Compounds > 1-2-dielaidoylphosphatidylethanolamine

1-2-dielaidoylphosphatidylethanolamine and lactacystin

1-2-dielaidoylphosphatidylethanolamine has been researched along with lactacystin* in 1 studies

Other Studies

1 other study(ies) available for 1-2-dielaidoylphosphatidylethanolamine and lactacystin

Article	Year
Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation. Biochimica et biophysica acta, 2001, Aug-15, Volume: 1527, Issue:3 We previously reported that exogenous antigens complexed with the cationic liposome lipofectin (LF) were efficiently presented via major histocompatibility complex (MHC) class I molecules on pulsed dendritic cells (DCs) in vitro. In the present study, we demonstrated that MHC class I-restricted antigen presentation on DC2.4 cells, a murine immature DC line, treated with LF-antigen complexes was remarkably suppressed through the inhibition of endocytosis, proteasome catalysis, and Golgi transport. We also found that LF did not influence expression of interleukin-12 p40 mRNA, MHC molecules, or co-stimulatory molecules in DC2.4 cells. These findings suggest that an antigen-loading procedure using LF could enhance delivery of exogenous antigens to the classical MHC class I pathway in DCs, but it does not initiate DC maturation. Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens; Brefeldin A; Cell Line; Cell Survival; Chloroquine; Cytochalasin B; Dendritic Cells; Histocompatibility Antigens Class I; Major Histocompatibility Complex; Mice; Ovalbumin; Phosphatidylethanolamines; Time Factors	2001

Article

Year

Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation.

Biochimica et biophysica acta, 2001, Aug-15, Volume: 1527, Issue:3

We previously reported that exogenous antigens complexed with the cationic liposome lipofectin (LF) were efficiently presented via major histocompatibility complex (MHC) class I molecules on pulsed dendritic cells (DCs) in vitro. In the present study, we demonstrated that MHC class I-restricted antigen presentation on DC2.4 cells, a murine immature DC line, treated with LF-antigen complexes was remarkably suppressed through the inhibition of endocytosis, proteasome catalysis, and Golgi transport. We also found that LF did not influence expression of interleukin-12 p40 mRNA, MHC molecules, or co-stimulatory molecules in DC2.4 cells. These findings suggest that an antigen-loading procedure using LF could enhance delivery of exogenous antigens to the classical MHC class I pathway in DCs, but it does not initiate DC maturation.

Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens; Brefeldin A; Cell Line; Cell Survival; Chloroquine; Cytochalasin B; Dendritic Cells; Histocompatibility Antigens Class I; Major Histocompatibility Complex; Mice; Ovalbumin; Phosphatidylethanolamines; Time Factors

2001