1-1-diphenyl-2-picrylhydrazyl and orientin

1-1-diphenyl-2-picrylhydrazyl has been researched along with orientin* in 2 studies

Other Studies

2 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and orientin

ArticleYear
The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities.
    Archives of pharmacal research, 2014, Volume: 37, Issue:10

    To investigate the effect of C-glycosylation at different positions of luteolin, the structure-activity relationships of luteolin and a pair of isomeric C-glycosylated derivatives orientin and isoorientin, were evaluated. We investigated the effects of C-glycosylation on the antioxidant, anti-Alzheimer's disease (AD), anti-diabetic and anti-inflammatory effects of luteolin and its two C-glycosides via in vitro assays of peroxynitrite (ONOO(-)), total reactive oxygen species (ROS), nitric oxide (NO), 1,1-diphenyl-2-picrylhydraxyl (DPPH), aldose reductase, protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor cleaving enzyme 1 (BACE1), and cellular assays of NO production and inducible nitric oxide synthase (iNOS)/cyclooxygenase-2 expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Of the three compounds, isoorientin showed the highest scavenging activity against DPPH, NO, and ONOO(-), while luteolin was the most potent inhibitor of ROS generation. In addition, luteolin showed the most potent anti-AD activity as determined by its inhibition of AChE, BChE, and BACE1. With respect to anti-diabetic effects, luteolin exerted the strongest inhibitory activity against PTP1B and rat lens aldose reductase. Luteolin also inhibited NO production and iNOS protein expression in LPS-stimulated macrophages, while orientin and isoorientin were inactive at the same concentrations. The effects of C-glycosylation at different positions of luteolin may be closely linked to the intensity and modulation of antioxidant, anti-AD, anti-diabetic, and anti-inflammatory effects of luteolin and its C-glycosylated derivatives.

    Topics: Aldehyde Reductase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartic Acid Endopeptidases; Biphenyl Compounds; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Flavonoids; Glucosides; Glycosylation; Hypoglycemic Agents; In Vitro Techniques; Luteolin; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Picrates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Reactive Oxygen Species; Structure-Activity Relationship

2014
Altitudinal variation of antioxidant components and capability in Indocalamus latifolius (Keng) McClure leaf.
    Journal of nutritional science and vitaminology, 2013, Volume: 59, Issue:4

    Indocalamus latifolius (Keng) McClure leaf is a popular food material in East Asia due to its antioxidant and anticorrosive activities. To utilize it more effectively, we investigated the discrepancy of antioxidant activities and active compound content in Indocalamus latifolius leaf along with the altitude change. Total flavonoids, phenolics, titerpenoids and eight characteristic active constituents, i.e, orientin, isoorientin, vitexin, homovitexin, p-coumaric acid, chlorogenic acid, caffeic acid, and ferulic acid, were determined by UV-spectrophotometer and synchronous RP-HPLC, respectively. Antioxidant activity was measured using DPPH and FRAP methods. Our data showed that the content of TP and TF, DPPH radical scavenging ability and ferric reduction power of Indocalamus latifolius leaf changed as altitude altered, with the trends of decreasing gradually when lower than 700 m and then increasing to 1,000 m. Chlorogenic acid and orientin were the main characteristic compounds in Indocalamus latifolius leaf and were also affected by altitude. Our result indicated that higher altitude with an adverse environment is conducive to secondary metabolite accumulation for Indocalamus latifolius. It would provide a theoretical basis to regulate the leaf collection conditions in the industrial use of Indocalamus latifolius leaf.

    Topics: Antioxidants; Apigenin; Asia; Biphenyl Compounds; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Diet; Ecosystem; Ferric Compounds; Flavonoids; Glucosides; Picrates; Plant Extracts; Plant Leaves; Poaceae; Polyphenols; Secondary Metabolism; Triterpenes

2013