1-24-25-trihydroxyvitamin-d3 has been researched along with 25-26-dihydroxycholecalciferol* in 2 studies
1 review(s) available for 1-24-25-trihydroxyvitamin-d3 and 25-26-dihydroxycholecalciferol
| Article | Year |
|---|---|
[Vitamin D: metabolism and biological properties].
Topics: 24,25-Dihydroxyvitamin D 3; Animals; Biological Transport; Bone and Bones; Bone Resorption; Calcifediol; Calcitonin; Calcitriol; Calcium; Calcium-Binding Proteins; Cartilage; Chemical Phenomena; Chemistry; Cholecalciferol; Dihydroxycholecalciferols; Female; Humans; Hydroxycholecalciferols; Intestinal Absorption; Intestines; Kidney; Liver; Minerals; Parathyroid Hormone; Phosphorus; Pregnancy; Skin; Steroid Hydroxylases; Ultraviolet Rays; Vitamin D; Vitamin D-Binding Protein | 1985 |
1 other study(ies) available for 1-24-25-trihydroxyvitamin-d3 and 25-26-dihydroxycholecalciferol
| Article | Year |
|---|---|
Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro.
The effects of six natural vitamin D metabolites of potential biological and therapeutic interest, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), 25-hydroxyvitamin D3 (25-OH-D3), 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3), 1,24R,25-trihydroxyvitamin D3 (1,24R,25-(OH)3D3), 25S,26-dihydroxyvitamin D3 (25S,26-(OH)2D3) and 1,25S,26-trihydroxyvitamin D3 (1,25S,26-(OH)3D3) on cell replication and expression of the osteoblastic phenotype in terms of osteocalcin production were examined in cultured human bone cells. At a dose of 5 X 10(-12) mol/1, 1,25-(OH)2D3 stimulated cell proliferation, whereas at higher doses (5 X 10(-9)-5 X 10(-6) mol/1) cell growth was inhibited in a dose-dependent manner. The same pattern of effects was seen for the other metabolites in a rank order of potency: 1,25-(OH)2D3 greater than 1,25S,26-(OH)3D3 = 1,24R,25-(OH)3D3 greater than 25S,26-(OH)2D3 = 24R,25-(OH)2D3 = 25-OH-D3. Synthesis of osteocalcin was induced by 1,25-(OH)2D3 in doses similar to those required to inhibit cell proliferation. Biphasic responses were observed for some of the metabolites in terms of osteocalcin synthesis, inhibitory effects becoming apparent at 5 X 10(-6) mol/1. The cells did not secrete osteocalcin spontaneously. These results indicate that vitamin D metabolites may regulate growth and expression of differentiated functions of normal human osteoblasts. Topics: 24,25-Dihydroxyvitamin D 3; Calcifediol; Calcitriol; Calcium-Binding Proteins; Cell Division; Dihydroxycholecalciferols; Humans; Hydroxycholecalciferols; In Vitro Techniques; Osteoblasts; Osteocalcin; Vitamin D | 1985 |