1-3-di-(4-amidinophenoxy)-2-2-bis-(4-amidinophenoxymethyl)propane and diminazene-aceturate

1-3-di-(4-amidinophenoxy)-2-2-bis-(4-amidinophenoxymethyl)propane has been researched along with diminazene-aceturate* in 1 studies

Other Studies

1 other study(ies) available for 1-3-di-(4-amidinophenoxy)-2-2-bis-(4-amidinophenoxymethyl)propane and diminazene-aceturate

Article	Year
DNA binding activity and inhibition of DNA-protein interactions. Differential effects of tetra-p-amidino-phenoxyneopentane and its 2'-bromo derivative. Biochemical pharmacology, 1992, Nov-17, Volume: 44, Issue:10 In the present study are reported the differential DNA binding activity of the anti-tumor polyamidine tetra-p-amidinophenoxyneopentane (TAPP-H) and its 2'-halo derivative (TAPP-Br), and their effects on the binding of the recombinant Epstein-Barr virus (EBV) nuclear antigen to a synthetic oligonucleotide mimicking the target DNA sequence present in the EBV genome. In addition, the proliferation kinetics and cell cycle analysis of human leukemia K562 cells treated with TAPP-H and TAPP-Br are reported. The possible in vivo relationship between DNA binding affinity and cytotoxicity is also discussed. Topics: Antigens, Viral; Base Sequence; Benzamidines; Cell Cycle; Cell Division; Diminazene; DNA-Binding Proteins; DNA, Viral; Dose-Response Relationship, Drug; Epstein-Barr Virus Nuclear Antigens; Humans; Molecular Sequence Data; Tumor Cells, Cultured	1992

Article

Year

DNA binding activity and inhibition of DNA-protein interactions. Differential effects of tetra-p-amidino-phenoxyneopentane and its 2'-bromo derivative.

Biochemical pharmacology, 1992, Nov-17, Volume: 44, Issue:10

In the present study are reported the differential DNA binding activity of the anti-tumor polyamidine tetra-p-amidinophenoxyneopentane (TAPP-H) and its 2'-halo derivative (TAPP-Br), and their effects on the binding of the recombinant Epstein-Barr virus (EBV) nuclear antigen to a synthetic oligonucleotide mimicking the target DNA sequence present in the EBV genome. In addition, the proliferation kinetics and cell cycle analysis of human leukemia K562 cells treated with TAPP-H and TAPP-Br are reported. The possible in vivo relationship between DNA binding affinity and cytotoxicity is also discussed.

Topics: Antigens, Viral; Base Sequence; Benzamidines; Cell Cycle; Cell Division; Diminazene; DNA-Binding Proteins; DNA, Viral; Dose-Response Relationship, Drug; Epstein-Barr Virus Nuclear Antigens; Humans; Molecular Sequence Data; Tumor Cells, Cultured

1992