Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and ucn 1028 c

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with ucn 1028 c in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	58 (81.69)	18.2507
2000's	12 (16.90)	29.6817
2010's	1 (1.41)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Felipo, V; Grisolía, S; Miñana, MD	2
Fukami, M; Maeda, Y; Minami, N; Tani, E; Yamaura, I	1
Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A	1
Brown, EJ; Zheleznyak, A	1
Del Vecchio, PJ; Goligorsky, MS; Malik, AB; Siflinger-Birnboim, A	1
Berridge, MV; Tan, AS	1
Chakrabarty, S	1
Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA	1
Denison, MS; Madhukar, BV; Schafer, MW; Swanson, HI; Tullis, K	1
Grant, S; Jarvis, WD; Povirk, LF; Traylor, RS; Turner, AJ	1
Chan, CF; Chang, YL; Jiang, MJ	1
Campenot, RB; Draker, DD; Senger, DL	1
Daniel, EE; Kwan, CY; Loke, JC; Low, AM	1
Allen, JM; Balbi, D	1
Blystone, SD; Brown, EJ; Graham, IL; Lindberg, FP	1
Huang, CK; Liang, L	1
Cabedo, H; Felipo, V; Grisolía, S; Miñana, MD	1
Findik, D; Hidaka, H; Lavin, M; Song, Q	1
Borosky, SA; Boxer, PA; Coughenour, LL; Hajimohammadreza, I; Marcoux, FW; Probert, AW; Wang, KK	1
Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A	1
Brooks, BJ; Elliott, MS; Eriotou, P; Hart, KL; Kelly, DF; Morris, RC; Sagar, S	1
Akard, L; Cui, Y; English, D; Garcia, JG; Harvey, K; Jansen, J; Martin, MI; Siddiqui, RA; Thompson, J; Wentland, J	1
Ciudad, CJ; Noé, V	1
Kopp, UC; Smith, LA	1
Ibuki, Y; Imagawa, T; Suketa, Y	1
Abayasekara, RE; Flint, AP; Searle, MJ	1
Felipo, V; Grisolía, S; Hermenegildo, C; Miñana, MD; Romero, FJ	1
Bischer, P; Cantu, AR; Pavone, A; Reiners, JJ; Schöller, A	1
Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y	1
Niedbala, MJ; Stein-Picarella, M	1
Kim, D	1
Bertrand, R; Jenkins, J; Pommier, Y; Solary, E	1
Audesirk, G; Cabell, L	1
Dussault, JH; Etongue-Mayer, P; Puymirat, J	1
Amino, K; Fujimoto, T; Honda, Y; Takahashi, M	1
Bosche, MC; Levine, RA; Nandi, J; Rotker, JD; Strapko, A	1
Duty, L; Gorelik, E; Kim, M; Prezioso, JA; Tweardy, DJ; Wang, J	1
Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R	1
Hirose, K; Isogai, E; Miura, H; Mizugai, H; Ueda, I	1
Breshnahan, BA; Kelefiotis, D; Lianos, EA; Stratidakis, I	1
Fuhrer, DK; Hamilton, J; Steussy, CN; Yang, L; Yang, YC	1
Chakravarthy, BR; Mealing, GA; Morley, P; Tsang, BK; Whitfield, JF	1
Gerritsen, ME; Moatter, T	1
Fujimoto, S; Satake, N; Shibata, S	1
Matsui, K; Miyamoto, H	1
Doherty, K; Paul, A; Plevin, R	1
Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H	1
Keiser, HR; Oriji, GK	1
Ito, H; Spurzem, JR; Veys, TJ; Wyatt, TA	1
Biwa, T; Hakamata, H; Horiuchi, S; Kobori, S; Matsuda, H; Matsumura, T; Sakai, M; Shichiri, M; Takemura, T	1
Hano, T; Kimura, K; Nishio, I; Sasajima, H; Shima, H; Toyoda, Y; Yoshikawa, A	1
Hayasaka, M; Horiuchi, K; Satoh, M; Takayanagi, I	1
Reinach, PS; Torres-zamorano, V; Wu, X; Yang, H	1
Kamitori, K; Kohsaka, S; Machide, M; Nakamura, Y	1
Barnum, SR; Carlino, JA; Drouin, SM; Kiley, SC	1
Hernández, ML; Martínez, MJ; Ochoa, B	1
Floreani, AA; Heires, AJ; Sanderson, SD; Wyatt, TA	1
Hojo, Y; Ikeda, U; Morishita, R; Okada, M; Shimada, K; Takahashi, M; Takizawa, T	1
Boland, R; Buitrago, C; de Boland, AR; Morelli, S	1
Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C	1
Choi, MR; Suh, HW; Won, JS	1
Hirata, I; Katsu, K; Kayazawa, M; Kojima, K; Matsuse, R; Nakagawa, K; Saitoh, O; Sugi, K; Tabata, K; Tanaka, S; Teranishi, T; Uchida, K	1
Spaan, JA; van der Meulen, ET; VanBavel, E; Wesselman, JP	1
Kravtsov, GM; Pang, SF; Poon, AM	1
Huang, SH; Shen, WJ; Wang, SM; Yeo, HL	1
Burnstock, G; Smith, NC	1
Frerking, M; Partovi, D	1
Nishikawa, T; Omura, M; Suematsu, S	1
Anderson, JM; Macewan, SR; McNally, AK	1
Heaps, CL; Parker, JL; Robles, JC; Sturek, M	1

Other Studies

71 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and ucn 1028 c

Article	Year
Differential effects of the protein kinase C inhibitors H7 and calphostin C on the cell cycle of neuroblastoma cells. Brain research, 1992, Nov-20, Volume: 596, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Cycle; Cell Membrane Permeability; Cell Survival; DNA; Isoquinolines; Light; Naphthalenes; Neuroblastoma; Piperazines; Polycyclic Compounds; Protein Kinase C; Sulfonamides; Tumor Cells, Cultured	1992
Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm. Journal of neurosurgery, 1992, Volume: 76, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calpain; Dipeptides; Dogs; Ischemic Attack, Transient; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Vasoconstriction	1992
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C. The Journal of cell biology, 1992, Volume: 116, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate	1992
Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes. The Journal of biological chemistry, 1992, Jun-15, Volume: 267, Issue:17 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Amino Acid Sequence; Biological Transport; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Eye Proteins; Humans; Immunoglobulin G; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; Naphthalenes; Phagocytosis; Phagosomes; Piperazines; Polycyclic Compounds; Protein Kinase C; Rod Opsins; Signal Transduction; Staurosporine; Sulfonamides	1992
Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Laboratory investigation; a journal of technical methods and pathology, 1992, Volume: 67, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Animals; Cattle; Cell Survival; Culture Techniques; Endothelium, Vascular; Enzyme Activation; Hydrogen Peroxide; Isoquinolines; Microscopy, Fluorescence; Naphthalenes; Permeability; Piperazines; Polycyclic Compounds; Protein Kinase C; Sulfonamides	1992
The protein kinase C inhibitor, calphostin C, inhibits succinate-dependent mitochondrial reduction of MTT by a mechanism that does not involve protein kinase C. Biochemical and biophysical research communications, 1992, Jun-30, Volume: 185, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow; Carbazoles; Cell Division; Cell Line; Coloring Agents; DNA Replication; Indoles; Isoquinolines; Kinetics; Mice; Mice, Inbred C3H; Mitochondria; Naphthalenes; Oxidation-Reduction; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Succinates; Tetrazolium Salts; Thiazoles; Thymidine	1992
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells. Journal of cellular physiology, 1992, Volume: 152, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoembryonic Antigen; Colonic Neoplasms; Humans; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured	1992
Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzimidazoles; Calmodulin; Coronary Disease; Heart; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Naphthalenes; Piperazines; Polycyclic Compounds; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Trifluoperazine	1992
Protein kinase C is not involved in Ah receptor transformation and DNA binding. Archives of biochemistry and biophysics, 1993, Volume: 307, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Cytosol; DNA; Enzyme Induction; Guinea Pigs; Isoquinolines; Liver; Male; Molecular Sequence Data; Naphthalenes; Piperazines; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Protein Binding; Protein Kinase C; Receptors, Aryl Hydrocarbon; Signal Transduction; Staurosporine	1993
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer research, 1994, Apr-01, Volume: 54, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Gossypol; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Naphthalenes; Perylene; Phenanthridines; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Time Factors; Tumor Cells, Cultured	1994
Intracellular calcium and myosin light chain phosphorylation during U46619-activated vascular contraction. Life sciences, 1994, Volume: 54, Issue:25 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium; Guinea Pigs; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Naphthalenes; Phosphorylation; Piperazines; Polycyclic Compounds; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents	1994
Evidence that protein kinase C activities involved in regulating neurite growth are localized to distal neurites. Journal of neurochemistry, 1994, Volume: 63, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies; Benzophenanthridines; Calcium; Cells, Cultured; Isoquinolines; Naphthalenes; Nerve Growth Factors; Neurites; Phenanthridines; Phosphorylation; Piperazines; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate	1994
Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta. British journal of pharmacology, 1994, Volume: 112, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Calcium; Guinea Pigs; Hypertonic Solutions; In Vitro Techniques; Indomethacin; Isoquinolines; Male; Mannitol; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nicardipine; Phentolamine; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar	1994
Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells. Brain research. Molecular brain research, 1994, Volume: 23, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic	1994
Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1. The Journal of cell biology, 1994, Volume: 127, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Cell Adhesion; Cell Line; Cloning, Molecular; Fibronectins; Flow Cytometry; Genistein; Humans; Integrins; Isoflavones; Isoquinolines; Kinetics; Lactams, Macrocyclic; Leukemia, Erythroblastic, Acute; Naphthalenes; Phagocytosis; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Receptors, Cytoadhesin; Receptors, Fibronectin; Receptors, Vitronectin; Rifabutin; Signal Transduction; Transfection; Tumor Cells, Cultured	1994
Activation of multiple protein kinases induced by cross-linking of Fc gamma RII in human neutrophils. Journal of leukocyte biology, 1995, Volume: 57, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Cross-Linking Reagents; Egtazic Acid; Enzyme Activation; Genistein; Humans; Isoflavones; Isoquinolines; Molecular Sequence Data; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Receptors, IgG; Superoxides	1995
Protein kinase C inhibitors, H7 and calphostin C, inhibit induction of DNA synthesis by cytosolic extracts of exponentially growing neuroblastoma cells in isolated nuclei. Brain research, 1994, Dec-26, Volume: 667, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Cycle; Cell Division; Cricetinae; Cytosol; DNA Replication; Enzyme Induction; Isoquinolines; Mice; Naphthalenes; Neuroblastoma; Phosphorylation; Piperazines; Polycyclic Compounds; Protein Kinase C; Serine Endopeptidases; Tumor Cells, Cultured	1994
Protein kinase A inhibitors enhance radiation-induced apoptosis. Journal of cellular biochemistry, 1995, Volume: 57, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Burkitt Lymphoma; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Tumor Cells, Cultured	1995
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:5 Pt 2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Genistein; Imidazoles; Indole Alkaloids; Isoflavones; Isoquinolines; Kinetics; N-Methylaspartate; Naphthalenes; Neurons; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrin	1995
Thromboxane A2-stimulated phospholipase D in osteoblast-like cells: possible involvement of PKC. The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cell Line; Choline; DNA; Isoquinolines; Mice; Naphthalenes; Osteoblasts; Phospholipase D; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane A2	1995
Activation of transfer RNA-guanine ribosyltransferase by protein kinase C. Nucleic acids research, 1995, Jul-11, Volume: 23, Issue:13 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Buffers; Diphosphates; Enzyme Activation; Enzyme Reactivators; Enzyme Stability; Isoquinolines; Liver; Naphthalenes; Pentosyltransferases; Phosphoric Monoester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sphingosine; Staurosporine	1995
Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts. Journal of leukocyte biology, 1995, Volume: 58, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Survival; Cell-Free System; Cytoplasmic Granules; Diglycerides; Dose-Response Relationship, Drug; Humans; Isoquinolines; Kinetics; Naphthalenes; Neutrophils; Phosphatidic Acids; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1995
Protein kinase C inhibitors reduce phorbol ester-induced resistance to methotrexate in Chinese hamster ovary cells. Biochemical pharmacology, 1995, Jul-31, Volume: 50, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; CHO Cells; Colony-Forming Units Assay; Cricetinae; Drug Resistance; Glycyrrhetinic Acid; Isoquinolines; Methotrexate; Molecular Sequence Data; Naphthalenes; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine	1995
A role for protein kinase C in bradykinin-mediated activation of renal pelvic sensory receptors. The American journal of physiology, 1995, Volume: 269, Issue:2 Pt 2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Enzyme Activation; Isoquinolines; Kidney Pelvis; Male; Naphthalenes; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Staurosporine	1995
A role of protein kinase C in the alteration of renal glucose-6-phosphatase activity caused by fluoride. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Membrane; Cytosol; Down-Regulation; Fluorides; Glucose-6-Phosphatase; In Vitro Techniques; Isoquinolines; Kidney; Male; Microsomes; Naphthalenes; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine	1995
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells. Biochemical Society transactions, 1995, Volume: 23, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts	1995
Sustained recovery of Na(+)-K(+)-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC. Diabetes, 1993, Volume: 42, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Isoquinolines; Kinetics; Male; Mice; Mice, Inbred Strains; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Reference Values; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Time Factors	1993
Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain research, 1993, Feb-26, Volume: 604, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Death; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Isoquinolines; Kinetics; Naphthalenes; Neurons; Neurotoxins; Piperazines; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Wistar	1993
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C. Archives of biochemistry and biophysics, 1993, Volume: 301, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoquinolines; Liver Neoplasms, Experimental; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1993
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle. The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction	1993
Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator. Blood, 1993, May-15, Volume: 81, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Induction; Extracellular Matrix; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Naphthalenes; Oligodeoxyribonucleotides; Piperazines; Plasminogen Activator Inhibitor 1; Polycyclic Compounds; Protein Kinase C; RNA; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins; Urokinase-Type Plasminogen Activator	1993
Mechanism of rapid desensitization of muscarinic K+ current in adult rat and guinea pig atrial cells. Circulation research, 1993, Volume: 73, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Adenosine Triphosphate; Animals; Cytoplasm; Electrophysiology; Guanosine Triphosphate; Guinea Pigs; Heart Atria; Isoquinolines; Naphthalenes; Phosphorylation; Piperazines; Polycyclic Compounds; Potassium Channels; Protein Kinases; Rats	1993
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. Experimental cell research, 1993, Volume: 207, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc	1993
Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1993, Volume: 11, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Dendrites; Female; Hippocampus; Imidazoles; Indoles; Isoquinolines; Naphthalenes; Neurites; Piperazines; Polycyclic Compounds; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Pyrroles; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate	1993
Thyroid hormones stabilize acetylcholinesterase mRNA in neuro-2A cells that overexpress the beta 1 thyroid receptor. The Journal of biological chemistry, 1995, Dec-22, Volume: 270, Issue:51 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholinesterase; Animals; Cell Line; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Ethers, Cyclic; Humans; Isoquinolines; Kinetics; Mice; Naphthalenes; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Thyroid Hormone; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Triiodothyronine; Tumor Cells, Cultured	1995
Redistribution of fodrin in an in vitro wound healing model of the corneal epithelium. Experimental eye research, 1995, Volume: 61, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carrier Proteins; Cattle; Cell Membrane; Cells, Cultured; Cornea; Cytoplasm; Egtazic Acid; Epithelial Cells; Epithelium; Isoquinolines; Membrane Proteins; Microfilament Proteins; Microscopy, Fluorescence; Naphthalenes; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Wound Healing	1995
Effects of cyclic adenosine monophosphate-dependent protein kinase and calcium-dependent protein kinase modulators on stimulated gastric acid secretion in the perfused rat stomach. Pharmacology, 1995, Volume: 51, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gastric Acid; Histamine; Injections, Intravenous; Isoquinolines; Male; Naphthalenes; Pentagastrin; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate	1995
Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. Cytokine, 1995, Volume: 7, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antineoplastic Agents; Arachidonic Acid; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Mice; Naphthalenes; Piperazines; Protein Kinase C; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1995
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets. FEBS letters, 1996, Mar-04, Volume: 381, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin	1996
Inductive effect of Porphyromonas gingivalis fimbriae on differentiation of human monocytic tumor cell line U937. Oral microbiology and immunology, 1996, Volume: 11, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Bacterial; Antigens, CD; Cell Differentiation; Enzyme Inhibitors; Fimbriae, Bacterial; Hematopoietic Stem Cells; Humans; Interleukin-1; Isoquinolines; Macrophage-1 Antigen; Macrophages; Monocytes; Naphthalenes; Neoplastic Stem Cells; Piperazines; Porphyromonas gingivalis; Protein Kinase C; Receptors, Fc; Rosette Formation; Second Messenger Systems; Signal Transduction; Sulfonamides; Tumor Cells, Cultured	1996
PGF2alpha-induced signaling events in glomerular mesangial cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1996, Volume: 212, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cells, Cultured; Diglycerides; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Genistein; Glomerular Mesangium; Inositol Phosphates; Isoflavones; Isoquinolines; Molecular Sequence Data; Naphthalenes; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Virulence Factors, Bordetella	1996
Interleukin-11 mRNA stabilization in phorbol ester-stimulated primate bone marrow stromal cells. Molecular and cellular biology, 1996, Volume: 16, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Cell Line; Cell Nucleus; Dactinomycin; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Interleukin-11; Isoflavones; Isoquinolines; Kinetics; Luciferases; Naphthalenes; Open Reading Frames; Piperazines; Primates; Protein Kinase C; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Stromal Cells; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Transfection	1996
Role of protein kinase C in the regulation of ATP-triggered intracellular Ca2+ oscillations in chicken granulosa cells. European journal of endocrinology, 1996, Volume: 134, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Chickens; Enzyme Activation; Female; Granulosa Cells; Intracellular Membranes; Naphthalenes; Osmolar Concentration; Protein Kinase C; Staurosporine	1996
Acidic fibroblast factor induction of cyclooxygenase II in rabbit cardiac muscle microvessel endothelial cells: mediation by protein kinase C. Microcirculation (New York, N.Y. : 1994), 1994, Volume: 1, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Blotting, Northern; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblast Growth Factor 1; Inositol Phosphates; Isoenzymes; Isoquinolines; Microcirculation; Myocardium; Naphthalenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Sulfonamides	1994
The potentiation of nitroglycerin-induced relaxation by PKG inhibition in rat aortic rings. General pharmacology, 1996, Volume: 27, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Potassium Channels; Protein Kinase C; Purinones; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Vasodilator Agents	1996
The characterization of tyrosine phosphorylation of 78 and 92 kDa proteins in rat basophilic RBL-2H3 cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cinnamates; Histamine Release; Leukemia, Basophilic, Acute; Molecular Weight; Naphthalenes; Phosphorylation; Protein Kinase C; Proteins; Rats; Receptors, IgE; Sulfides; Tyrosine	1996
Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells. British journal of pharmacology, 1997, Volume: 120, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Muscle, Smooth, Vascular; Naphthalenes; Nitric Oxide Synthase; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate	1997
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line. Biochimica et biophysica acta, 1996, Jan-10, Volume: 1310, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured	1996
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings. Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 57, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents	1997
Stimulation of protein kinase C activity by tumor necrosis factor-alpha in bovine bronchial epithelial cells. The American journal of physiology, 1997, Volume: 273, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bronchi; Cattle; Cell Movement; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fibronectins; Isoenzymes; Kinetics; Naphthalenes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha	1997
Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth. Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Division; DNA Replication; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Lipids; Lipoproteins, LDL; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Naphthalenes; Pertussis Toxin; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Virulence Factors, Bordetella	1997
Increased Ca2+ sensitivity of contractile elements via protein kinase C in alpha-toxin permeabilized SMA from young spontaneously hypertensive rats. Cardiovascular research, 1997, Volume: 36, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phorbol 12,13-Dibutyrate; Potassium; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Staphylococcus aureus; Type C Phospholipases	1997
Protein kinase C mediates increase of Ca2+ sensitivity for contraction by cholinoceptor partial agonist in ileal longitudinal muscle of guinea pig. General pharmacology, 1998, Volume: 30, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agents; Coloring Agents; Enzyme Inhibitors; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pilocarpine; Propylbenzilylcholine Mustard; Protein Kinase C; Receptors, Cholinergic; Sensitivity and Specificity	1998
ETA receptor mediated inhibition of intracellular pH regulation in cultured bovine corneal epithelial cells. Experimental eye research, 1998, Volume: 66, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arsenicals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclosporine; Diuretics; Egtazic Acid; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epithelium, Corneal; Hydrogen-Ion Concentration; Immunosuppressive Agents; Intracellular Fluid; Naphthalenes; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Endothelin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate	1998
Selective activation of phospholipase C gamma1 and distinct protein kinase C subspecies in intracellular signaling by hepatocyte growth factor/scatter factor in primary cultured rat neocortical cells. Journal of neurochemistry, 1998, Volume: 71, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fetus; Flavonoids; Hepatocyte Growth Factor; Isoenzymes; Isoquinolines; Naphthalenes; Neocortex; Neurons; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-met; Rats; Rats, Wistar; Signal Transduction; Subcellular Fractions; Substrate Specificity; Sulfonamides; Type C Phospholipases	1998
Transforming growth factor-beta2 regulates C3 secretion in monocytes through a protein kinase C-dependent pathway. Molecular immunology, 1998, Volume: 35, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Complement C3; Drug Interactions; Humans; Inflammation; Isoenzymes; Isoquinolines; Monocytes; Naphthalenes; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta	1998
The okadaic acid induced ACAT activation is prevented by a specific inhibitor of the Ca2+/calmodulin protein kinase II. Biochemical Society transactions, 1998, Volume: 26, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Kinetics; Liver; Maleimides; Naphthalenes; Okadaic Acid; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase	1998
Protein kinase C activation is required for cigarette smoke-enhanced C5a-mediated release of interleukin-8 in human bronchial epithelial cells. American journal of respiratory cell and molecular biology, 1999, Volume: 21, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetaldehyde; Bronchi; Complement C5a; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Humans; Interleukin-6; Interleukin-8; Naphthalenes; Protein Kinase C; Smoking; Time Factors; Tobacco Smoke Pollution	1999
Interaction between monocytes and vascular smooth muscle cells induces expression of hepatocyte growth factor. Journal of hypertension, 2000, Volume: 18, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Cardiovascular Diseases; Cell Communication; Cells, Cultured; Coculture Techniques; Enzyme Inhibitors; Gene Expression; Genistein; Hepatocyte Growth Factor; Humans; Immunohistochemistry; Inflammation Mediators; Interleukin-1; Interleukin-6; Monocytes; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase Inhibitors; Protein Kinases; RNA, Messenger; Tumor Necrosis Factor-alpha	2000
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium. Molecular and cellular endocrinology, 2001, Feb-28, Volume: 173, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcitriol; Calcium; Calmodulin; Chick Embryo; Egtazic Acid; Enzyme Activation; Fluphenazine; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Naphthalenes; Neomycin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases; Verapamil	2001
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity. Oncogene, 2001, Jan-11, Volume: 20, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured	2001
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. Brain research, 2001, Jun-08, Volume: 903, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1	2001
Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids. Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Caco-2 Cells; Decanoic Acids; Docosahexaenoic Acids; Eicosapentaenoic Acid; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fatty Acids; Humans; Indoles; Interleukin-8; Intestinal Mucosa; Maleimides; Naphthalenes; Oleic Acid; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger	2001
Role of protein kinase C in myogenic calcium-contraction coupling of rat cannulated mesenteric small arteries. Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Catheterization; Enzyme Inhibitors; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Protein Kinase C; Rats; Rats, Wistar; Saponins; Steroids; Vasoconstriction	2001
Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase. Journal of pineal research, 2002, Volume: 32, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apamin; Binding, Competitive; Cecum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Melatonin; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels; Protein-Tyrosine Kinases; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines	2002
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes. Journal of cellular biochemistry, 2004, Apr-01, Volume: 91, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Animals; Benzylamines; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Glycerol; Hydroxycholesterols; Indoles; Lignans; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthalenes; Oleic Acid; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vacuoles	2004
Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP. European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cantharidin; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Histamine; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Prazosin; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases; Vas Deferens	2004
Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors. Neuropharmacology, 2006, Volume: 51, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Alanine; Animals; Baclofen; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Agonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Naphthalenes; Neuromuscular Depolarizing Agents; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Kainic Acid; Receptors, Presynaptic; Thymine	2006
Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells. Endocrine journal, 2007, Volume: 54, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenocorticotropic Hormone; Animals; Bucladesine; Calcium; Calcium Signaling; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydrocortisone; Isoquinolines; Naphthalenes; Phospholipase A2 Inhibitors; Phospholipases A2; Primaquine; Protein Kinase C; Protein Kinase Inhibitors; Quinacrine; Second Messenger Systems; Sulfonamides; Zona Fasciculata	2007
Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. Experimental and molecular pathology, 2008, Volume: 84, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Benzopyrans; Carbazoles; Cell Fusion; Cells, Cultured; Enzyme Inhibitors; Giant Cells, Foreign-Body; Humans; Indoles; Isoenzymes; Isoquinolines; Macrophages; Maleimides; Monocytes; Naphthalenes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Signal Transduction	2008
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents	2011