Compounds > 1,(n2)-ethenoguanine

Page last updated: 2024-09-03

1,(n2)-ethenoguanine and guanine

1,(n2)-ethenoguanine has been researched along with guanine in 14 studies

Compound Research Comparison

Studies (1,(n2)-ethenoguanine)	Trials (1,(n2)-ethenoguanine)	Recent Studies (post-2010) (1,(n2)-ethenoguanine)	Studies (guanine)	Trials (guanine)	Recent Studies (post-2010) (guanine)
15	0	3	16,278	822	4,809

Protein Interaction Comparison

Protein	Taxonomy	1,(n2)-ethenoguanine (IC50)	guanine (IC50)
Purine nucleoside phosphorylase	Homo sapiens (human)		5

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (21.43)	18.2507
2000's	8 (57.14)	29.6817
2010's	1 (7.14)	24.3611
2020's	2 (14.29)	2.80

Authors

Authors	Studies
Guengerich, FP; Langouët, S; Müller, M	1
Fink, SP; Guengerich, FP; Langouët, S; Marnett, LJ; Mican, AN; Muhle, SA; Müller, M	1
Akasaka, S; Guengerich, FP	1
Ham, AJ; Morinello, EJ; Ranasinghe, A; Sangaiah, R; Swenberg, JA	1
Cai, H; Elder, RH; Guengerich, FP; Langouët, S; Laval, J; Privezentzev, CV; Saparbaev, M	1
Angerer, J; Drexler, H; Gonzalez-Reche, LM; Koch, HM; Müller, J; Weiss, T	1
He, C; Mishina, Y; Yang, CG	1
Chen, HJ; Chiu, WL	1
Angel, KC; Choi, JY; Goodenough, AK; Guengerich, FP; Kozekov, ID; Rizzo, CJ; Zang, H	1
Broyde, S; Dimitri, A; Goodenough, AK; Guengerich, FP; Scicchitano, DA	1
Delaney, JC; Essigmann, JM; Kartalou, M; Lee, CY; Lingaraju, GM; Maor-Shoshani, A; Samson, LD	1
Domańska, A; Falnes, PØ; Guengerich, FP; Kosicki, K; Prorok, P; Rizzo, CJ; Tudek, B; van den Born, E; Zdżalik, D	1
O'Brien, PJ; Thelen, AZ	1
Lenz, SAP; Li, D; Wetmore, SD	1

Other Studies

14 other study(ies) available for 1,(n2)-ethenoguanine and guanine

Article	Year
Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcripta Biochemistry, 1997, May-20, Volume: 36, Issue:20 Topics: Carcinogens; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Guanine; Imidazoles; Mutagenesis; Oligodeoxyribonucleotides; Purines; Transcription, Genetic	1997
Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidaz Biochemistry, 1998, Apr-14, Volume: 37, Issue:15 Topics: DNA Adducts; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Guanine; Imidazoles; Mutagens; Purines	1998
Mutagenicity of site-specifically located 1,N2-ethenoguanine in Chinese hamster ovary cell chromosomal DNA. Chemical research in toxicology, 1999, Volume: 12, Issue:6 Topics: Animals; CHO Cells; Chromosomes; Cricetinae; Genome; Guanine; Mutagenesis, Site-Directed; Mutagens	1999
Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay. Chemical research in toxicology, 2001, Volume: 14, Issue:3 Topics: Animals; Antibodies; Cell Transformation, Neoplastic; DNA Adducts; Gas Chromatography-Mass Spectrometry; Guanine; Immunoassay; Male; Oxidation-Reduction; Rabbits; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Vinyl Chloride	2001
1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase. The Journal of biological chemistry, 2002, Jul-26, Volume: 277, Issue:30 Topics: Animals; Cell-Free System; DNA Adducts; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Humans; Kinetics; Mice; Models, Chemical; N-Glycosyl Hydrolases; Oligonucleotides; Protein Binding; Substrate Specificity; Uracil-DNA Glycosidase	2002
Analysis of ethenoguanine adducts in human urine using high performance liquid chromatography-tandem mass spectrometry. Toxicology letters, 2002, Aug-05, Volume: 134, Issue:1-3 Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; DNA Adducts; Environmental Monitoring; Female; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2002
Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins. Journal of the American Chemical Society, 2005, Oct-26, Volume: 127, Issue:42 Topics: Adenine; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Alkylation; Cytosine; Dioxygenases; DNA; DNA Adducts; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Escherichia coli Proteins; Guanine; Humans; Hydrogen-Ion Concentration; Iron; Mixed Function Oxygenases; Molecular Structure; Time Factors	2005
Association between cigarette smoking and urinary excretion of 1,N2-ethenoguanine measured by isotope dilution liquid chromatography-electrospray ionization/tandem mass spectrometry. Chemical research in toxicology, 2005, Volume: 18, Issue:10 Topics: Adult; Biomarkers; Chromatography, Liquid; DNA Adducts; Female; Guanine; Humans; Indicator Dilution Techniques; Male; Middle Aged; Reproducibility of Results; Smoking; Spectrometry, Mass, Electrospray Ionization	2005
Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Chemical research in toxicology, 2006, Volume: 19, Issue:6 Topics: DNA Damage; DNA Primers; DNA-Directed DNA Polymerase; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Kinetics; Molecular Structure; Mutagenesis; Oligonucleotides	2006
Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase. Journal of molecular biology, 2008, Jan-11, Volume: 375, Issue:2 Topics: Bacteriophage T7; Base Sequence; Binding Sites; Carcinogens, Environmental; Computer Simulation; Crystallography, X-Ray; DNA-Directed RNA Polymerases; Guanine; HeLa Cells; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Plasmids; RNA Polymerase II; Saccharomyces cerevisiae; Sequence Analysis, RNA; Templates, Genetic; Transcription, Genetic; Viral Proteins	2008
Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). Biochemistry, 2009, Mar-10, Volume: 48, Issue:9 Topics: Adenine; Base Sequence; Catalysis; Catalytic Domain; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Electrophoretic Mobility Shift Assay; Guanine; Humans; Kinetics; Models, Molecular; Molecular Structure; Oligonucleotides; Protein Binding; Protein Structure, Tertiary; Sequence Deletion; Substrate Specificity	2009
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA repair, 2015, Volume: 30 Topics: Adenine; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Bacteria; Bacterial Proteins; Cytosine; Dioxygenases; DNA; DNA Adducts; DNA Glycosylases; DNA Repair; DNA Repair Enzymes; DNA, Single-Stranded; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; Mixed Function Oxygenases; Mycobacterium tuberculosis; Rhizobium etli; Streptomyces; Substrate Specificity; Xanthomonas campestris	2015
Recognition of 1, The Journal of biological chemistry, 2020, 02-07, Volume: 295, Issue:6 Topics: Catalytic Domain; DNA Glycosylases; Guanine; Humans; Kinetics; Molecular Docking Simulation; Substrate Specificity	2020
Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB. DNA repair, 2020, Volume: 96 Topics: Adenine; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Catalytic Domain; Computational Biology; Cytosine; DNA Adducts; DNA Repair; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; Mixed Function Oxygenases; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Substrate Specificity	2020