1-2-4-trioxane and ferric-sulfate

1-2-4-trioxane has been researched along with ferric-sulfate* in 1 studies

Other Studies

1 other study(ies) available for 1-2-4-trioxane and ferric-sulfate

Article	Year
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16 These data suggest that iron(II) reactivity for a set of homologous spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane peroxide heterocycles is a necessary, but insufficient, property of animalarial peroxides. Heme alkylation efficiency appears to give a more accurate prediction of antimalarial activity than FeSO(4)-mediated reaction rates, suggesting that antimalarial activity is not merely dependent on peroxide bond cleavage, but also on the ability of reactive intermediates to alkylate heme or other proximal targets. Topics: Alkylation; Animals; Antimalarials; Computer Simulation; Ferric Compounds; Ferrous Compounds; Heme; Heterocyclic Compounds; Mice; Parasitic Sensitivity Tests; Peroxides	2009

Article

Year

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

Bioorganic & medicinal chemistry letters, 2009, Aug-15, Volume: 19, Issue:16

These data suggest that iron(II) reactivity for a set of homologous spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane peroxide heterocycles is a necessary, but insufficient, property of animalarial peroxides. Heme alkylation efficiency appears to give a more accurate prediction of antimalarial activity than FeSO(4)-mediated reaction rates, suggesting that antimalarial activity is not merely dependent on peroxide bond cleavage, but also on the ability of reactive intermediates to alkylate heme or other proximal targets.

Topics: Alkylation; Animals; Antimalarials; Computer Simulation; Ferric Compounds; Ferrous Compounds; Heme; Heterocyclic Compounds; Mice; Parasitic Sensitivity Tests; Peroxides

2009