1-1-diphenyl-2-picrylhydrazyl has been researched along with allyl-alcohol* in 2 studies
2 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and allyl-alcohol
| Article | Year |
|---|---|
Coupling reactions of catechins with natural aldehydes and allyl alcohols and radical scavenging activities of the triglyceride-soluble products.
Hydrophobic catechin derivatives were produced by heating with natural aldehydes or allyl alcohols. (+)-Catechin or (-)-epigallocatechin-3-O-gallate was heated with trans-2-hexenal, citral, (+)-citronellal, geraniol, or phytol. Although each reaction generated complex mixtures of products, 11 compounds were isolated and characterized by spectroscopic methods. The unsaturated aldehydes were found to attach to the flavan A-ring. Besides C-C linkage between aldehyde and the C-8 and/or C-6 of the catechin A-ring, formation of ether linkages between unsaturated carbons of the aldehydes and phenolic hydroxyl groups was observed. The allyl alcohols, geraniol and phytols, reacted at the galloyl group as well as the A-ring. After partitioning between triglyceride and water, the lipid layer of the reaction products showed strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. In contrast, epigallocatechin-3-O-gallate was not transferred to the lipid layer. Topics: Aldehydes; Biphenyl Compounds; Catechin; Free Radical Scavengers; Hot Temperature; Picrates; Propanols; Solubility; Triglycerides; Water | 2009 |
Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum.
The aim of this study was to evaluate the cytoprotective effects upon primary human hepatocytes of silymarin extract and its main flavonolignans following exposure to the cytotoxic actions of model toxins. The conditions for the hepatocyte intoxication were optimised for allyl alcohol, carbon tetrachloride, D-galactosamine and paracetamol. Silymarin extract, silychristin and silydianin did not exert cytotoxicity (10-100 microM), whereas silybin and isosilybin at higher concentrations and after longer incubation periods were cytotoxic. All main flavonolignans of silymarin tested displayed concentration-dependent cytoprotection against the toxic effects of both allyl alcohol and carbon tetrachloride but neither paracetamol nor galactosamine. The best protection was achieved by silydianin and silychristin and to a lesser degree by silymarin, while silybin and isosilybin were less effective. It is concluded that these differing outcomes result from the varying abilities of the Silybum marianum substances tested to stabilize the cell membrane, exert antioxidant properties and exhibit intrinsic toxicity. Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Asteraceae; Biphenyl Compounds; Cell Separation; Cell Survival; Cells, Cultured; Flavonoids; Free Radical Scavengers; Galactosamine; Hepatocytes; Humans; L-Lactate Dehydrogenase; Lignans; Picrates; Plant Extracts; Propanols; Protein Biosynthesis; tert-Butylhydroperoxide; Toxins, Biological | 2003 |