Compounds > 1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane
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1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane and tamoxifen

1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane has been researched along with tamoxifen in 4 studies

Compound Research Comparison

Studies
(1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane)		Trials
(1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane)		Recent Studies (post-2010)
(1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane)		Studies
(tamoxifen)		Trials
(tamoxifen)		Recent Studies (post-2010) (tamoxifen)
50020,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomy1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Day, BW; Du, L; Hossain, MB; Ji, X; Magarian, RA; van der Helm, D1
Jain, PT; Magarian, RA; Pento, JT1
Abidi, SM; Dmytryk, JJ; Howard, EW; Pento, JT1
Balachandran, R; Day, BW; Grant, SG; Welsh, MJ1

Other Studies

4 other study(ies) available for 1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane and tamoxifen

ArticleYear
Structure of 1,1-dichloro-2-(4-methoxyphenyl)-2,3-diphenylcyclopropane.
    Acta crystallographica. Section C, Crystal structure communications, 1992, May-15, Volume: 48 ( Pt 5)

    Topics: Chemical Phenomena; Chemistry, Physical; Crystallization; Cyclopropanes; Estrogen Antagonists; Molecular Structure; Tamoxifen; X-Ray Diffraction

1992
The influence of a novel cyclopropyl antiestrogen (compound 7a) on human breast cancer cells in culture.
    Breast cancer research and treatment, 1993, Volume: 25, Issue:3

    Topics: Breast Neoplasms; Cell Division; Estradiol; Estrogen Antagonists; Female; Humans; Lung Neoplasms; Microscopy, Electron, Scanning; Microvilli; Protein Binding; Tamoxifen; Tumor Cells, Cultured

1993
The influence of antiestrogens on the release of plasminogen activator (uPA) by MDA-MB-231 and MCF-7 breast cancer cells.
    Clinical & experimental metastasis, 1998, Volume: 16, Issue:3

    Topics: Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Fibronectins; Fulvestrant; Humans; Neoplasm Invasiveness; Tamoxifen; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator

1998
Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis.
    The Prostate, 2000, Dec-01, Volume: 45, Issue:4

    Topics: Androgens; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Estrogen Receptor Modulators; Growth Inhibitors; Humans; Male; Neoplasms, Hormone-Dependent; Prostate-Specific Antigen; Prostatic Neoplasms; Tamoxifen; Tumor Cells, Cultured

2000