1-1-diphenyl-2-picrylhydrazyl and ethylenediamine

Overexpression of collagenase, elastase, and tyrosinase is caused by external factors such as ultraviolet (UV) radiation and stress, resulting in wrinkle formation and freckles through the loss of skin elasticity and skin pigmentation. In this study, we developed novel carbon quantum dots (CQDs) with antioxidant and anti-aging properties using tannic acid as a carbon source through a simple microwave-assisted pyrolysis method. The synthesized tannic acid-derived CQDs (T-CQDs) showed bright blue fluorescence (QY = 28.2 ± 4.0%), exhibiting maximum emission at 430 nm under 350 nm excitation. Even though small amount of the T-CQDs (3

Topics: Antioxidants; Ascorbic Acid; Biphenyl Compounds; Carbon; Cell Line, Tumor; Cell Survival; Collagenases; Enzyme Inhibitors; Ethylenediamines; Geroscience; Humans; Melanocytes; Microwaves; Monophenol Monooxygenase; Pancreatic Elastase; Picrates; Quantum Dots; Quercetin; Tannins

Co(II), Ni(II), Zn(II) and Cu(II) complexes of (3E)-3-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one (DEPH2) derived from ethylenediamine, 2',4'-dihydroxyacetophenone and 1-phenylbutane-1,3-dione have been synthesized and characterized by elemental analysis, FTIR, UV-Visible spectroscopy, and screened to establish their potential as antibacterial agents, antioxidants and DPPH radical scavengers. The FTIR spectra showed that the ligand behaves as a dibasic tetradentate ligand with the dioxygen-dinitrogen donor atom system oriented towards the central metal ion. The analytical and spectroscopic data suggest a square planar geometry for Cu(II) and Ni(II) complexes and an octahedral geometry for the Co(II) complex. The ligand and their metal complexes were screened for antibacterial activity against Gram (+) and Gram (-) bacteria by the agar well diffusion method. In addition, the antioxidant activities of the complexes were also investigated through their scavenging effect on DPPH and ABTS radicals. The obtained IC50 value of the DPPH activity for the copper complex (2.08 ± 0.47 µM) and that of the ABTS activity for the copper complex (IC50 = 2.11 + 1.69 µM) were higher than the values obtained for the other compounds.

Topics: Acetophenones; Anti-Bacterial Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Butanones; Cations, Divalent; Coordination Complexes; Copper; Ethylenediamines; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Nickel; Picrates; Schiff Bases; Sulfonic Acids