1-1-diphenyl-2-picrylhydrazyl has been researched along with hydrazine* in 2 studies
2 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and hydrazine
| Article | Year |
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Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties.
The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. Results show that hydrazide ligands (1-12) and their respective vanadium(V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and LOX, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds. Topics: Antioxidants; Biphenyl Compounds; Coordination Complexes; Drug Evaluation, Preclinical; Enzyme Inhibitors; Free Radical Scavengers; Hydrazines; Ligands; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Nitric Oxide; Picrates; Spectrophotometry, Infrared; Superoxide Dismutase; Vanadium; Vanadium Compounds; Xanthine Oxidase | 2017 |
Synthesis, spectral characterization, molecular structure and pharmacological studies of N'-(1, 4-naphtho-quinone-2yl) isonicotinohydrazide.
A simple and efficient procedure was employed for the synthesis of N'-(1,4-naphtho-quinone-2-yl) isonicotinohydrazide (NIH) by the reaction of 2-hydroxy-1,4-naphthaquinone (lawsone) and isonicotinoyl hydrazine in methanol using ultrasonic irradiation. Lawsone is the principal dye, isolated from the leaves of henna (Lawsonia inermis). Structural modification was done on the molecule aiming to get a more active derivative. The structure of the parent compound and the derivative was characterized by elemental analyses, infrared, electronic, (1)H, (13)C NMR and GC-MS spectra. The fluorescence spectral investigation of the compound was studied in DMSO and ethanol. Single crystal X-ray diffraction studies reveal that NIH crystallizes in monoclinic space group. The DNA cleavage study was monitored by gel electrophoresis method. The synthesized compound was found to have significant antioxidant activity against DPPH radical (IC50=58 μM). The in vitro cytotoxic studies of the derivative against two human cancer cell lines MCF-7 (human breast cancer) and HCT-15 (human colon carcinoma cells) using MTT assay revealed that the compound exhibited higher cytotoxic activity with a lower IC50 value indicating its efficiency in killing the cancer cells even at low concentrations. These results suggest that the structural modifications performed on lawsone could be considered a good strategy to obtain a more active drug. Topics: Ascorbic Acid; Biphenyl Compounds; Carbon-13 Magnetic Resonance Spectroscopy; Cell Death; Cell Line, Tumor; Crystallography, X-Ray; DNA Cleavage; Electrophoresis, Agar Gel; Free Radical Scavengers; Gas Chromatography-Mass Spectrometry; Humans; Hydrazines; Hydrogen Bonding; Isoniazid; Molecular Conformation; Picrates; Proton Magnetic Resonance Spectroscopy; Reference Standards; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2015 |