1-3-dibutyl-2-thiourea and 1-3-dimethylthiourea

1-3-dibutyl-2-thiourea has been researched along with 1-3-dimethylthiourea* in 1 studies

Other Studies

1 other study(ies) available for 1-3-dibutyl-2-thiourea and 1-3-dimethylthiourea

Article	Year
Difference in the developmental toxicity of ethylenethiourea and three N,N'-substituted thiourea derivatives in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 17, Issue:2 Sprague-Dawley rats were administered ethylenethiourea (ETU), 1,3-dimethyl-2-thiourea (DMT), 1,3-dibutyl-2-thiourea (DBT), or 1,3-diphenyl-2-thiourea (DPT) by gavage from Days 6 to 20 of gestation. Daily dosage levels (mg/kg/day) were ETU at 0, 15, 25 and 35; DMT at 0, 15, 25, 50, 100, and 200; DBT at 0, 15, 25, 50, 100, and 200; and DPT at 0, 25, 50, 100, and 200. There was evidence of maternal toxicity at all doses of DMT and at doses greater than or equal to 50 mg DBT/kg/day. DPT was embryolethal at 200 mg/kg/day. Fetotoxicity was observed at doses greater than or equal to 15 mg DMT/kg/day, greater than or equal to 15 mg DBT/kg/day, and greater than or equal to 100 mg DPT/kg/day. ETU was the only chemical tested that proved to be teratogenic. Topics: Animals; Behavior, Animal; Body Weight; Embryo, Mammalian; Ethylenethiourea; Female; Gestational Age; Intubation, Gastrointestinal; Pregnancy; Rats; Rats, Inbred Strains; Reproduction; Teratogens; Thiourea	1991

Article

Year

Difference in the developmental toxicity of ethylenethiourea and three N,N'-substituted thiourea derivatives in rats.

Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 17, Issue:2

Sprague-Dawley rats were administered ethylenethiourea (ETU), 1,3-dimethyl-2-thiourea (DMT), 1,3-dibutyl-2-thiourea (DBT), or 1,3-diphenyl-2-thiourea (DPT) by gavage from Days 6 to 20 of gestation. Daily dosage levels (mg/kg/day) were ETU at 0, 15, 25 and 35; DMT at 0, 15, 25, 50, 100, and 200; DBT at 0, 15, 25, 50, 100, and 200; and DPT at 0, 25, 50, 100, and 200. There was evidence of maternal toxicity at all doses of DMT and at doses greater than or equal to 50 mg DBT/kg/day. DPT was embryolethal at 200 mg/kg/day. Fetotoxicity was observed at doses greater than or equal to 15 mg DMT/kg/day, greater than or equal to 15 mg DBT/kg/day, and greater than or equal to 100 mg DPT/kg/day. ETU was the only chemical tested that proved to be teratogenic.

Topics: Animals; Behavior, Animal; Body Weight; Embryo, Mammalian; Ethylenethiourea; Female; Gestational Age; Intubation, Gastrointestinal; Pregnancy; Rats; Rats, Inbred Strains; Reproduction; Teratogens; Thiourea

1991