1,3-dipropyl-8-cyclopentylxanthine has been researched along with caffeine in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.87) | 18.7374 |
| 1990's | 33 (28.70) | 18.2507 |
| 2000's | 55 (47.83) | 29.6817 |
| 2010's | 24 (20.87) | 24.3611 |
| 2020's | 2 (1.74) | 2.80 |
| Authors | Studies |
|---|---|
| Ishii, A; Karasawa, A; Kawakita, T; Kubo, K; Mizumoto, H; Nonaka, H; Shimada, J; Suzuki, F | 1 |
| Ishii, A; Nonaka, H; Shimada, J; Suzuki, F | 1 |
| Ichikawa, S; Ishii, A; Nonaka, H; Shimada, J; Suzuki, F | 1 |
| Jacobson, KA; van Galen, PJ; Williams, M | 1 |
| Ishii, A; Karasawa, A; Kubo, K; Mizumoto, H; Nonaka, H; Ohno, T; Shimada, J; Suzuki, F | 1 |
| Daly, JW; Padgett, WL; Shamim, MT; Ukena, D | 1 |
| Jacobson, KA; Ji, XD; Kim, HO; Melman, N; Olah, ME; Stiles, GL | 1 |
| Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Martini, C; Messini, L; Senatore, G | 1 |
| Fuse, E; Ichikawa, S; Ishii, A; Kobayashi, H; Nakamura, J; Nonaka, H; Shimada, J; Shiozaki, S; Suzuki, F | 1 |
| Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U | 1 |
| Maurinsh, J; Müller, CE; Sauer, R | 1 |
| Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE | 1 |
| Hess, S; Hölzl, J; Khudeir, N; Müller, CE; Scholle, S; Schumacher, B | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| El-Tayeb, A; Inamdar, GS; Li, W; Müller, CE; Scheiff, AB; Sudarsanam, V; Vasu, KK; Yerande, SG | 1 |
| Cheng, F; Liu, G; Tang, Y; Xu, Z | 1 |
| Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L | 1 |
| Terre'Blanche, G; Van der Walt, MM | 1 |
| Azuaje, J; Carbajales, C; Crespo, A; El Maatougui, A; Escalante, L; García-Mera, X; González-Gómez, M; Gutiérrez-de-Terán, H; Miguez, G; Sotelo, E | 1 |
| Behrenswerth, A; Fiene, A; Gollos, S; Heisig, F; Karcz, T; Kieć-Kononowicz, K; Köse, M; Müller, CE; Namasivayam, V | 1 |
| Adén, U; Fredholm, BB; Johansson, B; Lindström, K; Svenningsson, P | 1 |
| Domenici, MR; Frank, C; Sagratella, S; Scotti de Carolis, A; Zeng, YC | 1 |
| Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z | 1 |
| Wells, JN; Zhang, Y | 1 |
| Imaizumi, M; Miyazaki, S; Onodera, K | 1 |
| Hespel, P; Richter, EA; Vergauwen, L | 2 |
| Beckmann, H; Berger, W; Deckert, J; Heckers, S; Heinsen, H; Kleopa, K; Ransmayr, G; Riederer, P | 1 |
| Ahlberg, S; Brené, S; Fredholm, BB; Johansson, B; Lindefors, N; Persson, H; van der Ploeg, I | 1 |
| Phillis, JW | 1 |
| Jackson, EK; Kusaka, H; Pfeifer, CA; Tofovic, SP | 1 |
| Eigler, A; Endres, S; Greten, TF; Haslberger, C; Sinha, B; Sullivan, GW | 1 |
| Albin, RL; Frey, KA; Kearney, JA | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Pisani, A | 1 |
| Fredholm, BB; Georgiev, V; Johansson, B; Lindström, K | 1 |
| Cunha, RA; Gonçalves, ML; Ribeiro, JA | 1 |
| Fenu, S; Morelli, M | 1 |
| Khandwala, H; Loomis, CW; Zhang, Z | 1 |
| Jennings, NM; Li, B; Maxwell, KM; Rosenbaum, PS; Roth, S | 1 |
| Richardt, G; Schreieck, J | 1 |
| Fredholm, BB; Johansson, B; Kuzmin, A; Zvartau, EE | 1 |
| Kopf, SR; Melani, A; Pedata, F; Pepeu, G | 1 |
| Schwartz, AD; Whitacre, CL; Wilson, DF | 1 |
| Mahy, N; Robledo, P; Ursu, G | 1 |
| Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM | 2 |
| Costentin, J; El Yacoubi, M; Ledent, C; Ménard, JF; Parmentier, M; Vaugeois, JM | 1 |
| Dunwiddie, TV; Thümmler, S | 1 |
| Materi, LM; Rasmusson, DD; Semba, K | 1 |
| Dixon, AK; Freeman, TC; Lee, K; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Adén, U; Fredholm, BB; Herlenius, E; Tang, LQ | 1 |
| Chilian, WM; Jones, DW; Merkus, D; Nishikawa, Y; Stepp, DW | 1 |
| Beilstein, M; Castagnoli, K; Castagnoli, N; Chen, JF; Petzer, JP; Schwarzschild, MA; Sonsalla, PK; Staal, R; Xu, K; Xu, YH | 1 |
| Emala, CW; Lee, HT | 1 |
| Hamann, M; Richter, A | 1 |
| Dassesse, D; Ledent, C; Parmentier, M; Schiffmann, SN | 1 |
| Grbović, L; Pesić, S; Prostran, M; Radenković, M | 1 |
| Flood, AJ; Headrick, JP; Willems, L | 1 |
| Bhat, SG; Mei, Y; Mishra, S; Nie, Z; Ramkumar, V; Rybak, LP; Whitworth, CA | 1 |
| Acquas, E; Di Chiara, G; Tanda, G | 1 |
| Albasanz, JL; Fernández, M; León, D; Martín, M; Ruíz, MA | 1 |
| Antoniou, K; Ferré, S; Fuxe, K; Goldberg, SR; Justinova, Z; Karcz-Kubicha, M; Müller, CE; Pezzola, A; Popoli, P; Quarta, D; Reggio, R; Solinas, M; Terasmaa, A | 1 |
| O'Regan, MH; Phillis, JW | 1 |
| Goulart, EC; Kaster, MP; Rodrigues, AL; Rosa, AO; Rosso, MM; Santos, AR | 1 |
| Bremer, HC; Elsner, P; Girolomoni, G; Herouy, Y; Idzko, M; Mockenhaupt, M; Norgauer, J; Panther, E; Sorichter, S; Windisch, W | 1 |
| Bodineau, L; Frugière, A; Gaytan, S; Gros, F; Saadani-Makki, F | 1 |
| Batista, LC; Prediger, RD; Takahashi, RN | 1 |
| Goto, W; Hirao, M; Ikeda, T; Kobayashi, T; Oku, H; Sugiyama, T | 1 |
| Connole, L; Harkin, A; Maginn, M | 1 |
| Prediger, RD; Takahashi, RN | 1 |
| Albino-Teixeira, A; Carvalho, F; Fernandes, E; Laranjinha, J; Morato, M; Nunes, C; Pinho, D; Sousa, T | 1 |
| Fernandes, D; Prediger, RD; Takahashi, RN | 1 |
| Kogi, K; Konno, T; Nagai, A; Nakahata, N; Uchibori, T | 2 |
| Fredholm, BB; Gimenez, L; Johansson, B; Kuzmin, A; Ogren, SO | 1 |
| Cohen, MV; Downey, JM; Solenkova, NV; Solodushko, V | 1 |
| Fischer, W; Franke, H; Gröger-Arndt, H; Günther, A; Illes, P; Köfalvi, A; Madarász, E; Nörenberg, W; Schneider, D; Sperlágh, B; Vizi, ES; Wirkner, K | 1 |
| Boskovic, B; Prostran, M; Stepanovic-Petrovic, R; Tomic, M; Ugresic, N; Vuckovic, S | 1 |
| Conde, SV; Gonzalez, C; Obeso, A; Rigual, R; Rocher, A; Vicario, I | 1 |
| Ceyhan, M; Kayir, H; Uzbay, TI | 1 |
| Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, N; Vucković, SM | 1 |
| Bairam, A; Kinkead, R; Montandon, G | 1 |
| Gu, R; Li, W; Shan, H; Wang, J; Wang, WH; Xu, Y; Yang, B; Zhang, Y | 1 |
| Bassareo, V; Bauer, A; De Luca, MA; Di Chiara, G | 1 |
| Cohen-Williams, ME; Grzelak, ME; Higgins, GA; Hodgson, RA; Pond, AJ; Varty, GB | 1 |
| Binfaré, RW; Budni, J; Lobato, KR; Rodrigues, AL; Rosa, AO; Santos, AR | 1 |
| Coskun, C; Mutlu, D; Savci, V; Suzer, O; Yalcin, M; Yilmaz, MS | 1 |
| Jesse, CR; Nogueira, CW; Savegnago, L | 1 |
| Grzelak, ME; Hodgson, RA; Hunter, JC; Parker, EM; Pond, AJ; Varty, GB | 1 |
| Akgun, A; Gidener, S; Hocaoglu, N; Kalkan, S; Tuncok, Y | 1 |
| Ahlawat, R; Chavez-Valdez, R; Cristofalo, EA; Gauda, EB; Nathan, A; Wills-Karp, M | 1 |
| Baghdoyan, HA; Lydic, R; Van Dort, CJ | 1 |
| Chen, CY; Chiu, TH; Hsu, CW; Wang, CS | 1 |
| Fernandes, D; Pamplona, FA; Pandolfo, P; Pires, VA; Prediger, RD; Takahashi, RN | 1 |
| Collins, LE; Farrar, AM; Font, L; Nunes, EJ; Patel, V; Sager, TN; Salamone, JD; Schlar, DE | 1 |
| Agostinho, PM; Cognato, GP; Cunha, RA; Hockemeyer, J; Müller, CE; Souza, DO | 1 |
| Eyanagi, R; Imoto, M; Kuroki, H; Nishimura, S; Shimeno, H; Soeda, S; Toda, A; Uchiyama, H; Watanabe, S | 1 |
| Hoffman, AF; Kawamura, M; Laaris, N; Lupica, CR; Masino, SA | 1 |
| Chiu, TH; Hsu, CW; Wang, CS | 1 |
| Gossen, A; Harkin, A; Vanattou-Saïfoudine, N | 1 |
| Chatterjee, D; Chiu, GS; Darmody, PT; Freund, GG; Johnson, RW; Meling, DD; Walsh, JP | 1 |
| Azevedo, MS; Cechinel-Filho, V; Ferreira, VM; Lucena, GM; Matheus, FC; Prediger, RD; Tessele, PB | 1 |
| Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J | 1 |
| Liu, J; Reid, AR; Sawynok, J | 1 |
| Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J | 1 |
| Dubroqua, S; Singer, P; Yee, BK | 1 |
| Andriolo, V; Castorina, A; Giunta, S | 1 |
| Boehm, SL; Fritz, BM | 1 |
| Acevedo, J; Cabezas-Bou, E; Díaz-Ríos, M; Marrero-Cordero, LR; Matos-Vergara, N; Santana-Almansa, A | 1 |
| Faingold, CL; Kommajosyula, SP; Randall, M | 1 |
| Bai, X; He, J; Li, T; Qiao, H; Xu, J; Ye, X; Zhang, J; Zhang, W | 1 |
| Caumo, W; Dos Santos, ARS; Martins, DF; Martins, TC; Medeiros, LF; Nucci-Martins, C; Siteneski, A; Souza, A; Torres, ILS | 1 |
| Muñoz, MD; Solís, JM | 1 |
| Almeida, AS; Alves, CB; Faé, AHL; Machado, ACL; Marques, DM; Oliveira, DL; Porciúncula, LO; Portela, LVC | 1 |
| Boehm, S; Valenti, O; Zambon, A | 1 |
2 review(s) available for 1,3-dipropyl-8-cyclopentylxanthine and caffeine
| Article | Year |
|---|---|
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship | 1992 |
Fluorescent ligands for adenosine receptors.
Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 2013 |
113 other study(ies) available for 1,3-dipropyl-8-cyclopentylxanthine and caffeine
| Article | Year |
|---|---|
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.
Topics: Acute Kidney Injury; Adenosine; Animals; Cations, Monovalent; Diuretics; Male; Potassium; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sodium; Structure-Activity Relationship; Xanthines | 1992 |
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Guinea Pigs; Humans; Molecular Conformation; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship; Xanthines | 1992 |
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Corpus Striatum; Guinea Pigs; Molecular Structure; Prosencephalon; Purinergic Antagonists; Rats; Structure-Activity Relationship; Xanthines | 1992 |
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
Topics: Animals; Diuretics; Indicators and Reagents; Kidney; Kidney Function Tests; Kinetics; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1991 |
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines | 1989 |
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Brain Chemistry; Caffeine; CHO Cells; Cricetinae; Gene Expression; Iodine Radioisotopes; Molecular Structure; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection; Xanthines | 1994 |
8-Azaxanthine derivatives as antagonists of adenosine receptors.
Topics: Animals; Brain; Cattle; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines | 1994 |
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.
Topics: Adenosine; Amnesia; Animals; Avoidance Learning; Diuretics; Male; Mice; Motor Activity; Phenylisopropyladenosine; Rats; Rats, Wistar; Receptors, Purinergic; Scopolamine; Structure-Activity Relationship; Xanthines | 1993 |
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium | 1999 |
Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors.
Topics: Animals; Corpus Striatum; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Styrenes; Xanthines | 2000 |
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines | 2002 |
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.
Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP; GABA-A Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Lignans; Plant Roots; Purinergic P1 Receptor Agonists; Rats; Serotonin Antagonists; Valerian | 2002 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
Topics: Adenosine A1 Receptor Antagonists; Animals; Drug Design; Humans; Molecular Structure; Rats; Receptor, Adenosine A1; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2010 |
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.
Topics: Adenosine A2 Receptor Antagonists; Amino Acid Sequence; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Receptor, Adenosine A2B; Reproducibility of Results; Sequence Homology, Amino Acid | 2010 |
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.
Topics: Adenosine A1 Receptor Antagonists; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Binding; Receptor, Adenosine A1; Structure-Activity Relationship; Xanthines | 2015 |
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.
Topics: Adenosine A2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Pyrimidinones; Receptor, Adenosine A2B; Structure-Activity Relationship | 2016 |
Fluorescent-Labeled Selective Adenosine A
Topics: Adenosine A2 Receptor Antagonists; Animals; Binding, Competitive; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Flow Cytometry; Fluorescent Dyes; Humans; Mice; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Radioligand Assay; Rats; Receptor, Adenosine A2B | 2018 |
Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Corpus Striatum; Dose-Response Relationship, Drug; Genes, fos; Purinergic Antagonists; Quinazolines; Rats; RNA, Messenger; Triazoles; Xanthines | 1992 |
Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices.
Topics: Adenosine; Animals; Caffeine; Dizocilpine Maleate; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Male; Membrane Potentials; Phenethylamines; Phenylisopropyladenosine; Potassium; Purinergic Antagonists; Rats; Rats, Inbred Strains; Synapses; Xanthines | 1992 |
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines | 1990 |
The effects of chronic caffeine administration on peripheral adenosine receptors.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Binding Sites; Caffeine; Cell Membrane; Colforsin; Lipolysis; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Receptors, Purinergic; Xanthines | 1990 |
Effects of xanthine derivatives in a light/dark test in mice and the contribution of adenosine receptors.
Topics: Adenosine; Animals; Antihypertensive Agents; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Interactions; Light; Male; Mice; Phenethylamines; Purinergic P1 Receptor Antagonists; Structure-Activity Relationship; Theophylline; Xanthines | 1994 |
Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle.
Topics: Animals; Biological Transport; Caffeine; Cyclic AMP; Glucose; Insulin; Male; Muscle Contraction; Muscles; Oxygen Consumption; Rats; Rats, Wistar; Receptors, Purinergic P1; Xanthines | 1994 |
Adenosine A1 receptors in human hippocampus: inhibition of [3H]8-cyclopentyl-1,3-dipropylxanthine binding by antagonist drugs.
Topics: Aged; Anticonvulsants; Autoradiography; Binding, Competitive; Caffeine; Carbamazepine; Female; Hippocampus; Humans; Male; Middle Aged; Oxcarbazepine; Purinergic Antagonists; Receptors, Purinergic; Xanthines | 1993 |
Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain.
Topics: Adenosine; Animals; Autoradiography; Base Sequence; Blotting, Northern; Brain; Caffeine; Corpus Striatum; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Organ Specificity; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; RNA, Messenger; Xanthines | 1993 |
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil.
Topics: Animals; Behavior, Animal; Caffeine; Carotid Arteries; Cerebral Cortex; Cerebrovascular Disorders; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Locomotion; Male; Purinergic P1 Receptor Antagonists; Pyrazines; Reperfusion Injury; Xanthines | 1995 |
Central effects of caffeine on renal renin secretion and norepinephrine spillover.
Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Hydralazine; Injections, Intraventricular; Kidney; Male; Norepinephrine; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin; Vasodilator Agents; Xanthines | 1996 |
Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis.
Topics: Adenosine; Adenosine Deaminase; Caffeine; Dipyridamole; Humans; Inosine; Leukocytes, Mononuclear; Lipopolysaccharides; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrrolidinones; Rolipram; Tumor Necrosis Factor-alpha; Xanthines | 1997 |
Metabotropic glutamate agonist-induced rotation: a pharmacological, FOS immunohistochemical, and [14C]-2-deoxyglucose autoradiographic study.
Topics: Animals; Autoradiography; Basal Ganglia; Behavior, Animal; Caffeine; Carbon Radioisotopes; Cycloleucine; Deoxyglucose; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glucose; Glycine; Immunohistochemistry; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, Purinergic P1; Resorcinols; Rotation; Salicylamides; Thalamic Nuclei; Xanthines | 1997 |
Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses.
Topics: Adenosine; Animals; Caffeine; Cerebral Cortex; Corpus Striatum; Evoked Potentials; Glipizide; Glucose; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Potassium Channel Blockers; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Theophylline; Tolbutamide; Xanthines | 1997 |
Adenosine exerts a glycogen-sparing action in contracting rat skeletal muscle.
Topics: Adenosine; Animals; Caffeine; Cyclic AMP; Drug Combinations; Glycogen; Glycogen Synthase; Male; Muscle Contraction; Muscle, Skeletal; Phosphorylase a; Rats; Rats, Wistar; Theobromine; Xanthines | 1997 |
A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment.
Topics: Adenosine; Animals; Antihypertensive Agents; Autoradiography; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; In Situ Hybridization; Male; Mice; Mice, Inbred Strains; Phenethylamines; Radioligand Assay; Receptors, Purinergic P1; RNA, Messenger; Time Factors; Tritium; Xanthines | 1997 |
Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes.
Topics: 2-Chloroadenosine; Adenosine; Animals; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Hippocampus; Male; omega-Agatoxin IVA; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Spider Venoms; Synaptosomes; Veratridine; Xanthines | 1997 |
Motor stimulant effects of caffeine in 6-hydroxydopamine-lesioned rats are dependent on previous stimulation of dopamine receptors: a different role of D1 and D2 receptors.
Topics: Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Male; Motor Activity; Oxidopamine; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Stimulation, Chemical; Triazoles; Xanthines | 1998 |
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Strychnine; Xanthines | 1998 |
Differing roles of adenosine receptor subtypes in retinal ischemia-reperfusion injury in the rat.
Topics: Animals; Caffeine; Electroretinography; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reperfusion Injury; Retina; Time Factors; Xanthines | 1999 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines | 1999 |
Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice.
Topics: Animals; Behavior, Animal; Caffeine; Cocaine; Extinction, Psychological; Male; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Reward; Substance Abuse, Intravenous; Theophylline; Triazoles; Xanthines | 1999 |
Adenosine and memory storage: effect of A(1) and A(2) receptor antagonists.
Topics: Adenosine; Animals; Avoidance Learning; Caffeine; Central Nervous System Stimulants; Male; Memory; Mice; Purinergic P1 Receptor Antagonists; Pyrimidines; Triazoles; Xanthines | 1999 |
Do ryanodine receptors regulate transmitter release at the neuromuscular junction of rat?
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Central Nervous System Stimulants; Gallic Acid; Membrane Potentials; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission; Theophylline; Xanthines | 1999 |
Effects of adenosine and gamma-aminobutyric acid A receptor antagonists on N-methyl-D-aspartate induced neurotoxicity in the rat hippocampus.
Topics: Animals; Atrophy; Caffeine; Functional Laterality; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; N-Methylaspartate; Neurons; Neurotoxins; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Xanthines | 1999 |
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists.
Topics: Adenosine; Administration, Oral; Animals; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Administration Schedule; Injections, Intraperitoneal; Light; Male; Maze Learning; Mice; Mice, Knockout; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Reaction Time; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2000 |
The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors.
Topics: Analysis of Variance; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mice; Mice, Knockout; Motor Activity; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles; Xanthines | 2000 |
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines | 2000 |
Inhibition of synaptically evoked cortical acetylcholine release by adenosine: an in vivo microdialysis study in the rat.
Topics: Acetylcholine; Adenosine; Analysis of Variance; Animals; Caffeine; Cerebral Cortex; Chromatography, High Pressure Liquid; Dipyridamole; Male; Microdialysis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synapses; Xanthines | 2000 |
Adenosine receptor expression and function in rat striatal cholinergic interneurons.
Topics: Acetylcholine; Adenosine; Adenosine Deaminase; Animals; Baclofen; Bicuculline; Caffeine; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; GABA Antagonists; Gene Expression; Male; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Tritium; Xanthines | 2000 |
Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain.
Topics: Adenosine; Animals; Animals, Newborn; Autoradiography; Brain; Caffeine; Female; Gene Expression Regulation, Developmental; In Situ Hybridization; Phenethylamines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Purinergic P1; Tritium; Xanthines | 2000 |
Adenosine preconditions against endothelin-induced constriction of coronary arterioles.
Topics: Adenosine; Animals; Arterioles; Caffeine; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelin-1; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Microcirculation; Purinergic P1 Receptor Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthines | 2000 |
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Caffeine; Catechols; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Immunity, Innate; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Parkinsonian Disorders; Purinergic P1 Receptor Antagonists; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines | 2001 |
Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation.
Topics: Adenosine; Analysis of Variance; Animals; Bucladesine; Caffeine; Kidney; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Reperfusion Injury; Vasodilation; Xanthines | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
Acute and chronic caffeine administration differentially alters striatal gene expression in wild-type and adenosine A(2A) receptor-deficient mice.
Topics: Animals; Caffeine; Cytoskeletal Proteins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Growth Response Protein 1; Enkephalins; Gene Expression Regulation; Genes, Immediate-Early; Glutamate Decarboxylase; Hippocampus; Immediate-Early Proteins; Isoenzymes; Male; Mice; Mice, Knockout; Neostriatum; Nerve Tissue Proteins; Neuropeptides; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Somatosensory Cortex; Substance P; Transcription Factors; Xanthines | 2001 |
Characterization of adenosine action in isolated rat renal artery. Possible role of adenosine A(2A) receptors.
Topics: Adenosine; Animals; Caffeine; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Isotonic Solutions; Male; Models, Animal; Muscle Relaxation; Nitroarginine; Potassium Chloride; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Renal Artery; Tetraethylammonium; Vasodilator Agents; Xanthines | 2000 |
Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Diphosphate; Animals; Caffeine; Coronary Circulation; Heart; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Contraction; Myocardial Reperfusion Injury; Nitroprusside; Perfusion; Phenethylamines; Purinergic P1 Receptor Antagonists; Vasodilator Agents; Xanthines | 2002 |
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney.
Topics: Aminophylline; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Caffeine; Catalase; Cisplatin; Glutathione Peroxidase; Kidney; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Superoxide Dismutase; Theophylline; Xanthines | 2002 |
Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats.
Topics: Acetylcholine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Space; Injections, Intraperitoneal; Male; Microdialysis; Neuroprotective Agents; Nucleus Accumbens; Prefrontal Cortex; Presynaptic Terminals; Pyrimidines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazoles; Xanthines | 2002 |
Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats.
Topics: Animals; Binding, Competitive; Brain; Caffeine; Down-Regulation; Female; Gestational Age; Pregnancy; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Tritium; Xanthines | 2002 |
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines | 2003 |
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
Topics: Adenosine; Administration, Inhalation; Animals; Caffeine; Carbon Dioxide; Cerebral Cortex; Cerebral Veins; Cerebrovascular Circulation; Drug Interactions; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2003 |
Caffeine reduces hypnotic effects of alcohol through adenosine A2A receptor blockade.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Body Temperature; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dipyridamole; Drug Overdose; Ethanol; Hypnotics and Sedatives; Male; Mice; Mice, Knockout; Neuroprotective Agents; Pentobarbital; Postural Balance; Pyrimidines; Receptor, Adenosine A2A; Triazoles; Vasodilator Agents; Xanthines | 2003 |
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Female; Male; Mice; Motor Activity; Receptor, Adenosine A1; Receptor, Adenosine A2A; Stress, Psychological; Triazines; Triazoles; Xanthines | 2004 |
Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors.
Topics: Actins; Antigens, CD; Caffeine; Calcium; Cell Differentiation; Chemotaxis; Cytokines; Dendritic Cells; Dose-Response Relationship, Drug; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Inosine; Pertussis Toxin; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazoles; Xanthines | 2004 |
Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats.
Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Female; In Vitro Techniques; Medulla Oblongata; Neural Pathways; Pons; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-fos; Rats; Receptor, Adenosine A1; Respiratory Center; Respiratory Physiological Phenomena; Spinal Cord; Xanthines | 2004 |
Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Male; Maze Learning; Mice; Receptor, Adenosine A1; Triazines; Triazoles; Xanthines | 2004 |
Effects of adenosine on optic nerve head circulation in rabbits.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine A1 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Animals; Caffeine; Capillaries; Dose-Response Relationship, Drug; Glyburide; Injections; Injections, Intravenous; Optic Disk; Phenethylamines; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rabbits; Regional Blood Flow; Stimulation, Chemical; Vasodilation; Vitreous Body; Xanthines | 2004 |
Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Depressants; Drug Interactions; Ethanol; Male; Motor Skills; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Triazoles; Xanthines | 2004 |
Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Male; Memory, Short-Term; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Social Behavior; Triazines; Triazoles; Xanthines | 2005 |
Scavenging of nitric oxide by an antagonist of adenosine receptors.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dose-Response Relationship, Drug; Free Radical Scavengers; Male; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Wistar; Receptor, Adenosine A1; Xanthines | 2005 |
Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Caffeine; Discrimination Learning; Habituation, Psychophysiologic; Male; Memory Disorders; Memory, Short-Term; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A2A; Recognition, Psychology; Smell; Social Behavior; Social Environment; Species Specificity; Triazines; Triazoles; Xanthines | 2005 |
2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Alkynes; Animals; Antihypertensive Agents; Caffeine; Decanoic Acids; Glyburide; Hydroxy Acids; Hypotonic Solutions; Intraocular Pressure; Male; Ocular Hypertension; Phenethylamines; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Receptor, Adenosine A2A; Sodium Chloride; Time Factors; Xanthines | 2005 |
Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Early Growth Response Protein 1; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuroprotective Agents; Pyrimidines; RNA, Messenger; Triazoles; Xanthines | 2006 |
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt.
Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Androstadienes; Animals; Butadienes; Caffeine; Female; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Purines; Rabbits; Receptors, Purinergic P1; Theophylline; Wortmannin; Xanthines | 2006 |
Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Anesthetics, Local; Animals; Bicuculline; Caffeine; Calcium; Cell Count; Cells, Cultured; Cerebral Cortex; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fura-2; GABA Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Immunohistochemistry; In Vitro Techniques; Ischemia; Membrane Potentials; Microscopy, Confocal; Microtubule-Associated Proteins; Neurons; Patch-Clamp Techniques; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrodotoxin; Time Factors; Triazines; Tritium; Xanthines | 2005 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Pain; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Touch; Xanthines | 2006 |
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Carotid Body; Catecholamines; Central Nervous System Stimulants; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Hypoxia; Immunohistochemistry; Male; Potassium; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Presynaptic; Respiratory Mechanics; Triazines; Triazoles; Xanthines | 2006 |
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Caffeine; Convulsants; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Male; Mice; Pentylenetetrazole; Reaction Time; Receptor, Adenosine A1; Thiazepines; Time Factors; Xanthines | 2007 |
Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors.
Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Synergism; Functional Laterality; Hyperalgesia; Male; Oxcarbazepine; Peripheral Nervous System; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptor, Adenosine A1; Xanthines | 2006 |
Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Hypercapnia; Injections, Intraperitoneal; Male; Plethysmography; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Rest; Time Factors; Triazines; Triazoles; Xanthines | 2007 |
Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Eye; Flavins; Intraocular Pressure; Male; Rabbits; Regional Blood Flow; Retinal Vessels; Vasodilator Agents; Xanthines | 2007 |
Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenylyl Cyclases; Algorithms; Animals; Bucladesine; Caffeine; Dose-Response Relationship, Drug; Enzyme Activation; Female; Kidney; Male; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Adenosine A2; Stimulation, Chemical; Xanthines | 2007 |
Caffeine and accumbens shell dopamine.
Topics: Anesthetics; Animals; Caffeine; Chloral Hydrate; Dialysis Solutions; Dopamine; Dose-Response Relationship, Drug; Ketamine; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Xanthines | 2007 |
The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Amphetamine; Animals; Antipsychotic Agents; Attention; Caffeine; Central Nervous System Stimulants; Choice Behavior; Dopamine; Dose-Response Relationship, Drug; Male; Motor Activity; Phenethylamines; Psychomotor Performance; Purines; Rats; Reaction Time; Reflex, Startle; Xanthines | 2007 |
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aniline Compounds; Animals; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Dipyridamole; Female; Male; Mice; Motor Activity; Nucleoside Transport Proteins; Receptor, Adenosine A1; Receptor, Adenosine A2A; Swimming; Triazines; Triazoles; Xanthines; Zinc | 2008 |
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines | 2008 |
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Injections, Intraperitoneal; Male; Mice; Neuroprotective Agents; Organoselenium Compounds; Pain Measurement; Phosphodiesterase Inhibitors; Pyrimidines; Triazoles; Xanthines | 2008 |
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antipsychotic Agents; Caffeine; Catalepsy; Cebus; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Neurologic Examination; Purines; Pyrimidines; Receptor, Adenosine A2A; Saimiri; Triazoles; Xanthines | 2008 |
Effects of adenosine receptor antagonists on amitriptyline-induced QRS prolongation in isolated rat hearts.
Topics: Amitriptyline; Animals; Caffeine; Dose-Response Relationship, Drug; Heart; Heart Diseases; In Vitro Techniques; Male; Purinergic P1 Receptor Antagonists; Random Allocation; Rats; Rats, Wistar; Xanthines | 2008 |
Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors.
Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adult; Blotting, Western; Caffeine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Humans; Infant, Newborn; Interleukins; Lipopolysaccharides; Middle Aged; Monocytes; Purines; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Xanthines | 2009 |
Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.
Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Arousal; Behavior, Animal; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Electromyography; Male; Mice; Microdialysis; Phenethylamines; Phosphodiesterase Inhibitors; Prefrontal Cortex; Receptor, Adenosine A1; Receptors, Adenosine A2; Spectrum Analysis; Triazines; Triazoles; Xanthines | 2009 |
Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Conditioning, Operant; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrimidines; Reward; Triazoles; Xanthines | 2009 |
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Caffeine; Disease Models, Animal; Female; Male; Memory, Short-Term; Methylphenidate; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Recognition, Psychology; Triazines; Triazoles; Xanthines | 2009 |
Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Behavior, Animal; Caffeine; Central Nervous System Agents; Choice Behavior; Conditioning, Operant; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Feeding Behavior; Haloperidol; Male; Motivation; Purines; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Xanthines | 2009 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines | 2010 |
The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Caffeine; Darkness; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Haloperidol; Male; Mice; Motor Activity; Neurotransmitter Agents; Oseltamivir; Pyrimidines; Random Allocation; Triazoles; Xanthines | 2010 |
Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzoxazines; Biophysics; CA1 Region, Hippocampal; Caffeine; Calcium Channel Blockers; Dronabinol; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Piperidines; Presynaptic Terminals; Propanolamines; Pyrazoles; Quinoxalines; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Xanthines | 2010 |
Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred BALB C; Neostriatum; Neuroprotective Agents; Phosphorylation; Pyrimidines; Serine; Triazoles; Tyrosine 3-Monooxygenase; Xanthines | 2010 |
A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Hypothalamus; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Xanthines | 2011 |
Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.
Topics: Adenosine; Amino Acid Chloromethyl Ketones; Amnesia, Anterograde; Amygdala; Animals; Caffeine; Caspase 1; Caspase Inhibitors; Conditioning, Classical; Cues; Enzyme Activation; Fear; Hypoxia, Brain; Interleukin 1 Receptor Antagonist Protein; Male; MAP Kinase Signaling System; Maze Learning; Mental Recall; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxygen; Receptors, Interleukin-1 Type I; Receptors, Purinergic P1; Recognition, Psychology; Theobromine; Xanthines | 2012 |
Effects of ethanolic extract and naphthoquinones obtained from the bulbs of Cipura paludosa on short-term and long-term memory: involvement of adenosine A₁ and A₂A receptors.
Topics: Animals; Avoidance Learning; Brazil; Caffeine; Ethanol; Furans; Iridaceae; Male; Memory, Long-Term; Memory, Short-Term; Mice; Naphthoquinones; Plant Extracts; Plant Roots; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Triazines; Triazoles; Xanthines | 2013 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; Fenclonine; Hyperalgesia; Male; Mice; Morphine; Pain, Postoperative; Receptor, Adenosine A1; Xanthines; Yohimbine | 2013 |
Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline.
Topics: Adenosine A1 Receptor Antagonists; Amitriptyline; Analgesics; Animals; Caffeine; Female; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Inbred C57BL; Peripheral Nervous System; Phenols; Pyrazoles; Receptor, Adenosine A1; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Sulfonamides; Tetrahydronaphthalenes; Time Factors; Xanthines | 2013 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines | 2013 |
Sensorimotor gating is disrupted by acute but not chronic systemic exposure to caffeine in mice.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Male; Mice; Mice, Inbred C57BL; Prepulse Inhibition; Purinergic P1 Receptor Antagonists; Pyrimidines; Sensory Gating; Triazoles; Xanthines | 2014 |
Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aluminum Chloride; Aluminum Compounds; Amyloid beta-Peptides; Apoptosis; Astringents; Blotting, Western; Caffeine; Cell Proliferation; Cells, Cultured; Chlorides; Humans; Lipid Peroxidation; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Purinergic P1 Receptor Antagonists; Pyrimidines; Reactive Oxygen Species; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Small Interfering; Triazoles; Xanthines | 2014 |
Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Alcohol Drinking; Animals; Binge Drinking; Caffeine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Motor Activity; Receptors, Purinergic P1; Sucrose; Xanthines | 2015 |
Caffeine stimulates locomotor activity in the mammalian spinal cord via adenosine A1 receptor-dopamine D1 receptor interaction and PKA-dependent mechanisms.
Topics: Animals; Animals, Newborn; Caffeine; Central Nervous System Stimulants; Cyclic AMP-Dependent Protein Kinases; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agents; In Vitro Techniques; Mice; Mice, Inbred ICR; Motor Activity; N-Methylaspartate; Purinergic Agents; Receptor, Adenosine A1; Receptors, Dopamine D1; Serotonin; Spinal Cord; Xanthines | 2016 |
Susceptibility to seizure-induced sudden death in DBA/2 mice is altered by adenosine.
Topics: Adenosine; Animals; Caffeine; Death, Sudden; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Male; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyrimidines; Receptors, Purinergic P1; Respiration; Respiration Disorders; Seizures; Tubercidin; Xanthines | 2016 |
Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.
Topics: Adenosine; Alkaloids; Animals; Caffeine; Camellia; Drug Synergism; Hippocampus; Male; Mice; Pentobarbital; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Sleep Stages; Triazoles; Uric Acid; Xanthines | 2017 |
Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain.
Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Flumazenil; GABA Modulators; Hyperalgesia; Male; Mice; Morpholines; Naloxone; Narcotic Antagonists; Neuralgia; Pain Threshold; Physical Stimulation; Pyrazoles; Transcranial Direct Current Stimulation; Xanthines | 2018 |
Characterisation of the mechanisms underlying the special sensitivity of the CA2 hippocampal area to adenosine receptor antagonists.
Topics: Adenylyl Cyclases; Animals; CA1 Region, Hippocampal; CA2 Region, Hippocampal; Caffeine; Colforsin; Excitatory Postsynaptic Potentials; Male; Phosphodiesterase Inhibitors; Purinergic Agonists; Purinergic P1 Receptor Antagonists; Rats, Sprague-Dawley; Receptor, Adenosine A1; Rolipram; Synapses; Tissue Culture Techniques; Xanthines | 2019 |
Caffeine and adenosine A
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Animals; Attention Deficit Disorder with Hyperactivity; Caffeine; Cells, Cultured; Disease Models, Animal; Female; Frontal Lobe; Neurons; Pregnancy; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Adenosine A2A; Xanthines | 2020 |
Orchestration of Dopamine Neuron Population Activity in the Ventral Tegmental Area by Caffeine: Comparison With Amphetamine.
Topics: Amphetamine; Animals; Caffeine; Central Nervous System Stimulants; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Hippocampus; Locomotion; Male; Mice; Ventral Tegmental Area; Xanthines | 2021 |