1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with tyrosine in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.13) | 18.7374 |
| 1990's | 35 (74.47) | 18.2507 |
| 2000's | 9 (19.15) | 29.6817 |
| 2010's | 2 (4.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akimaru, K; Inoue, M; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Colamonici, OR; Platanias, LC | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI; Wang, E; Yamazaki, M | 1 |
| Grove, RI; Kiener, PA; Mazzucco, CE; Radka, SF; Shoyab, M | 1 |
| Bonak, V; Casnellie, JE; Huang, CK; Laramee, GR | 1 |
| Nakajima, K; Wall, R | 1 |
| Eckert, D; Mufson, RA; Szabo, J | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Gottlieb, RA; Jiang, WP; Kinsey, WH; Lennarz, WJ | 1 |
| Houchi, H; Misbahuddin, M; Morita, K; Nakanishi, A; Oka, M | 1 |
| Evans, DL; Jaso-Friedmann, L; Leary, JH | 1 |
| Berti, L; Häring, H; Kellerer, M; Kiehn, R; Kroder, G; Mosthaf, L; Tippmer, S | 1 |
| Pratt, MM; Salathe, M; Wanner, A | 1 |
| Faris, M; Fu, SM; Gaskin, F; Parsons, JT | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Caldenhoven, E; Coffer, P; Heinrich, PC; Horn, F; Kruijer, W; Lütticken, C; Schindler, C; Schwartz, C; Yuan, J | 1 |
| Yang, YC; Yin, T | 1 |
| Fujitani, Y; Hirano, T; Kojima, H; Matsuda, T; Nakae, K; Nakajima, K; Takeda, T; Yamanaka, Y | 1 |
| Cutler, RL; Krystal, G; Liu, L | 1 |
| Broxmeyer, HE; Horie, M; Yip-Schneider, MT | 1 |
| Blenis, J; Chen-Kiang, S; Li, HC; Schindler, C; Zhang, X | 1 |
| Vietor, I; Vilcek, J | 1 |
| Leeb-Lundberg, LM; Mathis, SA; Song, XH | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Hertel, C; Kahle, P; Kuwahara, T; Mangold, M; Schubenel, R | 1 |
| Burridge, K; Chrzanowska-Wodnicka, M | 1 |
| Frank, DA; Huo, L; Karras, JG; Rothstein, TL; Wang, Z; Zimmet, JM | 1 |
| Matsui, K; Miyamoto, H | 1 |
| Becker, E; Bershadsky, A; Chausovsky, A; Geiger, B; Lyubimova, A | 1 |
| Fink, BD; Grunwald, GB; Lee, MM | 1 |
| Blenis, J; Chung, J; Grammer, TC; Uchida, E | 1 |
| Matsuoka, I; Nakahata, N; Nakanishi, H | 1 |
| Ashford, ML; Harvey, J | 1 |
| Hunzicker-Dunn, M; Lamm, ML; Rajagopalan-Gupta, RM | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Edsall, L; Kazlauskas, A; Olivera, A; Poulton, S; Spiegel, S | 1 |
| Aittomäki, S; Kovanen, PE; Lagerstedt, A; Pesu, M; Saksela, K; Silvennoinen, O; Takaluoma, K | 1 |
| Masumoto, N; Nakayama, K; Saito, M; Tanabe, Y | 1 |
| Cantrell, D; Decker, T; Lafont, V | 1 |
| Garcia-Marin, LJ; Jensen, RT; Leyton, J; Moody, TW; Tapia, JA | 1 |
| Berton, MT; Wick, KR | 1 |
| Baraldi, PG; Di Virgilio, F; Falzoni, S; Makaeva, R; Moro, S; Nuñez, Mdel C; Pavani, MG; Romagnoli, R; Spalluto, G | 1 |
| Calzetti, F; Cassatella, MA; Crepaldi, L; Pinardi, C; Silveri, L | 1 |
| Baraldi, PG; del Carmen Nuñez, M; Di Virgilio, F; Falzoni, S; Morelli, A; Romagnoli, R | 1 |
| Baraldi, PG; Borea, PA; Cara, CL; Carrion, MD; Cruz-Lopez, O; Fogli, E; Gessi, S; Moorman, AR; Preti, D; Romagnoli, R; Sacchetto, V; Tabrizi, MA | 1 |
| Edgley, AJ; Fujii, Y; Jenkins, MJ; Joshi, M; Kelly, DJ; Pearson, JT; Schwenke, DO; Shirai, M; Sonobe, T; Tsuchimochi, H; Umetani, K; Waddingham, MT; Yoshimoto, M | 1 |
| Batteux, F; Bei, Y; Chéreau, C; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Le-Dong, NN; Nicco, C; Tiev, KP | 1 |
47 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and tyrosine
| Article | Year |
|---|---|
Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Blotting, Western; Cell Membrane; Cytosol; Genistein; Granulocyte Colony-Stimulating Factor; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine | 1992 |
Interferon alpha induces rapid tyrosine phosphorylation of the alpha subunit of its receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Dose-Response Relationship, Drug; Genistein; Humans; Interferon Type I; Isoflavones; Isoquinolines; Kinetics; Macromolecular Substances; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Interferon; Recombinant Proteins; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cross-Linking Reagents; Cycloheximide; DNA, Neoplasm; Enzyme-Linked Immunosorbent Assay; Humans; Isoquinolines; Liver Neoplasms; Oncostatin M; Peptides; Phosphorylation; Piperazines; Receptors, Cell Surface; Receptors, Cytokine; Receptors, LDL; Receptors, Oncostatin M; Tumor Cells, Cultured; Tyrosine; Up-Regulation | 1991 |
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cycloheximide; DNA-Binding Proteins; Gene Expression Regulation; Genistein; Hybridomas; Immediate-Early Proteins; In Vitro Techniques; Interleukin-6; Isoflavones; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Tristetraprolin; Tyrosine | 1991 |
Human IL-3 induction of c-jun in normal monocytes is independent of tyrosine kinase and involves protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Enzyme Activation; Gene Expression Regulation; Genes, jun; Genistein; Humans; Interleukin-3; Isoflavones; Isoquinolines; Monocytes; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine | 1992 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Phorbol ester treatment stimulates tyrosine phosphorylation of a sea urchin egg cortex protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Ammonium Chloride; Animals; Carrier Proteins; Egg Proteins; Female; Hydrogen-Ion Concentration; Isoquinolines; Molecular Weight; Ovum; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Sea Urchins; Signal Transduction; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Stimulation by vasoactive intestinal polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Dihydroxyphenylalanine; In Vitro Techniques; Isoquinolines; Piperazines; Tetradecanoylphorbol Acetate; Tyrosine; Vasoactive Intestinal Peptide | 1987 |
Pathways of signaling in nonspecific cytotoxic cells: effects of protein kinase and phosphatase inhibitors and evidence for membrane tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Catfishes; Cell Membrane; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Isoquinolines; Male; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sulfonamides; Tyrosine | 1994 |
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Immunoblotting; Immunosorbent Techniques; Insulin Resistance; Isoquinolines; Kinetics; Phosphorylation; Phosphotyrosine; Piperazines; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 1994 |
Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Annexins; Carbazoles; Cell Fractionation; Cilia; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Erythrocytes; Indoles; Isoquinolines; Membrane Proteins; Movement; Phosphorylation; Phosphoserine; Phosphotyrosine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sheep; Tetradecanoylphorbol Acetate; Trachea; Tyrosine | 1993 |
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Burkitt Lymphoma; CD40 Antigens; Cell Line; Cell Line, Transformed; Enzyme Precursors; Genistein; Herpesvirus 4, Human; Humans; Intracellular Signaling Peptides and Proteins; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Palatine Tonsil; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Quinones; Rifabutin; Sulfonamides; Syk Kinase; Tumor Cells, Cultured; Tyrosine | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Macroglobulins; Animals; Base Sequence; DNA; DNA-Binding Proteins; Gene Expression Regulation; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-6; Isoquinolines; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoserine; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Rats; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 1995 |
Interleukin (IL)-11--mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; Calcium-Calmodulin-Dependent Protein Kinases; Cytokine Receptor gp130; Gene Expression Regulation; Interleukin-11; Isoquinolines; Janus Kinase 1; Janus Kinase 2; Membrane Glycoproteins; Mice; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Ribosomal Protein S6 Kinases; RNA, Messenger; Second Messenger Systems; Signal Transduction; Transcription Factors; Tyrosine | 1995 |
Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Macroglobulins; Animals; Antigens, CD; Base Sequence; Cloning, Molecular; Cytokine Receptor gp130; DNA-Binding Proteins; Genes, jun; Humans; Isoquinolines; Janus Kinase 1; Janus Kinase 2; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); Receptors, Interleukin; Receptors, Interleukin-6; Signal Transduction; Trans-Activators; Transcription Factors; Tyrosine | 1995 |
Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; In Vitro Techniques; Interleukin-3; Isoquinolines; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-3; Signal Transduction; Staurosporine; Tyrosine | 1995 |
Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cell Division; Gene Expression; Genes, myc; Humans; Immunoblotting; Interleukin-7; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1993 |
Requirement of serine phosphorylation for formation of STAT-promoter complexes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Nucleus; Ciliary Neurotrophic Factor; Cytoplasm; DNA; DNA-Binding Proteins; Humans; Interleukin-6; Isoquinolines; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Phosphorylation; Piperazines; Promoter Regions, Genetic; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Threonine; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1995 |
Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arsenites; Benzophenanthridines; Cell Line; Fibroblasts; Heat-Shock Proteins; Humans; Interleukin-1; Isoquinolines; Phenanthridines; Phosphorylation; Phosphotransferases; Piperazines; Sodium Compounds; Staurosporine; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bradykinin; Calcium; Cell Adhesion Molecules; Chelating Agents; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Isoquinolines; Mice; Paxillin; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Protein kinase inhibitor H-7 differentially affects early and delayed nerve growth factor responses in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Isoquinolines; Nerve Growth Factors; Osmolar Concentration; PC12 Cells; Phosphorylation; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Time Factors; Tyrosine | 1994 |
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actin Cytoskeleton; Actins; Alkaloids; Animals; Carbazoles; Cell Adhesion; Diacetyl; Enzyme Inhibitors; Fibroblasts; GTP-Binding Proteins; Indoles; Integrin beta1; Isoquinolines; Lysophospholipids; Mice; Mice, Inbred BALB C; Muscle Contraction; Myosin Light Chains; Myosins; Phosphorylation; Piperazines; Protein Kinase C; Rats; rhoA GTP-Binding Protein; Tyrosine | 1996 |
Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Cell Nucleus; DNA-Binding Proteins; Down-Regulation; Interferon Regulatory Factor-1; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Nucleoproteins; Phosphoproteins; Phosphorylation; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Receptors, Antigen, B-Cell; Sirolimus; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1996 |
The characterization of tyrosine phosphorylation of 78 and 92 kDa proteins in rat basophilic RBL-2H3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cinnamates; Histamine Release; Leukemia, Basophilic, Acute; Molecular Weight; Naphthalenes; Phosphorylation; Protein Kinase C; Proteins; Rats; Receptors, IgE; Sulfides; Tyrosine | 1996 |
Involvement of microtubules in the control of adhesion-dependent signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actin Cytoskeleton; Alkaloids; Animals; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Cytoskeletal Proteins; DNA; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Indoles; Integrins; Isoflavones; Mice; Microtubules; Myosin-Light-Chain Kinase; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Vinblastine | 1996 |
Evidence that tyrosine phosphorylation regulates N-cadherin turnover during retinal development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cadherins; Chick Embryo; Enzyme Inhibitors; Heart; Hydrogen Peroxide; Isoquinolines; Lens, Crystalline; Myocardium; Organ Culture Techniques; Peptide Mapping; Phosphorylation; Phosphoserine; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Retina; Sulfonamides; Tyrosine; Vanadates | 1997 |
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; COS Cells; DNA-Binding Proteins; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Substrate Specificity; Trans-Activators; Tyrosine | 1997 |
Selective inhibition of collagen-induced arachidonic acid liberation by 1-(5-iodonaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), a myosin light chain kinase inhibitor, in washed rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcium; Collagen; Enzyme Inhibitors; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Platelet Aggregation; Rabbits; Tyrosine | 1997 |
Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line CRI-G1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Androstadienes; Animals; Enzyme Inhibitors; Insulinoma; Leptin; Nitriles; Pancreatic Neoplasms; Phosphoric Monoester Hydrolases; Phosphorylation; Potassium Channels; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Rats; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 1998 |
Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell-Free System; Chorionic Gonadotropin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Ovary; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Receptors, LH; Time Factors; Tyrosine; Virulence Factors, Bordetella | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Substitution; Animals; Calcium; Cell Division; Cell Line; Chelating Agents; DNA; Dogs; Egtazic Acid; Enzyme Activation; Isoenzymes; Mutagenesis, Site-Directed; Phenylalanine; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Thapsigargin; Transfection; Type C Phospholipases; Tyrosine | 1999 |
Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Base Sequence; CCAAT-Enhancer-Binding Proteins; Cell Line; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Humans; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Janus Kinase 1; Janus Kinase 2; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, IgE; Recombinant Proteins; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrosine | 2000 |
Attenuation of pressure-induced myogenic contraction and tyrosine phosphorylation by fasudil, a cerebral vasodilator, in rat cerebral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell-Free System; Cerebral Arteries; In Vitro Techniques; Male; Muscle Contraction; Phosphorylation; Pressure; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Sprague-Dawley; Tyrosine; Vasodilator Agents | 2000 |
Antigen receptor signal transduction: activating and inhibitory antigen receptors regulate STAT1 serine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; DNA; DNA-Binding Proteins; Humans; Jurkat Cells; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, IgG; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2000 |
Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bombesin; Carcinoma, Non-Small-Cell Lung; Cell Division; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrin-Releasing Peptide; Genistein; Humans; Lung Neoplasms; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Tyrosine | 2001 |
IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Female; Interleukin-4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Serine; STAT6 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Membrane Permeability; Cells, Cultured; Humans; Indicators and Reagents; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Monocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Spectrophotometry, Infrared; Structure-Activity Relationship; Tetrahydroisoquinolines; Tyrosine | 2002 |
Molecular basis of the synergistic production of IL-1 receptor antagonist by human neutrophils stimulated with IL-4 and IL-10.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; DNA-Binding Proteins; Drug Synergism; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-10; Interleukin-4; Lipopolysaccharides; Neutrophils; Phosphorylation; Receptors, Interleukin; Receptors, Interleukin-10; RNA, Messenger; Sialoglycoproteins; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2002 |
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Arylsulfonates; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ethidium; Humans; Interleukin-1; Macrophages; Monocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Structure-Activity Relationship; Tyrosine | 2003 |
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; beta-Alanine; Calcium; Cell Line; Cell Membrane; Cell Membrane Permeability; Ethidium; Fluorescent Dyes; Glycine; Humans; Isoquinolines; Naphthalenes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfones; Tyrosine | 2007 |
Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Angiography; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Epoprostenol; Fibrosis; Male; Microcirculation; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Tyrosine; Vasoconstriction; Vasodilation; Vasodilator Agents | 2013 |
RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Disease Models, Animal; Female; Hypochlorous Acid; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Pneumonia; Pulmonary Fibrosis; rho-Associated Kinases; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Tyrosine | 2016 |