1-(5-isoquinolinesulfonyl)-2-methylpiperazine and transforming growth factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Collagen; Disease Models, Animal; Fibrosis; Glomerulosclerosis, Focal Segmental; Hypertension; Intracellular Signaling Peptides and Proteins; Kidney; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta, Thoracic; Biological Factors; Bucladesine; Cell Division; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fibronectins; Isoquinolines; Kinetics; Macromolecular Substances; Muscle, Smooth, Vascular; Pertussis Toxin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Wistar; Recombinant Proteins; Second Messenger Systems; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Virulence Factors, Bordetella

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoembryonic Antigen; Colonic Neoplasms; Humans; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Animals; Cells, Cultured; Down-Regulation; Gene Expression Regulation; Genes, fos; Genes, jun; Isoquinolines; Liver; Mice; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Cell Differentiation; Cycloheximide; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Growth Substances; Insulin-Like Growth Factor I; Isoquinolines; Mice; Osteoblasts; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Staurosporine; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Calcitriol; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Differentiation; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Isoquinolines; Leukemia; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tretinoin; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Line; DNA-Binding Proteins; Ethers, Cyclic; Isoquinolines; Lung; Mink; Nuclear Proteins; Okadaic Acid; Phosphates; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA; Transcription Factors; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bronchi; Bronchial Neoplasms; Calmodulin; Cell Communication; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Down-Regulation; Epidermal Growth Factor; Epithelium; Humans; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Sulfonamides; Time Factors; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Base Sequence; Chemokine CCL2; Chemotactic Factors; Cytokines; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Genes, fos; Genes, jun; Humans; Isoquinolines; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Osteoblasts; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cyclic AMP; Gene Expression; Isoquinolines; Mice; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; RNA, Messenger; Stromal Cells; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Macroglobulins; Animals; Cell Line; Dactinomycin; Drug Synergism; Ethers, Cyclic; Extracellular Matrix; Fibroblast Growth Factor 2; Gene Expression; Humans; Isoquinolines; Macrophages; Methylamines; Mice; Microcystins; Okadaic Acid; Peptides, Cyclic; Piperazines; Plasminogen Activator Inhibitor 1; Protein Kinase C; RNA, Messenger; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Bone Neoplasms; Calcitriol; Cell Division; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Osteocalcin; Osteosarcoma; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Calcitriol; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta; Tretinoin; Tumor Cells, Cultured; Vitamin D-Binding Protein

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; Binding Sites; Cells, Cultured; Endoglin; Endothelium, Vascular; Fibroblasts; Humans; Immunosorbent Techniques; Isoquinolines; Membrane Glycoproteins; Mice; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinase C; Receptors, Cell Surface; Recombinant Proteins; Transfection; Transforming Growth Factor beta; Umbilical Veins; Vascular Cell Adhesion Molecule-1

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Atrial Natriuretic Factor; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Endothelins; Glomerular Mesangium; Isoquinolines; Kinetics; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Nitroprusside; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Thymidine; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosylmethionine Decarboxylase; Apoptosis; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Humans; Isoquinolines; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitoguazone; Ornithine Decarboxylase; Piperazines; Polyamines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Transforming Growth Factor beta; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Isoquinolines; Kidney; Opossums; Phosphates; Piperazines; Protein Serine-Threonine Kinases; Signal Transduction; Time Factors; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Collagen; Enzyme Inhibitors; Ethers, Cyclic; Fetus; Fibroblasts; Gene Expression; Genistein; Humans; Isoflavones; Isoquinolines; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Skin; Staurosporine; Transcription, Genetic; Transforming Growth Factor beta; Vanadates

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Blotting, Northern; Cell Line; Curcumin; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression Regulation; Humans; Mice; Nuclear Proteins; Osteoblasts; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Bronchi; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; DNA Probes; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Protein Serine-Threonine Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Death; Cell Survival; Cytokines; Drug Synergism; Enzyme Inhibitors; Flavonoids; Humans; Hyaluronoglucosaminidase; Kinetics; L Cells; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Complement C3; Drug Interactions; Humans; Inflammation; Isoenzymes; Isoquinolines; Monocytes; Naphthalenes; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cartilage, Articular; Cattle; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-3; Transcriptional Activation; Transforming Growth Factor beta; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Blotting, Northern; Choriocarcinoma; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Pregnancy; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uterine Neoplasms

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Ganglia, Parasympathetic; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Mitogen-Activated Protein Kinases; Neurons; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carbazoles; Cells, Cultured; Culture Media, Conditioned; Cycloheximide; Cytokines; Dental Pulp; Enzyme Inhibitors; Gelatinases; Humans; Indoles; Interleukin-1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pulpitis; Reproducibility of Results; Time Factors; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aggregatibacter actinomycetemcomitans; Cells, Cultured; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Matrix Metalloproteinase 2; Periodontal Diseases; Periodontal Ligament; Porphyromonas gingivalis; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Antennapedia Homeodomain Protein; Binding Sites; Cell Line; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Homeodomain Proteins; Imidazoles; Mink; Molecular Mimicry; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Peptide Fragments; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Substrate Specificity; Trans-Activators; Transcription Factors; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Kv1.3 Potassium Channel; Macrophages; Mice; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Transforming Growth Factor beta; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Animals; Bacterial Proteins; Bacterial Toxins; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Botulinum Toxins; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Osteoblasts; Osteogenesis; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Skull; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; DNA-Binding Proteins; Drug Administration Schedule; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Hypertrophy, Left Ventricular; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Male; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Organ Size; Phosphorylation; Protein Processing, Post-Translational; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Ultrasonography; Ventricular Dysfunction, Left; Ventricular Remodeling

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Blood Pressure; Blotting, Western; Collagen Type I; Collagen Type III; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Intracellular Signaling Peptides and Proteins; Kidney Cortex; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Inbred Dahl; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Enzyme Activation; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kidney; Male; Nephrectomy; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Time Factors; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Collagen Type I; Collagen Type III; Gene Expression; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Function Tests; Male; NADP; Nephrosclerosis; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho GTP-Binding Proteins; rho-Associated Kinases; Sodium Chloride, Dietary; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Animals; Blood Glucose; Blood Pressure; Cholesterol; Connective Tissue Growth Factor; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Indoles; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Kidney Cortex; Male; NADPH Oxidase 4; NADPH Oxidases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; Streptozocin; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Collagen Type I; Collagen Type III; Drug Interactions; Enzyme Inhibitors; Hypertension, Renal; Intercellular Adhesion Molecule-1; Kidney; Male; NADPH Oxidases; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Superoxides; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Blotting, Western; Immunohistochemistry; Muscle, Smooth; Phosphorylation; Protein Kinase Inhibitors; Rabbits; rho-Associated Kinases; Transforming Growth Factor beta; Vitreoretinopathy, Proliferative; Wound Healing

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Animals, Newborn; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; rho-Associated Kinases; Skull; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Apamin; Barium; Calcium; Cations; Cell Line; Charybdotoxin; Dose-Response Relationship, Drug; Drug Combinations; Elapid Venoms; Electrodes; Electrophysiology; Fluorescent Antibody Technique, Direct; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Interferon-gamma; Lipopolysaccharides; Membrane Potentials; Mice; Mice, Inbred C57BL; Microglia; Neurotoxins; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrazoles; Scorpion Venoms; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginase; Cell- and Tissue-Based Therapy; Chemokine CCL20; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Immunomodulation; Interleukin-10; Interleukin-12; Macrophages; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Nitric Oxide Synthase Type II; Peptide Fragments; Primary Cell Culture; Receptors, IgG; Signal Transduction; T-Lymphocytes; Toll-Like Receptor 4; Transcription Factor RelA; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Neoplasm; Antiviral Agents; Apoptosis; Cell Line, Transformed; Collagen; Dogs; Epithelial Cells; Host-Pathogen Interactions; Humans; Immunoblotting; Influenza A Virus, H1N1 Subtype; Integrins; Lung; Madin Darby Canine Kidney Cells; Mice, Inbred C57BL; Mice, Knockout; Orthomyxoviridae Infections; Phosphorylation; Poly I-C; rho-Associated Kinases; Smad3 Protein; Toll-Like Receptor 3; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Interferon-gamma; Interleukin-10; Interleukin-17; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; rho-Associated Kinases; Spleen; T-Lymphocytes; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Aminopropionitrile; Animals; Cell Differentiation; Cells, Cultured; Collagen; Extracellular Matrix; Fibrosis; Heart; Humans; Male; Myocardium; Myofibroblasts; Protein-Lysine 6-Oxidase; Rats; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autophagy; Cell Proliferation; Cells, Cultured; Collagen; Collagen Type I; Fibroblasts; Phosphorylation; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rabbits; rho-Associated Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Urethra; Urethral Stricture