1,3-dipropyl-8-cyclopentylxanthine and enkephalin, ala(2)-mephe(4)-gly(5)-

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

Topics: Adenosine; Adenosine A1 Receptor Antagonists; Anilides; Drug Design; Ligands; Molecular Structure; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship

Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

Topics: Acetylcholine; Animals; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Male; Rabbits; Rats; Receptors, Opioid, mu; Retina; Strychnine; Xanthines

Topics: Analgesics, Opioid; Animals; Autoradiography; Binding, Competitive; Drug Therapy, Combination; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Male; Mesencephalon; Nociceptors; Pons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, Purinergic P1; Reticular Formation; Sleep, REM; Xanthines

Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Functional Laterality; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nociceptors; Pain Measurement; Photochemistry; Protein Binding; Radioligand Assay; Rats; Reaction Time; Receptor, Adenosine A1; Sciatica; Statistics, Nonparametric; Time Factors; Xanthines

Topics: Adenosine; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Receptors, Opioid, mu; Receptors, Purinergic P1; Substantia Gelatinosa; Synapses; Triazines; Triazoles; Xanthines

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotic Antagonists; Narcotics; Neurons; Oligopeptides; Patch-Clamp Techniques; Periaqueductal Gray; Protein Kinase Inhibitors; Receptors, Opioid, delta; Receptors, Opioid, mu; Strychnine; Sulfonamides; Synaptic Transmission; Time Factors; Xanthines

Topics: Adenosine; Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Cocaine; Dopamine Uptake Inhibitors; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Phenethylamines; Protein Binding; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred F344; Receptors, Opioid, mu; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Tritium; Up-Regulation; Xanthines

Topics: Adenosine A2 Receptor Antagonists; Analgesics, Opioid; Animals; Arachidonic Acids; Behavior, Animal; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Gene Expression Regulation; Heroin Dependence; Humans; Male; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Self Administration; Signal Transduction; Theobromine; Xanthines

Topics: Analysis of Variance; Animals; Arachidonic Acids; Autoradiography; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Operant; Eating; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Food Preferences; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Narcotic Antagonists; Peptides; Piperidines; Pons; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Sulfur Isotopes; Time Factors; Xanthines

Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Apnea; Brain Stem; Carotid Body; Central Nervous System Stimulants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Phrenic Nerve; Quinazolines; Rats, Sprague-Dawley; Respiration; Theobromine; Theophylline; Tissue Culture Techniques; Triazoles; Xanthines