1-2-4-trioxane and s-trioxane

1-2-4-trioxane has been researched along with s-trioxane* in 1 studies

Other Studies

1 other study(ies) available for 1-2-4-trioxane and s-trioxane

Article	Year
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. Organic letters, 2004, Sep-02, Volume: 6, Issue:18 [reaction: see text] Thiol-olefin co-oxygenation (TOCO) of substituted allylic alcohols generates alpha-hydroxyperoxides that can be condensed in situ with various ketones to afford a series of functionalized 1,2,4-trioxanes in good yields. Manipulation of the phenylsulfenyl group in 4a allows for convenient modification to the spiro-trioxane substituents, and we describe, for the first time, the preparation of a new class of antimalarial prodrug. Topics: Alkenes; Antimalarials; Combinatorial Chemistry Techniques; Heterocyclic Compounds; Molecular Structure; Oxidation-Reduction; Sulfhydryl Compounds	2004

Article

Year

Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.

Organic letters, 2004, Sep-02, Volume: 6, Issue:18

[reaction: see text] Thiol-olefin co-oxygenation (TOCO) of substituted allylic alcohols generates alpha-hydroxyperoxides that can be condensed in situ with various ketones to afford a series of functionalized 1,2,4-trioxanes in good yields. Manipulation of the phenylsulfenyl group in 4a allows for convenient modification to the spiro-trioxane substituents, and we describe, for the first time, the preparation of a new class of antimalarial prodrug.

Topics: Alkenes; Antimalarials; Combinatorial Chemistry Techniques; Heterocyclic Compounds; Molecular Structure; Oxidation-Reduction; Sulfhydryl Compounds

2004