1,3,4-oxadiazole has been researched along with oxadiazoles in 245 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.63) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 140 (57.14) | 24.3611 |
| 2020's | 101 (41.22) | 2.80 |
| Authors | Studies |
|---|---|
| BURKE, JC; CRAVER, BN; HASSERT, GL; POUTSIAKA, JW | 1 |
| ADAMS, AC; BLUMENTHAL, A; O'NEAL, JB; ROSEN, H; RUSSELL, PB | 1 |
| KODAMA, Y; SAIKAWA, I; TAKAI, A | 2 |
| Deep, A; Jain, J; Malhotra, M; Monga, V; Sahu, K; Sharma, G; Sharma, R | 1 |
| Bai, S; Shen, H; Wang, H; Yuan, A; Zhang, Z; Zheng, C | 1 |
| Dang, XF; Guo, FJ; Li, MH; Qian, SS; Sun, J; Wang, XM; Xue, YR; Zhu, HL | 1 |
| Docsa, T; Gergely, P; Somsák, L; Szőcs, B; Tóth, M | 1 |
| He, D; Huang, J; Li, X; Lu, H; Luo, C | 1 |
| He, LQ; Jiang, AQ; Liu, ZJ; Luo, Y; Yang, YH; Zhang, S; Zhu, HL | 1 |
| Docsa, T; Gergely, P; Kaszás, T; Somsák, L; Szőcs, B; Tóth, M | 1 |
| Wan, P; Wang, L; Xu, G; Zhao, L | 1 |
| Chen, X; Li, S; Lv, Q; Tu, G; Wang, J; Yan, Y | 1 |
| Agarwal, P; Bee, S; Gupta, A; Tandon, P | 1 |
| Bhatt, N; Desai, NC; Somani, H; Trivedi, A | 1 |
| Boger, DL; Campbell, EL; Duncan, KK; Sankar, K; Skepper, CK | 1 |
| Bangalore, P; Borhade, SD; Khandare, PK; Rane, RA | 1 |
| Akiyama, C; Chiba, K; Kagechika, K; Kobayashi, Y; Kubo, H; Nishi, M; Ono, M; Shibata, Y; Takano, H; Usui, H; Yamaguchi, M; Yoshikawa, K | 1 |
| Bhadraiah, UK; Doddaramappa, SD; Javarasetty, C; Keshavamurthy, S; Ningaiah, S | 1 |
| Airinei, A; Bruma, M; Hamciuc, C; Homocianu, M; Ipate, AM | 1 |
| Choi, MM; Dong, C; Feng, L; Hu, Q; Liu, Q; Shuang, S; Yuan, C; Zhang, L | 1 |
| He, D; Lu, H | 1 |
| Akhtar, T; Hameed, S; Iqbal, J; Jones, PG; Khan, MA | 1 |
| Black, DS; Griffith, R; Kandemir, H; Kumar, N; Kutty, SK; Lewis, PJ; Ma, C | 1 |
| Arrat, H; Lukas, TJ; Scheidt, K; Schiltz, GE; Siddique, T | 1 |
| Chen, XW; He, M; Hu, DY; Li, P; Shi, L; Shi, QC; Song, BA; Wu, F; Xu, WM; Yang, L; Yang, X | 1 |
| Chai, H; Fan, D; Kang, J; Liu, P; Yu, T; Zhang, H; Zhao, Y | 1 |
| Di, F; Li, Y; Li, Z; Wang, B; Xiong, L; Yang, N; Zhou, Y | 1 |
| Bala, M; Bansal, S; Bhardwaj, V; Bhattacharya, S; Choudhary, S; Joseph, A; Singla, S; Suthar, SK | 1 |
| Chai, X; Liao, J; Meng, Q; Wu, Q; Yang, F; Yu, S; Zhang, L; Zhao, Q; Zou, Y | 1 |
| Altucci, L; Bigogno, C; Brosch, G; De Luca, T; Del Bufalo, D; Dondio, G; Labella, D; Lenoci, A; Mai, A; Miceli, M; Nebbioso, A; Trisciuoglio, D; Valente, S | 1 |
| Bian, W; Choi, MM; Dong, C; Du, H; Fan, L; Hu, Q; Liu, Q; Ren, X; Shuang, S | 1 |
| De Jonghe, S; Gao, LJ; Herdewijn, P; Leonczak, P; Lescrinier, E; Ramadori, AT; Rozenski, J | 1 |
| Bala, S; Kajal, A; Kamboj, S; Prasad, DN; Saini, V | 1 |
| Al-Omary, F; Al-Saadi, AA; El-Emam, AA; Haress, NG; Mary, YS; Panicker, CY; Van Alsenoy, C; War, JA | 1 |
| Ali, A; Choi, EH; Lee, KH; Park, BJ; Saleem, M | 1 |
| Alam, MM; Alam, MS; Alam, P; Ali, Y; Bano, S; Dhulap, A; Haider, S; Hamid, H; Kharbanda, C; Nazreen, S; Pasha, MA; Pillai, KK; Shafi, S; Yar, MS | 1 |
| Chen, BQ; Fu, XY; Jing, F; Li, S; Liu, YM; Wang, P; Xuan, LN; Zhang, K | 1 |
| Awadallah, AM; Beadham, I; Elmanama, AA; Gardiner, JM; Mattar, MR; Mkadmh, AM; Morjan, RY; Pritchard, RG; Raftery, J | 1 |
| Abdel-Maksoud, MS; El-Gamal, MI; Gamal El-Din, MM; Oh, CH; Yoo, KH | 2 |
| Gao, MN; Hu, DY; Jin, LH; Li, P; Shi, L; Song, BA; Xue, W; Yang, X | 1 |
| Cangming, Z; Lin, C; Qi, W; Shaoyan, W | 1 |
| Qin, L; Zard, SZ | 1 |
| El Ashry, ESH; Hagar, M; Ibid, F; Soliman, SM | 1 |
| Bantu, R; Gurrala, S; Jain, N; Nagarapu, L; Polepalli, S; Srujana, G; Yadagiri, B | 1 |
| Chen, X; Gan, X; Hu, D; Li, P; Song, B; Wu, J; Xue, W | 1 |
| Cao, J; Chen, Q; He, M; Wang, L | 1 |
| Chen, Q; Jiang, G; Ouyang, G; Tai, A; Wu, W | 1 |
| Bajda, M; Khan, KM; Khan, ZA; Mahmood, N; Mutahir, S; Naqvi, SA; Shahzad, SA; Shahzadi, L; Yar, M | 1 |
| Emam, SH; Kamal, AM; Khalil, NA | 1 |
| Asati, V; Bajaj, S; Roy, PP; Singh, J | 1 |
| Alonso-Gil, S; Caignard, DH; de la Fuente Revenga, M; Fernández-Sáez, N; Herrera-Arozamena, C; Morales-García, JA; Pérez-Castillo, A; Rivara, S; Rodríguez-Franco, MI | 1 |
| Gao, Q; Liu, S; Wu, A; Wu, X; Zhang, J | 1 |
| Yıldırım, A | 1 |
| Gao, M; Hu, D; Li, P; Shi, L; Song, X; Wang, W; Wu, Z | 1 |
| Banerjee, AG; Das, N; Shengule, SA; Shrivastava, SK; Srivastava, RS | 1 |
| Dou, GF; Li, J; Li, P; Li, SC; Li, ZJ; Lou, YQ; Lu, C; Lu, YY; Meng, ZY; Ren, H; Wang, X; Zhang, GL | 1 |
| Ahmad, A; Al-Ghamdi, KJ; Shiekh, RA; Sobral, AJFN; Wani, MY | 1 |
| Bheemaraju, G; Mahesh, M; Manjunath, G; Venkata Ramana, P | 1 |
| Li, P; Luo, H; Ma, Y; Mao, Y; Wang, Z; Yan, J; Zhou, J | 1 |
| Chitra, S; Kiruthika, A; Parameswari, K; Saranya, J; Sounthari, P | 1 |
| Al-Blewi, FF; Al-Yahyawi, AM; Aouad, MR; Bardaweel, SK; Rezki, N | 1 |
| Hassan, MF; Rauf, A | 1 |
| Barker, TJ; Boger, DL; Sears, JE | 1 |
| Abdildinova, A; Choe, JH; Gong, YD; Yang, SJ | 1 |
| Alvarez, K; Barral, K; Benmansour, F; Canard, B; de Lamballerie, X; Eydoux, C; Guillemot, JC; Querat, G | 1 |
| Song, BA; Wang, PY; Wu, ZB; Xue, W; Yang, S; Zhou, J; Zhou, L | 1 |
| Bai, CG; Chen, Y; Chu, XQ; Ding, YH; Li, HY; Li, YT; Meng, FF; Pan, CW; Qu, WZ; Wang, JH; Yang, C; Zhang, Q | 1 |
| Abate, A; Baena, JP; Bellina, F; Bignozzi, CA; Caramori, S; Carli, S; Grätzel, M; Hagfeldt, A; Lessi, M; Marchetti, N; Marianetti, G | 1 |
| Cui, JR; Ge, ZM; Li, RD; Li, RT; Li, YB; Liu, P; Sun, SQ; Wang, X; Yan, X; Zhou, DM | 1 |
| Bhatt, K; Desai, NC; Jha, PC; Khedkar, VM; Nawale, L; Sarkar, D; Somani, H; Trivedi, A | 1 |
| Alarifi, A; Hussaini, SM; Kamal, A; Kapure, JS; Kumar, GB; Srikanth, PS; Suresh Babu, K; Vishnuvardhan, MV | 1 |
| Feng, J; Feng, L; He, H; Peng, H; Ren, Y; Wang, W; Xia, Q; Zhou, Y | 1 |
| Alam, P; Khan, RH; Laskar, K; Rauf, A | 1 |
| Choe, JH; Gong, YD; Yang, SJ | 1 |
| Chen, BQ; Li, B; Li, BL; Li, CW; Liu, JB; Liu, YM; Wang, XF; Zhang, RL; Zhao, JJ | 1 |
| Li, YH; Li, ZM; Liu, XH; Wang, BL; Zhan, YZ; Zhang, LY; Zhang, X; Zhang, Y | 1 |
| Abd-Ellah, HS; Abdel-Aziz, M; Ahmed, AF; Beshr, EA; Kaoud, TS; Shoman, ME | 1 |
| Asproni, B; Bagella, L; Marchesi, I; Murineddu, G; Nieddu, V; Pinna, G; Pinna, GA; Sanna, L | 1 |
| Chaves, JDS; Corrêa, CC; de Almeida, MV; de J Franco, CH; Fontes, APS; Francisco, TM; Monte-Neto, RL; Murta, SMF; Silva, H; Tunes, LG | 1 |
| Carazo, A; Hrabálek, A; Karabanovich, G; Klimešová, V; Konečná, K; Němeček, J; Pávek, P; Pavliš, O; Roh, J; Stolaříková, J; Valášková, L; Vávrová, K | 1 |
| Kameshwar, VH; Priya, BS; R, KJ; Swamy, SN | 1 |
| Lu, GH; Pang, YJ; Qi, JL; Qiu, HY; Sun, WX; Wang, X; Wang, XM; Wang, ZZ; Yang, YH; Yu, FG; Zhang, YH | 1 |
| Joshi, RA; Joshi, RR; Likhite, AP; Nawale, L; Rode, ND; Sarkar, D; Sonawane, AD | 1 |
| Chawla, G; Naaz, B; Siddiqui, AA | 1 |
| Nagarapu, L; Nanubolu, JB; Perumal, Y; Sajja, Y; Sriram, D; Vanguru, S; Vulupala, HR | 1 |
| Ahsan, MJ; Al-Tamimi, ABS; Bakht, MA; Choupra, A; Geesi, MH; Hassan, MZ; Jadav, SS; Padmaja, P; Sharma, RK | 1 |
| Bajaj, S; Roy, PP; Singh, J | 1 |
| El-Sayed, WA; El-Sofany, WI; Fathy, NM; Hussein, HAR | 1 |
| Doshi, H; Ray, A; Thakkar, SS; Thakor, P | 1 |
| Abdel-Aziz, SA; Aboelmagd, M; Abou-Seri, SM; Alfayomy, AM; Ragab, FAF | 1 |
| Abd-Ellah, HS; Abdel-Aziz, M; Ahmed, AFF; Beshr, EAM; Kaoud, T; Shoman, ME | 1 |
| Ahmad, K; Athar, F; Azam, A; Bhat, AR; Hejazi, II; Khanam, R; Kumar, V; Siddique, IA | 1 |
| Chen, Z; Gan, X; Hu, D; Song, B; Wang, Y | 1 |
| Bishayee, A; Kalle, AM; Pidugu, VR; Satya, AK; Yarla, NS | 1 |
| Becnel, JJ; Bloomquist, JR; Estep, AS; Geldenhuys, WJ; Gross, AD; Kocyigit-Kaymakcioglu, B; Tabanca, N; Tok, F | 1 |
| Chhikara, A; Chopra, M; Kumar, P; Yadav, N | 1 |
| Chen, Y; Hu, D; Jin, L; Li, P; Song, B; Song, X; Tian, P; Xue, W; Yang, S | 1 |
| Gong, YD; Ha, JE; Yang, SJ | 1 |
| Fuchs, BB; Kim, W; Liu, Q; Mylonakis, E; Tharmalingam, N; Zheng, Z | 1 |
| Alam, MS; Dhulap, A; Hamid, H; Kalam, A; Khan, I; Tantray, MA | 1 |
| Cao, C; He, X; Li, S; Li, XY; Liang, JW; Meng, FH; Zhang, TJ | 1 |
| Araniciu, C; Ionuț, I; Marc, G; Oniga, O; Oniga, S; Stoica, CI; Tiperciuc, B; Vlase, L | 1 |
| Chen, J; Hu, D; Jin, L; Li, P; Song, B; Xie, D | 1 |
| Bagul, SD; Bendre, RS; Rajput, JD; Srivastava, C | 1 |
| Çavuşoğlu, BK; Çiftçi, GA; Temel, HE; Yurttaş, L | 1 |
| Huszár, S; Janoušek, J; Korduláková, J; Krátký, M; Madacki, J; Mikušová, K; Stolaříková, J; Švarcová, M; Trejtnar, F; Vinšová, J; Vosátka, R | 1 |
| Benade, V; Birangal, SR; Bogaraju, N; Gagginapally, SR; Jayarajan, P; Kancharla, DM; Middekadi, VR; Mohammed, AR; Muddana, N; Nirogi, R; Palacharla, RC; Ravella, SR; Shinde, AK; Singh, P; Subramanian, R | 1 |
| Chen, L; Liu, M; Wang, M; Wang, X; Xue, W; Yan, J; Zhang, J | 1 |
| Hu, D; Li, M; Li, P; Luo, L; Song, B; Song, X; Yang, A; Yu, L | 1 |
| Bhadane, D; Bhutani, KK; Jariwala, N; Kulkarni, S; Kumar, S; Naik, D; Shah, P; Singh, IP | 1 |
| Almerico, AM; Pecoraro, B; Tutone, M | 1 |
| Liang, YY; Liu, ZP; Zhang, CM | 1 |
| Abbasi, MA; Khan, SG; Rasool, S; Rehman, A; Shah, SAA; Siddiqa, A; Siddiqui, SZ | 1 |
| Baldassano, S; Di Leonardo, A; Lentini, L; Melfi, R; Pace, A; Pibiri, I; Ricco Galluzzo, P; Tutone, M | 1 |
| He, D; Jian, W; Shang, J; Wen, L | 1 |
| Blundell, R; Butler, MS; Cooper, MA; Fraser, JA; Furlong, E; Kappler, U; Kobe, B; Kummari, LK; Nouwens, A; Robertson, AAB; Silva, AB | 1 |
| Akhtar, W; Akhter, M; Alam, MM; Khan, MF; Shaquiquzzaman, M; Verma, G | 1 |
| Bhutani, R; Husain, A; Iqbal, MA; Kapoor, G; Pathak, DP | 1 |
| Panchal, II; Patel, AD; Rajput, R | 1 |
| Ahmad, HA; Asim Raza Basra, M; Batool, M; Farhat, F; Khattak, ZAK; Munawar, MA; Shahid, M; Tajammal, A; Verpoort, F; Zia-Ur-Rehman, M | 1 |
| Abbas, SH; Abd El-Hafeez, AA; Abdel-Aziz, M; Abdelhamid, D; Fathi, MAA; Montano, MM | 1 |
| Glomb, T; Świątek, P; Szymankiewicz, K | 1 |
| Acar Çevik, U; Atlı, Ö; Kaplancıklı, ZA; Karaburun, AÇ; Kaya Çavuşoğlu, B; Koparal, AS; Levent, S; Osmaniye, D; Özkay, Y; Sağlık, BN | 1 |
| Caneschi, W; Carvalho de Mendonça, C; Costa Couri, MR; da Silva Martins, J; de Souza Fernandes, F; Dittz, D; Dos Santos, HF; Duarte, LM; Enes, KB; Le Hyaric, M; Leal de Oliveira, MA; Miguel, FB; Paz Lopes, MT; Pinho, RR; Silva, H | 1 |
| Seth, A; Sharma, P; Shrivastava, SK; Srivastava, P; Tripathi, PN | 1 |
| Archana, K; Arjun, HA; Elancheran, R; Kabilan, S; Lakshmithendral, K; Lokanath, NK; Manikandan, N; Ramanathan, M; Saravanan, K | 1 |
| Azger Dusthackeer, VN; Chopra, S; Krishna, EV; Krishna, VS; Mahizhaveni, B; Makane, VB; Misra, S; Rode, HB; Shukla, M; Sriram, D | 1 |
| Alvala, M; Angeli, A; Mohammed, A; Narella, SG; Shaik, MG; Supuran, CT | 1 |
| Jia, J; Liu, J; Wu, H; Yang, D; Zhao, G | 1 |
| Ashraf, Z; Hassan, M; Iqbal, A; Iqbal, Z; Latif, M; Nadeem, H | 1 |
| Bishayee, A; Khan, H; Patel, S; Shah, SM; Zafar, M | 1 |
| Gupta, SK; Krishnamurthy, S; Mishra, P; Seth, A; Sharma, P; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN | 1 |
| Bao, C; Fan, J; Guo, Y; Liu, Z; Qin, S; Xu, T; Yang, R | 1 |
| Albratty, M; Alhazmi, HA; El-Sharkawy, KA | 1 |
| Abbasi, MA; Aslam, SJ; Rasool, S; Rehman, A; Shah, SAA; Siddiqui, SZ | 1 |
| Mishra, P; Upadhyay, PK | 1 |
| Baev, DS; Frolova, TS; Popov, SA; Semenova, MD; Shults, EE; Sorokina, IV; Tolstikova, TG; Turks, M; Zhukova, NA | 1 |
| Abdel-Aal, MT; Awad, HM; El-Sayed, WA; Kassem, AF; Nassar, IF | 1 |
| Dömling, A; Konstantinidou, M; Mgimpatsang, KC; Shishkina, SV; Wang, Q | 1 |
| Sharma, P; Shrivastava, SK; Singh, SP; Singh, SS; Tripathi, A; Tripathi, PN | 1 |
| Efimova, J; Ivanovskii, S; Petzer, A; Petzer, JP; Shetnev, A; Shlenev, R; Tarasov, A | 1 |
| Adei, E; Haleegoah, JN; Opoku, E; Roland, D; Tia, R | 1 |
| Ahmed, I; Ashraf, M; Htar, TT; Iftikhar, M; Khan, SU; Rahman, J; Riaz, N; Saleem, M; Sharif, MS | 1 |
| Baev, DS; Frolova, TS; Popov, SA; Semenova, MD; Shults, EE; Turks, M; Wang, C | 1 |
| Li, Z; Liu, LW; Wang, MW; Wang, PY; Wu, YY; Wu, ZB; Yang, S; Zeng, D; Zhu, HH | 1 |
| Abulkhair, HS; El-Attar, AMM; Hagras, M; Hannoun, MH; Kotb, A | 1 |
| Andavar, S; Devanathan, K; Kumaran, AA; Selvaraj, D; Vaithilingam, M | 1 |
| Gong, P; Han, Y; Li, X; Tian, Y; Wang, R; Xu, C; Xu, S; Yue, M; Zhao, Y | 1 |
| Dong, W; Guo, L; Song, B; Wang, W; Wang, X; Yang, J; Zhang, J | 1 |
| Guo, Y; Hou, E; Jia, A; Liu, Z; Xu, H; Yang, R | 1 |
| Choubey, PK; Saraf, P; Seth, A; Sharma, P; Shrivastava, SK; Tripathi, A | 1 |
| Avram, S; Bădiceanu, CD; Bleotu, C; Bordei Telehoiu, AT; Căproiu, MT; Chifiriuc, MC; Dumitrascu, F; Ioniță, P; Limban, C; Nuță, DC; Zarafu, I | 1 |
| Čižmár, E; Herchel, R; Kuchár, J; Zoufalý, P | 1 |
| Ananth, AH; Bhattacharjee, A; Elancheran, R; Kabilan, S; Lakshmithendral, K; Manikandan, N; Rajan, RK; Ramanathan, M | 1 |
| Dong, HQ; Gu, YC; Guo, SK; Han, X; Liu, JR; Song, ZL; Sun, Q; Zhang, MZ; Zhang, WH; Zhu, Y | 1 |
| Chen, J; Hu, D; Luo, Y; Song, B; Wei, C; Wu, R; Wu, S | 1 |
| Angeli, A; Kumar, R; Sharma, PK; Sharma, V; Supuran, CT | 1 |
| Jin, L; Lu, H; Mu, X; Wang, L; Zhou, X | 1 |
| Alam, O; Nazar, S; Siddiqui, N | 1 |
| Ercetin, T; Gulcan, HO; Gurdal, EE; Koksal, M; Orak, D; Ozyazici, T; Sipahi, H | 1 |
| Chen, J; Hu, D; Luo, Y; Song, B; Wang, S; Wei, C; Wu, R; Wu, S | 1 |
| Alam, MM; Alzhrani, ZMM; Nazreen, S; Neamatallah, T | 1 |
| Ait Benhassou, H; Andrei, G; El Mansouri, AE; Lazrek, HB; Maatallah, M; Mehdi, A; Moumen, A; Snoeck, R; Zahouily, M | 1 |
| Ali Shah, F; Khan, AU; Li, S; Mohsin Alvi, A; Nadeem, H; Sadiq Sheikh, A; Tariq Al Kury, L; Tariq Khan, M; Umar Ijaz, M; Zeb, A | 1 |
| Costa, DS; de Almeida, MV; Espinosa, AV; Grazul, RM; Monte-Neto, RLD; Silva, H; Tunes, LG | 1 |
| Bleotu, C; Diaconu, CC; Hanganu, A; Ionita, P; Limban, C; Matei, L; Nemeș, RM; Nicolau, I; Nuta, DC; Păun, A; Radulescu, C; Tatibouët, A; Zarafu, I | 1 |
| Bansode, MU; Doshi, GM; Somani, RR | 1 |
| Aryan, R; Beyzaei, H; Moradi, A; Yarmohammadi, E | 1 |
| Chen, YF; Huang, GJ; Yu, X; Zhao, YF | 1 |
| Kaneko, D; Koketsu, M; Ninomiya, M; Nishina, A; Ono, Y; Sonawane, AD; Tanaka, K; Udagawa, T | 1 |
| Chen, J; Hu, D; Liu, D; Song, B; Xiang, J | 1 |
| Kaneko, D; Koketsu, M; Ninomiya, M; Nishina, A; Ono, Y; Sonawane, AD; Tanaka, K; Yoshikawa, R | 1 |
| Bagella, L; Bordoni, V; Chengxun, L; Kelvin, DJ; Murineddu, G; Pinna, GA; Sanna, L; Tiansheng, Z; Weidong, L | 1 |
| Bodetko, D; Czyżnikowska, Ż; Gębarowski, T; Gębczak, K; Glomb, T; Świątek, P; Wiatrak, B | 1 |
| Krzyżak, E; Marciniak, A; Peregrym, K; Potyrak, K; Świątek, P; Szczukowski, Ł; Wiatrak, B; Zając, P; Zborowska, A | 1 |
| Rana, K; Sahu, JK | 1 |
| Danielewski, M; Dzimira, S; Merwid-Ląd, A; Rutkowska, M; Świątek, P; Szandruk-Bender, M; Szczukowski, Ł; Szeląg, A; Wiatrak, B | 1 |
| Han, X; Liu, XH; Ma, D; Yu, YL; Zhang, ZY | 1 |
| AitItto, MY; El Mansouri, AE; Lazrek, HB; Mehdi, A; Morjani, H; Oubella, A; Zahouily, M | 1 |
| Abedinifar, F; Asemanipoor, N; Biglar, M; Faramarzi, MA; Hajimiri, MH; Hamedifar, H; Larijani, B; Mahdavi, M; Mohammadi-Khanaposhtani, M; Mojtabavi, S | 1 |
| Abbasi, MA; Ali Shah, SA; Aziz-Ur-Rehman, -; Rasool, S; Sattar, A; Siddiqui, SZ | 1 |
| Hu, ZH; Lin, QX; Liu, HY; Tu, GG; Yang, BW; Zhao, TS | 1 |
| Ahsan, MJ | 1 |
| Edries, TB; Elbarbary, AA; Hamada, EGI; Kenawy, ER; Meshrif, WS | 1 |
| Bajaj, S; Kumar, MS; Tinwala, H; Yc, M | 1 |
| Abdel-Aziz, SA; Aboraia, AS; El-Koussi, NA; Gomaa, HAM; Hofny, HA; Mohamed, MFA; Youssif, BGM | 1 |
| Kaplancıklı, ZA; Koçyiğit-Kaymakçıoğlu, B; Özkay, Y; Sağlık, BN; Tok, F; Uğraş, Z | 1 |
| Choubey, PK; Seth, A; Shrivastava, SK; Tripathi, A; Tripathi, MK | 1 |
| Bader, M; Celik, T; Dedeoglu-Erdogan, A; Gurdal, EE; Koksal, M; Ozgurbuz, M; Reis, R; Sipahi, H; Sippl, W | 1 |
| Asgari, MS; Barzegari, E; Gulçin, İ; Larijani, B; Mahdavi, M; Mirzazadeh, R; Mohammadi-Khanaposhtani, M; Pedrood, K; Rahmani, H; Rastegar, H; Sherafati, M; Taslimi, P; Üç, EM | 1 |
| Ahmad Lone, B; Ahmad, F; Ahmad, N; Ali Khan, I; Ali, I; Grover, A; Khan, A; Kumari, A; Naaz, F; Rajput, VS; Shafi, S | 1 |
| Banwala, S; Husain, A; Kaur, S; Khokra, SL; Wadhwa, K | 1 |
| Ahsan, MJ; Joshi, S; Kumar, R; Kumari, S; Mazumder, A; Saxena, S; Sharma, D; Sharma, V; Yar, MS | 1 |
| Ahmad, M; Andrei, G; Dânoun, K; El Mansouri, AE; Jochmans, D; Lazrek, HB; Morjani, H; Neyts, J; Oubella, A; Snoeck, R; Zahouily, M | 1 |
| Huang, X; Su, K; Wei, W; Xiang, S; Yang, H; Zeng, X | 1 |
| Bibire, N; Buron, F; Constantin, SM; Focșa, AV; Lupașcu, FG; Panainte, A; Profire, L; Routier, S; Sava, A | 1 |
| Glomb, T; Świątek, P | 1 |
| Allaka, TR; Anireddy, JS; Chepuri, K; Kummari, B; Kuntala, N; Polkam, N | 1 |
| Dong, NH; Hong Do, TT; Pham, EC; Truong, TN; Vo, DD | 1 |
| Amjad, H; Ashraf, M; Bashir, B; Bhattarai, K; Imran, M; Muzaffar, S; Riaz, N; Saleem, M; Shahid, W | 1 |
| Cao, Z; Cui, Y; Yang, J; Yang, Y; Zhai, X; Zhao, T; Zuo, D | 1 |
| Franco-Molina, MA; Hernandez-Fernandez, E; Lopez, I; Michaelis, DJ; Nava-Ramirez, JC; Ortega-Villarreal, AS; Santana-Krimskaya, SE | 1 |
| Bhandari, S; Patil, S | 1 |
| Cheng, Z; Fang, L; Liu, Y; Tian, J; Zhang, H; Zhang, K; Zhang, X; Zhou, J | 1 |
| Baykov, SV; Boyarskiy, VP; Geyl, KK; Gureev, MA; Mikherdov, AS; Novikov, AS; Tarasenko, MV | 1 |
| Devi, M; Duhan, M; Kumar, A; Kumar, P; Kumar, R; Lal, S; Sindhu, J; Singh, R | 1 |
| Feng, B; Gao, LX; Li, J; Meng, XD; Satheeshkumar, R; Wang, WL; Wang, ZJ; Zhang, C; Zhou, YB; Zhu, YL | 1 |
| Chen, F; Li, M; Li, Y; Shi, Y; Wang, H; Zhao, X | 1 |
| Chai, Y; Jiang, B; Liu, M; Lu, Y; Lv, K; Qin, X; Wang, A; Wang, B; Wang, D; Wu, W; Xia, G; Xu, S | 1 |
| Angelova, VT; K-Yovkova, E; Karabeliov, VR; Kondeva-Burdina, MS; Vassilev, NG | 1 |
| Chaudhary, T; Upadhyay, PK | 2 |
| Ali, M; Khan, KM; Khan, M; Salar, U; Shah, S; Shah, Z; Ur Rehman, A; Wadood, A; Yousaf, M | 1 |
| Ding, H; Huang, S; Jiang, X; Li, D; Liu, M; Liu, W; Tian, C; Wu, L; Xu, Z; Zhao, Q; Zhu, C | 1 |
| Chawla, K; Gaonkar, SL; Guru, BR; Hakimane, SS; Hari, G; Hazra, D; Nayak, S; Pai, KSR | 1 |
| Caruso, U; Concilio, S; Di Costanzo, L; Diana, R; Panunzi, B; Piotto, S; Sessa, L | 1 |
| Babu, BN; Kaki, VR; Kiranmai, G; Makhal, PN; Nagesh, N; Parimala Devi, G; Shaikh, AS; Shankaraiah, N; Sigalapalli, DK; Tangellamudi, ND; Tokala, R | 1 |
| A A Abd El-Wahab, H; Abdel-Fattah, HA; E A Hassan, A; Ghanim, AM; Hamoud, MMS; Osman, NA; Rezq, S; Romero, DG | 1 |
| Asproni, B; Bagella, L; Bordoni, V; Borghi, F; Corona, P; Murineddu, G; Pinna, GA; Sanna, L; Zoroddu, S | 1 |
| Bai, LP; Cheng, W; Chu, J; Guo, Y; Liu, JZ; Ma, N; Meng, JR; Xu, T; Zhang, Q | 1 |
| Devgun, M; Lal, S; Narang, R; Singh, V; Sudhakar, K; Tiwari, D | 1 |
| Abbasi, I; Bukhari, A; Bukhari, U; Hamid, I; Khan, MT; Nadeem, H; Sarwar, S | 1 |
| Hu, T; Liu, JQ; Ma, LY; Wei, B; Wu, YX; Xu, XL; Yang, FF; Zhou, JZ | 1 |
| Chu, PL; Ji, J; Qi, PY; Shao, WB; Wang, PY; Xiang, HM; Yang, S; Zhou, X | 1 |
| Ashraf, M; Bao, X; Hussain, S; Khan, IU; Khan, MA; Mutahir, S; Mutahir, Z; Stark, CBW; Tariq, S; Zhou, B | 1 |
| El-Idreesy, TT; Mekky, AEM; Sanad, SMH | 1 |
| Chen, L; Hu, D; Lu, P; Pan, M | 1 |
| Durmaz, Ş; Evren, AE; Sağlık, BN; Tay, NF; Yurttaş, L | 1 |
| Bian, M; Jia, WD; Sun, W; Wang, JJ; Yu, LJ | 1 |
| Devi, M; Kumar, A; Kumar, P; Lal, S; Sindhu, J; Singh, D; Singh, R; Toropov, AA; Toropova, AP | 1 |
| Ahsan, MJ; Datt, V; Kumar, R; Mazumder, A; Shabana, K; Sharma, AS; Tyagi, S; Yar, MS | 1 |
| Abd Ghani, MS; Awang, K; Azmi, MN; Hasmaruddin, NS; Hassan, MZ; Mat Ali, NA; Mohamad, S; Osman, H; Parumasivam, T | 1 |
| Aydın, E; Güzel, M; Küçük, HB; Şentürk, AM | 1 |
| Gogisetti, G; Kanna, U; Rao Allaka, T; Rao Tadiboina, B; Sharma, V | 1 |
| Carrick, JD; Dzeagu, FO | 1 |
| Arafa, RK; Castanet, AS; Nafie, MS; Said, SA | 1 |
| Al-Sehemi, AG; Asha, TM; Chakrapani, PSB; Deepti, A; P A, U; Prakash, P; Remya, TM | 1 |
| Dahiya, H; Jhaa, G; Kumar, A; Kumar, S; Om, H; Sharma, AK; Sharma, D; Sharma, MK; Sharma, R; Sihmar, A; Thakur, A | 1 |
| Korduláková, J; Krátký, M; Pál, A; Pflégr, V; Stolaříková, J | 1 |
| Beshay, BY; El-Sadek, M; Fawzy, SM; Ibrahim, SM; Kothayer, H; Loksha, YM; Shamaa, MM | 1 |
| Åstrand, A; Collins, M; Ek, M; Gunnarsson, A; Hughes, G; Johansson, J; Jung, B; Li, Q; Llinas, A; Mogemark, M; Novén, A; Pemberton, N; Ripa, L; Sandmark, J; Shamovsky, I; Tångefjord, S; Xiong, Y | 1 |
| Almahmoud, SA; Chigurupati, S; Fatima, B; Felemban, SG; Khan, KM; Salar, U; Saleem, F; Shah, STA; Taha, M; Tariq, SS; Ul-Haq, Z | 1 |
| Alghamadi, A; De Luca, L; Douglas, EJA; Duggan, S; Joseph, EA; Laabei, M; Marshall, B; Serpi, M; Vittorio, S | 1 |
16 review(s) available for 1,3,4-oxadiazole and oxadiazoles
| Article | Year |
|---|---|
1,3,4-Oxadiazoles: An emerging scaffold to target growth factors, enzymes and kinases as anticancer agents.
Topics: Antineoplastic Agents; Humans; Oxadiazoles; Protein Kinases; Vascular Endothelial Growth Factors | 2015 |
Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Molecular Structure; Oxadiazoles | 2018 |
1,3,4-Oxadiazoles as Telomerase Inhibitor: Potential Anticancer Agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Inhibitors; Humans; Molecular Structure; Neoplasms; Oxadiazoles; Telomerase | 2018 |
A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Obesity Agents; Antihypertensive Agents; Antineoplastic Agents; Antioxidants; Drug Development; Drug Discovery; Humans; Oxadiazoles | 2019 |
Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Humans; Molecular Structure; Neoplasms; Oxadiazoles; Structure-Activity Relationship | 2018 |
Recent progress of 1,3,4-oxadiazoles as anticonvulsants: Future horizons.
Topics: Anticonvulsants; Drug Development; Humans; Oxadiazoles; Seizures | 2020 |
Significance of 1,3,4-Oxadiazole Containing Compounds in New Drug Development.
Topics: Analgesics; Anti-Inflammatory Agents; Drug Development; Humans; Oxadiazoles | 2021 |
1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy.
Topics: Antineoplastic Agents; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Neoplasms; Oxadiazoles; Structure-Activity Relationship | 2022 |
1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles | 2021 |
Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.
Topics: Animals; Anti-Infective Agents; Bacteria; Fungi; Humans; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Parasites; Structure-Activity Relationship; Viruses | 2021 |
A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcone; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Neoplasms; Oxadiazoles; Structure-Activity Relationship | 2022 |
A Review on Novel Synthesis Approaches and Biological Activities of 1,2,4- Oxadiazole and 1,3,4-Oxadiazole Tailored Compounds.
Topics: Oxadiazoles | 2022 |
1,3,4-oxadiazole derivatives as potential antimicrobial agents.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship | 2022 |
Exploring Therapeutic Potential of 1,3,4-Oxadiazole Nucleus as Anticancer Agents: A Mini-review.
Topics: Antineoplastic Agents; Cardiovascular Diseases; HeLa Cells; Humans; Oxadiazoles | 2023 |
Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review.
Topics: Anti-Bacterial Agents; Chemistry Techniques, Synthetic; Chemistry, Pharmaceutical; Oxadiazoles | 2022 |
Recent Updates on Synthesis, Biological Activity, and Structure-activity Relationship of 1,3,4-Oxadiazole-quinoline Hybrids: A Review.
Topics: Antimalarials; Oxadiazoles; Quinolines; Structure-Activity Relationship | 2023 |
229 other study(ies) available for 1,3,4-oxadiazole and oxadiazoles
| Article | Year |
|---|---|
Pharmacologic and toxicologic studies with 2-amino-5-phenyl-1,3,4-oxadiazole hydrochloride.
Topics: Azoles; Oxadiazoles; Salts | 1961 |
POTENTIAL HYPOGLYCEMIC AGENTS: 1,3,4-OXADIAZOLES AND RELATED COMPOUNDS.
Topics: Chemical Phenomena; Chemistry; Dogs; Hypoglycemic Agents; Oxadiazoles; Pharmacology; Rats; Research; Thiazoles | 1962 |
[STUDIES ON NITROFURAN AND RELATED COMPOUNDS FOR MEDICINAL PURPOSE. X. SYNTHESES OF 2-(SUBSTITUTED AMINO)-1,3,4-OXADIAZOLE DERIVATIVES WITH NITROFURAN NUCLEUS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIP].
Topics: Anti-Infective Agents; Chemistry, Pharmaceutical; Escherichia coli; Nitrofurans; Oxadiazoles; Pharmacology; Pharmacy; Research; Staphylococcus; Structure-Activity Relationship | 1964 |
[STUDIES ON NITROFURAN AND RELATED COMPOUNDS FOR MEDICINAL PURPOSE. XI. SYNTHESES OF 1,3,4-OXADIAZOLE DERIVATIVES WITH NITROFURAN NUCLEUS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIP].
Topics: Anti-Infective Agents; Chemistry, Pharmaceutical; Escherichia coli; Nitrofurans; Oxadiazoles; Pharmacology; Pharmacy; Research; Staphylococcus; Structure-Activity Relationship | 1964 |
Synthesis, characterization of (Z)-N-(1-(2-(2-amino-3-(dimethylamino) methyl)phenyl)-5-phenyl-1,3,4, oxadiazol-3(2H)-yl)ethanone analogs as potent antimicrobial and hydrogen peroxide scavenging agents.
Topics: Anti-Infective Agents; Free Radical Scavengers; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydrogen Peroxide; Microbial Sensitivity Tests; Mitosporic Fungi; Molecular Structure; Oxadiazoles | 2013 |
Synthesis of pyridine-based 1,3,4-oxadiazole derivative as fluorescence turn-on sensor for high selectivity of Ag+.
Topics: Chemistry Techniques, Analytical; Chemistry Techniques, Synthetic; Fluorescent Dyes; Optical Phenomena; Oxadiazoles; Pyridines; Silver; Spectrometry, Fluorescence | 2013 |
Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.
Topics: Aminopeptidases; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dioxanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glycoproteins; Human Umbilical Vein Endothelial Cells; Humans; Methionyl Aminopeptidases; Models, Molecular; Molecular Structure; Oxadiazoles; Protease Inhibitors; Structure-Activity Relationship | 2013 |
Synthesis of 2-(β-D-glucopyranosyl)-5-(substituted-amino)-1,3,4-oxa- and -thiadiazoles for the inhibition of glycogen phosphorylase.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Phosphorylase, Muscle Form; Molecular Structure; Muscle, Skeletal; Oxadiazoles; Rabbits; Structure-Activity Relationship; Thiadiazoles | 2013 |
Synthesis, fluorescence properties and theoretical calculations of novel stilbene derivatives based on 1,3,4-oxadiazole bearing anthracene core.
Topics: Anthracenes; Fluorescence; Molecular Structure; Oxadiazoles; Quantum Theory; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stilbenes | 2013 |
Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity.
Topics: Antineoplastic Agents; Focal Adhesion Protein-Tyrosine Kinases; HT29 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Neoplasms; Oxadiazoles; Protein Kinase Inhibitors; Structure-Activity Relationship; Triazoles | 2013 |
Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Phosphorylase, Muscle Form; Molecular Structure; Muscle, Skeletal; Oxadiazoles; Rabbits; Structure-Activity Relationship | 2013 |
Linear oxygen-sensing response from a rhenium complex induced by heavy atom: synthesis, characterization, photophysical study and sensing performance.
Topics: Bromine; Coordination Complexes; Crystallography, X-Ray; Diamines; Luminescent Measurements; Models, Molecular; Nanofibers; Oxadiazoles; Oxygen; Rhenium; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2013 |
Synthesis and antiproliferative assay of 1,3,4-oxadiazole and 1,2,4-triazole derivatives in cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Hep G2 Cells; HT29 Cells; Humans; K562 Cells; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2013 |
Use of vibrational spectroscopy to study 2-[4-(N-dodecanoylamino)phenyl]-5-(4-nitrophenyl)-1,3,4-oxadiazole: a combined theoretical and experimental approach.
Topics: Magnetic Resonance Spectroscopy; Models, Molecular; Nitrophenols; Oxadiazoles; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 2013 |
Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Escherichia coli; Fungi; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pyogenes; Structure-Activity Relationship; Thiazoles | 2013 |
Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.
Topics: Cyclization; Molecular Structure; Oxadiazoles; Stereoisomerism; Vinblastine | 2013 |
Synthesis and evaluation of novel 4-nitropyrrole-based 1,3,4-oxadiazole derivatives as antimicrobial and anti-tubercular agents.
Topics: Animals; Antibiotics, Antitubercular; Antifungal Agents; Bacillus subtilis; Candida albicans; Chlorocebus aethiops; Dose-Response Relationship, Drug; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Vero Cells | 2013 |
Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Design; Hypoglycemic Agents; Mice; Oxadiazoles; PPAR alpha; PPAR gamma; Structure-Activity Relationship | 2013 |
Novel pyrazole integrated 1,3,4-oxadiazoles: synthesis, characterization and antimicrobial evaluation.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Dose-Response Relationship, Drug; Fungi; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Pyrazoles; Structure-Activity Relationship | 2014 |
Photophysical behavior of some aromatic poly(1,3,4-oxadiazole-ether)s derivatives.
Topics: Dimethyl Sulfoxide; Dimethylformamide; Ethers; Luminescent Measurements; Oxadiazoles; Polymers; Spectrophotometry, Ultraviolet | 2014 |
A highly selective fluorescent probe for cadmium ions in aqueous solution and living cells.
Topics: Cadmium; Egtazic Acid; Fluorescent Dyes; Humans; MCF-7 Cells; Oxadiazoles; Solutions | 2014 |
Asymmetric 1,3,4-oxadiazole derivatives containing naphthalene and stilbene units: synthesis, optical and electrochemical properties.
Topics: Electrochemistry; Models, Molecular; Naphthalenes; Optical Phenomena; Oxadiazoles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stilbenes | 2014 |
A facile one-pot synthesis of 2-arylamino-5-aryloxylalkyl-1,3,4-oxadiazoles and their urease inhibition studies.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Oxadiazoles; Phaseolus; Structure-Activity Relationship; Urease | 2014 |
Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3,4-oxadiazoles, and 2- and 7-indolyl 2-(1,3,4-thiadiazolyl)ketones as antimicrobials.
Topics: Anti-Bacterial Agents; DNA-Directed RNA Polymerases; Ketones; Oxadiazoles; Structure-Activity Relationship | 2014 |
Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Gene Expression Regulation; Mice; Oxadiazoles; Small Molecule Libraries; Structure-Activity Relationship; Superoxide Dismutase | 2014 |
Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Oryza; Oxadiazoles; Plant Diseases; Plant Leaves; Structure-Activity Relationship; Sulfones; Thiadiazoles; Xanthomonas | 2014 |
Synthesis, crystal structures and photo- and electro-luminescence of copper(I) complexes containing electron-transporting diaryl-1,3,4-oxadiazole.
Topics: Copper; Crystallography, X-Ray; Electron Transport; Electrons; Light; Luminescence; Models, Molecular; Molecular Structure; Organometallic Compounds; Oxadiazoles | 2014 |
Synthesis and biological activities of 2,3-dihydro-1,3,4-oxadiazole compounds and its derivatives as potential activator of ryanodine receptors.
Topics: Animals; Drug Design; Insecticides; Moths; Oxadiazoles; Ryanodine Receptor Calcium Release Channel; Structure-Activity Relationship | 2014 |
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Male; Mice; Molecular Docking Simulation; Oxadiazoles; Protein Conformation; Rats; Stomach Ulcer; Structure-Activity Relationship; Substrate Specificity | 2014 |
Synthesis and biological evaluation of novel fluconazole analogues bearing 1,3,4-oxadiazole moiety as potent antifungal agents.
Topics: Antifungal Agents; Binding Sites; Candida albicans; Drug Evaluation, Preclinical; Fluconazole; Humans; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship | 2015 |
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; HCT116 Cells; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Tumor Cells, Cultured | 2014 |
Design of ratiometric emission probe with visible light excitation for determination of Ca2+ in living cells.
Topics: Calcium; Cations, Divalent; Egtazic Acid; Fluorescent Dyes; Human Umbilical Vein Endothelial Cells; Humans; Light; Microscopy, Confocal; Optical Imaging; Oxadiazoles; Spectrometry, Fluorescence | 2014 |
Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.
Topics: Adenosine Triphosphate; Apoptosis Regulatory Proteins; Binding Sites; Humans; Inhibitory Concentration 50; Kinetics; Oxadiazoles; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Structure-Activity Relationship | 2014 |
1,3,4-oxadiazole derivatives: synthesis, characterization, antimicrobial potential, and computational studies.
Topics: Amidohydrolases; Amino Acids; Amoxicillin; Anti-Infective Agents; Bacteria; Catalytic Domain; Cefixime; Microbial Sensitivity Tests; Oxadiazoles | 2014 |
Spectroscopic investigation (FT-IR and FT-Raman), vibrational assignments, HOMO-LUMO analysis and molecular docking study of 2-(Adamantan-1-yl)-5-(4-nitrophenyl)-1,3,4-oxadiazole.
Topics: Adamantane; Electrons; Ligands; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Nonlinear Dynamics; Optical Phenomena; Oxadiazoles; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics; Vibration | 2015 |
Optical properties of some novel 2,5-disubstituted 1,3,4-oxadiazole derivatives and their application as an efficient cell staining azo dyes.
Topics: Animals; Cells, Cultured; Coloring Agents; Fibroblasts; Fluorescence; Fluorescent Dyes; Mice; Molecular Imaging; Molecular Structure; Optical Phenomena; Oxadiazoles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2014 |
Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists.
Topics: Animals; Blood Glucose; Computer Simulation; Diabetes Mellitus, Experimental; Drug Design; Female; Gene Expression Regulation; Glucose Tolerance Test; HEK293 Cells; Humans; Hypoglycemic Agents; Liver; Male; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Structure-Activity Relationship; Thiazolidinediones | 2014 |
Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Oxadiazoles; Schiff Bases; Thiadiazoles | 2014 |
Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N-acetyl-1,3,4-oxadiazoles.
Topics: Aldehydes; Anti-Bacterial Agents; Crystallography, X-Ray; Disk Diffusion Antimicrobial Tests; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydrazines; Ketones; Molecular Conformation; Nicotinic Acids; Oxadiazoles | 2014 |
Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Sulfonamides | 2015 |
Antibacterial activities against rice bacterial leaf blight and tomato bacterial wilt of 2-mercapto-5-substituted-1,3,4-oxadiazole/thiadiazole derivatives.
Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Plant Diseases; Plant Leaves; Ralstonia solanacearum; Solanum lycopersicum; Structure-Activity Relationship; Thiadiazoles; Xanthomonas | 2015 |
Comparative study on bulk and composite fibrous samples photophysical feature: synthesis and characterization of a fluorine-containing Re(I) complex and its electrospinning fibers.
Topics: Coordination Complexes; Crystallization; Crystallography, X-Ray; Diamines; Fluorine; Halogenation; Ligands; Luminescent Measurements; Models, Molecular; Oxadiazoles; Rhenium | 2015 |
Radical-based route to 2-(trifluoromethyl)-1,3,4-oxadiazoles and trifluoromethyl-substituted polycyclic 1,2,4-triazoles and dihydrofurans.
Topics: Alkenes; Cycloaddition Reaction; Furans; Molecular Structure; Oxadiazoles; Triazoles | 2015 |
Experimental and theoretical spectroscopic studies, HOMO-LUMO, NBO analyses and thione-thiol tautomerism of a new hybrid of 1,3,4-oxadiazole-thione with quinazolin-4-one.
Topics: Electrons; Magnetic Resonance Spectroscopy; Molecular Conformation; Nonlinear Dynamics; Optical Phenomena; Oxadiazoles; Quinazolines; Quinazolinones; Static Electricity; Stereoisomerism; Sulfhydryl Compounds; Thermodynamics; Thiones; Vibration | 2015 |
Synthesis and broad-spectrum antiproliferative activity of diarylamides and diarylureas possessing 1,3,4-oxadiazole derivatives.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Niacinamide; Oxadiazoles; Phenylurea Compounds; Sorafenib; Structure-Activity Relationship; Urea | 2015 |
Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents.
Topics: Antineoplastic Agents; Azoles; Cell Line, Tumor; Cell Proliferation; Coumarins; Humans; Molecular Structure; Oxadiazoles; Thiadiazoles; Triazoles | 2015 |
Design, synthesis, antiviral activity and three-dimensional quantitative structure-activity relationship study of novel 1,4-pentadien-3-one derivatives containing the 1,3,4-oxadiazole moiety.
Topics: Antiviral Agents; Curcumin; Drug Design; Microbial Sensitivity Tests; Molecular Conformation; Oxadiazoles; Quantitative Structure-Activity Relationship; Tobacco Mosaic Virus | 2016 |
One-Pot Synthesis of 2,5-Diaryl 1,3,4-Oxadiazoles via Di-tert-butyl Peroxide Promoted N-Acylation of Aryl Tetrazoles with Aldehydes.
Topics: Acylation; Aldehydes; Molecular Structure; Oxadiazoles; Peroxides; Tetrazoles | 2015 |
Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives.
Topics: Antiviral Agents; Crystallography, X-Ray; Cytidine; Drug Design; Inhibitory Concentration 50; Models, Molecular; Oxadiazoles; Structure-Activity Relationship; Tobacco Mosaic Virus | 2015 |
Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives.
Topics: Enzyme Inhibitors; Escherichia coli; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Oxadiazoles; Thiones; Thymidine Phosphorylase | 2015 |
Design, Synthesis, and Antitumor Activity of Novel 5-Pyridyl-1,3,4-oxadiazole Derivatives against the Breast Cancer Cell Line MCF-7.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; MCF-7 Cells; Oxadiazoles; Structure-Activity Relationship | 2015 |
Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetulus; Humans; Male; Melatonin; Models, Molecular; Neural Stem Cells; Neurogenesis; Oxadiazoles; Rats; Rats, Wistar; Receptors, Melatonin; Thiadiazoles | 2015 |
Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles via Oxidative C(CO)-C(Methyl) Bond Cleavage of Methyl Ketones.
Topics: Carbonates; Hydrazines; Ketones; Molecular Structure; Oxadiazoles; Oxidation-Reduction; Potassium | 2015 |
Improved Protocol Toward 1,3,4-Oxadiazole-2(3H)-thiones and Scale-up Synthesis in the Presence of SDS as a Micelle Promoted Catalyst.
Topics: Catalysis; Micelles; Oxadiazoles; Sodium Dodecyl Sulfate; Thiones | 2015 |
Antibacterial Activity and Mechanism of Action of Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties on Rice Bacterial Leaf Blight.
Topics: Anti-Bacterial Agents; Chlorophyll; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Peroxidases; Plant Leaves; Sulfones; Superoxide Dismutase; Xanthomonas | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Kinetics; Mice; Molecular Dynamics Simulation; Molecular Structure; Oxadiazoles; Pain; Rats; Stomach Ulcer; Structure-Activity Relationship; Triazines | 2015 |
Quantitative and qualitative analysis of the novel antitumor 1,3,4-oxadiazole derivative (GLB) and its metabolites using HPLC-UV and UPLC-QTOF-MS.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Half-Life; Hydroxylation; Male; Oxadiazoles; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2015 |
Imidazole clubbed 1,3,4-oxadiazole derivatives as potential antifungal agents.
Topics: Antifungal Agents; Candida; Drug Evaluation, Preclinical; Imidazoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Sterols; Structure-Activity Relationship | 2015 |
Synthesis of new 5-((2-(substituted phenoxymethyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazole-2-thiol: A novel class of potential antibacterial and antifungal agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Benzimidazoles; Drug Design; Fungi; Imidazoles; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship; Sulfhydryl Compounds | 2015 |
The Efficacy and Underlying Mechanism of Sulfone Derivatives Containing 1,3,4-oxadiazole on Citrus Canker.
Topics: Biofilms; Catechol Oxidase; Cell Membrane; Cell Membrane Permeability; Citrus; Electric Conductivity; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Peroxidase; Phenylalanine Ammonia-Lyase; Plant Diseases; Polymerase Chain Reaction; Polysaccharides; Reference Standards; Sulfones; Xanthomonas | 2015 |
Corrosion inhibition property of polyester-groundnut shell biodegradable composite.
Topics: Corrosion; Dielectric Spectroscopy; Microscopy, Electron, Scanning; Nuts; Oxadiazoles; Polyesters; Polymers; Spectrophotometry, Atomic; Spectroscopy, Fourier Transform Infrared; Steel; Surface-Active Agents; Temperature | 2016 |
Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents.
Topics: Anti-Infective Agents; Antineoplastic Agents; Oxadiazoles; Proton Magnetic Resonance Spectroscopy; Schiff Bases; Thiadiazoles; Triazoles | 2015 |
Synthesis and multi-spectroscopic DNA binding study of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives of fatty acid.
Topics: Animals; Cattle; Circular Dichroism; Cyclization; DNA; Electrons; Ethidium; Fatty Acids; Iodobenzenes; Molecular Docking Simulation; Nucleic Acid Denaturation; Oxadiazoles; Proton Magnetic Resonance Spectroscopy; Solvents; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Temperature; Thiadiazoles | 2016 |
Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.
Topics: Alkadienes; Cycloaddition Reaction; Molecular Structure; Oxadiazoles; Stereoisomerism; Vinblastine | 2015 |
A Highly Efficient Diversification of 2-Amino/Amido-1,3,4-oxadiazole and 1,3,4-Thiadiazole Derivatives via Reagent-Based Cyclization of Thiosemicarbazide Intermediate on Solid-Phase.
Topics: Cyclization; Indicators and Reagents; Molecular Structure; Oxadiazoles; Semicarbazides; Thiadiazoles | 2015 |
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
Topics: Animals; Antiviral Agents; Cell Line; Dengue; Dengue Virus; Humans; Oxadiazoles; RNA-Dependent RNA Polymerase; Thiophenes; Viral Nonstructural Proteins | 2016 |
Synthesis and antibacterial activity of pyridinium-tailored 2,5-substituted-1,3,4-oxadiazole thioether/sulfoxide/sulfone derivatives.
Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Oxadiazoles; Pyridines; Ralstonia solanacearum; Structure-Activity Relationship; Sulfides; Sulfones; Sulfoxides; Xanthomonas | 2016 |
Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Imatinib Mesylate; K562 Cells; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2016 |
A New 1,3,4-Oxadiazole-Based Hole-Transport Material for Efficient CH3 NH3 PbBr3 Perovskite Solar Cells.
Topics: Calcium Compounds; Calorimetry, Differential Scanning; Electric Power Supplies; Microscopy, Electron, Scanning; Oxadiazoles; Oxides; Solar Energy; Titanium | 2016 |
Discovery of novel heteroarylmethylcarbamodithioates as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Oxadiazoles; Structure-Activity Relationship; Thiocarbamates | 2016 |
Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents.
Topics: Animals; Antitubercular Agents; Cell Line; Humans; Indoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium bovis; Mycobacterium tuberculosis; Oxadiazoles; Pyridines; Structure-Activity Relationship; Tuberculosis | 2016 |
Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bibenzyls; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; HeLa Cells; Humans; Immunohistochemistry; Mice; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Polymerization; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2016 |
Rational design, synthesis and biological evaluation of 1,3,4-oxadiazole pyrimidine derivatives as novel pyruvate dehydrogenase complex E1 inhibitors.
Topics: Anti-Bacterial Agents; Antifungal Agents; Cyanobacteria; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Escherichia coli; Fungi; Molecular Structure; Oxadiazoles; Pyrimidines; Pyruvate Dehydrogenase (Lipoamide); Structure-Activity Relationship | 2016 |
Synthesis, characterization and interaction studies of 1,3,4-oxadiazole derivatives of fatty acid with human serum albumin (HSA): A combined multi-spectroscopic and molecular docking study.
Topics: Chemistry Techniques, Synthetic; Humans; Molecular Docking Simulation; Oxadiazoles; Protein Binding; Protein Conformation; Serum Albumin; Spectrum Analysis | 2016 |
Solid-Phase Synthesis of 1,3,4-Thiadiazole Derivatives via Desulfurative Cyclization of Thiosemicarbazide Intermediate Resin.
Topics: Acylation; Alkylation; Amides; Amines; Combinatorial Chemistry Techniques; Cyclization; Molecular Structure; Oxadiazoles; Resins, Synthetic; Semicarbazides; Small Molecule Libraries; Solid-Phase Synthesis Techniques; Thiadiazoles | 2016 |
Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety.
Topics: Antineoplastic Agents; Cell Line, Tumor; Disulfides; Fluorouracil; Humans; Inhibitory Concentration 50; Oxadiazoles | 2016 |
Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors.
Topics: Carbon-13 Magnetic Resonance Spectroscopy; Enzyme Inhibitors; Ketol-Acid Reductoisomerase; Mannich Bases; Molecular Structure; Oxadiazoles; Proton Magnetic Resonance Spectroscopy; Spectrophotometry, Infrared; Structure-Activity Relationship | 2016 |
Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Granuloma; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Oximes; Rats; Structure-Activity Relationship; Ulcer | 2016 |
Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2016 |
Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents.
Topics: Antimony; Antineoplastic Agents; Antiprotozoal Agents; Cell Line, Tumor; Drug Design; Drug Resistance; Gold; Humans; Leishmania infantum; Organogold Compounds; Oxadiazoles; Phosphines | 2017 |
S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
Topics: Antifungal Agents; Antitubercular Agents; Drug Design; Drug Resistance; Hep G2 Cells; Humans; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrazoles | 2017 |
Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A
Topics: Animals; Enzyme Inhibitors; Fenoprofen; Group II Phospholipases A2; Hemolysis; Ibuprofen; Male; Mice; Molecular Docking Simulation; Oxadiazoles; Protein Structure, Secondary | 2017 |
Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Neoplasms; Oxadiazoles; Podophyllotoxin; Quantitative Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2017 |
Synthesis and biological evaluation of 1,2,4-triazole-3-thione and 1,3,4-oxadiazole-2-thione as antimycobacterial agents.
Topics: Antitubercular Agents; Cell Line, Tumor; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; Thiones; Triazoles; Tuberculosis | 2017 |
Design, synthesis, and in vitro antituberculosis activity of benzo[6,7]cyclohepta[1,2-b]pyridine-1,3,4-oxadiazole derivatives.
Topics: Antitubercular Agents; Drug Design; Humans; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium tuberculosis; Oxadiazoles; Pyridines; Structure-Activity Relationship; Tuberculosis | 2017 |
Rationale Design, Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of 1,3,4-oxadiazole Analogues.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2018 |
Synthesis and anticancer activity of new [(Indolyl)pyrazolyl]-1,3,4-oxadiazole thioglycosides and acyclic nucleoside analogs.
Topics: Antineoplastic Agents; Catalytic Domain; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclization; Humans; Molecular Docking Simulation; Nucleosides; Oxadiazoles; Structure-Activity Relationship; Thioglycosides | 2017 |
1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities.
Topics: Anti-Infective Agents; Antimalarials; Folic Acid Antagonists; Molecular Docking Simulation; Oxadiazoles; Spectrum Analysis; Triazoles | 2017 |
Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Pyrimidines; Structure-Activity Relationship; Thiones | 2017 |
New 1,3,4-oxadiazole/oxime hybrids: Design, synthesis, anti-inflammatory, COX inhibitory activities and ulcerogenic liability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Humans; Male; Molecular Structure; Oxadiazoles; Oximes; Rats; Sheep; Structure-Activity Relationship | 2017 |
Inhibitory growth evaluation and apoptosis induction in MCF-7 cancer cells by new 5-aryl-2-butylthio-1,3,4-oxadiazole derivatives.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Humans; MCF-7 Cells; Oxadiazoles | 2017 |
Synthesis and antiviral evaluation of novel 1,3,4-oxadiazole/thiadiazole-chalcone conjugates.
Topics: Antiviral Agents; Chalcone; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles; Tobacco Mosaic Virus | 2017 |
Novel histone deacetylase 8-selective inhibitor 1,3,4-oxadiazole-alanine hybrid induces apoptosis in breast cancer cells.
Topics: Acetylation; Alanine; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; CDC2 Protein Kinase; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histone Deacetylases; Histones; Humans; Inhibitory Concentration 50; K562 Cells; MCF-7 Cells; Organ Specificity; Oxadiazoles; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; Signal Transduction | 2017 |
Synthesis and structure-activity relationships of carbohydrazides and 1,3,4-oxadiazole derivatives bearing an imidazolidine moiety against the yellow fever and dengue vector, Aedes aegypti.
Topics: Aedes; Animals; Female; Hydrazines; Imidazolidines; Insecticides; Larva; Oxadiazoles; Structure-Activity Relationship | 2018 |
Development of 1,3,4-oxadiazole thione based novel anticancer agents: Design, synthesis and in-vitro studies.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; DNA Fragmentation; Drug Design; Humans; Inhibitory Concentration 50; Oxadiazoles; Staining and Labeling; Thiones | 2017 |
Novel bisthioether derivatives containing a 1,3,4-oxadiazole moiety: design, synthesis, antibacterial and nematocidal activities.
Topics: Animals; Anti-Bacterial Agents; Antinematodal Agents; Caenorhabditis elegans; Drug Design; Oxadiazoles; Sulfides; Xanthomonas | 2018 |
Construction of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Library with a High Level of Skeletal Diversity Based on Branching Diversity-Oriented Synthesis on Solid-Phase Supports.
Topics: Amides; Amines; Amino Acids; Combinatorial Chemistry Techniques; Cyclization; Molecular Structure; Oxadiazoles; Semicarbazides; Small Molecule Libraries; Solid-Phase Synthesis Techniques; Structure-Activity Relationship; Thiadiazoles; Thiourea | 2018 |
Antimicrobial activity of 1,3,4-oxadiazole derivatives against planktonic cells and biofilm of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Biofilms; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Plankton; Staphylococcus aureus; Structure-Activity Relationship | 2018 |
Synthesis of benzimidazole-linked-1,3,4-oxadiazole carboxamides as GSK-3β inhibitors with in vivo antidepressant activity.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glycogen Synthase Kinase 3 beta; Hindlimb Suspension; Humans; Male; Molecular Dynamics Simulation; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Design, synthesis and anticancer activities evaluation of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units.
Topics: Antineoplastic Agents; Azepines; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2018 |
Lipophilicity evaluation of some thiazolyl-1,3,4-oxadiazole derivatives with antifungal activity.
Topics: Antifungal Agents; Chromatography, Reverse-Phase; Chromatography, Thin Layer; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Oxadiazoles; Principal Component Analysis; Thiazoles | 2018 |
Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents.
Topics: Anti-Bacterial Agents; Drug Design; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Plant Diseases; Structure-Activity Relationship; Xanthomonas | 2018 |
Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles.
Topics: Animals; Cymenes; Juvenile Hormones; Larva; Monoterpenes; Oxadiazoles; Pupa; Spodoptera; Thiadiazoles | 2018 |
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Oxadiazoles; Structure-Activity Relationship | 2018 |
New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.
Topics: Antitubercular Agents; Drug Resistance, Bacterial; Hep G2 Cells; Humans; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; Tuberculosis | 2018 |
Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT
Topics: Amides; Animals; Chemistry Techniques, Synthetic; Drug Evaluation, Preclinical; Humans; Male; Oxadiazoles; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Structure-Activity Relationship | 2018 |
Synthesis and three-dimensional quantitative structure-activity relationship study of quinazoline derivatives containing a 1,3,4-oxadiazole moiety as efficient inhibitors against Xanthomonas axonopodis pv. citri.
Topics: Anti-Bacterial Agents; Chemistry Techniques, Synthetic; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Oxadiazoles; Quantitative Structure-Activity Relationship; Quinazolines; Xanthomonas axonopodis | 2018 |
Synthesis and investigation of the antibacterial activity and action mechanism of 1,3,4-oxadiazole thioether derivatives.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biological Assay; Microbial Sensitivity Tests; Oxadiazoles; Proteomics; Purines; Spectrum Analysis; Sulfides; Xanthomonas | 2018 |
Synthesis of C-2 and C-3 substituted quinolines and their evaluation as anti-HIV-1 agents.
Topics: Anti-HIV Agents; Cell Line; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Molecular Docking Simulation; Oxadiazoles; Quinolines | 2018 |
Investigation on Quantitative Structure-Activity Relationships of 1,3,4-Oxadiazole Derivatives as Potential Telomerase Inhibitors.
Topics: Antineoplastic Agents; Datasets as Topic; Drug Screening Assays, Antitumor; Inhibitory Concentration 50; Least-Squares Analysis; Models, Biological; Models, Molecular; Molecular Structure; Oxadiazoles; Quantitative Structure-Activity Relationship; Telomerase | 2020 |
Evaluation of WO2017018805: 1,3,4-oxadiazole sulfamide derivatives as selective HDAC6 inhibitors.
Topics: Drug Design; Drug Discovery; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Humans; Oxadiazoles; Patents as Topic; Sulfonamides | 2018 |
Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Escherichia coli; Humans; Microbial Sensitivity Tests; Oxadiazoles | 2018 |
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs.
Topics: Cell Survival; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; HeLa Cells; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; RNA, Messenger; Structure-Activity Relationship | 2018 |
Synthesis and antifungal activities of novel thiophene-based stilbene derivatives bearing an 1,3,4-oxadiazole unit.
Topics: Botrytis; Fungicides, Industrial; Microbial Sensitivity Tests; Oxadiazoles; Phyllachorales; Stilbenes; Thiophenes | 2019 |
Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
Topics: Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Fungal Proteins; HEK293 Cells; Hep G2 Cells; Humans; IMP Dehydrogenase; Models, Molecular; Oxadiazoles; Thiophenes | 2018 |
Novel hybrids of benzothiazole-1,3,4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment.
Topics: Administration, Oral; Animals; Benzothiazoles; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glucose Tolerance Test; Hypoglycemic Agents; Male; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Streptozocin; Structure-Activity Relationship; Thiazolidines | 2019 |
Design, Synthesis and Pharmacological Evalution of 1,3,4-Oxadiazole Derivatives as Collapsin Response Mediator Protein 1 (CRMP 1) Inhibitors.
Topics: Antineoplastic Agents; Bevacizumab; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Targeted Therapy; Nerve Tissue Proteins; Oxadiazoles; Small Cell Lung Carcinoma; Structure-Activity Relationship | 2020 |
Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives.
Topics: Adult; Animals; Anticoagulants; Binding Sites; Fibrinolytic Agents; Humans; Imaging, Three-Dimensional; Male; Molecular Docking Simulation; Oxadiazoles; Rats, Sprague-Dawley; Static Electricity; Time Factors; Young Adult | 2018 |
1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcone; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Interleukin-6; Molecular Structure; Oxadiazoles; Protein Kinase Inhibitors; STAT3 Transcription Factor; Structure-Activity Relationship | 2019 |
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds.
Topics: Amphotericin B; Animals; Antifungal Agents; Benzimidazoles; Candida albicans; Cell Survival; Drug Design; Ketoconazole; Mice; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; NIH 3T3 Cells; Oxadiazoles; Protein Binding; Structure-Activity Relationship | 2019 |
Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Structure-Activity Relationship | 2019 |
Design and development of novel N-(pyrimidin-2-yl)-1,3,4-oxadiazole hybrids to treat cognitive dysfunctions.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Design; Humans; Mice; Models, Molecular; Molecular Structure; Oxadiazoles; Pyrimidines; Structure-Activity Relationship | 2019 |
Design, synthesis and biological evaluation of 2-(phenoxymethyl)-5-phenyl-1,3,4-oxadiazole derivatives as anti-breast cancer agents.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2019 |
Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.
Topics: Antitubercular Agents; Cell Line; Humans; Models, Molecular; Mycobacterium tuberculosis; Oxadiazoles; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2019 |
Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Coumarins; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2019 |
High pressure behavior of crystal [2,2'-bi(1,3,4-oxadiazole)]-5,5'-dinitramide: A DFT investigation.
Topics: Crystallography, X-Ray; Density Functional Theory; Electrons; Heterocyclic Compounds; Hydrogen Bonding; Oxadiazoles | 2019 |
Synthesis and docking studies of N-(5-(alkylthio)-1,3,4-oxadiazol-2-yl)methyl)benzamide analogues as potential alkaline phosphatase inhibitors.
Topics: Alkaline Phosphatase; Benzamides; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Protein Conformation; Structure-Activity Relationship | 2019 |
Pharmacophore studies of 1, 3, 4-oxadiazole nucleus: Lead compounds as α-glucosidase inhibitors.
Topics: alpha-Glucosidases; Drug Discovery; Glycoside Hydrolase Inhibitors; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2019 |
Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Avoidance Learning; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Development; Electrophorus; Horses; Humans; Male; Memory; Mice; Molecular Structure; Oxadiazoles; Peptide Fragments; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2019 |
Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Animals; Anti-Bacterial Agents; Cell Line; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Norfloxacin; Oxadiazoles; Rats; Staphylococcal Infections; Structure-Activity Relationship; Vancomycin | 2019 |
Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents.
Topics: Antiviral Agents; Oxadiazoles; Structure-Activity Relationship; Viruses | 2019 |
Synthesis, spectral analysis and biological evaluation of sulfamoyl and 1,3,4-oxadiazole derivatives of 3-pipecoline.
Topics: Anti-Bacterial Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Piperidines; Spectrophotometry, Infrared; Sulfonamides; Urease | 2019 |
Synthesis and antimicrobial screening of some 1, 3, 4-oxadiazoles and their molecular properties prediction through 'rule of five'.
Topics: Anti-Infective Agents; Aspergillus niger; Candida albicans; Drug Evaluation, Preclinical; Escherichia coli; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Pseudomonas aeruginosa; Staphylococcus aureus | 2019 |
Lupane-type conjugates with aminoacids, 1,3,4- oxadiazole and 1,2,5-oxadiazole-2-oxide derivatives: Synthesis, anti-inflammatory activity and in silico evaluation of target affinity.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Computer Simulation; Concanavalin A; Disease Models, Animal; Edema; Female; Fibroblasts; Histamine; Inflammation; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Molecular Docking Simulation; NF-E2-Related Factor 2; NF-kappa B; Oxadiazoles; Triterpenes | 2019 |
Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives.
Topics: Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Furans; Hep G2 Cells; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Sugars; Thiadiazoles | 2019 |
1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction.
Topics: Molecular Structure; Oxadiazoles; Tetrazoles | 2019 |
Novel Molecular Hybrids of
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Drug Design; Molecular Docking Simulation; Oxadiazoles; Piperidines; Rats; Structure-Activity Relationship | 2019 |
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B.
Topics: Amino Acid Sequence; Antidepressive Agents; Benzenesulfonamides; Benzoates; Binding Sites; Drug Evaluation, Preclinical; Humans; Isomerism; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Protein Binding; Protein Conformation; Structure-Activity Relationship; Sulfonamides; Zonisamide | 2019 |
Mechanistic studies on tandem cascade [4 + 2]/ [3 + 2] cycloaddition of 1,3,4-oxadiazoles with olefins.
Topics: Alkenes; Cycloaddition Reaction; Molecular Structure; Oxadiazoles; Stereoisomerism; Thermodynamics | 2019 |
A novel five-step synthetic route to 1,3,4-oxadiazole derivatives with potent α-glucosidase inhibitory potential and their in silico studies.
Topics: alpha-Glucosidases; Chemistry Techniques, Synthetic; Computer Simulation; Drug Design; Glycoside Hydrolase Inhibitors; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Saccharomyces cerevisiae | 2019 |
Synthesis of cytotoxic urs-12-ene- and 28-norurs-12-ene- type conjugates with amino- and mercapto-1,3,4-oxadiazoles and mercapto-1,2,4-triazoles.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Stereoisomerism; Triazoles; Triterpenes | 2020 |
Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action.
Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Oxadiazoles; Plant Diseases; Ralstonia; Sulfides; Xanthomonas | 2019 |
Synthesis and antibacterial evaluation of a novel library of 2-(thiazol-5-yl)-1,3,4-oxadiazole derivatives against methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2020 |
Design, Synthesis and Evaluation of Novel Substituted (5-methyl-1H-pyrazol-3-yl)- 1,3,4-oxadiazole as Potent Androgen Receptor Antagonist.
Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; PC-3 Cells; Receptors, Androgen; Structure-Activity Relationship | 2020 |
Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker.
Topics: Acetamides; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship | 2020 |
Novel diosgenin derivatives containing 1,3,4-oxadiazole/thiadiazole moieties as potential antitumor agents: Design, synthesis and cytotoxic evaluation.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Diosgenin; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles | 2020 |
Natural Product-Based Fungicides Discovery: Design, Synthesis and Antifungal Activities of Some Sarisan Analogs Containing 1,3,4-Oxadiazole Moieties.
Topics: Alternaria; Antifungal Agents; Ascomycota; Biological Products; Dioxolanes; Drug Design; Fusarium; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship | 2020 |
Design, synthesis, and biological evaluation of ferulic acid based 1,3,4-oxadiazole hybrids as multifunctional therapeutics for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Administration, Oral; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Coumaric Acids; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Male; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Oxadiazoles; Protein Aggregates; Rats; Rats, Wistar; Scopolamine; Structure-Activity Relationship | 2020 |
Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Candida albicans; Carbazoles; Escherichia coli; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2020 |
The Structural and Magnetic Properties of Fe
Topics: Anisotropy; Cobalt; Coordination Complexes; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Furans; Iron; Magnetic Resonance Spectroscopy; Models, Molecular; Oxadiazoles; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Mossbauer | 2020 |
Design, Synthesis, and Biological Evaluation of 2-(2-Bromo-3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole Derivatives as Possible Anti-Breast Cancer Agents.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Breast Neoplasms; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Humans; Imatinib Mesylate; Molecular Conformation; Molecular Docking Simulation; Oxadiazoles; Structure-Activity Relationship | 2020 |
Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety.
Topics: Antifungal Agents; Biological Products; Indoles; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Pythium; Structure-Activity Relationship; Sulfides | 2021 |
Novel 1,3,4-oxadiazole thioether derivatives containing flexible-chain moiety: Design, synthesis, nematocidal activities, and pesticide-likeness analysis.
Topics: Animals; Citrus; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Nematoda; Oxadiazoles; Pesticides; Structure-Activity Relationship; Sulfides | 2020 |
Tail approach synthesis of novel benzenesulfonamides incorporating 1,3,4-oxadiazole hybrids as potent inhibitor of carbonic anhydrase I, II, IX, and XII isoenzymes.
Topics: Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Sulfonamides | 2020 |
Synthesis and Antibacterial Evaluation of Novel 1,3,4-Oxadiazole Derivatives Containing Sulfonate/Carboxylate Moiety.
Topics: Anti-Bacterial Agents; Carboxylic Acids; Drug Design; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Structure-Activity Relationship; Sulfonic Acids; Xanthomonas; Xanthomonas axonopodis | 2020 |
Synthesis, anti-inflammatory activity, and molecular docking studies of some novel Mannich bases of the 1,3,4-oxadiazole-2(3H)-thione scaffold.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Lipopolysaccharides; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Nitric Oxide; Oxadiazoles; Structure-Activity Relationship; Thiones | 2020 |
Novel sulfone derivatives containing a 1,3,4-oxadiazole moiety: design and synthesis based on the 3D-QSAR model as potential antibacterial agent.
Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Plant Diseases; Quantitative Structure-Activity Relationship; Sulfones; Xanthomonas | 2020 |
Design, synthesis and
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiazolidinediones; Thymidylate Synthase | 2020 |
Design, synthesis, chemical characterization, biological evaluation, and docking study of new 1,3,4-oxadiazole homonucleoside analogs.
Topics: Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Herpesvirus 3, Human; HL-60 Cells; Humans; MCF-7 Cells; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Nucleosides; Oxadiazoles; Protein Kinase Inhibitors; Receptor, ErbB-2 | 2020 |
Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration.
Topics: Animals; Antioxidants; Brain Ischemia; Inflammation; Ischemic Stroke; Male; Molecular Structure; Neuroprotective Agents; Oxadiazoles; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2020 |
Anticancer and antileishmanial in vitro activity of gold(I) complexes with 1,3,4-oxadiazole-2(3H)-thione ligands derived from δ-D-gluconolactone.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Cell Line; Cell Survival; Coordination Complexes; Cyclization; Gluconates; Gold; Humans; Lactones; Leishmania; Ligands; Mice; Oxadiazoles; Structure-Activity Relationship; Thiones | 2021 |
Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives.
Topics: Anti-Infective Agents; Antineoplastic Agents; Antitubercular Agents; Arylamine N-Acetyltransferase; Benzoates; Carboxylic Acids; Drug Evaluation, Preclinical; G1 Phase; Gene Expression Regulation; Humans; Hydrazines; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; RNA, Messenger | 2020 |
Evaluation of Biological Activity of Derivatives of 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and 1,2,4-Triazole.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Erythrocyte Membrane; Female; Male; Oxadiazoles; Peptide Hydrolases; Protease Inhibitors; Rats; Thiadiazoles; Triazoles | 2021 |
Ultrasound-assisted, low-solvent and acid/base-free synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols as potent antimicrobial and antioxidant agents.
Topics: Oxadiazoles | 2021 |
Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Drug Design; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2021 |
Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein.
Topics: Antineoplastic Agents; Apoptosis; Density Functional Theory; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Design and synthesis of novel 1,3,4-oxadiazole sulfone compounds containing 3,4-dichloroisothiazolylamide moiety and evaluation of rice bacterial activity.
Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Oryza; Oxadiazoles; Plant Diseases; Sulfones; Xanthomonas | 2020 |
Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Quinoxalines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2020 |
Target identification of a novel unsymmetrical 1,3,4-oxadiazole derivative with antiproliferative properties.
Topics: Binding Sites; Cell Cycle; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; HeLa Cells; Humans; Molecular Docking Simulation; Oxadiazoles; Protein Interaction Maps; Reproducibility of Results; RNA-Seq | 2021 |
New 1,3,4-Oxadiazole Derivatives of Pyridothiazine-1,1-Dioxide with Anti-Inflammatory Activity.
Topics: Anti-Inflammatory Agents; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; DNA Damage; Drug Design; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Nitric Oxide; Oxadiazoles; Oxides; Protein Binding; Reactive Oxygen Species; Structure-Activity Relationship; Thiazines | 2020 |
Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-
Topics: Antioxidants; Catalytic Domain; Cell Line; Cell Survival; Circular Dichroism; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Female; Fibroblasts; Humans; Inhibitory Concentration 50; Mannich Bases; Middle Aged; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Pyridazines; Pyrroles; Serum Albumin, Bovine; Structure-Activity Relationship | 2020 |
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-
Topics: Analgesics; Animals; Dinoprostone; Gastric Mucosa; Male; Nociception; Nociceptive Pain; Oxadiazoles; Pain Measurement; Peroxidase; Pyridazines; Pyrroles; Rats; Rats, Wistar | 2020 |
Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety.
Topics: Amides; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Nuclear Proteins; Oxadiazoles; Staurosporine; Structure-Activity Relationship; Telomerase | 2021 |
Design, synthesis, biological evaluation and molecular docking of new 1,3,4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Nucleosides; Oxadiazoles; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Synthesis and biological evaluation of a new series of benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides as potential α-glucosidase inhibitors.
Topics: Acetamides; alpha-Glucosidases; Glycoside Hydrolase Inhibitors; Oxadiazoles; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2021 |
Report - Synthesis of new antibacterial agents encompassing tosyl, piperidine, propanamide and 1,3,4-oxadiazole functionalities.
Topics: Anti-Bacterial Agents; Hydrazines; Microbial Sensitivity Tests; Oxadiazoles; Piperidines; Tosyl Compounds | 2020 |
Synthesis and receptor dependent 4D-QSAR studies of 4,5-dihydro-1,3,4-oxadiazole derivatives targeting cannabinoid receptor.
Topics: A549 Cells; Cell Proliferation; Humans; Molecular Conformation; Molecular Dynamics Simulation; Oxadiazoles; Quantitative Structure-Activity Relationship; Receptors, Cannabinoid | 2021 |
Insecticidal activity of some synthesized 1,3,4-oxadiazole derivatives grafted on chitosan and polymethylmethacrylate against the cotton leafworm Spodoptera littoralis.
Topics: Animals; Cell Line; Cell Survival; Chitosan; Gossypium; Humans; Insecticides; Larva; Models, Chemical; Molecular Structure; Oxadiazoles; Polymethyl Methacrylate; Spectroscopy, Fourier Transform Infrared; Spodoptera; X-Ray Diffraction | 2021 |
Design, synthesis, modelling studies and biological evaluation of 1,3,4-oxadiazole derivatives as potent anticancer agents targeting thymidine phosphorylase enzyme.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Structure-Activity Relationship; Thymidine Phosphorylase | 2021 |
Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV.
Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Dose-Response Relationship, Drug; Drug Design; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Quinolines; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors; Triazoles | 2021 |
Novel 2,5-disubstituted-1,3,4-oxadiazole derivatives as MAO-B inhibitors: Synthesis, biological evaluation and molecular modeling studies.
Topics: Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Structure-Activity Relationship | 2021 |
Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Male; Maze Learning; Molecular Structure; Neuroprotective Agents; Oxadiazoles; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Structure-Activity Relationship | 2021 |
Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Enzyme Inhibitors; Indomethacin; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Nitric Oxide Synthase Type II; Oxadiazoles; RAW 264.7 Cells; Structure-Activity Relationship | 2021 |
New quinoxalin-1,3,4-oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies.
Topics: Carbonic Anhydrase Inhibitors; Cholinesterase Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Models, Molecular; Molecular Docking Simulation; Oxadiazoles; Quinoxalines; Structure-Activity Relationship | 2021 |
1,3,4-oxadiazole conjugates of capsaicin as potent NorA efflux pump inhibitors of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Capsaicin; Cell Line, Tumor; Cell Survival; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Docking Simulation; Multidrug Resistance-Associated Proteins; Oxadiazoles; Staphylococcus aureus; Structure-Activity Relationship | 2021 |
Synthesis, Molecular Docking, and Biological Evaluation of Some Novel 2- (5-Substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole Derivatives as Anticonvulsant Agents.
Topics: Anticonvulsants; Benzothiazoles; Molecular Docking Simulation; Oxadiazoles; Structure-Activity Relationship | 2021 |
Discovery of novel furo[2,3-d]pyrimidin-2-one-1,3,4-oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis.
Topics: Acyclovir; Antineoplastic Agents; Antiviral Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Herpesvirus 3, Human; Humans; Molecular Docking Simulation; Neoplasms; Oxadiazoles; Pyrimidines; Structure-Activity Relationship | 2021 |
A ready-to-use fluorescence probe of Pd
Topics: Fluorescent Dyes; Oxadiazoles; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Water | 2021 |
Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-oxadiazole-2-thiol Scaffold.
Topics: Cyclooxygenase 2; Humans; Indomethacin; Molecular Docking Simulation; Nitric Oxide; Oxadiazoles | 2021 |
Novel heterocyclic 1,3,4-oxadiazole derivatives of fluoroquinolones as a potent antibacterial agent: Synthesis and computational molecular modeling.
Topics: Anti-Bacterial Agents; Escherichia coli; Fluoroquinolones; Microbial Sensitivity Tests; Oxadiazoles; Staphylococcus aureus; Structure-Activity Relationship | 2022 |
Synthesis of a Series of Novel 2-Amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Antibacterial Agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiadiazoles | 2022 |
Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies.
Topics: Amides; Arachidonate 15-Lipoxygenase; Cell Survival; Dose-Response Relationship, Drug; Humans; Leukocytes, Mononuclear; Lipoxygenase Inhibitors; Models, Molecular; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2021 |
Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Harmine; Humans; Imidazoles; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiazoles | 2021 |
Synthesis of ɑ,β-Unsaturated Benzotriazolyl-1,3,4-Oxadiazole Derivatives: Anticancer Activity, Cytotoxicity, and Cell Imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mice; Oxadiazoles; Structure-Activity Relationship | 2022 |
Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction.
Topics: Animals; B7-H1 Antigen; Dose-Response Relationship, Drug; Drug Discovery; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Oxadiazoles; Programmed Cell Death 1 Receptor; Protein Binding; Structure-Activity Relationship | 2021 |
π-π Noncovalent Interaction Involving 1,2,4- and 1,3,4-Oxadiazole Systems: The Combined Experimental, Theoretical, and Database Study.
Topics: Crystallography, X-Ray; Databases, Factual; Hydrogen Bonding; Models, Molecular; Oxadiazoles | 2021 |
Exploring biological efficacy of novel benzothiazole linked 2,5-disubstituted-1,3,4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization, inhibition, molecular docking, molecular dynamics and Monte Carlo based QSAR studies.
Topics: alpha-Amylases; Benzothiazoles; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Oxadiazoles; Quantitative Structure-Activity Relationship; Structure-Activity Relationship | 2021 |
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Dynamics Simulation; Molecular Structure; Oxadiazoles; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Structure-Activity Relationship | 2021 |
Intramolecular charge transfer dynamics in the excited states of diphenylamine substituted 1,3,4-oxadiazole derivatives.
Topics: Diphenylamine; Kinetics; Oxadiazoles; Spectrometry, Fluorescence; Thermodynamics | 2022 |
Design, synthesis and biological evaluation of nitrofuran-1,3,4-oxadiazole hybrids as new antitubercular agents.
Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Drug Design; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitrofurans; Oxadiazoles; Structure-Activity Relationship | 2022 |
Neuroprotective evaluation of novel substituted 1,3,4-oxadiazole and aroylhydrazone derivatives.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Glutathione; Hydrazones; Molecular Structure; Neuroprotective Agents; Oxadiazoles; Rats; Structure-Activity Relationship | 2022 |
Bis-1,3,4-Oxadiazole Derivatives as Novel and Potential Urease Inhibitors; Synthesis, In Vitro, and In Silico Studies.
Topics: Enzyme Inhibitors; Methanol; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Urease | 2022 |
Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects.
Topics: Antineoplastic Agents; Carbolines; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2022 |
Synthesis, Molecular Docking and Evaluation of 1,3,4-Oxadiazole-Isobenzofuran Hybrids as Antimicrobial and Anticancer Agents.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Escherichia coli; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Structure-Activity Relationship | 2022 |
A Water Soluble 2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazole Based Probe: Antimicrobial Activity and Colorimetric/Fluorescence pH Response.
Topics: Anti-Infective Agents; Colorimetry; Fluorescent Dyes; Hydrogen-Ion Concentration; Oxadiazoles; Water | 2022 |
Exploration of mercaptoacetamide-linked pyrimidine-1,3,4-oxadiazole derivatives as DNA intercalative topo II inhibitors: Cytotoxicity and apoptosis induction.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; DNA; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Pyrimidines; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2022 |
Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Interleukin-6; Lipopolysaccharides; Macrophages; Molecular Docking Simulation; Nitric Oxide; Oxadiazoles; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles | 2022 |
Novel 1,3,4-oxadiazole chalcogen analogues: Synthesis and cytotoxic activity.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chalcogens; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Tubulin | 2022 |
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.
Topics: alpha-Glucosidases; Angiotensin-Converting Enzyme 2; Biphenyl Compounds; COVID-19 Drug Treatment; HEK293 Cells; Humans; Lignans; Molecular Docking Simulation; Oxadiazoles; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Sulfides | 2022 |
Discovery of 1,3,4-oxadiazole derivatives containing a bisamide moiety as a novel class of potential cardioprotective agents.
Topics: Cardiotonic Agents; Myocytes, Cardiac; Oxadiazoles; Oxidative Stress | 2022 |
1,3,4-Oxadiazole Derivatives as Plant Activators for Controlling Plant Viral Diseases: Preparation and Assessment of the Effect of Auxiliaries.
Topics: Antiviral Agents; Drug Design; Humans; Oxadiazoles; Plant Diseases; Structure-Activity Relationship; Tobacco Mosaic Virus; Virus Diseases | 2022 |
Synthesis, in Vitro Cholinesterase Inhibition, Molecular Docking, DFT, and ADME Studies of Novel 1,3,4-Oxadiazole-2-Thiol Derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Sulfhydryl Compounds | 2022 |
Chloramine Trihydrate-Mediated Tandem Synthesis of New Pyrrole and/or Arene-Linked Mono- and Bis(1,3,4-Oxadiazole) Hybrids as Potential Bacterial Biofilm and MRSA Inhibitors.
Topics: Anti-Bacterial Agents; Bacteria; Biofilms; Chloramines; Escherichia coli; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxadiazoles; Pseudomonas aeruginosa; Pyrroles; Staphylococcus aureus | 2022 |
Combined Experimental and Computational Study on the Transformation of a Novel 1,3,4-Oxadiazole Thioether Nematicide in Aqueous Solutions.
Topics: Ecosystem; Kinetics; Oxadiazoles; Photolysis; Sulfides; Sulfur; Water; Water Pollutants, Chemical | 2022 |
Synthesis, anticholinesterase activity, molecular docking, and molecular dynamic simulation studies of 1,3,4-oxadiazole derivatives.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship | 2022 |
Identifications of good and bad structural fragments of hydrazone/2,5-disubstituted-1,3,4-oxadiazole hybrids with correlation intensity index and consensus modelling using Monte Carlo based QSAR studies, their molecular docking and ADME analysis.
Topics: alpha-Amylases; Benzothiazoles; Consensus; Diabetes Mellitus, Type 2; Humans; Hydrazones; Models, Molecular; Molecular Docking Simulation; Oxadiazoles; Quantitative Structure-Activity Relationship | 2022 |
Synthesis, characterization, anti-mycobacterial activity and in silico study of new 2,5-disubstituted-1,3,4-oxadiazole derivatives.
Topics: Antitubercular Agents; Isoniazid; Ligands; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles | 2022 |
Cytotoxic Activity and Docking Studies of 2-arenoxybenzaldehyde N-acyl Hydrazone and 1,3,4-Oxadiazole Derivatives against Various Cancer Cell Lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Hydrazones; Molecular Docking Simulation; Molecular Structure; Neoplasms; Oxadiazoles; Structure-Activity Relationship | 2022 |
Design, Synthesis and Bio-Evaluation of Novel Chalcones Bridged with 1,3,4-Oxadiazole Linkers: ADMET and Docking Analysis.
Topics: Acetamides; Anti-Bacterial Agents; Chalcones; Molecular Docking Simulation; Oxadiazoles; Structure-Activity Relationship | 2022 |
Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole.
Topics: Humans; Oxadiazoles; Raltegravir Potassium | 2023 |
Synthetic Access to Unsymmetric, Tridentate, Pyridyl-1,3,4-oxadiazole Complexants via Intramolecular Oxidative Annulation of Arylhydrazides with Heteroaryl Carbaldehydes.
Topics: Indicators and Reagents; Molecular Structure; Oxadiazoles; Oxidative Stress | 2023 |
Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Male; Mice; Oxadiazoles; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Staurosporine; Structure-Activity Relationship | 2023 |
Biological and Sensing Applications of a Few 1,3,4-Oxadiazole Based Donor-Acceptor Systems.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Bacteria; Fungi; Microbial Sensitivity Tests; Oxadiazoles; Structure-Activity Relationship | 2023 |
Effective corrosion inhibition of mild steel using novel 1,3,4-oxadiazole-pyridine hybrids: Synthesis, electrochemical, morphological, and computational insights.
Topics: Corrosion; Oxadiazoles; Pyridines; Steel | 2023 |
Novel pyrimidine-1,3,4-oxadiazole hybrids and their precursors as potential antimycobacterial agents.
Topics: Amines; Anti-Bacterial Agents; Antitubercular Agents; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles; Pyrimidines; Structure-Activity Relationship | 2023 |
Synthesis of 1,2,4-triazole and 1,3,4-oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer.
Topics: Breast Neoplasms; Female; Humans; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; STAT3 Transcription Factor; Structure-Activity Relationship | 2023 |
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Topics: Animals; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Mice; Neoplasms; Oxadiazoles; Rats; Tubulin | 2023 |
Multitargeted inhibition of key enzymes associated with diabetes and Alzheimer's disease by 1,3,4-oxadiazole derivatives: Synthesis, in vitro screening, and computational studies.
Topics: Acarbose; Acetylcholinesterase; alpha-Amylases; alpha-Glucosidases; Alzheimer Disease; Butyrylcholinesterase; Diabetes Mellitus; Humans; Molecular Docking Simulation; Oxadiazoles; Structure-Activity Relationship | 2023 |
Improved Antibacterial Activity of 1,3,4-Oxadiazole-Based Compounds That Restrict
Topics: Animals; Anti-Bacterial Agents; Mammals; Methicillin-Resistant Staphylococcus aureus; Oxadiazoles; Staphylococcal Infections; Staphylococcus aureus | 2023 |