1-1-diphenyl-2-picrylhydrazyl and butenolide

Two new butenolide derivatives (±)-asperteretal D ((±)-1) and asperteretal E (2) containing rare 2-benzyl-3-phenyl substituted lactone core, together with nine known analogues (3-11) were obtained from a fungus Aspergillus terreus derived from the marine sponge Phakellia fusca. All the structures were elucidated on the basis of extensive NMR spectroscopic data. The chiral chromatography analyses allowed the separation of the (±)-asperteretal D, of which the absolute configurations were determined by comparing the experimental to calculated electronic circular dichroic (ECD) spectra. Compounds (±)-1, 2-5, and 7 exhibited potent inhibitory activities against α-glucosidase with IC

Topics: 4-Butyrolactone; alpha-Glucosidases; Antioxidants; Aspergillus; Biphenyl Compounds; Density Functional Theory; Dose-Response Relationship, Drug; Glycoside Hydrolase Inhibitors; Molecular Structure; Picrates; Structure-Activity Relationship