Compounds > 1,3-dipropyl-8-cyclopentylxanthine

1,3-dipropyl-8-cyclopentylxanthine and adenosine-5'-(n-ethylcarboxamide)

1,3-dipropyl-8-cyclopentylxanthine has been researched along with adenosine-5'-(n-ethylcarboxamide) in 135 studies

Research

Studies (135)

TimeframeStudies, this research(%)All Research%
pre-19903 (2.22)18.7374
1990's82 (60.74)18.2507
2000's36 (26.67)29.6817
2010's13 (9.63)24.3611
2020's1 (0.74)2.80

Authors

AuthorsStudies
Jacobson, KA; van Galen, PJ; Williams, M1
Jacobson, KA; Olah, ME; Stiles, GL1
Jacobson, MA; Johnson, RG; Linden, J; Salvatore, CA; Taylor, HE1
Arslan, G; Dionisotti, S; Fredholm, BB; Kull, B; Ongini, E; Zocchi, C1
Glashofer, M; Jacobson, KA; Jiang, Q; Lee, BX; van Rhee, AM1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C1
Camp, D; Green, JM; Kaiser, SM; Moni, RW; Quinn, RJ; Schofield, PR; Townsend-Nicholson, A1
Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U1
Barbhaiya, H; IJzerman, AP; Rivkees, SA1
Baraldi, PG; Borea, PA; Cacciari, B; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Romagnoli, R; Spalluto, G; Varani, K1
Da Settimo, F; Greco, G; La Motta, C; Lavecchia, A; Marini, AM; Martini, C; Novellino, E; Primofiore, G; Taliani, S; Trincavelli, L1
Castelhano, AL; Ma, C; MacLennan, SJ; McKibben, B; Song, JP; Steinig, AG; Stewart, M1
Calabri, FR; Catarzi, D; Colotta, V; Deflorian, F; Filacchioni, G; Lenzi, O; Martini, C; Moro, S; Trincavelli, L; Varano, F1
Cosimelli, B; Da Settimo, A; Da Settimo, F; Ehlardo, M; Greco, G; Iadanza, M; Klotz, KN; La Motta, C; Lavecchia, A; Martini, C; Novellino, E; Primofiore, G; Rimoli, MG; Sala, A; Taliani, S; Trincavelli, ML; Tuscano, D1
Cohen, FE; Legname, G; May, BC; Prusiner, SB; Sherrill, J; Wallace, AC; Witkop, J; Zorn, JA1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Ciampi, O; Cosimelli, B; Da Settimo, F; Greco, G; La Motta, C; Marini, AM; Martinelli, A; Martini, C; Novellino, E; Primofiore, G; Salerno, S; Sergianni, V; Simorini, F; Taliani, S; Trincavelli, ML; Tuccinardi, T1
Bellandi, M; Ciampi, O; Cosimelli, B; Da Settimo, F; Ehlardo, M; Greco, G; La Motta, C; Martinelli, A; Martini, C; Novellino, E; Taliani, S; Trincavelli, ML; Tuccinardi, T1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Beukers, MW; Brussee, J; de Graaf, O; de Vries, H; Göblyös, A; Ijzerman, AP; Link, R; Mantri, M; Mulder-Krieger, T; van Veldhoven, J; von Frijtag Drabbe Künzel, JK1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Ciampi, O; Cosconati, S; Cosimelli, B; Da Settimo, F; Daniele, S; Greco, G; La Motta, C; Limongelli, V; Marinelli, L; Marini, AM; Martini, C; Mugnaini, L; Novellino, E; Salerno, S; Simorini, F; Taliani, S; Trincavelli, ML1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K1
Barresi, E; Cosconati, S; Cosimelli, B; Da Settimo, F; Daniele, S; Di Maro, S; Greco, G; La Motta, C; Marinelli, L; Marini, AM; Martini, C; Novellino, E; Pugliesi, I; Salerno, S; Simorini, F; Taliani, S; Trincavelli, ML1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L1
Barresi, E; Cosimelli, B; Da Settimo, F; Daniele, S; Giacomelli, C; Greco, G; Laneri, S; Martini, C; Novellino, E; Pugliesi, I; Severi, E; Taliani, S; Trincavelli, ML1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E1
Barresi, E; Collina, S; Cosconati, S; Cosimelli, B; Greco, G; Laneri, S; Martini, C; Novellino, E; Rossi, D; Sacchi, A; Taliani, S; Trincavelli, ML1
Comeo, E; Halls, ML; Hill, SJ; Kellam, B; Kindon, ND; May, LT; Nguyen, AT; Nowell, CJ; Scammells, PJ; Soave, M; Stoddart, LA; Trinh, P; White, JM1
López-Novoa, JM; Olivera, A; Tomás, M1
Földes, FF; Nagano, O; Nakatsuka, H; Ohta, Y; Reich, D; Sperlagh, B; Vizi, ES1
O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE1
Martin, PL1
Hourani, SM; Kitchen, I; Nicholls, J1
Canela, EI; Casadó, V; Casillas, T; Franco, R; Lluis, C; Mallol, J1
Correia-de-Sá, P; Ribeiro, JA; Sebastião, AM1
Galbani, P; Limbruno, U; Mariani, M; Ronca, G; Ronca-Testoni, S; Zucchi, R1
Ameri, A; Jurna, I1
Bowersox, S; Dement, W; Hawkins, M; Mignot, E; O'Connor, S; Radulovacki, M1
Palczewski, K; Ragazzi, E; Shryock, J1
IJzerman, AP; Nissen, P; Soudijn, W; van Galen, PJ; van Wijngaarden, I1
Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z1
Behnke, N; Müller, W; Neumann, J; Schmitz, W; Scholz, H; Stein, B1
Bruns, RF; Fergus, JH1
Illes, P; Regenold, JT1
Barry, SR1
Jamal, Z; Saggerson, ED1
Lohse, MJ; Schmitz, W; Scholz, H; Scholz, J; Schwabe, U; von der Leyen, H1
Ball, SG; Freshney, RI; Vaughan, PF; Woods, MD1
Lee, KS; Reddington, M1
Borea, PA; Dalpiaz, A; Gilli, G; Guerra, L; Varani, K1
Black, JW; Prentice, DJ; Shankley, NP1
Jarvis, JE; Reeves, JJ; Sheehan, MJ; Strong, P1
Chiba, S; Furukawa, Y; Kasama, M; Oguchi, T; Sawaki, S1
Späth, L; Starke, K; von Kügelgen, I1
Alexander, SP; Curtis, AR; Hill, SJ; Kendall, DA1
Coates, J; Green, MA; Sheehan, MJ; Strong, P1
Khoo, HE; Tan, CH; Tey, HB1
Akatsuka, Y; Egashira, K; Katsuda, Y; Narishige, T; Shimokawa, H; Takeshita, A; Ueno, H1
Martin, PL; Potts, AA1
Martin, PL; May, JM1
Figueira, MA; Hernandez, J; Pinto, F; Riberio, JA1
Baker, SP; Belardinelli, L; Olsson, RA; Scammells, PJ1
Yagil, Y1
Hunt, RH; Muller, MJ; Prior, T; Rangachari, PK1
Edwards, RM; Spielman, WS1
Alexander, SP; Cartmell, J; Kemp, JA; Kendall, DA1
Gupta, RC; Neumann, J; Watanabe, AM1
Joad, JP; Kott, KS1
Berman, RF; Janusz, CA1
Halfhide, EJ; Hourani, SM; Kitchen, I; Lee, BS; Nicholls, J1
Belloni, FL; Lee, HT; Linden, J; Thompson, CI1
Alexander, SP; Cooper, JA; Hill, SJ; Horn, EH; Rubin, PC1
Dickenson, JM; Hill, SJ; Megson, AC; Townsend-Nicholson, A1
Bottrill, FE; Hiley, CR; Richardson, PJ; Warnock, J1
Brownhill, VR; Hourani, SM; Kitchen, I2
Berger, M; Christoffel, F; Gebicke-Haerter, PJ; Northoff, H; Timmer, J; Van Calker, D1
Anderson, GF; Barraco, RA; Helfman, CC; Zhong, H1
Andrés, A; Fernández, M; Ros, M; Sanz, JM; Vendite, D1
Brownhill, VR; Hourani, SM; Kitchen, I; Peachey, JA1
Liang, B; Stein, B; Xu, H1
De Sarro, A; De Sarro, G; Donato Di Paola, E; Falconi, U; Ferreri, G1
Fredholm, BB; Svenningsson, P1
Eleno, N; Lopez-Novoa, JM; MacLaughlin, M; Martinez-Salgado, C; Olivera, A1
Gagalo, IT; Matuszek, MT1
Florio, C; Rosati, AM; Traversa, U; Vertua, R1
Coupar, IM; Hancock, DL1
Chopde, CT; Ghosh, AK; Mandhane, SN1
Antal, K; Cseppentö, A; Kovács, P; Szabó, JZ; Szentmiklósi, AJ; Ujfalusi, A1
Buxton, IL; Cheek, DJ; Smith, AD; Westfall, DP1
Bauer, J; Fiebich, BL; Heese, K; Otten, U1
Barlinski, J; Cano, E; Frossard, N; Lagente, V1
McGrath, JC; Moore, FP; Thomson, NC1
Hourani, SM; Nicholls, J1
Jarrott, B; Krstew, E; Lawrence, AJ1
Cutler, BS; Dobson, JG; Fenton, RA; Li, Jm; Peyton, BD; Powell, CC; Wheeler, HB1
Jankowski, J; Schlüter, H; Tepel, M; van der Giet, M; Zidek, W1
Hourani, SM; Kitchen, I; Peachey, JA1
Barahona, MV; Bustamante, S; García-Sacristán, A; Hernández, M; Orensanz, LM1
Coupar, IM1
Gandolfi, O; Lucchi, R; Notari, S; Poli, A; Traversa, U; Zampacavallo, G1
Khoo, HE; Mittal, RA; Tan, CH1
Enyeart, JJ; Xu, L1
Fei, Q; Loutzenhiser, R; Parker, M; Tang, L1
Leaney, JL; Milligan, G; Tinker, A1
Caruso-Neves, C; de Oliveira, CF; Filho, CC; Lopes, AG; Monteiro, SO1
Caigneaux, E; Falcón, J; Lelièvre, V; Muller, JM1
Dobson, JG; Fenton, RA; Monahan, TS; Sawmiller, DR1
Doering, A; Middlekauff, HR; Weiss, JN1
Kubota, Y; Kunitomo, M; Kwon, YM; Nakamura, K; Shinozuka, K; Tanaka, N; Tanioka, Y1
Coupar, IM; Tran, BL1
Dar, MS1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P1
Belem, PC; Chen, JF; Cronstein, B; Elson, G; Fink, JS; Jacobson, M; Leibovich, SJ; Montesinos, C; Pinhal-Enfield, G; Ramanathan, M; Rosania, A; Schwarzschild, MA1
Diniz, C; Gonçalves, J; Leal, S1
Frydenberg, M; Haynes, JM; Preston, A1
Mustafa, SJ; Oldenburg, PJ; Schnermann, J; Tawfik, HE1
Briones, R; Donoso, MV; Huidobro-Toro, JP; López, R; Miranda, R1
Hikichi, T; Kawahara, A; Kitaya, N; Mori, F; Takahashi, J; Yoshida, A1
Ji, XQ; Jiang, CL; Liu, DZ; Xie, KQ; Ye, Y; Zhu, XZ1
Cao, Y; Xie, KQ; Zhu, XZ1
Cohen, MV; Cui, L; Davis, AM; Downey, JM; Philipp, S; Yang, XM1
Anthes, JC; Correll, CC; Phelps, PT1
Jenner, TL; Rose'Meyer, RB1
Nakata, H; Namba, K; Suzuki, T; Tsuga, H1
Kubota, Y; Kunitomo, M; Mizuno, H; Morikawa, T; Nakamura, K; Shinozuka, K; Tanaka, N1
Hurley, DJ; Linden, JM; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML1
Krahn, T; Ledent, C; Mustafa, SJ; Ponnoth, DS; Roush, K; Sanjani, MS1
Blackburn, MR; Chen, JF; Desrosiers, MD; Mucsi, AD; Schnermann, JB; Shi, Y; Yang, A1
Adams, L; Baker, JG; Briddon, SJ; Hill, SJ; Kellam, B; May, LT; Middleton, R1

Reviews

2 review(s) available for 1,3-dipropyl-8-cyclopentylxanthine and adenosine-5'-(n-ethylcarboxamide)

ArticleYear
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship

1992
Fluorescent ligands for adenosine receptors.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1

2013

Other Studies

133 other study(ies) available for 1,3-dipropyl-8-cyclopentylxanthine and adenosine-5'-(n-ethylcarboxamide)

ArticleYear
Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.
    The Journal of biological chemistry, 1994, Oct-07, Volume: 269, Issue:40

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Animals; Binding Sites; Cattle; Cells, Cultured; Molecular Sequence Data; Rats; Receptors, Purinergic P1; Recombinant Fusion Proteins; Structure-Activity Relationship; Xanthines

1994
Molecular cloning and characterization of the human A3 adenosine receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21

    Topics: Adenosine; Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Consensus Sequence; Corpus Striatum; Cricetinae; DNA Primers; Gene Expression; Humans; Iodobenzenes; Kinetics; Liver; Lung; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Sheep; Transfection

1993
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261.
    British journal of pharmacology, 1997, Volume: 121, Issue:3

    Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Species Specificity; Transfection; Triazoles

1997
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors.
    Journal of medicinal chemistry, 1997, Aug-01, Volume: 40, Issue:16

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; COS Cells; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Iodobenzenes; Ligands; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Receptors, Biogenic Amine; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines

1997
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines

1998
Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.
    Bioorganic & medicinal chemistry letters, 1998, Mar-17, Volume: 8, Issue:6

    Topics: Animals; Brain; Cells, Cultured; Corpus Striatum; Humans; Microchemistry; Models, Chemical; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Pyrimidines; Rats; Receptors, Purinergic P1; Silicon

1998
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors.
    Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium

1999
Identification of the adenine binding site of the human A1 adenosine receptor.
    The Journal of biological chemistry, 1999, Feb-05, Volume: 274, Issue:6

    Topics: Adenine; Amides; Amino Acid Sequence; Amino Acids; Binding Sites; DNA, Complementary; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Purinergic P1

1999
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
    Molecular pharmacology, 2000, Volume: 57, Issue:5

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Tritium

2000
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.
    Journal of medicinal chemistry, 2001, Feb-01, Volume: 44, Issue:3

    Topics: Amino Acid Sequence; Animals; Benzimidazoles; Brain; Cattle; In Vitro Techniques; Ligands; Models, Molecular; Molecular Sequence Data; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1

2001
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors.
    Biochemical pharmacology, 2004, Jul-15, Volume: 68, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Cells, Cultured; Humans; Pyrimidines; Pyrroles; Radioligand Assay; Time Factors; Tritium

2004
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.
    Journal of medicinal chemistry, 2004, Jul-01, Volume: 47, Issue:14

    Topics: Adenosine A3 Receptor Antagonists; Animals; Cattle; CHO Cells; Cricetinae; Humans; Ligands; Models, Molecular; Quinoxalines; Radioligand Assay; Receptor, Adenosine A3; Structure-Activity Relationship; Triazoles

2004
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.
    Journal of medicinal chemistry, 2005, Dec-29, Volume: 48, Issue:26

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzimidazoles; Binding, Competitive; CHO Cells; Cricetinae; Databases, Factual; Drug Design; Humans; Quinoxalines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Xanthines

2005
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
    Journal of medicinal chemistry, 2007, Jan-11, Volume: 50, Issue:1

    Topics: Aminopyridines; Animals; Cell Line, Tumor; Combinatorial Chemistry Techniques; Membranes, Artificial; Mice; Models, Molecular; Nitriles; Permeability; PrPSc Proteins; Solubility; Structure-Activity Relationship

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
    Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23

    Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Humans; Models, Molecular; Radioligand Assay; Structure-Activity Relationship; Triazines; Triazoles

2007
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.
    Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Pyrimidines; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds

2008
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.
    Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15

    Topics: Adenosine A2 Receptor Antagonists; Amines; Animals; Cell Line; Cricetinae; Cyclic AMP; Furans; Humans; Models, Molecular; Molecular Structure; Nicotinic Acids; Nitriles; Receptor, Adenosine A2A; Structure-Activity Relationship

2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.
    Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10

    Topics: Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Antineoplastic Agents; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Chemotherapy, Adjuvant; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Enzyme Activation; Glioblastoma; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Phosphorylation; Pyrazoles; Pyrimidines; Radioligand Assay; Structure-Activity Relationship

2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship

2010
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.
    Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4

    Topics: Adenosine A2 Receptor Antagonists; Animals; Benzimidazoles; Caco-2 Cells; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Design; Humans; Models, Molecular; Radioligand Assay; Receptor, Adenosine A2B; Structure-Activity Relationship; Triazines

2012
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
    Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10

    Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

2013
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Animals; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Receptor, Adenosine A2B; Structure-Activity Relationship

2013
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A
    MedChemComm, 2018, Jan-01, Volume: 9, Issue:1

    Topics:

2018
Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A
    Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10

    Topics: Adenosine A1 Receptor Antagonists; Bridged Bicyclo Compounds; Drug Design; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; HEK293 Cells; Humans; Kinetics; Ligands; Octanes; Receptor, Adenosine A1; Structure-Activity Relationship; Xanthine

2021
Effect of adenosine A1 and A2 agonists and antagonists on cAMP and Ca2+ in cultured rat mesangial cells.
    The American journal of physiology, 1992, Volume: 262, Issue:4 Pt 1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Glomerular Mesangium; Purines; Rats; Sulfonamides; Xanthines

1992
Presynaptic A1-purinoceptor-mediated inhibitory effects of adenosine and its stable analogues on the mouse hemidiaphragm preparation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:2

    Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Diaphragm; Dipyridamole; Electric Stimulation; In Vitro Techniques; Magnesium; Male; Mice; Muscle Contraction; Neuromuscular Junction; Phrenic Nerve; Purinergic Antagonists; Receptors, Purinergic; Synapses; Synaptic Transmission; Theophylline; Tritium; Tubocurarine; Xanthines

1992
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
    Journal of neurochemistry, 1992, Volume: 58, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines

1992
Evidence that adenosine receptors in the dog left atrium are not of the typical A1 or A2 adenosine receptor subtypes.
    European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3

    Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dogs; Female; Heart Atria; In Vitro Techniques; Male; Myocardium; Norbornanes; Receptors, Purinergic; Theophylline; Vasodilation; Xanthines

1992
Characterization of P1-purinoceptors on rat duodenum and urinary bladder.
    British journal of pharmacology, 1992, Volume: 105, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Duodenum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Urinary Bladder; Vasodilator Agents; Xanthines

1992
The adenosine receptors present on the plasma membrane of chromaffin cells are of the A2b subtype.
    Journal of neurochemistry, 1992, Volume: 59, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; Cell Fractionation; Cell Membrane; Chromaffin System; Phenylisopropyladenosine; Radioligand Assay; Receptors, Purinergic; Tritium; Vasodilator Agents; Xanthines

1992
Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve ending of the rat.
    British journal of pharmacology, 1991, Volume: 103, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Diaphragm; In Vitro Techniques; Male; Motor Endplate; Nerve Endings; Neurotransmitter Agents; Phenylisopropyladenosine; Phrenic Nerve; Purines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sulfonamides; Vasodilator Agents; Xanthines

1991
Effect of ischaemia on cardiac adenosine binding sites.
    Advances in experimental medicine and biology, 1991, Volume: 309A

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; Coronary Disease; In Vitro Techniques; Kinetics; Myocardium; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reference Values; Xanthines

1991
Adenosine A1 and non-A1 receptors: intracellular analysis of the actions of adenosine agonists and antagonists in rat hippocampal neurons.
    Brain research, 1991, Apr-12, Volume: 546, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Electric Stimulation; Electrodes; Hippocampus; Male; Membrane Potentials; Neurons; Phenylisopropyladenosine; Purinergic Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic; Synapses; Theophylline; Xanthines

1991
Radioligand binding to adenosine receptors and adenosine uptake sites in different brain regions of normal and narcoleptic dogs.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Brain; Cataplexy; Dogs; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Kinetics; Membranes; Narcolepsy; Phenylisopropyladenosine; Radioligand Assay; Receptors, Purinergic; Thioinosine; Xanthines

1991
Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain.
    Pharmacological research, 1991, Volume: 24, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain Chemistry; Cattle; Cholic Acids; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxyapatites; In Vitro Techniques; Membranes; Nerve Tissue Proteins; Phenylisopropyladenosine; Phosphatidylcholines; Receptors, Purinergic; Xanthines

1991
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Imidazoles; Molecular Structure; Quinolines; Rats; Receptors, Purinergic; Structure-Activity Relationship; Xanthines

1991
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
    Psychopharmacology, 1990, Volume: 100, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines

1990
Differential antagonism by 1,3-dipropylxanthine-8-cyclopentylxanthine and 9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo(1,5-c)quinazolin-5-im ine of the effects of adenosine derivatives in the presence of isoprenaline on contractile response and cycli
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Heart; Isoproterenol; Male; Myocardial Contraction; Quinazolines; Receptors, Purinergic; Triazoles; Vasodilator Agents; Xanthines

1990
Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.
    Molecular pharmacology, 1990, Volume: 38, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Allosteric Regulation; Animals; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Humans; Models, Biological; Rats; Receptors, Purinergic; Species Specificity; Structure-Activity Relationship; Xanthines

1990
Inhibitory adenosine A1-receptors on rat locus coeruleus neurones. An intracellular electrophysiological study.
    Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Electrophysiology; Guanosine; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Thionucleosides; Xanthines

1990
Adenosine depresses spontaneous transmitter release from frog motor nerve terminals by acting at an A1-like receptor.
    Life sciences, 1990, Volume: 46, Issue:19

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Membrane Potentials; Motor Neurons; Phenylisopropyladenosine; Purinergic Antagonists; Rana pipiens; Receptors, Purinergic; Theophylline; Xanthines

1990
Differences in the properties of A1-type adenosine receptors in rat white and brown adipocytes.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adipose Tissue; Adipose Tissue, Brown; Animals; Binding, Competitive; Cell Membrane; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Lipolysis; Male; Norepinephrine; Phenylisopropyladenosine; Purinergic Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic; Xanthines

1990
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoenzymes; Male; Myocardial Contraction; Papillary Muscles; Phenylisopropyladenosine; Phosphoric Diester Hydrolases; Receptors, Purinergic; Theophylline; Xanthines

1989
Regulation of cyclic AMP formation in cultures of human foetal astrocytes by beta 2-adrenergic and adenosine receptors.
    Journal of neurochemistry, 1989, Volume: 53, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylate Cyclase Toxin; Adrenergic beta-Antagonists; Astrocytes; Brain; Cells, Cultured; Cyclic AMP; Humans; Isoproterenol; Pertussis Toxin; Phenylisopropyladenosine; Propanolamines; Receptors, Adrenergic, beta; Receptors, Purinergic; Virulence Factors, Bordetella; Xanthines

1989
1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N-ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors.
    Brain research, 1986, Mar-19, Volume: 368, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Membranes; Rats; Receptors, Cell Surface; Receptors, Purinergic; Subcellular Fractions; Xanthines

1986
Binding thermodynamics of adenosine A2a receptor ligands.
    Biochemical pharmacology, 1995, Feb-14, Volume: 49, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; Brain Chemistry; In Vitro Techniques; Ligands; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Temperature; Thermodynamics; Xanthines

1995
Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum.
    British journal of pharmacology, 1995, Volume: 115, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cecum; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Heart Atria; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Xanthines

1995
Further investigations into adenosine A1 receptor-mediated contraction in rat colonic muscularis mucosae and its augmentation by certain alkylxanthine antagonists.
    British journal of pharmacology, 1995, Volume: 114, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colon; Cyclooxygenase Inhibitors; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Theophylline; Triazoles; Vasodilator Agents; Xanthines

1995
Are negative chronotropic and inotropic responses to adenosine differentiated at the receptor or postreceptor levels in isolated dog hearts?
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2

    Topics: 2-Chloroadenosine; 4-Aminopyridine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Depression, Chemical; Dogs; Heart Rate; In Vitro Techniques; Myocardial Contraction; Piperidines; Pyridines; Receptors, Purinergic P1; Xanthines

1995
Evidence for P2-purinoceptor-mediated inhibition of noradrenaline release in rat brain cortex.
    British journal of pharmacology, 1994, Volume: 113, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cerebral Cortex; Male; Norepinephrine; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Tetrodotoxin; Xanthines; Yohimbine

1994
A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cerebral Cortex; Colforsin; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Phenylisopropyladenosine; Phosphatidylinositols; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Receptors, Purinergic P1; Sulfonamides; Vasodilator Agents; Xanthines

1994
Characterization of the prejunctional adenosine receptors in the rat anococcygeus muscle.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:11

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Phenylephrine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic P1; Theophylline; Vasodilator Agents; Xanthines

1994
Modulation of DNA synthesis via adenosine receptors in human epidermoid carcinoma (A431) cells.
    BioFactors (Oxford, England), 1994, Volume: 4, Issue:3-4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Carcinoma, Squamous Cell; DNA, Neoplasm; Epidermal Growth Factor; Humans; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Tumor Cells, Cultured; Xanthines

1994
ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog.
    Cardiovascular research, 1994, Volume: 28, Issue:6

    Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Glyburide; Guanidines; Ion Channel Gating; Pinacidil; Potassium Channels; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P2; Theophylline; Vasodilator Agents; Xanthines

1994
The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Theophylline; Vasodilator Agents; Xanthines

1994
Identification and functional characterization of A1 and A2 adenosine receptors in the rat vas deferens: a comparison with A1 receptors in guinea pig left atrium and A2 receptors in guinea pig aorta.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Guinea Pigs; Heart; In Vitro Techniques; Male; Norbornanes; Phenethylamines; Rats; Receptors, Purinergic P1; Theophylline; Vas Deferens; Xanthines

1994
Evidence for a cooperation between adenosine A2 receptors and beta 1-adrenoceptors on cardiac automaticity in the isolated right ventricle of the rat.
    British journal of pharmacology, 1994, Volume: 111, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Female; Isoproterenol; Male; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Receptors, Purinergic P1; Ventricular Function; Xanthines

1994
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.
    Journal of medicinal chemistry, 1994, Aug-19, Volume: 37, Issue:17

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Drug Design; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; PC12 Cells; Purinergic P1 Receptor Antagonists; Radioligand Assay; Structure-Activity Relationship; Xanthines

1994
The effects of adenosine on water and sodium excretion.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Body Water; Diuresis; Infusions, Intra-Arterial; Infusions, Intravenous; Kidney; Male; Natriuresis; Rats; Rats, Wistar; Sodium; Xanthines

1994
Adenosine A1 receptors are not involved in contraction of canine gastric muscularis mucosae by adenosine analogues.
    European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3

    Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dogs; Drug Interactions; Female; Gastric Mucosa; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Purinergic P1 Receptor Antagonists; Pyrilamine; Receptors, Purinergic P1; Stimulation, Chemical; Tetrodotoxin; Xanthines

1994
Adenosine A1 receptor-mediated inhibition of vasopressin action in inner medullary collecting duct.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine Vasopressin; Cyclic AMP; In Vitro Techniques; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Male; Pertussis Toxin; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Virulence Factors, Bordetella; Xanthines

1994
Endogenous adenosine regulates the apparent efficacy of 1-aminocyclopentyl-1S,3R-dicarboxylate inhibition of forskolin-stimulated cyclic AMP accumulation in rat cerebral cortical slices.
    Journal of neurochemistry, 1993, Volume: 60, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloleucine; Female; In Vitro Techniques; Kinetics; Male; Neurotoxins; Rats; Rats, Inbred Strains; Xanthines

1993
Comparison of adenosine and muscarinic receptor-mediated effects on protein phosphatase inhibitor-1 activity in the heart.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carrier Proteins; Colforsin; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phenylisopropyladenosine; Phosphoprotein Phosphatases; Protein Kinases; Proteins; Receptors, Muscarinic; Receptors, Purinergic; Stimulation, Chemical; Ventricular Function; Xanthines

1993
Effect of adenosine receptor ligands on cAMP content in human airways and peripheral lung.
    American journal of respiratory cell and molecular biology, 1993, Volume: 9, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Aged; Child; Cromolyn Sodium; Cyclic AMP; Female; Humans; Ligands; Lung; Male; Middle Aged; Phenethylamines; Receptors, Purinergic; Respiratory System; Theophylline; Xanthines

1993
Adenosinergic modulation of the EEG and locomotor effects of the A2 agonist, CGS 21680.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Caudate Nucleus; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Injections; Male; Motor Activity; Phenethylamines; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Stereotaxic Techniques; Xanthines

1993
Characterization and ontogeny of P1-purinoceptors on rat vas deferens.
    British journal of pharmacology, 1993, Volume: 108, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Animals, Newborn; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle Development; Muscle, Smooth; Norepinephrine; Rats; Rats, Wistar; Receptors, Purinergic; Tetrodotoxin; Vas Deferens; Vasodilator Agents; Xanthines

1993
Differential sensitization of cardiac actions of adenosine in rats after chronic theophylline treatment.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Heart; Heart Atria; Male; Myocardium; Rats; Rats, Wistar; Receptors, Purinergic; Theophylline; Time Factors; Up-Regulation; Xanthines

1993
Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Antihypertensive Agents; Cyclic AMP; Humans; Middle Aged; Phenethylamines; Phenylisopropyladenosine; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Purines; Receptors, Purinergic P1; Serotonin; Sulfonamides; Theophylline; Vasodilator Agents; Xanthines

1995
Synergy between the inositol phosphate responses to transfected human adenosine A1-receptors and constitutive P2-purinoceptors in CHO-K1 cells.
    British journal of pharmacology, 1995, Volume: 115, Issue:8

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; Cells, Cultured; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Humans; Inositol Phosphates; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Uridine Triphosphate; Virulence Factors, Bordetella; Xanthines

1995
Effects of pH on responses to adenosine, CGS 21680, carbachol and nitroprusside in the isolated perfused superior mesenteric arterial bed of the rat.
    British journal of pharmacology, 1995, Volume: 116, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Carbachol; Colforsin; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Nitroprusside; Perfusion; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents; Xanthines

1995
Differential distribution of adenosine A2 receptors in the epididymal and prostatic portions of the rat vas deferens.
    European journal of pharmacology, 1996, May-06, Volume: 303, Issue:1-2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Wistar; Receptors, Purinergic P1; Vas Deferens; Xanthines

1996
Both adenosine A1- and A2-receptors are required to stimulate microglial proliferation.
    Neurochemistry international, 1996, Volume: 29, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Cell Division; Cells, Cultured; Microglia; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Thymidine; Xanthines

1996
The effects of 5'-N-ethylcarboxamidoadenosine on evoked release of [3H]serotonin in the rat nucleus tractus solitarius.
    Neuroscience letters, 1996, Jul-26, Volume: 213, Issue:1

    Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Antihypertensive Agents; Binding, Competitive; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; Male; Neurotransmitter Agents; Organ Culture Techniques; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Sensitivity and Specificity; Serotonin; Solitary Nucleus; Tritium; Vasodilator Agents; Xanthines

1996
Adenosine A1 receptors in cultured cerebellar granule cells: role of endogenous adenosine.
    Journal of neurochemistry, 1996, Volume: 67, Issue:4

    Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; GTP-Binding Proteins; Kinetics; Neurons; Phenylisopropyladenosine; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Time Factors; Xanthines

1996
The ontogenetic profiles of the pre- and postjunctional adenosine receptors in the rat vas deferens.
    British journal of pharmacology, 1996, Volume: 117, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Age Factors; Animals; Animals, Suckling; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Development; Muscle, Smooth; Neuroeffector Junction; Rats; Rats, Wistar; Receptors, Purinergic P1; Vas Deferens; Xanthines

1996
Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte.
    The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cyclic AMP; Heart Ventricles; Myocardial Contraction; Myocardium; Pertussis Toxin; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Virulence Factors, Bordetella; Xanthines

1996
Repeated treatment with adenosine A1 receptor agonist and antagonist modifies the anticonvulsant properties of CPPene.
    European journal of pharmacology, 1996, Dec-19, Volume: 317, Issue:2-3

    Topics: Acoustic Stimulation; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Piperazines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Triazoles; Xanthines

1996
Differential ontogeny of adenosine receptors in the longitudinal muscle and muscularis mucosae of the rat isolated duodenum.
    European journal of pharmacology, 1996, Dec-19, Volume: 317, Issue:2-3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Duodenum; Intestinal Mucosa; Male; Muscle Development; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Xanthines

1996
Glucocorticoids regulate the expression of adenosine A1 but not A(2A) receptors in rat brain.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenalectomy; Analysis of Variance; Animals; Autoradiography; Brain; Cyclic AMP; Dexamethasone; Enkephalins; Gene Expression; Glucocorticoids; Humans; In Situ Hybridization; Jurkat Cells; Male; Organ Specificity; PC12 Cells; Phenethylamines; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; RNA, Messenger; Transcription, Genetic; Tritium; Xanthines

1997
Adenosine activates mesangial cell proliferation.
    Cellular signalling, 1997, Volume: 9, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cell Division; Cells, Cultured; Cyclic AMP; Glomerular Mesangium; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Sulfonamides; Theophylline; Thymidine; Xanthines

1997
Thermoregulatory effects of 5'-N-ethylcarboxamidoadenosine in rabbits.
    Annals of the New York Academy of Sciences, 1997, Mar-15, Volume: 813

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics, Non-Narcotic; Animals; Blood Pressure; Body Temperature Regulation; Dose-Response Relationship, Drug; Energy Metabolism; Female; Fever; Male; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Purinergic P1; Xanthines

1997
Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice.
    Life sciences, 1997, Volume: 60, Issue:17

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antineoplastic Agents; Male; Mice; Motor Activity; Purinergic P1 Receptor Agonists; Purines; Sulfonamides; Theophylline; Xanthines

1997
Studies investigating the possible involvement of adenosine in the antisecretory action of morphine.
    General pharmacology, 1997, Volume: 28, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Decerebrate State; Female; Intestinal Mucosa; Jejunum; Male; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Reserpine; Sympatholytics; Vasoactive Intestinal Peptide; Xanthines

1997
Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats.
    European journal of pharmacology, 1997, Jun-11, Volume: 328, Issue:2-3

    Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Catalepsy; Dopamine Antagonists; Haloperidol; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Scopolamine; Theobromine; Theophylline; Xanthines

1997
Regulation of purinoceptors in guinea pig pulmonary artery: functional evidences.
    Acta physiologica Hungarica, 1996, Volume: 84, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Female; Guinea Pigs; Pulmonary Artery; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic; Vasoconstriction; Vasodilation; Xanthines

1996
Competition of adenine nucleotides for a 1,3-[3H]-dipropyl-8-cyclopentylxanthine binding site in rat vas deferens.
    Clinical and experimental pharmacology & physiology, 1997, Volume: 24, Issue:7

    Topics: 2-Chloroadenosine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; Binding, Competitive; In Vitro Techniques; Kinetics; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vas Deferens; Xanthines

1997
Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a-receptors.
    Neuroscience letters, 1997, Aug-08, Volume: 231, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Antihypertensive Agents; Bucladesine; Colforsin; Gene Expression; Microglia; Nerve Growth Factors; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilator Agents; Xanthines

1997
Adenosine reduces airway excitatory non-cholinergic (e-NC) contraction through both A1 and A2 adenosine receptor activation in the guinea pig.
    Fundamental & clinical pharmacology, 1997, Volume: 11, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bronchi; Cholinergic Fibers; Dipyridamole; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance P; Theobromine; Vasodilator Agents; Xanthines

1997
Adenosine A1 receptor-mediated activation of AMP-activated protein kinase in bovine bronchial rings.
    Biochemical Society transactions, 1997, Volume: 25, Issue:4

    Topics: Adenosine-5'-(N-ethylcarboxamide); Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bronchi; Cattle; Enzyme Activation; In Vitro Techniques; Multienzyme Complexes; Phenylisopropyladenosine; Protein Kinases; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Ribonucleotides; Triazines; Triazoles; Xanthines

1997
Characterization of adenosine receptors on rat ileum, ileal longitudinal muscle and muscularis mucosae.
    European journal of pharmacology, 1997, Nov-05, Volume: 338, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Electric Stimulation; Ileum; Intestinal Mucosa; Male; Muscle, Smooth; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Vasodilator Agents; Xanthines

1997
Autoradiographic visualisation of axonal transport of adenosine A1 receptors along the rat vagus nerve and characterisation of adenosine A1 receptor binding in the dorsal vagal complex of hypertensive and normotensive rats.
    Brain research, 1998, Aug-17, Volume: 802, Issue:1-2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autoradiography; Axonal Transport; Binding, Competitive; Hypertension; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Purinergic P1; Reference Values; Solitary Nucleus; Vagus Nerve; Xanthines

1998
Adenosine A2a receptors increase arterial endothelial cell nitric oxide.
    The Journal of surgical research, 1998, Volume: 80, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carotid Arteries; Cells, Cultured; Endothelium, Vascular; Humans; Iliac Artery; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Xanthines

1998
Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors.
    Journal of hypertension, 1998, Volume: 16, Issue:12 Pt 2

    Topics: Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Dinucleoside Phosphates; In Vitro Techniques; Male; Perfusion; Pyridoxal Phosphate; Rats; Rats, Inbred WKY; Receptors, Purinergic; Receptors, Purinergic P1; Receptors, Purinergic P2; Renal Artery; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents; Xanthines

1998
Ontogeny of adenosine receptors in the longitudinal muscle and muscularis mucosae of the rat distal colon.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Autoradiography; Binding Sites; Binding, Competitive; Colon; Male; Muscle Contraction; Muscle Development; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Subcellular Fractions; Vasodilator Agents; Xanthines

1999
A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission.
    British journal of pharmacology, 1999, Volume: 126, Issue:4

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Indomethacin; Male; Muscle Relaxation; Receptors, Purinergic P1; Swine; Synaptic Transmission; Theophylline; Ureter; Xanthines

1999
Characterization and tissue location of the neural adenosine receptor in the rat ileum.
    British journal of pharmacology, 1999, Volume: 126, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Female; Ileum; Male; Neurons; Rats; Rats, Wistar; Receptors, Purinergic P1; Xanthines

1999
Pharmacological characterization of adenosine A1 receptors and its functional role in brown trout (Salmo trutta) brain.
    Brain research, 1999, Aug-07, Volume: 837, Issue:1-2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain; Cell Membrane; Glutamic Acid; Guanosine Diphosphate; Kinetics; Neuroprotective Agents; Radioligand Assay; Receptors, Purinergic P1; Synaptosomes; Theophylline; Tritium; Trout; Xanthines

1999
Evidence for A1 and A2B adenosine receptors in baby hamster kidney (BHK) cells.
    BioFactors (Oxford, England), 1999, Volume: 10, Issue:1

    Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Base Sequence; Cell Line; Cell Membrane; Cricetinae; Humans; Kidney; Mice; Molecular Sequence Data; Radioligand Assay; Rats; Receptor, Adenosine A2B; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology; Tritium; Xanthines

1999
Adenosine inhibits a non-inactivating K+ current in bovine adrenal cortical cells by activation of multiple P1 receptors.
    The Journal of physiology, 1999, Nov-15, Volume: 521 Pt 1

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; GTP-Binding Proteins; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Purinergic P1; Signal Transduction; Triazines; Triazoles; Xanthines; Zona Fasciculata

1999
Afferent arteriolar adenosine A2a receptors are coupled to KATP in in vitro perfused hydronephrotic rat kidney.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Blood Pressure; Enzyme Inhibitors; Hydronephrosis; Kidney; Perfusion; Potassium Channels; Potassium Chloride; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Triazines; Triazoles; Vasoconstriction; Vasodilation; Vasodilator Agents; Xanthines

1999
The G protein alpha subunit has a key role in determining the specificity of coupling to, but not the activation of, G protein-gated inwardly rectifying K(+) channels.
    The Journal of biological chemistry, 2000, Jan-14, Volume: 275, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Cell Line; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Pertussis Toxin; Phenethylamines; Point Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radioligand Assay; Recombinant Fusion Proteins; Recombinant Proteins; Transfection; Virulence Factors, Bordetella; Xanthines

2000
Adenosine modulates the (Na(+)+K(+))ATPase activity in malpighian tubules isolated from Rhodnius prolixus.
    Archives of insect biochemistry and physiology, 2000, Volume: 43, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Malpighian Tubules; Receptors, Purinergic P1; Rhodnius; Sodium-Potassium-Exchanging ATPase; Theobromine; Xanthines

2000
Extracellular adenosine deprivation induces epithelial differentiation of HT29 cells: evidence for a concomitant adenosine A(1)/A(2) receptor balance regulation.
    European journal of pharmacology, 2000, Mar-10, Volume: 391, Issue:1-2

    Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Caco-2 Cells; Cell Differentiation; Cell Division; Clone Cells; Culture Media; Cyclic AMP; Epithelial Cells; HT29 Cells; Humans; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Xanthines

2000
Adenosine A(2a)-receptor activation increases contractility in isolated perfused hearts.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic beta-Antagonists; Animals; Atenolol; Drug Synergism; Heart; In Vitro Techniques; Male; Myocardial Contraction; Perfusion; Pertussis Toxin; Pressure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilation; Vasodilator Agents; Virulence Factors, Bordetella; Xanthines

2000
Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons.
    Circulation, 2001, Mar-06, Volume: 103, Issue:9

    Topics: Action Potentials; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cadmium; Colforsin; Neurons, Afferent; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic P1; Time Factors; Vagus Nerve; Xanthines

2001
Characterization of prejunctional purinoceptors inhibiting noradrenaline release in rat mesenteric arteries.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:1

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Norepinephrine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Wistar; Tetrodotoxin; Xanthines

2001
Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine.
    Life sciences, 2001, Jul-06, Volume: 69, Issue:7

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Female; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Muscle Contraction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Theobromine; Xanthines

2001
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.
    Brain research bulletin, 2001, Jul-01, Volume: 55, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; Antihypertensive Agents; Ataxia; Azides; Benzodiazepines; Central Nervous System Depressants; Corpus Striatum; Ethanol; Male; Mice; Mice, Inbred ICR; Microinjections; Motor Activity; Pertussis Toxin; Phenethylamines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilator Agents; Virulence Factors, Bordetella; Xanthines

2001
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
    British journal of pharmacology, 2001, Volume: 134, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines

2001
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.
    The American journal of pathology, 2002, Volume: 160, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blotting, Western; Cells, Cultured; Drosophila Proteins; Endothelial Growth Factors; Female; Interferon-gamma; Lipopolysaccharides; Lymphokines; Macrophages, Peritoneal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenethylamines; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Theobromine; Toll-Like Receptor 4; Toll-Like Receptors; Triazines; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthines

2002
Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.
    European journal of pharmacology, 2003, Jan-24, Volume: 460, Issue:2-3

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Epididymis; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenethylamines; Prostate; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazines; Triazoles; Vas Deferens; Xanthines

2003
A1 and A2A adenosine receptor modulation of alpha 1-adrenoceptor-mediated contractility in human cultured prostatic stromal cells.
    British journal of pharmacology, 2004, Volume: 141, Issue:2

    Topics: Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Aged; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Male; Prostate; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Adrenergic, alpha-1; Stromal Cells; Xanthines

2004
Role of A1 adenosine receptors in regulation of vascular tone.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:3

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Female; In Vitro Techniques; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Receptor, Adenosine A1; Type C Phospholipases; Vasodilation; Vasodilator Agents; Xanthines

2005
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Arachidonic Acid; Chorion; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Placenta; Pregnancy; Receptor, Adenosine A2B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triazines; Triazoles; Vasoconstriction; Vasodilator Agents; Xanthines

2005
Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits.
    Experimental eye research, 2005, Volume: 80, Issue:4

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport, Active; Dihydropyridines; Fluorescein; Fluoresceins; Fluorophotometry; Injections, Intravenous; Male; Pigment Epithelium of Eye; Purinergic P1 Receptor Antagonists; Rabbits; Retinal Detachment; Triazines; Triazoles; Xanthines

2005
Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists.
    British journal of pharmacology, 2005, Volume: 146, Issue:4

    Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Benzoates; Binding, Competitive; Bridged-Ring Compounds; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Glucosides; Infarction, Middle Cerebral Artery; Inhibitory Concentration 50; Ischemic Attack, Transient; Male; Monoterpenes; Neuroprotective Agents; Paeonia; Plant Roots; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Time Factors; Xanthines

2005
Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction.
    Biochemical pharmacology, 2006, Mar-14, Volume: 71, Issue:6

    Topics: Adenine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Tertiary; Rats; Receptor, Adenosine A1; Xanthines

2006
Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.
    Cardiovascular research, 2006, May-01, Volume: 70, Issue:2

    Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Androstadienes; Animals; Aorta; Benzophenanthridines; Constriction; Enzyme Activators; Female; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Phenanthridines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Purines; Rabbits; Receptor, Adenosine A2B; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin; Xanthines

2006
Characterization of adenosine receptors in the human bladder carcinoma T24 cell line.
    European journal of pharmacology, 2006, Apr-24, Volume: 536, Issue:1-2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Calcium; Cell Line, Tumor; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Intracellular Fluid; Protein Isoforms; Purines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Urinary Bladder Neoplasms; Xanthines

2006
Loss of vascular adenosine A1 receptors with age in the rat heart.
    Vascular pharmacology, 2006, Volume: 45, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Age Factors; Aging; Animals; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Down-Regulation; Heart; Heart Rate; In Vitro Techniques; Male; Pertussis Toxin; Rats; Rats, Wistar; Receptor, Adenosine A1; Vasoconstriction; Vasodilation; Vasodilator Agents; Ventricular Function, Left; Xanthines

2006
Regulation of pharmacology by hetero-oligomerization between A1 adenosine receptor and P2Y2 receptor.
    Biochemical and biophysical research communications, 2006, Dec-15, Volume: 351, Issue:2

    Topics: Adenosine A1 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cell Line; Cell Membrane; Cloning, Molecular; Cyclic AMP; Humans; Protein Binding; Purinergic P2 Receptor Agonists; Rats; Receptor, Adenosine A1; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Uridine Triphosphate; Xanthines

2006
ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate.
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:7

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Norepinephrine; Presynaptic Terminals; Prostate; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Presynaptic; Receptors, Purinergic P2; Suramin; Sympathetic Nervous System; Thionucleotides; Xanthines

2007
Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils.
    American journal of veterinary research, 2007, Volume: 68, Issue:9

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cyclic AMP; Horses; Inhibitory Concentration 50; Kinetics; Lipopolysaccharides; Neutrophils; Phenethylamines; Piperidines; Radioligand Assay; Reactive Oxygen Species; Receptor, Adenosine A2A; Xanthines

2007
Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aminopyridines; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Flavins; Gene Expression Regulation; In Vitro Techniques; Male; Mice; Mice, Knockout; Phenethylamines; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazoles; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Xanthines

2009
Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
    European journal of immunology, 2010, Volume: 40, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Cyclic AMP; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Receptor, Adenosine A1; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spleen; T-Lymphocytes; Xanthines

2010
Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.
    British journal of pharmacology, 2010, Volume: 159, Issue:4

    Topics: Adenosine-5'-(N-ethylcarboxamide); Alkaline Phosphatase; Animals; Boron Compounds; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dansyl Compounds; Fluorescent Dyes; Genes, Reporter; GPI-Linked Proteins; Humans; Isoenzymes; Ligands; Microscopy, Confocal; Molecular Imaging; Molecular Probe Techniques; Molecular Structure; Radioligand Assay; Receptor, Adenosine A1; Response Elements; Transfection; Xanthines

2010