Compounds > 1,3-butadiene
Page last updated: 2024-08-18

1,3-butadiene and diepoxybutane

1,3-butadiene has been researched along with diepoxybutane in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's34 (52.31)18.2507
2000's17 (26.15)29.6817
2010's13 (20.00)24.3611
2020's1 (1.54)2.80

Authors

AuthorsStudies
Chichłowska-Sliwińska, M; Sasiadek, M1
Norppa, H; Sasiadek, M; Sorsa, M1
Järventaus, H; Sasiadek, M; Sorsa, M1
Tates, AD; Xiao, Y1
Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Pei, L; Thornton-Manning, JR1
Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Thornton-Manning, JR2
Asgharian, B; Bond, JA; Himmelstein, MW; Turner, MJ2
Jones, NJ; Kostiainen, R; Leuratti, C; Marafante, E; Peltonen, K; Waters, R1
Cochrane, JE; Skopek, TR1
Kelsey, KT; Wiencke, JK1
Bolt, HM; Laib, RJ; Vangala, RR1
Adler, ID; Anderson, D; Benigni, R; Ehling, UH; Laehdetie, J; Pacchierotti, F; Russo, A; Tates, AD1
Bechtold, WE; Dahl, AR; Henderson, RF; Thornton-Manning, JR2
Lähdetie, J; Sjöblom, T1
Mabon, N; Moorthy, B; Randerath, E; Randerath, K1
Bond, JA; Janszen, DB; Leavens, TL; Moss, OR; Turner, MJ1
Bond, JA; Medinsky, MA; Schlosser, PM; Sweeney, LM1
Lähdetie, J; Peltonen, K; Sjöblom, T1
Bond, JA; Farris, GM; James, RA; Leavens, TL; Marshall, MW; Shah, R; Wong, VA1
Anderson, D; Brinkworth, MH; Dobrzyńka, MM; Jackson, LI; Yu, TW1
Kilpeläinen, I; Koivisto, P; Lähdetie, J; Landin, H; Osterman-Golkar, S; Peltonen, K; Pérez, HL1
Smith, MT; Wang, Y; Xi, L; Zhang, L1
Adler, ID; Kliesch, U; Nylund, L; Peltonen, K1
de Zwart, FA; Tates, AD; van Dam, FJ; van Teylingen, CM; Zwinderman, AH1
Cordelli, E; Leter, G; Pacchierotti, F; Spanò, M1
de Conti, S; Dobrzyńska, MM; Russo, A; Tommasi, AM1
Adler, ID; Anderson, D; Brinkworth, M; Demopoulos, NA; Lähdetie, J; Osterman-Golkar, S; Pacchierotti, F; Peltonen, K; Russo, A; Tates, A; Waters, R1
Allen, ML; Bechtold, WE; Dahl, AR; Griffith, WC; Henderson, RF; Thornton-Manning, JR1
Chiang, SY; Swenberg, JA; Walker, VE1
Cordelli, E; Leter, G; Pacchierotti, F; Spanò, M; Tiveron, C1
DeMarini, DM; Doerr, CL; Hanley, NM; Kligerman, AD; Milholland, VS; Tennant, AH1
Blair, IA; Chaudhary, AK; Kambouris, SJ; Meng, Q; Oe, T; Recio, L; Walker, VE; Wherli, S1
Bauer, MJ; Heflich, RH; Meng, Q; Singh, N; Walker, VE1
Carmical, JR; Harris, CM; Harris, TM; Kowalczyk, A; Lloyd, RS; Nechev, LV; Van Houten, B; Zou, Y1
Barr, EB; Belinsky, SA; Benson, JM; Hahn, FF; Henderson, RF; Ménache, MG1
Jackson, MA; Rice, JM; Stack, HF; Waters, MD1
Kohn, MC; Melnick, RL1
Erexson, GL; Tindall, KR1
Bhowmik, S; Csanády, GA; Faller, TH; Filser, JG; Kessler, W; Pütz, C; Schuster, A1
Gargas, ML; Himmelstein, MW; Sweeney, LM1
Meyer, KG; Pluta, LJ; Recio, L; Saranko, CJ; Steen, AM1
Ball, LM; Georgieva, NI; Gold, A; Jayaraj, K; Klapper, DG; Koc, H; Reddy, AP; Sangaiah, R; Swenberg, JA1
Abdel-Rahman, SZ; Ammenheuser, MM; Hastings-Smith, DA; Lloyd, RS; Postlethwait, EM; Salazar, JJ; Ward, JB; Wickliffe, JK1
Boysen, G; Georgieva, NI; Jayaraj, K; Li, Y; Swenberg, JA; Upton, PB; Walker, VE1
Csanády, GA; Filser, JG; Hutzler, C; Meischner, V; Veereshwarayya, V1
Abdel-Rahman, SZ; Ammenheuser, MM; Friedberg, EC; Galbert, LA; Hallberg, LM; Herring, SM; Lloyd, RS; Masters, OE; Ward, JB; Wickliffe, JK; Xie, J1
Bois, FY; Brochot, C; Smith, TJ1
Goggin, M; Swenberg, JA; Tretyakova, N; Walker, VE1
Antsypovich, S; Dorr, DQ; Goggin, M; Guza, R; Moser, A; Seneviratne, U; Thompson, C; Tretyakova, N; York, DM1
Goggin, M; Seneviratne, U; Swenberg, JA; Tretyakova, N; Walker, VE1
Albertini, RJ; Carson, ML; Gargas, ML; Kirman, CR1
Goggin, M; Sangaraju, D; Swenberg, JA; Tretyakova, N; Walker, VE; Wickliffe, J1
Bradley, SQ; McGowan, EE; Millard, JT1
Csanády, GA; Filser, JG; Kessler, W; Klein, D; Li, Q; Pütz, C; Richter, N; Riester, MB; Semder, B; Steinhoff, R1
Albertini, RJ; Bordeerat, NK; Boysen, G; Georgieva, NI; Sram, RJ; Swenberg, JA; Vacek, P1
Cho, SH; Guengerich, FP2
An, J; Wen, Y; Wu, MH; Yu, YX; Zhang, PP; Zhang, XY1
Fabiani, R; Fuccelli, R; Morozzi, G; Rosignoli, P; Sepporta, MV; Servili, M1
Barajas Torres, RL; Borjas Gutiérrez, C; Domínguez Cruz, MD; González García, JR; Magaña Torres, MT; Ramírez Dueñas, Mde L1
Albertini, RJ; Carter, EW; Degner, A; Nicklas, JA; Tretyakova, N; Walker, DM; Walker, VE1
Boysen, G; Chao, C; Hurben, AK; Hutchins, S; Jokipii Krueger, CC; Pujari, SS; Tretyakova, N1

Reviews

4 review(s) available for 1,3-butadiene and diepoxybutane

ArticleYear
[Genotoxic properties of 1,3-butadiene and its derivatives].
    Medycyna pracy, 1991, Volume: 42, Issue:3

    Topics: Animals; Butadienes; Chromosome Aberrations; DNA Damage; Epoxy Compounds; In Vitro Techniques; Mice; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Rats; Sister Chromatid Exchange

1991
Synthesis report of the step project detection of germ cell mutagens.
    Mutation research, 1996, Jun-12, Volume: 353, Issue:1-2

    Topics: Acrylamide; Acrylamides; Animals; Blastocyst; Butadienes; Cyclophosphamide; Epoxy Compounds; Germ Cells; Information Systems; Mice; Micronucleus Tests; Mutagens; Rats; Urethane

1996
A review of the genetic and related effects of 1,3-butadiene in rodents and humans.
    Mutation research, 2000, Volume: 463, Issue:3

    Topics: Air Pollutants, Occupational; Alkylating Agents; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Biotransformation; Butadienes; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; DNA Damage; Epoxy Compounds; Female; Glycols; Hemoglobins; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Occupational Exposure; Organ Specificity; Oxidation-Reduction; Proteins; Rats; Rats, Sprague-Dawley; Single-Blind Method; Sister Chromatid Exchange; Species Specificity

2000
1,3-Butadiene: II. Genotoxicity profile.
    Critical reviews in toxicology, 2010, Volume: 40 Suppl 1

    Topics: Animals; Biomarkers; Butadienes; Carcinogenicity Tests; Chromosome Aberrations; DNA Adducts; DNA Damage; Drosophila; Epoxy Compounds; Female; Humans; Male; Mice; Mutation; Rats

2010

Other Studies

61 other study(ies) available for 1,3-butadiene and diepoxybutane

ArticleYear
1,3-Butadiene and its epoxides induce sister-chromatid exchanges in human lymphocytes in vitro.
    Mutation research, 1991, Volume: 261, Issue:2

    Topics: Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; In Vitro Techniques; Mutagenicity Tests; Mutagens; Sister Chromatid Exchange

1991
Sister-chromatid exchanges induced by 1.3-butadiene and its epoxides in CHO cells.
    Mutation research, 1991, Volume: 263, Issue:1

    Topics: Animals; Butadienes; Cells, Cultured; Cricetinae; Cricetulus; Epoxy Compounds; Mutagens; Sister Chromatid Exchange

1991
Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo.
    Environmental and molecular mutagenesis, 1995, Volume: 26, Issue:2

    Topics: Administration, Inhalation; Animals; Body Weight; Butadienes; Chromosomes; Epoxy Compounds; Germ Cells; Golgi Apparatus; Male; Mice; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Inbred Lew; Species Specificity; Spermatids; Spermatozoa; Spleen; Testis

1995
Gender differences in the metabolism of 1,3-butadiene in Sprague-Dawley rats following a low level inhalation exposure.
    Carcinogenesis, 1995, Volume: 16, Issue:11

    Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Male; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity

1995
Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following a low-level inhalation exposure to 1,3-butadiene.
    Carcinogenesis, 1995, Volume: 16, Issue:8

    Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Male; Mice; Myocardium; Rats; Rats, Sprague-Dawley; Species Specificity

1995
Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation.
    Carcinogenesis, 1994, Volume: 15, Issue:8

    Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; In Vitro Techniques; Male; Mice; Rats; Rats, Sprague-Dawley; Respiration; Species Specificity

1994
Biomonitoring of exposure to 1,3-butadiene: detection by high-performance liquid chromatography and 32P-postlabelling of an adenine adduct formed by diepoxybutane.
    IARC scientific publications, 1993, Issue:127

    Topics: Adenine; Adenosine Monophosphate; Alkylation; Animals; Butadienes; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Cricetulus; Deoxyadenosines; DNA; Environmental Exposure; Epoxy Compounds; Female; Mutagens; Ovary

1993
Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice.
    IARC scientific publications, 1993, Issue:127

    Topics: Animals; Butadienes; Cells, Cultured; Epoxy Compounds; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; T-Lymphocytes

1993
Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes.
    IARC scientific publications, 1993, Issue:127

    Topics: Butadienes; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; Mechlorethamine; Mutagens; Occupational Exposure; Sister Chromatid Exchange; T-Lymphocytes

1993
Evaluation of DNA damage by alkaline elution technique after inhalation exposure of rats and mice to 1,3-butadiene.
    Archives of toxicology, 1993, Volume: 67, Issue:1

    Topics: Animals; Butadienes; Cattle; Cross-Linking Reagents; DNA Damage; DNA, Single-Stranded; Epoxy Compounds; Hydrogen-Ion Concentration; Liver; Lung; Male; Mice; Mice, Inbred Strains; Mutagens; Proteins; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence

1993
Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice.
    Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3

    Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Glutathione; Male; Mice; Rats; Rats, Sprague-Dawley; Species Specificity

1996
Gender and species differences in the metabolism of 1,3-butadiene to butadiene monoepoxide and butadiene diepoxide in rodents following low-level inhalation exposures.
    Toxicology, 1996, Oct-28, Volume: 113, Issue:1-3

    Topics: Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Male; Mice; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity

1996
Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not by 1,2-epoxy-3-butene and 1,2-dihydroxy-3,4-epoxybutane.
    Mutagenesis, 1996, Volume: 11, Issue:5

    Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Glycols; Male; Meiosis; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley; Spermatids

1996
Monophosphate 32P-postlabeling assay of DNA adducts from 1,2:3,4-diepoxybutane, the most genotoxic metabolite of 1,3-butadiene: in vitro methodological studies and in vivo dosimetry.
    Mutation research, 1996, Nov-04, Volume: 371, Issue:1-2

    Topics: Animals; Autoradiography; Butadienes; Cattle; Chromatography, Thin Layer; DNA Adducts; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Mice; Mice, Inbred ICR; Phosphorus Radioisotopes; Rats

1996
Metabolic interactions of 1,3-butadiene and styrene in male B6C3F1 mice.
    Toxicology and applied pharmacology, 1996, Volume: 141, Issue:2

    Topics: Animals; Butadienes; Epoxy Compounds; Male; Mice; Mutagens; Styrene; Styrenes

1996
Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats.
    Carcinogenesis, 1997, Volume: 18, Issue:4

    Topics: Administration, Inhalation; Animals; Butadienes; Epoxy Compounds; Injections, Intravenous; Mice; Models, Biological; Rats; Species Specificity

1997
Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo.
    Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:3

    Topics: Animals; Body Weight; Butadienes; Cell Survival; DNA Replication; Epoxy Compounds; Glycols; Male; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Sprague-Dawley; Spermatids; Testis

1997
Genotoxicity and cytotoxicity in male B6C3F1 mice following exposure to mixtures of 1,3-butadiene and styrene.
    Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:4

    Topics: Animals; Bone Marrow; Butadienes; Carcinogens; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; Erythrocytes; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Spleen; Styrene; Styrenes; Thymus Gland; Toxicity Tests

1997
Somatic and germ cell effects in rats and mice after treatment with 1,3-butadiene and its metabolites, 1,2-epoxybutene and 1,2,3,4-diepoxybutane.
    Mutation research, 1997, Jul-14, Volume: 391, Issue:3

    Topics: Administration, Inhalation; Animals; Bone Marrow; Butadienes; DNA; Dose-Response Relationship, Drug; Electrophoresis; Epoxy Compounds; Liver; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Species Specificity; Spermatozoa; Testis

1997
Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides.
    Chemico-biological interactions, 1997, Aug-01, Volume: 105, Issue:3

    Topics: Air Pollutants, Occupational; Animals; Butadienes; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Glycols; Hemoglobins; Humans; Magnetic Resonance Spectroscopy; Male; Micronucleus Tests; Rats; Rats, Sprague-Dawley; Rats, Wistar; Valine

1997
Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene.
    Carcinogenesis, 1997, Volume: 18, Issue:9

    Topics: Aneuploidy; Butadienes; Carcinogens; Cells, Cultured; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 7; Diploidy; Epoxy Compounds; Genotype; Glutathione Transferase; Humans; Interphase; Lymphocytes; Male; Metaphase; Micronuclei, Chromosome-Defective; Micronucleus Tests

1997
Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation.
    Toxicology, 1997, Nov-21, Volume: 123, Issue:1-2

    Topics: Adipose Tissue; Administration, Inhalation; Animals; Butadienes; Carcinogens; Epoxy Compounds; Female; Femur; Lung; Mammary Glands, Animal; Mice; Rats; Rats, Sprague-Dawley

1997
In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane.
    Mutagenesis, 1997, Volume: 12, Issue:5

    Topics: Animals; Bone Marrow Cells; Butadienes; Crosses, Genetic; Epoxy Compounds; Female; Fetal Death; Genes, Lethal; Glycols; Litter Size; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pregnancy; Salmonella typhimurium; Structure-Activity Relationship

1997
Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo.
    Mutation research, 1998, Jan-16, Volume: 397, Issue:1

    Topics: Age Factors; Animals; Butadienes; Cells, Cultured; Clone Cells; Enzyme Induction; Epoxy Compounds; Ethylnitrosourea; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; Rats; Rats, Inbred Lew; Spleen

1998
Diepoxybutane cytotoxicity on mouse germ cells is enhanced by in vivo glutathione depletion: a flow cytometric approach.
    Mutation research, 1998, Jan-16, Volume: 397, Issue:1

    Topics: Animals; Butadienes; Cell Cycle; DNA; Environmental Pollution; Epoxy Compounds; Flow Cytometry; Fluorescent Dyes; Germ Cells; Glutathione; Indoles; Ketones; Male; Mice; Mice, Inbred Strains; Mutagens; Organ Size; Ploidies; Spermatids

1998
Evaluation and characterization of micronuclei in early spermatids of mice exposed to 1,3-butadiene.
    Mutation research, 1998, Jan-16, Volume: 397, Issue:1

    Topics: Animals; Butadienes; Cell Cycle; Centromere; Environmental Pollution; Epoxy Compounds; Male; Meiosis; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagens; Spermatids; Telomere

1998
Genetic effects of 1,3-butadiene and associated risk for heritable damage.
    Mutation research, 1998, Jan-16, Volume: 397, Issue:1

    Topics: Animals; Butadienes; DNA Adducts; Embryo, Mammalian; Epoxy Compounds; Germ Cells; Humans; Mice; Mutagenicity Tests; Mutagens; Rats; Risk Factors; Translocation, Genetic

1998
Disposition of butadiene epoxides in Sprague-Dawley rats following exposures to 8000 ppm 1,3-butadiene: comparisons with tissue epoxide concentrations following low-level exposures.
    Toxicological sciences : an official journal of the Society of Toxicology, 1998, Volume: 41, Issue:2

    Topics: Animals; Biotransformation; Butadienes; Carcinogens; Epoxy Compounds; Female; Inhalation Exposure; Mutagens; Rats; Rats, Sprague-Dawley

1998
Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography electrospray ionization tandem mass spectrometry.
    Journal of mass spectrometry : JMS, 1998, Volume: 33, Issue:4

    Topics: Animals; Butadienes; Cattle; Cells, Cultured; Chromatography, Gas; Chromatography, Liquid; DNA; DNA Adducts; Epoxy Compounds; Humans; Hydrolysis; Lymphocytes; Mass Spectrometry; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Inbred F344

1998
Glutathione depletion enhances germ cell toxicity of butadiene metabolites: a flow cytometric study.
    European journal of histochemistry : EJH, 1997, Volume: 41 Suppl 2

    Topics: Animals; Butadienes; Cell Survival; DNA; Dose-Response Relationship, Drug; Epoxy Compounds; Flow Cytometry; Glutathione; Ketones; Male; Mice; Mice, Inbred Strains; Organ Size; Spermatids; Spermatogonia; Testis; Time Factors

1997
Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3, 4-diepoxybutane in mouse, rat and human lymphocytes following in vitro G0 exposures.
    Mutation research, 1999, Feb-02, Volume: 439, Issue:1

    Topics: Animals; Butadienes; Carcinogens; Cell Cycle; Chromosome Aberrations; Epoxy Compounds; Erythrocytes; Genotype; Glutathione Transferase; Humans; Interphase; Lymphocytes; Mice; Mutagenicity Tests; Rats; Regression Analysis; Sister Chromatid Exchange

1999
Persistence of N7-(2,3,4-trihydroxybutyl)guanine adducts in the livers of mice and rats exposed to 1,3-butadiene.
    Chemical research in toxicology, 1999, Volume: 12, Issue:3

    Topics: Animals; Butadienes; Chromatography, Liquid; DNA Adducts; Epoxy Compounds; Female; Guanine; Half-Life; Hydrolysis; Inhalation Exposure; Liver; Mass Spectrometry; Mice; Mice, Inbred Strains; Mutagens; Rats; Rats, Inbred F344; Spectrophotometry, Ultraviolet; Stereoisomerism

1999
Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane.
    Mutation research, 2000, Jan-24, Volume: 464, Issue:2

    Topics: Administration, Inhalation; Animals; Butadienes; Cells, Cultured; Crosses, Genetic; DNA Mutational Analysis; Epoxy Compounds; Exons; Female; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Spleen; T-Lymphocytes

2000
Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis.
    The Journal of biological chemistry, 2000, Jun-30, Volume: 275, Issue:26

    Topics: Adenosine Triphosphatases; Bacterial Proteins; Base Sequence; Butadienes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; DNA; DNA Adducts; DNA-Binding Proteins; DNA, Complementary; Epoxy Compounds; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Genes, ras; Guanine; Humans; Molecular Sequence Data; Mutagenesis; Mutagens; Nucleic Acid Hybridization; Oligonucleotides; Stereoisomerism

2000
1,3-butadiene: cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-diepoxybutane.
    Research report (Health Effects Institute), 2000, Issue:92

    Topics: Administration, Inhalation; Animals; Butadienes; Carcinogenicity Tests; Carcinogens; DNA Adducts; Epoxy Compounds; Female; Genes, ras; Mice; Mutagens; Mutation; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley

2000
The privileged access model of 1,3-butadiene disposition.
    Environmental health perspectives, 2000, Volume: 108 Suppl 5

    Topics: Animals; Butadienes; Carcinogens; Cytochrome P-450 Enzyme System; Cytosol; Digestive System Physiological Phenomena; Endoplasmic Reticulum; Epoxy Compounds; Hydrolysis; Kidney; Liver; Lung; Metabolic Clearance Rate; Mice; Models, Animal; Oxidation-Reduction; Rats; Tissue Distribution

2000
Micronuclei and gene mutations in transgenic big Blue((R)) mouse and rat fibroblasts after exposure to the epoxide metabolites of 1, 3-butadiene.
    Mutation research, 2000, Dec-20, Volume: 472, Issue:1-2

    Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Apoptosis; Biotransformation; Butadienes; Cell Survival; Cells, Cultured; Epoxy Compounds; Fibroblasts; Glycols; Humans; Mice; Mice, Transgenic; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Rats; Rats, Mutant Strains

2000
Urinary butadiene diepoxide: a potential biomarker of blood diepoxide.
    Toxicology, 2001, Mar-07, Volume: 160, Issue:1-3

    Topics: Animals; Biomarkers; Butadienes; Carcinogens; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Species Specificity

2001
First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice.
    Chemico-biological interactions, 2001, Jun-01, Volume: 135-136

    Topics: Aldehydes; Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Kinetics; Liver; Male; Mice; Perfusion; Rats; Rats, Sprague-Dawley; Species Specificity

2001
Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment.
    Chemico-biological interactions, 2001, Jun-01, Volume: 135-136

    Topics: Animals; Butadienes; Epoxy Compounds; Female; Humans; Mice; Models, Biological; Rats; Risk Assessment; Sensitivity and Specificity; Species Specificity

2001
Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms.
    Chemico-biological interactions, 2001, Jun-01, Volume: 135-136

    Topics: Air Pollutants; Animals; Bacterial Proteins; Butadienes; Cell Line; Epoxy Compounds; Escherichia coli Proteins; Female; Humans; Lac Repressors; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Rats; Repressor Proteins; Spleen

2001
Synthesis and characterization of peptides containing a cyclic Val adduct of diepoxybutane, a possible biomarker of human exposure to butadiene.
    Chemical research in toxicology, 2003, Volume: 16, Issue:5

    Topics: Amides; Biomarkers; Butadienes; Carcinogens; Environmental Pollutants; Epoxy Compounds; Globins; Humans; Magnetic Resonance Spectroscopy; Oligopeptides; Pyrrolidines; Stereoisomerism; Valine

2003
A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene.
    Environmental and molecular mutagenesis, 2003, Volume: 42, Issue:2

    Topics: Administration, Inhalation; Animals; Butadienes; Comet Assay; DNA Damage; Drug Resistance; Epoxide Hydrolases; Epoxy Compounds; Hypoxanthine Phosphoribosyltransferase; Injections, Intraperitoneal; Mice; Mice, Knockout; Mutation

2003
Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene.
    Cancer research, 2004, Dec-01, Volume: 64, Issue:23

    Topics: Amino Acid Sequence; Animals; Butadienes; Carcinogens; Chromatography, Liquid; Epoxy Compounds; Female; Globins; Humans; Inhalation Exposure; Mass Spectrometry; Mice; Pyrrolidines; Rabbits; Rats; Rats, Inbred F344; Valine

2004
Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats.
    Chemico-biological interactions, 2007, Mar-20, Volume: 166, Issue:1-3

    Topics: Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Inhalation Exposure; Male; Mice; Rats; Rats, Sprague-Dawley; Time Factors

2007
Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene.
    Chemico-biological interactions, 2007, Mar-20, Volume: 166, Issue:1-3

    Topics: Animals; Butadienes; DNA Damage; DNA Repair; Epoxide Hydrolases; Epoxy Compounds; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Inhalation Exposure; Injections, Intraperitoneal; Mice; Models, Animal; Mutation

2007
Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues.
    Chemico-biological interactions, 2007, May-01, Volume: 167, Issue:3

    Topics: Administration, Inhalation; Adult; Biotransformation; Body Fluid Compartments; Breath Tests; Butadienes; Butylene Glycols; Epoxy Compounds; Glycols; Humans; Kinetics; Male; Models, Biological; Reference Values; Sensitivity and Specificity; Software; Time Factors

2007
Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation.
    Cancer research, 2009, Mar-15, Volume: 69, Issue:6

    Topics: Animals; Butadienes; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Epoxy Compounds; Female; Inhalation Exposure; Male; Mice; Rats; Rats, Inbred F344; Sex Factors; Tandem Mass Spectrometry

2009
Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural elucidation, and mechanistic studies.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Base Pairing; Butadienes; Chromatography, High Pressure Liquid; Deoxyadenosines; DNA Adducts; Epoxy Compounds; Models, Molecular; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2010
Column switching HPLC-ESI(+)-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene.
    Chemical research in toxicology, 2010, Apr-19, Volume: 23, Issue:4

    Topics: Adenine; Animals; Butadienes; Carcinogens; Chromatography, High Pressure Liquid; Deoxyadenosines; DNA; DNA Adducts; Epoxy Compounds; Inhalation; Mice; Rats; Spectrometry, Mass, Electrospray Ionization

2010
Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation.
    Chemical research in toxicology, 2011, Jun-20, Volume: 24, Issue:6

    Topics: Air Pollutants; Animals; Butadienes; Carcinogens; DNA; DNA Adducts; DNA Glycosylases; DNA Repair; Epoxy Compounds; Gene Deletion; Humans; Mice; Rats; Rats, Inbred F344; Xeroderma Pigmentosum Group A Protein

2011
Diepoxybutane interstrand cross-links induce DNA bending.
    Biochimie, 2012, Volume: 94, Issue:2

    Topics: Base Sequence; Butadienes; Carcinogens; Cross-Linking Reagents; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Epoxy Compounds; Molecular Sequence Data; Nucleic Acid Conformation; Stereoisomerism

2012
1,2:3,4-Diepoxybutane in blood of male B6C3F1 mice and male Sprague-Dawley rats exposed to 1,3-butadiene.
    Toxicology letters, 2011, Dec-15, Volume: 207, Issue:3

    Topics: Animals; Butadienes; Carcinogens; Dose-Response Relationship, Drug; Epoxy Compounds; Inhalation Exposure; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Species Specificity; Tandem Mass Spectrometry

2011
Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 125, Issue:1

    Topics: Air Pollutants, Occupational; Biomarkers; Butadienes; Chromatography, High Pressure Liquid; Epoxy Compounds; Erythrocytes; Hemoglobins; Humans; Hypoxanthine Phosphoribosyltransferase; Male; Mutation; Occupational Exposure; Pyrrolidines; Tandem Mass Spectrometry; Valine

2012
Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene.
    Chemical research in toxicology, 2012, Jul-16, Volume: 25, Issue:7

    Topics: Animals; Butadienes; Cell Survival; Chromatography, High Pressure Liquid; DNA; DNA Adducts; DNA-Directed RNA Polymerases; Epoxy Compounds; Escherichia coli; Escherichia coli Proteins; Glutathione; Glutathione Transferase; Mice; Microsomes, Liver; Mutagenicity Tests; Mutation; Rats; Tandem Mass Spectrometry

2012
DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.
    Mutation research, 2012, Sep-18, Volume: 747, Issue:2

    Topics: Butadienes; Butylene Glycols; Carcinogens; Cell Line, Transformed; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; Epoxy Compounds; Hepatocytes; Humans; Mutagens

2012
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
    Chemical research in toxicology, 2013, Nov-18, Volume: 26, Issue:11

    Topics: Animals; Butadienes; Buthionine Sulfoximine; Chromatography, High Pressure Liquid; DNA Adducts; DNA Mutational Analysis; Epoxy Compounds; Ethylene Dibromide; Glutathione; Glutathione Transferase; Guanine; Liver; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; Mutation Rate; O(6)-Methylguanine-DNA Methyltransferase; Spectrometry, Mass, Electrospray Ionization

2013
Preventive activity of olive oil phenolic compounds on alkene epoxides induced oxidative DNA damage on human peripheral blood mononuclear cells.
    Nutrition and cancer, 2014, Volume: 66, Issue:8

    Topics: Acetylcysteine; Butadienes; Catalase; Comet Assay; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Epoxy Compounds; Humans; Leukocytes, Mononuclear; Olive Oil; Oxidative Stress; Phenols; Plant Oils

2014
1,2:3,4-Diepoxybutane Induces Multipolar Mitosis in Cultured Human Lymphocytes.
    Cytogenetic and genome research, 2016, Volume: 148, Issue:2-3

    Topics: Aneuploidy; Butadienes; Cells, Cultured; Epoxy Compounds; Healthy Volunteers; Humans; Lymphocytes; Mitomycin; Mitosis; Mutagens; Toxicity Tests

2016
1,3-Butadiene metabolite 1,2,3,4 diepoxybutane induces DNA adducts and micronuclei but not t(9;22) translocations in human cells.
    Chemico-biological interactions, 2019, Oct-01, Volume: 312

    Topics: Butadienes; DNA Adducts; Epoxy Compounds; HL-60 Cells; Humans; Radiation, Ionizing; Translocation, Genetic

2019
DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2022, Jan-13, Volume: 28, Issue:3

    Topics: Butadienes; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Epoxy Compounds; Formamides; Furans; Humans; Pyrimidines

2022