-Dipeptidase A; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Xanthines	1989
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoenzymes; Male; Myocardial Contraction; Papillary Muscles; Phenylisopropyladenosine; Phosphoric Diester Hydrolases; Receptors, Purinergic; Theophylline; Xanthines	1989
Apparent affinity of 1,3-dipropyl-8-cyclopentylxanthine for adenosine A1 and A2 receptors in isolated tissues from guinea-pigs. British journal of pharmacology, 1989, Volume: 97, Issue:4 Topics: Adenosine; Animals; Aorta, Thoracic; Binding, Competitive; Guinea Pigs; Heart Rate; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Receptors, Purinergic; Theophylline; Trachea; Xanthines	1989
Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement. Cardiovascular research, 1994, Volume: 28, Issue:7 Topics: Adenosine; Animals; Antihypertensive Agents; Cells, Cultured; Glucose; Myocardial Infarction; Myocardial Ischemia; Myocardium; Naphthalenes; Phenethylamines; Phenylisopropyladenosine; Polycyclic Compounds; Protein Kinase C; Purinergic Antagonists; Pyruvates; Pyruvic Acid; Rabbits; Receptors, Purinergic P1; Theophylline; Time Factors; Trypan Blue; Xanthines	1994
Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum. British journal of pharmacology, 1995, Volume: 115, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cecum; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Heart Atria; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Xanthines	1995
8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor. European journal of pharmacology, 1995, Aug-15, Volume: 290, Issue:3 Topics: Adenosine; Adenylyl Cyclases; Animals; Cells, Cultured; Heart Rate; In Vitro Techniques; Kinetics; Purinergic P1 Receptor Agonists; Rats; Theophylline; Xanthines	1995
In vitro ischaemic preconditioning of isolated rabbit cardiomyocytes: effects of selective adenosine receptor blockade and calphostin C. Cardiovascular research, 1995, Volume: 29, Issue:5 Topics: Animals; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Naphthalenes; Protein Kinase C; Purinergic P1 Receptor Antagonists; Rabbits; Theophylline; Xanthines	1995
Effects of xanthine derivatives in a light/dark test in mice and the contribution of adenosine receptors. Methods and findings in experimental and clinical pharmacology, 1994, Volume: 16, Issue:9 Topics: Adenosine; Animals; Antihypertensive Agents; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Interactions; Light; Male; Mice; Phenethylamines; Purinergic P1 Receptor Antagonists; Structure-Activity Relationship; Theophylline; Xanthines	1994
Relative binding orientations of adenosine A1 receptor ligands--a test case for Distributed Multipole Analysis in medicinal chemistry. Journal of computer-aided molecular design, 1995, Volume: 9, Issue:1 Topics: Adenosine; Computer Graphics; Drug Design; Electrochemistry; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Xanthines	1995
Further investigations into adenosine A1 receptor-mediated contraction in rat colonic muscularis mucosae and its augmentation by certain alkylxanthine antagonists. British journal of pharmacology, 1995, Volume: 114, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colon; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Theophylline; Triazoles; Vasodilator Agents; Xanthines	1995
Adenosine antagonists have differential effects on induction of long-term potentiation in hippocampal slices. Hippocampus, 1995, Volume: 5, Issue:1 Topics: Adenosine; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	1995
Action of adenosine receptor antagonists on the cardiovascular response to defence area stimulation in the rat. British journal of pharmacology, 1994, Volume: 113, Issue:1 Topics: Adenosine; Animals; Behavior, Animal; Blood Pressure; Ethanol; Heart Rate; Hemodynamics; Hypothalamus; In Vitro Techniques; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	1994
Endogenous adenosine exerts inhibitory effects upon the development of spreading depression and glutamate release induced by microdialysis with high K+ in rat hippocampus. Brain research, 1994, Sep-26, Volume: 658, Issue:1-2 Topics: Adenosine; Animals; Cortical Spreading Depression; Dipyridamole; Glutamic Acid; Hippocampus; Male; Microdialysis; Potassium; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Theophylline; Thioinosine; Xanthines	1994
Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts. The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2 Topics: Animals; Glyburide; Heart; Hydrogen Peroxide; Hypoxia; In Vitro Techniques; Male; Myocardium; Purinergic Antagonists; Rats; Theophylline; Xanthines	1995
Characterization of the prejunctional adenosine receptors in the rat anococcygeus muscle. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:11 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Phenylephrine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic P1; Theophylline; Vasodilator Agents; Xanthines	1994
Modulation of DNA synthesis via adenosine receptors in human epidermoid carcinoma (A431) cells. BioFactors (Oxford, England), 1994, Volume: 4, Issue:3-4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Carcinoma, Squamous Cell; DNA, Neoplasm; Epidermal Growth Factor; Humans; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Tumor Cells, Cultured; Xanthines	1994
ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog. Cardiovascular research, 1994, Volume: 28, Issue:6 Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Glyburide; Guanidines; Ion Channel Gating; Pinacidil; Potassium Channels; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P2; Theophylline; Vasodilator Agents; Xanthines	1994
The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Theophylline; Vasodilator Agents; Xanthines	1994
Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart. Cardiovascular research, 1994, Volume: 28, Issue:7 Topics: Adenosine; Animals; Antihypertensive Agents; Female; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Ischemia; Perfusion; Purinergic Antagonists; Rabbits; Receptors, Purinergic P1; Theophylline; Xanthines	1994
A potential role of central A1 adenosine receptors in the responses to hypothalamic stimulation in the anaesthetized cat. Journal of the autonomic nervous system, 1994, Volume: 49, Issue:1 Topics: Adenosine; Anesthesia; Animals; Blood Pressure; Cats; Chemoreceptor Cells; Electric Stimulation; Ethanol; Hypothalamus; Phrenic Nerve; Pressoreceptors; Receptors, Purinergic P1; Theophylline; Xanthines	1994
Identification and functional characterization of A1 and A2 adenosine receptors in the rat vas deferens: a comparison with A1 receptors in guinea pig left atrium and A2 receptors in guinea pig aorta. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3 Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Guinea Pigs; Heart; In Vitro Techniques; Male; Norbornanes; Phenethylamines; Rats; Receptors, Purinergic P1; Theophylline; Vas Deferens; Xanthines	1994
Prejunctional autoinhibition of purinergic transmission in circular muscle of guinea-pig ileum; a mechanism distinct from P1-purinoceptor activation. Journal of the autonomic nervous system, 1994, Volume: 48, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Animals; Electrophysiology; Guinea Pigs; Ileum; Intercellular Junctions; Male; Muscle, Smooth; Neural Inhibition; Purinergic Antagonists; Purines; Receptors, Purinergic; Synaptic Transmission; Theophylline; Xanthines	1994
Blockade by 1,3-dipropyl-8-cyclopentylxanthine (CPX) of purine protection against kainate neurotoxicity. Brain research, 1994, May-02, Volume: 644, Issue:2 Topics: Animals; Kainic Acid; Male; Nerve Degeneration; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Xanthines	1994
Adenosine receptor-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbit model. The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 1 Topics: Adenosine; Animals; Bronchi; Bronchoconstriction; Dust; Immunization; Mites; Rabbits; Receptors, Purinergic P1; Respiratory Hypersensitivity; Theophylline; Xanthines	1994
The P1-purinoceptors that mediate the prejunctional inhibitory effect of adenosine on capsaicin-sensitive nonadrenergic noncholinergic neurotransmission in the rat mesenteric arterial bed are of the A1 subtype. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: Adenosine; Adrenergic Fibers; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cholinergic Fibers; Drug Interactions; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Muscle Tonus; Muscle, Smooth, Vascular; Neuromuscular Junction; Rats; Rats, Wistar; Receptors, Purinergic P1; Sensitivity and Specificity; Synaptic Transmission; Theophylline; Vasodilation; Xanthines	1993
Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts. Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:8 Topics: Adenosine; Adenosine Deaminase; Animals; Blood Flow Velocity; Cardiac Output; Coronary Circulation; Disease Models, Animal; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Lactates; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Neutrophils; Receptors, Purinergic P1; Theophylline; Xanthines	1993
Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents. Neuroscience letters, 1993, Sep-03, Volume: 159, Issue:1-2 Topics: Adenosine; Animals; Electrophysiology; Hypoxia; In Vitro Techniques; Models, Neurological; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Synapses; Theophylline; Xanthines	1993
Adenosine, a "retaliatory" metabolite, promotes anoxia tolerance in turtle brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1993, Volume: 13, Issue:4 Topics: Adenosine; Animals; Brain; Cerebellum; Hypoxia; In Vitro Techniques; Purinergic Antagonists; Theophylline; Turtles; Xanthines	1993
Effect of adenosine on heart rate in isolated muskrat and guinea pig hearts. The American journal of physiology, 1993, Volume: 265, Issue:1 Pt 2 Topics: Adenosine; Adenosine Deaminase; Animals; Arvicolinae; Guinea Pigs; Heart Rate; In Vitro Techniques; Reference Values; Theophylline; Thioinosine; Xanthines	1993
A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide. British journal of pharmacology, 1993, Volume: 109, Issue:2 Topics: Adenosine; Animals; Antihypertensive Agents; Arginine; Coronary Vessels; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenethylamines; Prostaglandins; Receptors, Purinergic; Theophylline; Vasodilation; Xanthines	1993
Effect of adenosine receptor ligands on cAMP content in human airways and peripheral lung. American journal of respiratory cell and molecular biology, 1993, Volume: 9, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Aged; Child; Cromolyn Sodium; Cyclic AMP; Female; Humans; Ligands; Lung; Male; Middle Aged; Phenethylamines; Receptors, Purinergic; Respiratory System; Theophylline; Xanthines	1993
Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus. Neuroscience letters, 1993, May-14, Volume: 154, Issue:1-2 Topics: Adenosine; Animals; Dendrites; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Neurons, Afferent; Purinergic Antagonists; Rats; Synapses; Synaptic Transmission; Theophylline; Xanthines	1993
Blockade of adenosine receptors unmasks a stimulatory effect of ATP on cardiac contractility. British journal of pharmacology, 1993, Volume: 109, Issue:4 Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Protein Synthesis Inhibitors; Purinergic P1 Receptor Antagonists; Stimulation, Chemical; Suramin; Theophylline; Triazines; Xanthines	1993
Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 2 Topics: Adenosine; Allosteric Regulation; Animals; Atrial Function; Depression, Chemical; Drug Synergism; Heart; Heart Atria; Heart Rate; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Theophylline; Thiophenes; Xanthines	1993
Differential sensitization of cardiac actions of adenosine in rats after chronic theophylline treatment. The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Heart; Heart Atria; Male; Myocardium; Rats; Rats, Wistar; Receptors, Purinergic; Theophylline; Time Factors; Up-Regulation; Xanthines	1993
Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets. British journal of clinical pharmacology, 1995, Volume: 40, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Antihypertensive Agents; Cyclic AMP; Humans; Middle Aged; Phenethylamines; Phenylisopropyladenosine; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Purines; Receptors, Purinergic P1; Serotonin; Sulfonamides; Theophylline; Vasodilator Agents; Xanthines	1995
The role of adenosine in the hypotensive actions of morphine. European journal of pharmacology, 1995, Nov-24, Volume: 286, Issue:3 Topics: Adenosine; Animals; Blood Pressure; Female; Guanethidine; Morphine; Narcotics; Rats; Rats, Wistar; Receptors, Purinergic P1; Theobromine; Theophylline; Xanthines	1995
Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine. Life sciences, 1996, Volume: 58, Issue:9 Topics: Analysis of Variance; Animals; Brain; Caudate Nucleus; Cerebellum; Cerebral Cortex; Globus Pallidus; Hippocampus; Male; Organ Specificity; Phenylisopropyladenosine; Putamen; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reference Values; RNA, Messenger; Theophylline; Time Factors; Xanthines	1996
Action of adenosine receptor antagonists on hypoxia-induced effects in the rat hippocampus in vitro. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: Adenosine; Animals; Corpus Striatum; Dizocilpine Maleate; Hypoxia; Male; Membrane Potentials; Microelectrodes; Neuroglia; Neuroprotective Agents; Phosphodiesterase Inhibitors; Potassium; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	1995
Characterization of P1-purinoceptors on rat isolated duodenum longitudinal muscle and muscularis mucosae. British journal of pharmacology, 1996, Volume: 117, Issue:1 Topics: Adenosine; Animals; Duodenum; Male; Muscle Relaxation; Muscle, Smooth; Rats; Receptors, Purinergic P1; Theophylline; Xanthines	1996
Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells. Journal of neurochemistry, 1996, Volume: 67, Issue:5 Topics: 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylyl Cyclases; Animals; Binding, Competitive; Cell Membrane; Cerebellum; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Kinetics; Neurons; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline; Time Factors; Xanthines	1996
Modulation by extracellular ATP of L-type calcium channels in guinea-pig single sinoatrial nodal cell. British journal of pharmacology, 1996, Volume: 119, Issue:7 Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Extracellular Space; Female; Guinea Pigs; In Vitro Techniques; Male; Nucleosides; Nucleotides; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Pyridoxal Phosphate; Sinoatrial Node; Theophylline; Xanthines	1996
Role of adenosine receptor subtypes in neural stunning of sympathetic coronary innervation. The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2 Topics: Adenosine; Animals; Coronary Vessels; Dogs; Female; Male; Myocardial Stunning; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Sympathetic Nervous System; Theobromine; Theophylline; Vasoconstriction; Xanthines	1997
Dual activation of adenosine A1 and A3 receptors mediates preconditioning of isolated cardiac myocytes. European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3 Topics: Animals; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Myocardium; Polymerase Chain Reaction; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic P1; Theophylline; Transcription, Genetic; Xanthines	1997
Adenosine release mediates cyanide-induced suppression of CA1 neuronal activity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Apr-01, Volume: 17, Issue:7 Topics: Adenosine; Animals; Dipyridamole; Evoked Potentials; Excitatory Postsynaptic Potentials; Glyburide; Hippocampus; In Vitro Techniques; Male; Neurons; Potassium Cyanide; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Synapses; Theophylline; Xanthines	1997
Adenosine activates mesangial cell proliferation. Cellular signalling, 1997, Volume: 9, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cell Division; Cells, Cultured; Cyclic AMP; Glomerular Mesangium; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Sulfonamides; Theophylline; Thymidine; Xanthines	1997
Effects of theophylline and dibutyryl-cAMP on adenosine receptors and heart rate in cultured cardiocytes. Journal of basic and clinical physiology and pharmacology, 1996, Volume: 7, Issue:4 Topics: Animals; Bucladesine; Cells, Cultured; Creatine Kinase; Dose-Response Relationship, Drug; Heart Rate; Kinetics; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptors, Purinergic P1; Reproducibility of Results; Theophylline; Xanthines	1996
A1-adenosine receptor antagonists block endotoxin-induced lung injury. The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 1 Topics: Animals; Cats; Endotoxins; Lung; Lung Diseases; Microscopy, Electron; Purinergic P1 Receptor Antagonists; Theophylline; Xanthines	1997
Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice. Life sciences, 1997, Volume: 60, Issue:17 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antineoplastic Agents; Male; Mice; Motor Activity; Purinergic P1 Receptor Agonists; Purines; Sulfonamides; Theophylline; Xanthines	1997
Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jun-15, Volume: 17, Issue:12 Topics: Adenosine; Animals; Caffeine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Glipizide; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Theophylline; Tolbutamide; Xanthines	1997
Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats. European journal of pharmacology, 1997, Jun-11, Volume: 328, Issue:2-3 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Catalepsy; Dopamine Antagonists; Haloperidol; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Scopolamine; Theobromine; Theophylline; Xanthines	1997
Prevention of radiocontrast-induced nephropathy by adenosine antagonists in rats with chronic nitric oxide deficiency. Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:7 Topics: Acute Kidney Injury; Adenosine; Animals; Blood Pressure; Contrast Media; Disease Models, Animal; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Renal Circulation; Theophylline; Vasoconstriction; Xanthines	1997
Adenosine depresses transmitter release but is not the basis for 'tetanic fade' at the neuromuscular junction of the rat. Neuroscience letters, 1997, Jul-18, Volume: 230, Issue:2 Topics: Adenosine; Animals; Diaphragm; Electric Stimulation; Feedback; Female; In Vitro Techniques; Motor Endplate; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Rats; Theophylline; Xanthines	1997
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Enzyme Inhibitors; Hippocampus; Neurons; Neurotoxins; Nitric Oxide; Organ Culture Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Theophylline; Xanthines	1997
Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats. Kidney international, 1997, Volume: 52, Issue:2 Topics: Adenine; Adenosine; Adenosine Diphosphate; Animals; Antihypertensive Agents; Carbon Monoxide; Dipyridamole; Diuretics; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Gene Expression; Hypoxia; Kidney; Male; Oxygen; Phenethylamines; Phosphodiesterase Inhibitors; Piperazines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Theophylline; Vasodilator Agents; Xanthines	1997
A possible mechanism for the aglycemia-induced depression of glutamatergic excitation in the striatum. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:10 Topics: Adenosine Triphosphate; Animals; Corpus Striatum; Electric Conductivity; Electrophysiology; Glucose; Glutamic Acid; Hypoglycemia; Microelectrodes; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synaptic Transmission; Theophylline; Xanthines	1997
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists. Neuropharmacology, 1997, Volume: 36, Issue:9 Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain; Brain Ischemia; Cerebrovascular Circulation; Female; Hypoxia, Brain; Male; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; RNA, Messenger; Theophylline; Triazoles; Xanthines	1997
Adenosine-induced relaxation of cultured bovine retinal pericytes. Investigative ophthalmology & visual science, 1997, Volume: 38, Issue:13 Topics: Adenosine; Animals; Capillaries; Cattle; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Purinergic P1 Receptor Antagonists; Pyrazines; Receptors, Purinergic P1; Retinal Vessels; Theophylline; Vasodilator Agents; Xanthines	1997
Cyclopentyladenosine-induced homologous down-regulation of A1 adenosine receptors (A1AR) in intact neurons is accompanied by receptor sequestration but not a reduction in A1AR mRNA expression or G protein alpha-subunit content. Journal of neurochemistry, 1998, Volume: 71, Issue:1 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cells, Cultured; Cerebellum; Down-Regulation; Gene Expression; GTP-Binding Protein alpha Subunits, Gs; Neurons; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Theophylline; Tritium; Xanthines	1998
Decreased presynaptic sensitivity to adenosine after cocaine withdrawal. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Oct-01, Volume: 18, Issue:19 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Affinity Labels; Animals; Cocaine; Dipyridamole; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Nucleus Accumbens; Phosphodiesterase Inhibitors; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Thioinosine; Vasodilator Agents; Xanthines	1998
Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochemical pharmacology, 1998, Dec-01, Volume: 56, Issue:11 Topics: Adenosine; Alanine; Amino Acid Substitution; Animals; Binding, Competitive; CHO Cells; Cricetinae; Entropy; Humans; Kinetics; Point Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptors, Purinergic P1; Theophylline; Thermodynamics; Threonine; Transfection; Xanthines	1998
Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells. The European journal of neuroscience, 1999, Volume: 11, Issue:2 Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carotid Body; Catecholamines; Chemoreceptor Cells; Dose-Response Relationship, Drug; Electrophysiology; Hypoxia; Ion Channel Gating; Membrane Potentials; Neuroprotective Agents; omega-Conotoxin GVIA; Peptides; Potassium; Rabbits; Sodium; Tetrodotoxin; Theophylline; Tritium; Xanthines	1999
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1 Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines	1999
A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission. British journal of pharmacology, 1999, Volume: 126, Issue:4 Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Indomethacin; Male; Muscle Relaxation; Receptors, Purinergic P1; Swine; Synaptic Transmission; Theophylline; Ureter; Xanthines	1999
Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine. Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:2 Topics: Adenosine; Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Combinations; Male; Pentylenetetrazole; Phenobarbital; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Theophylline; Xanthines	1999
Effects of A1-adenosine receptor antagonists on purinergic transmission in the guinea-pig vas deferens in vitro. British journal of pharmacology, 1999, Volume: 126, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Neuroeffector Junction; Phentolamine; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Synaptic Transmission; Theophylline; Thioinosine; Vas Deferens; Xanthines; Yohimbine	1999
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices. British journal of pharmacology, 1999, Volume: 127, Issue:3 Topics: Adenosine; Animals; Brain Ischemia; Extracellular Space; Hippocampus; In Vitro Techniques; Kinetics; Male; Oxygen; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synaptic Transmission; Theophylline; Xanthines	1999
Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2 Topics: Animals; Behavior, Animal; Caffeine; Cocaine; Extinction, Psychological; Male; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Reward; Substance Abuse, Intravenous; Theophylline; Triazoles; Xanthines	1999
Pharmacological characterization of adenosine A1 receptors and its functional role in brown trout (Salmo trutta) brain. Brain research, 1999, Aug-07, Volume: 837, Issue:1-2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain; Cell Membrane; Glutamic Acid; Guanosine Diphosphate; Kinetics; Neuroprotective Agents; Radioligand Assay; Receptors, Purinergic P1; Synaptosomes; Theophylline; Tritium; Trout; Xanthines	1999
Do ryanodine receptors regulate transmitter release at the neuromuscular junction of rat? Neuroscience letters, 1999, Oct-29, Volume: 274, Issue:3 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Central Nervous System Stimulants; Gallic Acid; Membrane Potentials; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Theophylline; Xanthines	1999
Acute peroxide treatment of rat hippocampal slices induces adenosine-mediated inhibition of excitatory transmission in area CA1. Neuroscience letters, 1999, Oct-22, Volume: 274, Issue:2 Topics: Adenosine; Adrenergic alpha-1 Receptor Antagonists; Animals; Excitatory Postsynaptic Potentials; Ferrous Compounds; Hippocampus; Hydrogen Peroxide; Male; Neural Inhibition; Organ Culture Techniques; Oxidants; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline; Xanthines	1999
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism. Journal of neurophysiology, 2000, Volume: 83, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines	2000
Distinct modulation of evoked and spontaneous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat. The Journal of physiology, 2001, Feb-01, Volume: 530, Issue:Pt 3 Topics: Adenosine Triphosphate; Animals; Brain Stem; Evoked Potentials; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Male; Neurons; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Purinergic; Solitary Nucleus; Theophylline; Uridine Triphosphate; Xanthines	2001
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. Cardiovascular research, 2001, Volume: 49, Issue:4 Topics: Adenosine; Analysis of Variance; Animals; Brimonidine Tartrate; Electric Stimulation; Enzyme Inhibitors; Male; Myocardial Stunning; Myocardium; Norepinephrine; Perfusion; Phenethylamines; Phenylisopropyladenosine; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Sympathetic Nervous System; Theophylline; Time Factors; Xanthines	2001
Effect of intracarotid injection of adenosine on the activity of RVLM neurons in barodenervated rats. Sheng li xue bao : [Acta physiologica Sinica], 1998, Volume: 50, Issue:6 Topics: Adenosine; Animals; Carotid Arteries; Carotid Sinus; Electrophysiology; Injections, Intra-Arterial; Medulla Oblongata; Neurons; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	1998
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil. Brain research, 2001, Aug-10, Volume: 910, Issue:1-2 Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Ischemic Preconditioning; Male; Nerve Degeneration; Neurons; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Xanthines	2001
Effect of intracarotid administration of adenosine on the activity of area postrema neurons in barodenervated rats. Sheng li xue bao : [Acta physiologica Sinica], 1999, Volume: 51, Issue:6 Topics: Adenosine; Animals; Carotid Arteries; Carotid Sinus; Denervation; Electrophysiology; Injections, Intra-Arterial; Male; Medulla Oblongata; Neurons; Pressoreceptors; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Theophylline; Xanthines	1999
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines	2001
Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. Autonomic neuroscience : basic & clinical, 2000, Oct-02, Volume: 83, Issue:3 Topics: Adenosine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Glycogen; Hypoglycemic Agents; Insulin; Male; Muscle, Skeletal; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Streptozocin; Theophylline; Triglycerides; Xanthines	2000
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	2001
Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:5 Topics: Adenine; Administration, Topical; Animals; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials, Somatosensory; Injections, Intraperitoneal; Male; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines	2001
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats. Japanese journal of pharmacology, 2001, Volume: 87, Issue:2 Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preconditioning; Kidney; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Renal Artery Obstruction; Renal Circulation; Reperfusion Injury; Theobromine; Theophylline; Time Factors; Ultrasonography, Doppler, Pulsed; Xanthines	2001
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP. Cellular signalling, 2002, Volume: 14, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; B-Lymphocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Spleen; Theophylline; Tumor Cells, Cultured; Up-Regulation; Xanthines	2002
Effects of microinjection of adenosine into area postrema on heart rate, blood pressure and renal sympathetic nerve activity in rats. Sheng li xue bao : [Acta physiologica Sinica], 2000, Volume: 52, Issue:4 Topics: Adenosine; Animals; Blood Pressure; Glyburide; Heart Rate; Kidney; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Theophylline; Xanthines	2000
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney. European journal of pharmacology, 2002, May-10, Volume: 442, Issue:3 Topics: Aminophylline; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Caffeine; Catalase; Cisplatin; Glutathione Peroxidase; Kidney; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Superoxide Dismutase; Theophylline; Xanthines	2002
Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. Journal of neurochemistry, 2002, Volume: 82, Issue:3 Topics: Animals; Binding, Competitive; Brain; Caffeine; Down-Regulation; Female; Gestational Age; Pregnancy; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Tritium; Xanthines	2002
Glucose-induced islet blood flow increase in rats: interaction between nervous and metabolic mediators. American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:3 Topics: Adenosine; Animals; Dipyridamole; Glucose; Islets of Langerhans; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Theobromine; Theophylline; Vagotomy; Vasodilator Agents; Xanthines	2002
Characterization of the cAMP binding site of purified S-adenosyl-homocysteine hydrolase from bovine kidney. Biochemical pharmacology, 2002, Oct-15, Volume: 64, Issue:8 Topics: Adenosylhomocysteinase; Animals; Binding Sites; Cattle; Cyclic AMP; Hydrolases; Hypoxanthine; Kidney; Theophylline; Tritium; Xanthines	2002
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7 Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines	2003
Adenosine mediates decreased cerebral metabolic rate and increased cerebral blood flow during acute moderate hypoxia in the near-term fetal sheep. The Journal of physiology, 2003, Dec-15, Volume: 553, Issue:Pt 3 Topics: Adenosine; Animals; Blood Flow Velocity; Blood Gas Analysis; Blood Glucose; Brain; Cerebrovascular Circulation; Energy Metabolism; Fetal Hypoxia; Gestational Age; Hemoglobins; Infusions, Intravenous; Lactic Acid; Oxyhemoglobins; Purinergic P1 Receptor Antagonists; Sheep; Theophylline; Xanthines	2003
Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice. Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:10 Topics: Adenosine A1 Receptor Antagonists; Analgesia; Animals; Behavior, Animal; Formaldehyde; Male; Mice; Mice, Inbred Strains; Pain; Receptor, Adenosine A1; Stress, Psychological; Theophylline; Triazines; Triazoles; Walking; Xanthines	2003
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. Brain research, 2004, Jul-23, Volume: 1015, Issue:1-2 Topics: Adrenergic alpha-Antagonists; Animals; Enzyme Inhibitors; Intraocular Pressure; Ischemia; Ischemic Preconditioning; Male; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Vessels; Theophylline; Time Factors; Xanthines	2004
A "locked-on," constitutively active mutant of the adenosine A1 receptor. European journal of pharmacology, 2005, Mar-07, Volume: 510, Issue:1-2 Topics: Adenosine; Animals; Binding, Competitive; Cell Line; Cell Membrane; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Mutation; Plasmids; Radioligand Assay; Receptor, Adenosine A1; Sodium; Sulfur Radioisotopes; Theophylline; Thiophenes; Transfection; Tritium; Xanthines	2005
Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice. Peptides, 2005, Volume: 26, Issue:5 Topics: Analgesics; Animals; Gene Expression; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Neuropeptides; Nociceptin; Opioid Peptides; Orexin Receptors; Orexins; Pain Measurement; Purinergic P1 Receptor Antagonists; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Theophylline; Xanthines	2005
Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. Cardiovascular research, 2005, Jul-01, Volume: 67, Issue:1 Topics: Adenosine; Animals; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Perfusion; Purinergic P1 Receptor Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Xanthines	2005
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1 Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Androstadienes; Animals; Butadienes; Caffeine; Female; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Purines; Rabbits; Receptors, Purinergic P1; Theophylline; Wortmannin; Xanthines	2006
Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience, 2006, Volume: 138, Issue:4 Topics: 2-Chloroadenosine; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Disease Models, Animal; Endocytosis; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia-Ischemia, Brain; Male; Neural Inhibition; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Adenosine A1; Synaptic Transmission; Theophylline; Xanthines	2006
The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat. The Journal of physiology, 2006, Aug-15, Volume: 575, Issue:Pt 1 Topics: Adenosine; Animals; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Guanidines; Heart Rate; Hemodynamics; Hypoxia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptor, Adenosine A1; Respiration; Respiratory Function Tests; Theophylline; Xanthines	2006
Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:4 Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Chemical and Drug Induced Liver Injury; Denervation; Disease Models, Animal; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Renal Insufficiency; Sodium; Theobromine; Theophylline; Thioacetamide; Urine; Xanthines	2006
Flavonoids as antagonists at A1 adenosine receptors. Phytotherapy research : PTR, 2006, Volume: 20, Issue:11 Topics: Adenosine A1 Receptor Antagonists; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Conductivity; Female; Flavonoids; Guinea Pigs; Ileum; Male; Muscle Contraction; Quercetin; Radioligand Assay; Receptor, Adenosine A1; Theophylline; Xanthines	2006
Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine. Experimental physiology, 2007, Volume: 92, Issue:1 Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Receptor, Adenosine A1; Theophylline; Time Factors; Ventricular Function, Left; Ventricular Pressure; Xanthines	2007
A preliminary study on the interaction of fluvoxamine and adenosine receptor on isolated Guinea-pig atria. The International journal of neuroscience, 2006, Volume: 116, Issue:12 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Atropine; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluvoxamine; Guinea Pigs; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pilot Projects; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Selective Serotonin Reuptake Inhibitors; Theophylline; Xanthines	2006
Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Ischemic Preconditioning; Lung; Male; Malondialdehyde; Muscle Contraction; Muscle, Smooth, Vascular; Organ Size; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Receptor, Adenosine A1; Reperfusion Injury; Theophylline; Xanthines	2007
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines. European journal of pharmacology, 2007, Aug-13, Volume: 569, Issue:1-2 Topics: 5'-Nucleotidase; Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Gene Expression Regulation, Enzymologic; Glioma; Humans; Indomethacin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Time Factors; Triazoles; Xanthines	2007
Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007, Volume: 58 Suppl 5, Issue:Pt 1 Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Humans; Monocytes; Papaverine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Reactive Oxygen Species; Receptor, Adenosine A1; Receptors, Adenosine A2; Theophylline; Xanthines	2007
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines	2008
Adenosine as an endogenous regulating factor of hippocampal sharp waves. Hippocampus, 2009, Volume: 19, Issue:2 Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Membrane Potentials; Mice; Mice, Inbred C57BL; Microelectrodes; Nucleoside Transport Proteins; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Theophylline; Xanthines	2009
Endogenous adenosine A1 receptor activation underlies the transient post-ischemic rhythmic delta EEG activity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2011, Volume: 122, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Delta Rhythm; Disease Models, Animal; Electrocardiography; Electroencephalography; Heart Rate; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Statistics, Nonparametric; Theophylline; Xanthines	2011
Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. The Journal of physiology, 2010, Dec-15, Volume: 588, Issue:Pt 24 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bradycardia; Endothelium, Vascular; Female; Hypoxia; Male; Muscle, Skeletal; Pregnancy; Prenatal Exposure Delayed Effects; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Theophylline; Vasodilation; Xanthines	2010
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor. The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:1 Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Chromatography, High Pressure Liquid; Constriction; Disease Models, Animal; Dogs; Ischemic Preconditioning; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Nucleoside Transport Proteins; Receptor, Adenosine A1; Theophylline; Thioinosine; Xanthines	2012
Evidence for constitutively-active adenosine receptors at mammalian motor nerve endings. European journal of pharmacology, 2012, Jun-15, Volume: 685, Issue:1-3 Topics: Acetylcholine; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Animals; Calcium; Dose-Response Relationship, Drug; Drug Inverse Agonism; Magnesium; Mice; Motor Neurons; Nerve Endings; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Xanthines	2012
Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices. Neuroscience, 2012, Oct-25, Volume: 223 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Biophysics; Brain; CA1 Region, Hippocampal; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Mice; Mice, Inbred C57BL; Nerve Fibers; Neural Inhibition; Potassium Chloride; Quinoxalines; Receptors, Purinergic P1; Theophylline; Time Factors; Xanthines	2012
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping. Circulation, 2014, Jul-22, Volume: 130, Issue:4 Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Atrial Fibrillation; Bradycardia; Cardiac Pacing, Artificial; Dogs; Dose-Response Relationship, Drug; Fibrosis; Heart Conduction System; Heart Failure; Receptor, Adenosine A1; Sinoatrial Node; Tachycardia; Theophylline; Up-Regulation; Voltage-Sensitive Dye Imaging; Xanthines	2014
Methylxanthine reversal of opioid-induced respiratory depression in the neonatal rat: mechanism and location of action. Respiratory physiology & neurobiology, 2014, Aug-15, Volume: 200 Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Apnea; Brain Stem; Carotid Body; Central Nervous System Stimulants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Phrenic Nerve; Quinazolines; Rats, Sprague-Dawley; Respiration; Theobromine; Theophylline; Tissue Culture Techniques; Triazoles; Xanthines	2014
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system. Scientific reports, 2015, Nov-03, Volume: 5 Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease Models, Animal; Edema; Freund's Adjuvant; Hyperalgesia; Interleukin-1beta; Medicine, Chinese Traditional; Mice; Monoterpenes; Motor Activity; Paclitaxel; Pain Measurement; Theobromine; Theophylline; Xanthines	2015
Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation. Scientific reports, 2020, 08-25, Volume: 10, Issue:1 Topics: Animals; Benzilates; Clozapine; Freund's Adjuvant; Genes, Synthetic; GTP-Binding Protein alpha Subunits, Gq-G11; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscarinic Agonists; Neuroglia; Nociception; Nortropanes; Promoter Regions, Genetic; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Muscarinic M3; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Theophylline; Touch; Xanthines	2020