1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with w 7 in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (17.12) | 18.7374 |
| 1990's | 100 (68.49) | 18.2507 |
| 2000's | 18 (12.33) | 29.6817 |
| 2010's | 3 (2.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayakawa, T; Hidaka, H; Ishiguro, H; Kitagawa, M; Kondo, T; Nakae, Y; Sakai, Y; Shibata, T; Sobajima, H; Tanikawa, M | 1 |
| Jung, T; Lee, C; Moor, RM | 1 |
| Hagiwara, M; Hidaka, H; Kato, M | 1 |
| Gordon, PB; Holen, I; Seglen, PO | 1 |
| Duman, RS; Hayward, MD; Nestler, EJ; Tallman, JF; Vaccarino, FM | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Katabami, T; Nemoto, K; Ogura, M; Ohira, K; Okano, K; Shimizu, M; Suzuki, S; Tsukamoto, T; Yamada, Y; Yano, Y | 1 |
| Chen, LC; Ito, A; Mori, Y; Nagase, H; Ojima, Y | 1 |
| Koide, Y; Miyachi, H; Sekiguchi, S; Shibata, T; Takemura, Y; Tukemura, Y | 1 |
| Kennedy, AR; Umans, RS | 1 |
| Arakaki, N; Daikuhara, Y; Hara, H; Hirono, S; Ishii, T; Kawakami, S; Tsubouchi, H | 1 |
| Fusamoto, H; Hayashi, N; Kamada, T; Kasahara, A; Katayama, K; Sasaki, Y; Takehara, T; Towata, T | 1 |
| Fukami, Y; Furuichi, H; Imai, S; Onozuka, M | 1 |
| Brown, JH; Glembotski, CC; Irons, CE; McDonough, PM; Sei, CA; Sprenkle, AB | 1 |
| Izawa, T; Komabayashi, T; Rubin, RP; Suda, K; Tsuboi, M; Yakata, A | 1 |
| Hashioka, T; Kato, M | 1 |
| Bitar, KN; Cease, KB; Hailat, N; Kaminski, MS; Strahler, JR | 1 |
| Chiou, S; Davis, JS; Fineberg, NS; Ganguly, A | 1 |
| Hidaka, H; Hoshino, T; Mizutani, A; Shimizu, S; Yamane, T | 1 |
| Caldwell, CW; Patterson, WP; Yesus, YW | 1 |
| Celada, A; Maki, RA | 1 |
| Chen, H; Dryden, WF; Singh, YN | 1 |
| Crowley, JJ; Raffin, TA | 1 |
| Asano, T; Johshita, H; Matsui, T; Sugawa, M; Takuwa, Y | 1 |
| Albright, CD; Fontana, JA; Grimley, PM; Jones, RT; Keenan, KP; Resau, JH | 1 |
| Bement, WM; Capco, DG | 1 |
| Hidaka, H; Ishikawa, T; Tokumitsu, H | 1 |
| Leszczynski, D; Ustinov, J | 1 |
| Aoki, Y; Matsumura, K; Sato, K; Shimada, M | 1 |
| Djeu, JY; Richards, AL | 1 |
| Aguet, M; Ballotti, R; Mao, C; Merlin, G; Metzler, M | 1 |
| Manganel, M; Turner, RJ | 1 |
| Brandwein, SR | 1 |
| Dinarello, CA; Morse, C; Zucali, JR | 1 |
| Mattila, P; Renkonen, R; Turunen, JP | 1 |
| Hishinuma, K; Hosono, A; Inaba, H; Kimura, S | 1 |
| Betts, WH; French, JK; Hurst, NP | 1 |
| Larsson, R; Nygren, P | 1 |
| Chijiwa, T; Hagiwara, M; Hidaka, H | 1 |
| Baba, A; Hano, T; Masuyama, Y; Nakamura, Y; Nishio, I; Shiotani, M; Tomobuchi, Y; Ura, M | 1 |
| Hashiba, Y; Hidaka, H; Ishikawa, N | 1 |
| Gabbay, RA; Lebovitz, HE; Siconolfi-Baez, L | 1 |
| Herbert, JM; Maffrand, JP; Seban, E | 1 |
| Hinson, JP; Laird, SM; Mallick, N; Marsigliante, S; Teja, R; Vinson, GP | 1 |
| Conroy, MC; Kennedy, JA; Thueson, DO; Wright, CD | 1 |
| Gleich, GJ; Thomas, LL; Zheutlin, LM | 1 |
| Clark, EA; Meier, KE; Rossie, S; Valentine, MA | 1 |
| Dileepan, KN; Stechschulte, DJ; Suzuki, T; Yamada, A | 1 |
| Albouz, S; Baumann, N; Boutry, JM; Castagna, M; Masson, M; Spezzatti, B | 1 |
| Shen, SS | 1 |
| Kabemura, M; Kimura, G; Matsuzaki, A; Ohtsu, M; Shimura, H | 1 |
| Bright, EC; Colombani, PM; Hess, AD; Wells, M | 1 |
| Hamasaki, T; Kashiwa, H; Sakano, T; Taniguchi, H; Ueda, K | 1 |
| Barile, G; Faggioni, A; Frati, L; Grimaldi, S; Lazdins, J; Venanzoni, M; Zompetta, C | 1 |
| Hashimoto, H; Ishida, A; Ito, T; Ogawa, K; Okumura, K; Satake, T; Tanahashi, T | 1 |
| Devenyi, ZJ; Holian, A; Jordan, MK; Nguyen, HV | 1 |
| Hoffman, MD; Wright, CD | 2 |
| Hidaka, H; Inagaki, M; Tanaka, T | 1 |
| Kuroki, T; Nose, K; Shibanuma, M | 1 |
| Ina, Y; Koide, Y; Nezu, N; Yoshida, TO | 1 |
| Fujita, T; Katakami, N; Katakami, Y; Koizumi, T; Matsui, T; Nakao, Y | 1 |
| Chapekar, MS; Glazer, RI; Hartman, KD; Knode, MC | 1 |
| Kaneko, Y; Oka, H; Toda, G | 1 |
| Fuse, I; Tai, HH | 1 |
| Kimura, K; Masuyama, Y; Nishio, I; Shima, H; Takeda, J; Tsuda, K; Ura, M | 1 |
| Kovacs, EJ; Radzioch, D; Varesio, L; Young, HA | 1 |
| Carroll, AG; Eckberg, WR; Szuts, EZ | 1 |
| Ishibashi, S; Ohtsuka, T; Okamura, N | 1 |
| Barber, LE; Lu, M; Renfro, JL | 1 |
| Blaheta, RA; Encke, A; Hailer, NP; Harder, S; Markus, BH; Scholz, M | 1 |
| Gukovskaya, AS; Pandol, SJ | 1 |
| Hashioka, T | 1 |
| Fusamoto, H; Hayashi, N; Horimoto, M; Ito, T; Kamada, T; Kaneko, A; Sasaki, Y; Tanaka, Y | 1 |
| Golombek, DA; Ralph, MR | 1 |
| Ganguly, A; Haxton, M; Li, L | 1 |
| Terrian, DM; Ways, DK | 1 |
| Fujita, S; Horiuchi, T; Watanabe, I | 1 |
| Grebenkämper, K; Nicolau, C | 1 |
| Audette, M; Bouillon, M | 1 |
| Fusamoto, H; Hayashi, N; Horimoto, M; Ito, T; Kamada, T; Kaneko, A; Kasahara, A; Sasaki, Y; Tanaka, Y | 1 |
| Cheng, H; Lakatta, EG; Lederer, WJ; Suzuki, T; Xiao, RP | 1 |
| Bouzinba-Segard, H; Castagna, M; Fan, XT; Perderiset, M | 1 |
| Li, GC; Qian, DH; Tian, M; Zhang, JP | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Kano, M; Nakabayashi, Y; Satoh, R | 1 |
| Hasegawa, T | 1 |
| Dunlop, J; Ennis, C; Minchin, MC; Rossiter, J | 1 |
| Kordon, C; L'Héritier, A; Leblanc, P; Rasolonjanahary, R | 1 |
| Grabié, V; Scemama, JL; Seidel, ER | 1 |
| Koide, Y; Matsuyama, S; Yoshida, TO | 1 |
| Ichikawa, T; Yano, T | 1 |
| Behar, J; Biancani, P; De Petris, G; Harnett, KM; Yu, P | 1 |
| Larner, J; Nagasaka, Y; Okubo, M | 1 |
| Arizono, K; Brady, FO; Peterson, KL | 1 |
| Grabie, V; Robertson, JB; Scemama, JL; Seidel, ER | 1 |
| Lewis, CE; McGee, JO; Pusztai, L | 1 |
| Beezhold, DH; Chang, ZL; Personius, CD; Shen, ZL | 1 |
| Fleer, A; Mattsson, E; Rollof, J; Van Dijk, H; Van Kessel, K; Verhoef, J | 1 |
| Ekokoski, E; Törnquist, K | 1 |
| Chock, PB; Huang, CY; Tekle, E; Zhu, DM | 1 |
| Hidaka, H; Yokokura, H | 1 |
| Choi, KJ; Kim, SC; Lee, JH; Park, HJ; Park, KH; Park, KM; Rhee, MH; Song, YB | 1 |
| Ogawa, T; Uchida, H | 1 |
| Furukawa, S; Shono, T; Taniai, K; Yamakawa, M | 1 |
| Ikeuchi, Y; Nishizaki, T; Okada, Y | 1 |
| Honda, K; Kamiya, H; Takano, Y | 1 |
| Hashimoto, Y; Higashihara, M; Kurokawa, K; Satoh, H; Sunaga, S; Togo, M; Watanabe, T | 1 |
| Hayashi, M; Kaiho, F; Shibasaki, T; Takahashi, H; Takeshita, K | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Higuchi, H; Hirokawa, M; Hokari, R; Ishii, H; Kimura, H; Kurose, I; Miura, S; Nakaki, T; Saito, H; Shigematsu, T; Yoshida, H | 1 |
| Borg, M; Dhindsa, RS; Monroy, AF; Sangwan, V; Tähtiharju, S | 1 |
| Marunaka, Y; Niisato, N; Shintani, Y | 1 |
| Juhn, SK; Kim, Y; Lin, J | 1 |
| Hasebe, A; Sasaki, T; Shibata, K; Watanabe, T | 1 |
| Himmelreich, NH; Pozdnyakova, NG; Storchak, LG | 1 |
| Hartfield, PJ; Robinson, JM | 1 |
| Ayuso, MS; Ibarreta, D; Parrilla, R; Urcelay, E | 1 |
| Bernal, RM; Muñoz, ML; Santos, JI; Tovar, R | 1 |
| Hidaka, H; Naito, Y | 1 |
| Geertsma, MF; Nibbering, PH; Van Den Barselaar, MT; Van Furth, R; Zheng, L; Zomerdijk, TP | 1 |
| Chen, J; Hoffman, BB; Hu, ZW; Lin, R | 1 |
| Gadea, A; López-Colomé, AM | 1 |
| Ishikawa, I; Iwasaki, K; Noguchi, K | 1 |
| Anouar, Y; Castel, H; Cazin, L; Le Foll, F; Louiset, E; Vaudry, H | 1 |
| Aikawa, R; Hayashi, D; Komuro, I; Kudoh, S; Mizukami, M; Nagai, R; Shibasaki, F; Shiojima, I; Toko, H; Yazaki, Y; Zhu, W; Zou, Y | 1 |
| Bhattacharya, A; Chandok, MR; Deswal, R; Pandey, GK; Sopory, SK; Yadav, N | 1 |
| Lankisch, TO; Mitamura, K; Nozu, F; Owyang, C; Tsunoda, Y; Yoshida, H | 1 |
| Hishinuma, S; Ogura, K | 1 |
| Ikewaki, N; Inoko, H; Inoue, H; Mori, N; Tamauchi, H; Yamada, A; Yamao, H | 1 |
| Higo, A; Katsura, M; Mohri, Y; Ohkuma, S; Shuto, K; Takesue, M; Tarumi, C; Tsujimura, A | 1 |
| Miyata, Y; Nagano, M; Sato, S; Ui-Tei, K | 1 |
| Courjaret, R; Lapied, B | 1 |
| Basavappa, S; Chang, CB; Huang, CC; Lim, PH; Liu, JY | 1 |
| Arbogast, LA | 1 |
| Cui, WR; Li, A; Lin, JS; Wang, JL; Wu, BW; Wu, Y; Yuan, SY | 1 |
| Fukushi, H; Morishima, Y; Shirasaki, Y; Takano, H | 1 |
| Hackman, JC; Holohean, AM | 1 |
| Bliss, SP; Clay, CM; Farmerie, TA; Navratil, AM; Roberson, MS; Wolfe, MW; Xie, J | 1 |
| Imai, H; Kitahara, J; Nakagawa, Y; Sakamoto, H; Tosaki, T | 1 |
| Kudo, T; Murakami, I; Sutou, S; Takahashi, S; Takeuchi, S | 1 |
| Bai, HB; Cui, YR; Fang, X; Guan, CX; Khunkhun, R; Zhang, M | 1 |
| Tano, JY; Vazquez, G | 1 |
| Balezina, OP; Bogatcheva, PO | 1 |
| Cao, Y; Liu, R; Qu, L; Wang, P; Wang, W; Wang, X; Wang, Y; Yu, J; Yue, W; Zhang, Q | 1 |
4 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and w 7
| Article | Year |
|---|---|
Molecular pharmacology of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Enzyme Activation; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides | 1990 |
[Molecular pharmacology on intracellular calcium messenger system].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actomyosin; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Calmodulin-Binding Proteins; Extracellular Space; Humans; Isoquinolines; Muscle Contraction; Phosphotransferases; Piperazines; Sulfonamides | 1986 |
Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein kinase II (CaM kinase II) inhibitor, KN-62, and proposal of CaM kinase phosphorylation cascades.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cardiovascular System; Dihydroxyphenylalanine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Islets of Langerhans; Molecular Sequence Data; Molecular Structure; Muscle, Smooth; Myosin Light Chains; Neurons; Pancreas; Phosphorylation; Protein Kinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Tyrosine 3-Monooxygenase | 1996 |
[Inhibitor of calmodulin and calmodulin dependent enzyme].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Myosin-Light-Chain Kinase; Naphthalenes; Naphthalenesulfonates; Phenothiazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Sulfonamides; Vinca Alkaloids | 1998 |
142 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and w 7
| Article | Year |
|---|---|
Effects of calmodulin inhibitors on amylase secretion from rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Calcium; Calmodulin; Isoquinolines; Male; Pancreas; Piperazines; Protein Kinase Inhibitors; Rats; Second Messenger Systems; Sulfonamides | 1992 |
Effects of protein kinase inhibitors on pig oocyte maturation in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Isoquinolines; Oocytes; Phosphorylation; Piperazines; Protein Biosynthesis; Protein Kinase C; Protein Kinase Inhibitors; Sulfonamides; Swine | 1992 |
Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay (RBA).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Calmodulin-Binding Proteins; Chromatography, Affinity; Cytosol; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Substrate Specificity; Sulfonamides | 1992 |
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Cytoskeleton; Ethers, Cyclic; Indole Alkaloids; Indoles; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Raffinose; Rats; Rats, Inbred Strains; Sulfonamides; Tritium | 1992 |
Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Corpus Striatum; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, fos; Genes, jun; Genes, Regulator; Glutamates; Glutamic Acid; Glycine; Immediate-Early Proteins; Isoquinolines; Neurons; Piperazines; Protein Kinase Inhibitors; Proto-Oncogenes; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Sulfonamides; Transcription Factors | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzimidazoles; Calmodulin; Coronary Disease; Heart; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Naphthalenes; Piperazines; Polycyclic Compounds; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Trifluoperazine | 1992 |
Intracellular signal transduction for interleukin-1 beta-induced endothelin production in human umbilical vein endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Endothelins; Endothelium, Vascular; Genistein; Humans; Indomethacin; Interleukin-1; Isoflavones; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; Signal Transduction; Sulfonamides; Umbilical Veins | 1992 |
Influence of specific calmodulin and protein kinase C inhibitors on the interleukin 1 induced collagenase production in human uterine cervical fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cells, Cultured; Cervix Uteri; Collagenases; Culture Media, Conditioned; Enzyme Induction; Female; Fibroblasts; Humans; Interleukin-1; Isoquinolines; Macrophages; Piperazines; Protein Kinase C; Rabbits; Rats; Recombinant Proteins; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Blotting, Northern; Calcimycin; Calmodulin; Cell Line; Egtazic Acid; Genes, MHC Class I; Genes, myc; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Neoplasm; Signal Transduction; Sulfonamides; Tumor Necrosis Factor-alpha; Verapamil | 1992 |
Effects of activators and inhibitors of protein kinase C on X-ray induced malignant transformation in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipain; Calcimycin; Cell Transformation, Neoplastic; Diglycerides; Enzyme Activation; Isoquinolines; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Piperazines; Protein Kinase C; Sulfonamides; Trifluoperazine; Trypsin Inhibitor, Bowman-Birk Soybean | 1992 |
Effects of protein kinase inhibitors on the mitogenic activity of human hepatocyte growth factor on rat hepatocytes in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cells, Cultured; Genistein; Growth Substances; Hepatocyte Growth Factor; Isoflavones; Isoquinolines; Liver; Male; Mitogens; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides | 1992 |
Signal transduction pathways in the induction of HLA class I antigen expression on Huh 6 cells by interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Carcinoma, Hepatocellular; Cell Line; Cyclic CMP; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Liver Neoplasms; Piperazines; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Evidence that Ca2+/calmodulin-dependent protein phosphorylation is involved in the opening process of potassium channels in identified snail neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Ion Channel Gating; Isoquinolines; Neurons; Phosphorylation; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Snails; Sulfonamides; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calmodulin; Cells, Cultured; Gene Expression; Heart; Hydrolysis; Isoquinolines; Myocardium; Nifedipine; Phenylephrine; Phosphatidylinositols; Piperazines; Protein Kinase C; Rats; Sulfonamides | 1991 |
Protein kinase C-dependent diacylglycerol formation is mediated via Ca2+/calmodulin in parotid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Calmodulin; Carbachol; Diglycerides; Isoquinolines; Lanthanum; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Verapamil | 1991 |
Effects of inhibitors of intracellular messenger systems on amylase release from rat parotid gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Azepines; Calmodulin; Exocytosis; Isoquinolines; Male; Myosin-Light-Chain Kinase; Parotid Gland; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Second Messenger Systems; Sulfonamides | 1990 |
Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anal Canal; Animals; Antibodies, Monoclonal; Bombesin; Cell Membrane Permeability; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phosphates; Phosphorus Radioisotopes; Piperazines; Protein Kinase C; Rabbits; Substance P; Sulfonamides | 1991 |
Greater importance of Ca(2+)-calmodulin in maintenance of ang II- and K(+)-mediated aldosterone secretion: lesser role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium; Calmodulin; Cattle; Diglycerides; Dose-Response Relationship, Drug; Egtazic Acid; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitrendipine; Piperazines; Potassium; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1992 |
Calcium ion regulates the release of lipase of Fusarium oxysporum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calmodulin; Fusarium; Isoquinolines; Kinetics; Lipase; Piperazines; Protein Kinase Inhibitors; Subcellular Fractions; Sulfonamides | 1991 |
Translocation of CD45RA in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Cell Membrane; Flow Cytometry; Gene Expression Regulation; Histocompatibility Antigens; Humans; Isoantigens; Isoquinolines; Leukocyte Common Antigens; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation | 1991 |
IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Calcimycin; Calmodulin; Gene Expression Regulation; Histocompatibility Antigens Class II; Interferon-gamma; Ionomycin; Isoquinolines; Macrophages; Major Histocompatibility Complex; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Trifluoperazine; Tumor Necrosis Factor-alpha | 1991 |
Transduction of the modulatory effect of catecholamines at the mammalian motor neuron terminal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Catecholamines; Epinephrine; Female; GTP-Binding Proteins; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred ICR; Motor Endplate; Motor Neurons; Nerve Endings; Norepinephrine; Phenylephrine; Piperazines; Protein Kinase Inhibitors; Receptors, Adrenergic, alpha; Signal Transduction; Sulfonamides | 1991 |
Tumor necrosis factor-induced protein phosphorylation in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; In Vitro Techniques; Isoelectric Point; Isoquinolines; Molecular Weight; Neutrophils; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; Sulfonamides; Tumor Necrosis Factor-alpha | 1991 |
Activation of the protein kinase C-mediated contractile system in canine basilar artery undergoing chronic vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Chronic Disease; Dinoprost; Dogs; Enzyme Activation; In Vitro Techniques; Ischemic Attack, Transient; Isoquinolines; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Serotonin; Subarachnoid Hemorrhage; Sulfonamides | 1991 |
Cell-to-cell communication: a differential response to TGF-beta in normal and transformed (BEAS-2B) human bronchial epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bronchi; Bronchial Neoplasms; Calmodulin; Cell Communication; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Down-Regulation; Epidermal Growth Factor; Epithelium; Humans; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Sulfonamides; Time Factors; Transforming Growth Factor beta | 1991 |
Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Egtazic Acid; Exocytosis; Interphase; Isoquinolines; Oocytes; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Xenopus laevis | 1990 |
[Calmodulin dependent regulation of smooth muscle contraction].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Calmodulin; Isoquinolines; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Piperazines; Sulfonamides; Thyroxine | 1990 |
Protein kinase C-regulated production of prostacyclin by rat endothelium is increased in the presence of lipoxin A4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cells, Cultured; Endothelium; Epoprostenol; Homeostasis; Hydroxyeicosatetraenoic Acids; Isoquinolines; Kinetics; Lipoxins; Myocardium; Piperazines; Protein Kinase C; Rats; Sulfonamides | 1990 |
Praziquantel-induced secretion of proteolytic enzyme from Schistosoma mansoni cercariae.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Induction; Isoquinolines; Peptide Hydrolases; Piperazines; Praziquantel; Schistosoma mansoni; Sulfonamides; Verapamil | 1990 |
Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cell Line; Cytotoxicity, Immunologic; Egtazic Acid; Gallic Acid; Immunity, Cellular; Isoquinolines; Killer Cells, Natural; Mice; Piperazines; Protein Kinase C; Sulfonamides; Verapamil | 1990 |
Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Humans; In Vitro Techniques; Interferon-gamma; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinases; Receptors, Immunologic; Receptors, Interferon; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Agonist-induced activation of Na+/H+ exchange in rat parotid acinar cells is dependent on calcium but not on protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Carbachol; Carrier Proteins; Diglycerides; Epinephrine; Isoquinolines; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium-Hydrogen Exchangers; Sulfonamides; Trifluoperazine | 1990 |
Differential regulation of soluble interleukin 1 release and membrane expression by pharmacologic agents.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies; Calcimycin; Calmodulin; Cell Membrane; Diglycerides; Dinoprostone; In Vitro Techniques; Interleukin-1; Isoquinolines; L-Lactate Dehydrogenase; Leukotriene B4; Macrophages; Mice; Mice, Inbred C3H; Nucleotides, Cyclic; Piperazines; Protein Kinase C; Solubility; Sulfonamides; Thymus Gland | 1990 |
The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Bone Marrow Cells; Bucladesine; Calcium Channel Blockers; Calmodulin; Cell Line; Colforsin; Colony-Forming Units Assay; Colony-Stimulating Factors; Cyclic AMP; Fibroblasts; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Interleukin-1; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha | 1990 |
cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Endothelium, Vascular; Gene Expression; In Vitro Techniques; Inflammation; Interleukin-1; Isoquinolines; Lymphocytes; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides | 1990 |
Effects of intraperitoneally administered dietary fibers on superoxide generation from peritoneal exudate macrophages in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Dietary Fiber; Isoquinolines; Luminescent Measurements; Macrophages; Male; Mice; Mice, Inbred C3H; Oxygen; Peritoneum; Phagocytosis; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Phorbol 12-myristate 13-acetate, A23187 and L-adrenaline inhibit phospholipid methylation in human monocytes and lymphocytes. Inhibition is independent of oxyradical production and phospholipid hydrolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Epinephrine; Free Radicals; Humans; Hydrolysis; Isoquinolines; Lymphocytes; Methylation; Monocytes; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Piperazines; Protein Kinase Inhibitors; S-Adenosylmethionine; Sodium Fluoride; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Modulation of vincristine sensitivity of human kidney tumor cells by pharmacological agents interfering with intracellular signals. No apparent relationship to changes in cytoplasmic Ca2+ or pH.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Calcium; Colforsin; Cytoplasm; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Sensitivity and Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 1990 |
Contribution of calmodulin and protein kinase C to renin release in spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Hypertension; In Vitro Techniques; Isoquinolines; Kidney Glomerulus; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Sulfonamides | 1990 |
Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Calmodulin; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Heart Rate; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfonamides; Vasodilator Agents | 1990 |
Calcium-dependent protein kinase activity is decreased in diabetic rat sciatic nerve.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Chromatography, Gel; Diabetes Mellitus, Experimental; Diglycerides; Enzyme Activation; Isoquinolines; Male; Phosphatidylserines; Phospholipids; Piperazines; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Sciatic Nerve; Sulfonamides; Trifluoperazine | 1990 |
Characterization of specific binding sites for [3H]-staurosporine on various protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Carbazoles; Indole Alkaloids; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Sulfonamides | 1990 |
Trypsin stimulation of aldosterone and 18-hydroxycorticosterone production by rat adrenal zona glomerulosa tissue is mediated by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 18-Hydroxycorticosterone; Aldosterone; Animals; Corticosterone; Enzyme Activation; Female; Gallic Acid; Humans; Isoelectric Focusing; Isoquinolines; Male; Piperazines; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Trypsin; Type C Phospholipases; Zona Glomerulosa | 1990 |
Specific inhibition of phorbol ester and DiC8-induced histamine release from human basophils by the protein kinase C inhibitors, H-7 and H-9.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Basophils; Calcimycin; Calmodulin; Diglycerides; Glycerides; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Isoquinolines; Kinetics; Perphenazine; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
Pharmacological control of human basophil histamine release stimulated by eosinophil granule major basic protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Basophils; Blood Proteins; Calcium; Eosinophil Granule Proteins; Eosinophils; Histamine Release; Humans; Isoquinolines; Pertussis Toxin; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Ribonucleases; Sulfonamides; Theophylline; Virulence Factors, Bordetella | 1989 |
Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. Regulation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Humans; Immunoglobulin M; Isoquinolines; Lymphocyte Activation; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Antigen, B-Cell; Sulfonamides; Tetradecanoylphorbol Acetate; Trypsin | 1989 |
Regulation of Fc gamma 2a receptor-mediated phagocytosis by a murine macrophage-like cell line, P388D1: involvement of casein kinase II activity associated with Fc gamma 2a receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigen-Antibody Complex; Antigens, Differentiation; Casein Kinases; Cell Line; Cytoplasmic Granules; Cytoskeletal Proteins; Down-Regulation; Heparin; Immunoglobulin G; Isoquinolines; Macrophages; Mast Cells; Mice; Phagocytosis; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Fc; Receptors, IgG; Sulfonamides | 1989 |
Calmodulin antagonist W-7 inhibits lysosomal sphingomyelinase activity in C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Desipramine; Glioma; Isoquinolines; Lysosomes; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Sphingomyelin Phosphodiesterase; Sulfonamides; Tumor Cells, Cultured | 1989 |
Na+-H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Carbazoles; Carrier Proteins; Female; Fertilization; Indole Alkaloids; Isoquinolines; Kinetics; Ovum; Piperazines; Protein Kinase C; Sea Urchins; Sodium-Hydrogen Exchangers; Sulfonamides; Tetradecanoylphorbol Acetate | 1989 |
Induction of DNA synthesis by cholera toxin in the temperature-sensitive cell-cycle mutants of rat 3Y1 fibroblasts at a restrictive temperature.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cell Cycle; Cholera Toxin; Colforsin; Cyclic AMP; DNA; Fibroblasts; Isoquinolines; Membrane Proteins; Mutation; Pertussis Toxin; Piperazines; Rats; Sulfonamides; Temperature; Verapamil; Virulence Factors, Bordetella | 1989 |
Drug-drug interaction between cyclosporine and agents affecting calcium-dependent lymphocyte proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Cells, Cultured; Cyclosporins; Drug Interactions; Humans; Imidazoles; Isoquinolines; Lymphocyte Activation; Piperazines; Protein Kinase C; Sulfonamides; Trifluoperazine; Verapamil | 1989 |
Effect of protein kinase C inhibitor (H-7) and calmodulin antagonist (W-7) on pertussis toxin-induced IL-1 production by human adherent monocytes. Comparison with lipopolysaccharide as a stimulator of IL-1 production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calmodulin; Cells, Cultured; Chelating Agents; Fluorescent Dyes; Interleukin-1; Isoquinolines; Lipopolysaccharides; Male; Mice; Mice, Inbred C3H; Monocytes; Pertussis Toxin; Piperazines; Protein Kinase C; Sulfonamides; Virulence Factors, Bordetella | 1989 |
TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Antigens, Viral; Burkitt Lymphoma; Calmodulin; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1987 |
A calmodulin antagonist (W-7) and a protein kinase C inhibitor (H-7) have no effect on atrial natriuretic peptide release induced by atrial stretch.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine Vasopressin; Atrial Function; Atrial Natriuretic Factor; Bucladesine; Calmodulin; Dibutyryl Cyclic GMP; Heart; Heart Atria; Isoquinolines; Male; Phenylephrine; Physical Stimulation; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides | 1988 |
Inhibition of macrophage activation by isoquinolinesulfonamides, phenothiazines, and a napthalenesulfonamide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Fluphenazine; Guinea Pigs; Isoquinolines; Macrophage Activation; Macrophages; Male; Naphthalenes; Phenothiazines; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Pulmonary Alveoli; Sulfonamides; Superoxides; Trifluoperazine | 1988 |
The protein kinase C inhibitors H-7 and H-9 fail to inhibit human neutrophil activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; Isoquinolines; Lysosomes; Muramidase; Neutrophils; Oxygen Consumption; Peroxidase; Piperazines; Protein Kinase C; Secretory Rate; Sulfonamides; Superoxides | 1986 |
Comparison of the roles of calmodulin and protein kinase C in activation of the human neutrophil respiratory burst.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate; Trifluoperazine | 1987 |
Effects of the protein kinase C inhibitor H-7 and calmodulin antagonist W-7 on superoxide production in growing and resting human histiocytic leukemia cells (U937).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Cell Division; Cell Line; Humans; Isoquinolines; Kinetics; Leukemia, Myeloid; Piperazines; Protein Kinase C; Sulfonamides; Superoxides | 1987 |
Regulation of HLA class II antigen expression: intracellular signaling molecules responsible for the regulation by IFN-gamma and cross-linking of Fc receptors in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Calcimycin; Calcium; Calmodulin; Cell Line; Cyclic AMP; Gene Expression Regulation; Histocompatibility Antigens Class II; Humans; Immunoglobulin G; Interferon-gamma; Isoquinolines; Leukemia, Myeloid, Acute; Male; Middle Aged; Piperazines; Protein Kinase C; Receptors, Fc; Recombinant Proteins; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
Inhibitors of IL-2 production and IL-2 receptor expression in human leukemic T-cell line, Jurkat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cyclosporins; Dose-Response Relationship, Drug; Humans; Interleukin-2; Isoquinolines; Leukemia, Lymphoid; Piperazines; Receptors, Immunologic; Receptors, Interleukin-2; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Synergistic effect of retinoic acid and calcium ionophore A23187 on differentiation, c-myc expression, and membrane tyrosine kinase activity in human promyelocytic leukemia cell line HL-60.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Cell Differentiation; Cell Line; Cell Membrane; Drug Synergism; Gene Expression Regulation; Hematopoiesis; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Piperazines; Protein-Tyrosine Kinases; Proto-Oncogenes; RNA, Messenger; Sulfonamides; Tretinoin; Trifluoperazine | 1987 |
Effects of teleocidin on the morphology and c-myc expression of hepatoma cells which are not inhibited by protein kinase antagonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butyrates; Cell Division; Diglycerides; Isoquinolines; Liver; Liver Neoplasms, Experimental; Lyngbya Toxins; Novobiocin; Piperazines; Protein Kinase Inhibitors; Proto-Oncogenes; Rats; Sulfonamides; Transcription, Genetic | 1987 |
Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Enzyme Activation; Gallic Acid; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2 | 1988 |
Protein kinase C-dependent and calmodulin-dependent regulation of neurotransmitter release and vascular responsiveness in spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Blood Vessels; Calmodulin; Electric Stimulation; Hypertension; Isoquinolines; Male; Mesentery; Norepinephrine; Piperazines; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Sulfonamides | 1988 |
Differential inhibition of IL-1 and TNF-alpha mRNA expression by agents which block second messenger pathways in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Interleukin-1; Isoquinolines; Macrophages; Male; Mice; Mice, Inbred C57BL; Piperazines; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Second Messenger Systems; Sulfonamides; Tumor Necrosis Factor-alpha | 1988 |
Protein kinase C activity, protein phosphorylation and germinal vesicle breakdown in Spisula oocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bivalvia; Fertilization; Isoquinolines; Oocytes; Phorbol Esters; Phosphoproteins; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Vitamin A | 1987 |
Involvement of protein kinase C in the phosphorylation of 46 kDa proteins which are phosphorylated in parallel with activation of NADPH oxidase in intact guinea-pig polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Calcium; Cell-Free System; Chlorpromazine; Enzyme Activation; Female; Guinea Pigs; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidylserines; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
Renal transepithelial phosphate secretion: luminal membrane voltage and Ca2+ dependence.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Charybdotoxin; Electrophysiology; Epithelium; Flounder; In Vitro Techniques; Isoquinolines; Kidney; Kinetics; Mannitol; Membrane Potentials; Models, Biological; Phorbol Esters; Phosphates; Phosphorus Radioisotopes; Piperazines; Potassium Chloride; Protein Kinase C; Scorpion Venoms; Sulfonamides; Terpenes; Thapsigargin; Time Factors; Verapamil | 1994 |
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzimidazoles; Calcium Channel Blockers; Calmodulin; Cell Adhesion Molecules; Cells, Cultured; Diltiazem; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Mibefradil; Piperazines; Protein Kinase C; Sulfonamides; Tetrahydronaphthalenes; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Verapamil | 1994 |
Dual regulation of cGMP formation by calcium in pancreatic acinar cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Oxidoreductases; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Cyclic GMP; Cytosol; Guanylate Cyclase; Guinea Pigs; Homeostasis; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitric Oxide Synthase; Pancreas; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides; Trifluoperazine | 1995 |
Recepto-secretory mechanism in histamine-stimulated amylase release from rat parotid gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Azepines; Calmodulin; Cimetidine; Culture Techniques; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Isoquinolines; Male; Myosin-Light-Chain Kinase; Parotid Gland; Piperazines; Protein Kinase C; Pyrilamine; Rats; Rats, Wistar; Sulfonamides | 1995 |
Activation of Na+/H+ exchanger by hepatocyte growth factor in hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Cells, Cultured; Genistein; Hepatocyte Growth Factor; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides | 1995 |
Circadian responses to light: the calmodulin connection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Circadian Rhythm; Cricetinae; Cyclic AMP Response Element-Binding Protein; Immunohistochemistry; Isoquinolines; Light; Male; Mesocricetus; Phosphorylation; Piperazines; Sulfonamides; Suprachiasmatic Nucleus | 1995 |
Inhibition of angiotensin II- and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca(2+)-calmodulin dependent protein kinase II in aldosterone secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Isoquinolines; Kinetics; Piperazines; Potassium; Sulfonamides; Zona Glomerulosa | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Calcium; Cells, Cultured; Complement C2; Complement Factor B; Enzyme Activation; Fibroblasts; Genistein; Glioblastoma; Humans; Interferon gamma Receptor; Interferon-gamma; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Monocytes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Receptors, Interferon; Rifabutin; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Up-Regulation | 1995 |
Signal transduction in SF9 insect cells: endocytosis of recombinant CD4 after phorbol ester treatment.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; Calmodulin; CD4 Antigens; Cell Line; Cell Membrane; Endocytosis; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Spodoptera; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1995 |
Retinoic acid-stimulated intercellular adhesion molecule-1 expression on SK-N-SH cells: calcium/calmodulin-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Adhesion Molecules; Enzyme Activation; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Sulfonamides; Terpenes; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1994 |
Characterization of signaling pathways to Na+/H+ exchanger activation with epidermal growth factor in hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Epidermal Growth Factor; Genistein; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Imidodiphosphate; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Egtazic Acid; Electric Conductivity; Electric Stimulation; Heart; Isoenzymes; Isoproterenol; Isoquinolines; Kinetics; Membrane Potentials; Myocardium; Norepinephrine; Piperazines; Protein Kinase Inhibitors; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Thioridazine; Time Factors | 1994 |
Synergy between phorbol esters and retinoic acid in inducing protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Chlorpromazine; Cytosol; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Isoquinolines; Kinetics; Phosphorylation; Piperazines; Protein Binding; Protein Kinase C; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Tretinoin; Trifluoperazine; Tritium | 1994 |
[Inhibitory effects of protein kinase C inhibitor and calmodulin antagonist on tumor necrosis factor production by mouse macrophages].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calmodulin; Female; Isoquinolines; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Piperazines; Protein Kinase C; Sulfonamides; Tumor Necrosis Factor-alpha | 1993 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Ca2+/calmodulin-dependent regulation of the density of Na+ channels in embryonic chick skeletal muscle cells during their development in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Chick Embryo; Electrophysiology; Isoquinolines; Muscles; Piperazines; Sodium Channels; Sulfonamides | 1994 |
Production of a unique antibody specific for membrane ruffles and its use to characterize the behavior of two distinct types of ruffles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Antigens, Surface; Calmodulin; Cell Membrane; Chick Embryo; Culture Media, Serum-Free; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoquinolines; Kinetics; Membrane Proteins; Molecular Weight; Nocodazole; Paclitaxel; Piperazines; Protein Kinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
The effect of 3 calmodulin antagonists on K(+)-stimulated neurotransmitter release from rat cortical slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Potassium; Rats; Serotonin; Sulfonamides; Trifluoperazine | 1993 |
Neuropeptide Y enhances LHRH binding to rat gonadotrophs in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cells, Cultured; Colforsin; Cyclic AMP; Gonadotropin-Releasing Hormone; GTP-Binding Proteins; Isoquinolines; Male; Neuropeptide Y; Pertussis Toxin; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Characterization of univectorial polyamine transport in duodenal crypt cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Azepines; Biological Transport; Calmodulin; Cell Line; Duodenum; Epithelium; Humans; Imidazoles; Isoquinolines; Kinetics; Naphthalenes; Piperazines; Protein Kinase Inhibitors; Putrescine; Spermidine; Sulfonamides | 1993 |
HLA class II molecule-mediated signal transduction mechanism responsible for the expression of interleukin-1 beta and tumor necrosis factor-alpha genes induced by a staphylococcal superantigen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Enterotoxins; Gene Expression Regulation; Histocompatibility Antigens Class II; Humans; Interleukin-1; Isoquinolines; Molecular Sequence Data; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Staphylococcus aureus; Sulfonamides; Superantigens; Tumor Necrosis Factor-alpha | 1993 |
A mechanism of vitamin E-enhanced active oxygen formation in concanavalin A-stimulated alveolar macrophage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Concanavalin A; Diglycerides; Enzyme Activation; Hypoxanthine; Hypoxanthines; Isoquinolines; Macrophages, Alveolar; Male; Oxygen; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Superoxides; Vitamin E; Xanthine Oxidase | 1993 |
Interaction between signal transduction pathways contributing to gallbladder tonic contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cats; Diglycerides; Female; Gallbladder; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Isoquinolines; Male; Models, Biological; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Phosphorylation; Piperazines; Protein Kinase C; Signal Transduction; Strontium; Sulfonamides; Tetrodotoxin | 1993 |
Mechanisms of aluminum fluoride- and insulin-stimulated p33 mRNA accumulation in rat hepatoma cells: involvement of a G protein and kinase action and demonstration of effects on mRNA turnover.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Aluminum Compounds; Animals; Cyclic AMP; Diglycerides; Fluorides; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Half-Life; Insulin; Isoquinolines; Kinetics; Liver Neoplasms, Experimental; Pertussis Toxin; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proteins; Rats; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Sulfonamides; Virulence Factors, Bordetella | 1993 |
Inhibitors of Ca2+ channels, calmodulin and protein kinases prevent A23187 and other inductions of metallothionein mRNA in EC3 rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Gallic Acid; Isoquinolines; Liver Neoplasms, Experimental; Metallothionein; Norepinephrine; Piperazines; Protein Kinase Inhibitors; Rats; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1993 |
Paraquat uptake in the cultured gastrointestinal epithelial cell line, IEC-6.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Calmodulin; Cell Count; Cell Line; Intestinal Mucosa; Isoquinolines; Paraquat; Piperazines; Putrescine; Rats; Spermidine; Sulfonamides | 1993 |
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Division; DNA, Neoplasm; Ethers, Cyclic; Humans; Isoquinolines; Okadaic Acid; Piperazines; Protein Kinase C; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Division; Cells, Cultured; Chymotrypsin; Dactinomycin; Fibronectins; Humans; Isoquinolines; Kinetics; L Cells; Lipopolysaccharides; Mice; Monocytes; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 1993 |
Intracellular pathways involved in tumor necrosis factor-alpha release by human monocytes on stimulation with lipopolysaccharide or staphylococcal peptidoglycan are partly similar.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Antimalarials; Cell Communication; Chloroquine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; GTP-Binding Proteins; Humans; Isoquinolines; Lipopolysaccharides; Monocytes; Pentoxifylline; Peptidoglycan; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Staphylococcus epidermidis; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1996 |
Inhibition of agonist-mediated calcium entry by calmodulin antagonists and by the Ca2+/calmodulin kinase II inhibitor KN-62. Studies with thyroid FRTL-5 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Barium; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Calmodulin; Cell Line; Depression, Chemical; Fluphenazine; Imidazoles; Isoquinolines; Membrane Potentials; Phenoxybenzamine; Piperazines; Rats; Sulfonamides; Terpenes; Thapsigargin; Thyroid Gland | 1996 |
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides | 1996 |
Effect of ginsenoside Rb1 on rat liver phosphoproteins induced by carbon tetrachloride.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Tetrachloride; Ginsenosides; Glycogen; Liver; Male; Microsomes, Liver; Molecular Weight; Panax; Phosphoproteins; Phosphorylation; Plants, Medicinal; Protein Kinase C; Rats; Rats, Wistar; Saponins; Sulfonamides | 1996 |
Differential induction of IL-1 beta and IL-6 production by the nontoxic lipid A from Porphyromonas gingivalis in comparison with synthetic Escherichia coli lipid A in human peripheral blood mononuclear cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Escherichia coli; Flow Cytometry; Humans; Interleukin-1; Interleukin-6; Lactams, Macrocyclic; Leukocytes, Mononuclear; Lipid A; Lipopolysaccharide Receptors; Molecular Structure; Porphyromonas gingivalis; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; Sulfonamides; Up-Regulation | 1996 |
Elicitors triggering the simultaneous gene expression of antibacterial proteins of the silkworm, Bombyx mori.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Infective Agents; Bombyx; Cell Adhesion; Enzyme Inhibitors; Gene Expression; Genes, Insect; Hemocytes; Insect Hormones; Insect Proteins; Isoquinolines; Larva; Lipid A; Lipopolysaccharides; Peptidoglycan; Protein Biosynthesis; Signal Transduction; Sugar Acids; Sulfonamides | 1996 |
Repetitive applications of ATP potentiate potassium current by Ca2+/calmodulin kinase in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Hippocampus; Indoles; Ion Channel Gating; Isoquinolines; Maleimides; Neurons; Patch-Clamp Techniques; Potassium; Protein Kinase C; Rats; Signal Transduction; Sulfonamides | 1996 |
Involvement of protein kinase C in muscarinic agonist-induced contractions of guinea pig ileal longitudinal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Diglycerides; Guinea Pigs; Ileum; In Vitro Techniques; Inositol Phosphates; Muscarinic Agonists; Muscle Contraction; Protein Kinase C; Sulfonamides | 1996 |
Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Calcium; Cell Line; Cyclic AMP; Dinoprostone; Hematopoietic Stem Cells; Humans; Iloprost; Ionomycin; Megakaryocytes; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Receptors, Prostaglandin; Receptors, Thrombin; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1996 |
The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Rectal; Animals; Cefoxitin; Cephamycins; Decanoic Acids; Intestinal Absorption; Male; Myosin-Light-Chain Kinase; Protein Kinase C; Rats; Rats, Wistar; Rectum; Sulfonamides; Suppositories | 1997 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Pressure stimulates proliferation and DNA synthesis in rat intestinal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Carbamates; Cell Division; Cell Line; DNA Replication; Enzyme Inhibitors; Interleukin-2; Intestinal Mucosa; Phenylcarbamates; Physical Stimulation; Pressure; Protein Kinase C; Rats; Signal Transduction; Sulfonamides; Type C Phospholipases | 1997 |
The induction of kin genes in cold-acclimating Arabidopsis thaliana. Evidence of a role for calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acclimatization; Amino Acid Sequence; Antifreeze Proteins; Arabidopsis; Calcium; Calcium Channel Blockers; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cold Temperature; Enzyme Inhibitors; Gadolinium; Gene Expression Regulation, Plant; Glycoproteins; Lanthanum; Molecular Sequence Data; Protein Kinases; RNA, Messenger; Ruthenium Red; Sequence Homology, Amino Acid; Sulfonamides | 1997 |
Protein phosphatase 2B-dependent pathway of insulin action on single Cl- channel conductance in renal epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcineurin; Calcineurin Inhibitors; Calmodulin; Cell Line; Chloride Channels; Cyclosporine; Cytosol; Electric Conductivity; Enzyme Inhibitors; Epithelial Cells; Insulin; Isoquinolines; Kidney; Phenols; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides | 1998 |
Increase of mucous glycoprotein secretion by tumor necrosis factor alpha via a protein kinase C-dependent mechanism in cultured chinchilla middle ear epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Cells, Cultured; Chinchilla; Dose-Response Relationship, Drug; Ear, Middle; Enzyme Inhibitors; Epithelium; Glycoproteins; Otitis Media with Effusion; Protein Kinase C; Sulfonamides; Tumor Necrosis Factor-alpha | 1998 |
Mycoplasma salivarium induces interleukin-6 and interleukin-8 in human gingival fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cattle; Cell Fractionation; Cell Line; Densitometry; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Genistein; Gingiva; Humans; Interleukin-6; Interleukin-8; Mice; Mycoplasma; Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1997 |
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes | 1998 |
Arachidonic acid activates NADPH oxidase by a direct, calmodulin-regulated mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; NADPH Oxidases; Neutrophils; Nitric Oxide Synthase; Onium Compounds; Spectrophotometry; Staurosporine; Sulfonamides; Superoxides; Vasodilator Agents | 1998 |
Distinct pH homeostatic features in lymphoblasts from Alzheimer's disease patients.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid-Base Equilibrium; Aged; Alzheimer Disease; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cytosol; DNA; Enzyme Inhibitors; Humans; Immunoglobulin M; Ion Exchange; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; Reference Values; Sulfonamides | 1998 |
Possible role of calmodulin in excystation of Giardia lamblia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Calmodulin; Child; Enzyme Activation; Feces; Giardia lamblia; Giardiasis; Humans; Protein Kinase C; Sulfonamides; Trifluoperazine | 1998 |
Arachidonic acid, but not its metabolites, is essential for FcgammaR-stimulated intracellular killing of Staphylococcus aureus by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Immunoglobulin G; Indomethacin; Lipoxygenase Inhibitors; Monocytes; Oxygen; Phagocytosis; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, IgG; Staphylococcus aureus; Sulfonamides | 1999 |
alpha1-adrenergic receptor activation of c-fos expression in transfected rat-1 fibroblasts: role of Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium; Calmodulin; Doxazosin; Egtazic Acid; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Genes, fos; Imidazoles; Kinetics; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Sulfonamides; Transcription, Genetic; Trifluoperazine | 1999 |
Regulation of glycine transport in cultured Müller cells by Ca2+/calmodulin-dependent enzymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Transport Systems, Neutral; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carrier Proteins; Cell Line; Chick Embryo; Enzyme Inhibitors; Glycine Plasma Membrane Transport Proteins; Imidazoles; Kinetics; Sulfonamides; Trifluoperazine | 1999 |
Prostaglandin F2 alpha upregulates intercellular adhesion molecule-1 expression in human gingival fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Protein Kinase C; Recombinant Proteins; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 1999 |
Regulation of GABAA receptor by protein tyrosine kinases in frog pituitary melanotrophs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Inhibitors; Evoked Potentials; gamma-Aminobutyric Acid; Genistein; Patch-Clamp Techniques; Phenols; Pituitary Gland; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rana ridibunda; Receptors, GABA-A; Sulfonamides; Vanadates | 2000 |
Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcimycin; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Gene Expression Regulation; Heart; Ionomycin; Kinetics; Models, Cardiovascular; Myocardium; Myosin Heavy Chains; Promoter Regions, Genetic; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 2000 |
A novel protein kinase from Brassica juncea stimulated by a protozoan calcium binding protein. Purification and partial characterization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brassica; Calcium; Calcium Signaling; Calcium-Binding Proteins; Calmodulin; Chelating Agents; Egtazic Acid; Entamoeba histolytica; Histones; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Peptides; Phosphorylation; Phosphoserine; Plant Proteins; Protein Kinases; Protein Processing, Post-Translational; Protozoan Proteins; Recombinant Fusion Proteins; Staurosporine; Sulfonamides | 2000 |
A possible role for Ca(2+)/calmodulin-dependent protein kinase IV during pancreatic acinar stimulus-secretion coupling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Immunoblotting; Indole Alkaloids; Male; Myosin-Light-Chain Kinase; Pancreas; Phosphotransferases; Rats; Rats, Sprague-Dawley; Sincalide; Sulfonamides | 2000 |
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclosporine; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Okadaic Acid; Piperidines; Pyrilamine; Ranitidine; Receptors, Histamine H1; Sulfonamides; Tacrolimus; Tumor Cells, Cultured | 2000 |
A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Antibodies, Monoclonal; Antibody Specificity; Calcium; Calmodulin; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Chelating Agents; Cycloheximide; Cytochalasin D; Edetic Acid; Endothelium, Vascular; Enzyme Inhibitors; Epitopes; Flow Cytometry; Genistein; HL-60 Cells; Humans; K562 Cells; Microtubules; Nocodazole; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins | 2000 |
Mechanism for increase in expression of cerebral diazepam binding inhibitor mRNA by nicotine: involvement of L-type voltage-dependent calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Local; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dibucaine; Enzyme Inhibitors; Gene Expression; Hexamethonium; Lidocaine; Membrane Potentials; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; omega-Agatoxin IVA; omega-Conotoxin GVIA; Platelet Aggregation Inhibitors; Procainamide; RNA, Messenger; Sulfonamides; Tetrodotoxin; Tritium | 2000 |
Calmodulin-dependent and -independent apoptosis in cell of a Drosophila neuronal cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcimycin; Calcium; Calmodulin; Caspases; Cell Line; Chelating Agents; Cycloheximide; Dactinomycin; DNA Fragmentation; Drosophila melanogaster; Egtazic Acid; Enzyme Inhibitors; Ionophores; Neurons; Protein Synthesis Inhibitors; Sulfonamides | 2000 |
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adenylyl Imidodiphosphate; Animals; Bungarotoxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Imidazoles; Insecta; Insecticides; Isoquinolines; Median Nerve; Neonicotinoids; Neurons; Niacin; Nitro Compounds; Okadaic Acid; Permeability; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Nicotinic; Signal Transduction; Sulfonamides | 2001 |
Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Size; Enzyme Inhibitors; Erythroid Precursor Cells; Humans; Hypotonic Solutions; K562 Cells; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Taurine; Trifluoperazine | 2001 |
Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cyclic Nucleotide-Regulated Protein Kinases; Dopamine; Enzyme Inhibitors; Female; Hypothalamus; Neurons; Prolactin; Rats; Rats, Sprague-Dawley; Sheep; Sulfonamides; Tyrosine 3-Monooxygenase | 2001 |
Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cell Division; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Liver Neoplasms; Sodium-Hydrogen Exchangers; Sulfonamides; Tumor Cells, Cultured | 2003 |
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Death; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Enzyme Inhibitors; Fetus; Kinetics; Membrane Potentials; Neurons; NG-Nitroarginine Methyl Ester; Nifedipine; Nitriles; Pyrethrins; Rats; Sulfonamides; Tacrolimus; Trifluoperazine; Veratridine | 2003 |
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Gallopamil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Indoles; Magnesium; Memantine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nifedipine; Protein Kinase C; Pyridines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Staurosporine; Sulfonamides; Tetrodotoxin | 2004 |
Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Gonadotropin-Releasing Hormone; JNK Mitogen-Activated Protein Kinases; Luciferases; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins c-raf; Signal Transduction; Sulfonamides | 2005 |
Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Antioxidants; Arachidonic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Endothelial Cells; Genistein; Glutathione; Humans; Hydrogen Peroxide; Maleates; Oxidants; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Umbilical Veins | 2007 |
Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Dexamethasone; Gene Deletion; Gene Expression Regulation; Glucocorticoids; Homeodomain Proteins; Nifedipine; Paired Box Transcription Factors; Pro-Opiomelanocortin; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; T-Box Domain Proteins; Transfection | 2007 |
Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bronchi; Cadherins; Calmodulin; Cell Line; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Immunochemistry; Isoquinolines; Ki-67 Antigen; Models, Biological; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Vasoactive Intestinal Peptide; Wound Healing | 2007 |
Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Humans; I-kappa B Proteins; Imidazoles; Macrophages; NF-kappaB-Inducing Kinase; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides | 2011 |
Multidirectional effects of calmodulin kinase II on transmitter release in mature and newly formed mouse motor synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Mice; Motor Endplate; Neurotransmitter Agents; Nitrendipine; Okadaic Acid; Phosphoric Monoester Hydrolases; Sulfonamides; Synapses; Synaptic Transmission | 2013 |
Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Female; Kinetics; Male; Membrane Potentials; Neurons; Nociceptin; Opioid Peptides; Parietal Lobe; Patch-Clamp Techniques; Potassium Channels; Rats, Wistar; Sulfonamides | 2014 |