Compounds > 1-1-diphenyl-2-picrylhydrazyl

1-1-diphenyl-2-picrylhydrazyl and exifone

1-1-diphenyl-2-picrylhydrazyl has been researched along with exifone* in 1 studies

Other Studies

1 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and exifone

Article	Year
The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model. Molecules (Basel, Switzerland), 2013, Jan-28, Volume: 18, Issue:2 Alzheimer's disease (AD) pathogenesis involves an imbalance between free radical formation and destruction. In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free radical activity, and screened their effects on scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Compound C7, 4,2'-dihydroxy-3,5-dimethoxychalcone was found to have potent activity in these anti-free radical activity tests. Further research revealed that C7 could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in vivo in the Alzheimer's model. The indication of C7's effect on AD needs further study. Topics: Alzheimer Disease; Animals; Benzophenones; Biphenyl Compounds; Brain; Chalcone; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Glutathione Peroxidase; Hydroxylation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Malondialdehyde; Mice; Oxidation-Reduction; Picrates; Scopolamine; Superoxide Dismutase	2013

Article

Year

The synthesis and evaluation of novel hydroxyl substituted chalcone analogs with in vitro anti-free radicals pharmacological activity and in vivo anti-oxidation activity in a free radical-injury Alzheimer's model.

Molecules (Basel, Switzerland), 2013, Jan-28, Volume: 18, Issue:2

Alzheimer's disease (AD) pathogenesis involves an imbalance between free radical formation and destruction. In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free radical activity, and screened their effects on scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Compound C7, 4,2'-dihydroxy-3,5-dimethoxychalcone was found to have potent activity in these anti-free radical activity tests. Further research revealed that C7 could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in vivo in the Alzheimer's model. The indication of C7's effect on AD needs further study.

Topics: Alzheimer Disease; Animals; Benzophenones; Biphenyl Compounds; Brain; Chalcone; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Glutathione Peroxidase; Hydroxylation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Malondialdehyde; Mice; Oxidation-Reduction; Picrates; Scopolamine; Superoxide Dismutase

2013