1,2,3,4-tetrahydroxy-nor-tropane has been researched along with isofagomine in 3 studies
| Studies (1,2,3,4-tetrahydroxy-nor-tropane) | Trials (1,2,3,4-tetrahydroxy-nor-tropane) | Recent Studies (post-2010) (1,2,3,4-tetrahydroxy-nor-tropane) | Studies (isofagomine) | Trials (isofagomine) | Recent Studies (post-2010) (isofagomine) |
|---|---|---|---|---|---|
| 27 | 0 | 9 | 95 | 0 | 47 |
| Protein | Taxonomy | 1,2,3,4-tetrahydroxy-nor-tropane (IC50) | isofagomine (IC50) |
|---|---|---|---|
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | 0.0555 | |
| Glycogen phosphorylase, liver form | Homo sapiens (human) | 0.685 | |
| Glycogen phosphorylase, liver form | Rattus norvegicus (Norway rat) | 0.68 | |
| Lactase-phlorizin hydrolase | Rattus norvegicus (Norway rat) | 0.12 | |
| Beta-galactosidase | Bos taurus (cattle) | 3.6 | |
| Non-lysosomal glucosylceramidase | Homo sapiens (human) | 0.02 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blériot, Y; Davies, GJ; Dumon, C; Gilbert, HJ; Gratien, J; Heck, MP; Morland, C; Offen, WA; Smith, NL; Stick, RV; Tailford, LE; Vasella, A | 1 |
| Allman, S; Butters, TD; Jensen, HH; Rasmussen, TS; Twigg, G | 1 |
| Adachi, I; Hirono, S; Kato, A; Koike, Y; Nakagawa, S; Nakagome, I; Nash, RJ | 1 |
3 other study(ies) available for 1,2,3,4-tetrahydroxy-nor-tropane and isofagomine
| Article | Year |
|---|---|
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.
Topics: beta-Mannosidase; Enzyme Inhibitors; Hydrolysis; Molecular Mimicry; Protein Conformation | 2008 |
Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.
Topics: Enzyme Assays; Gaucher Disease; Glucosylceramidase; Humans; Inhibitory Concentration 50; Nortropanes | 2011 |
Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.
Topics: Binding Sites; Catalytic Domain; Cell Line; Gaucher Disease; Glucosylceramidase; Humans; Hydrogen Bonding; Imino Pyranoses; Isomerism; Molecular Docking Simulation; Nortropanes; Solanaceous Alkaloids; Static Electricity; Structure-Activity Relationship; Tropanes | 2014 |