1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with thiazoles in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 11 (47.83) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Aussel, C; Breittmayer, JP; Pelassy, C | 1 |
| Berridge, MV; Tan, AS | 1 |
| Bast, A; Leurs, R; Timmerman, H | 1 |
| Chow, SC; Jondal, M | 1 |
| David, JD; Faser, CR; Perrot, GP | 1 |
| Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI | 1 |
| Halenda, SP; Rehm, AG | 1 |
| Berti, L; Häring, H; Kellerer, M; Kiehn, R; Kroder, G; Mosthaf, L; Tippmer, S | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Isbrucker, R; Peterson, TC; Slysz, G | 1 |
| Epstein, DL; Roberts, BC; Rowlette, LL | 1 |
| Hayakawa, A; Nakashima, I; Okamoto, T; Tajiri, H; Yokoyama, I | 1 |
| Kim, JY; Lee, SH; Moon, CH; Woo, HG | 1 |
| Lunn, JA; Rozengurt, E; Walsh, JH; Wong, H | 1 |
| Leopoldt, D; Rozengurt, E; Yee, HF | 1 |
| Baraldi, PG; Bianchini, E; Gambari, R; Lambertini, E; Penolazzi, L; Piva, R; Romagnoli, R | 1 |
| Orlando, KA; Pittman, RN; Stone, NL | 1 |
| Gabelt, BT; Kaufman, PL; Kiland, JA; Kim, CB; Miller, CL; Nork, TM; Peterson, J; Ver Hoeve, JN | 1 |
| Bradley, HJ; Browne, LE; Jiang, LH; Yang, W | 1 |
| Kanjanamekanant, K; Luckprom, P; Pavasant, P | 1 |
| Talbot, P; Weng, NJ | 1 |
| Bin Dayel, A; Evans, RJ; Schmid, R | 1 |
| Fu, A; Huang, R; Liang, J; Tang, M; Wang, L; Zhou, J | 1 |
23 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and thiazoles
| Article | Year |
|---|---|
A diacylglycerol kinase is involved in the regulation of interleukin-2 synthesis in Jurkat T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Humans; Interleukin-2; Isoquinolines; Phosphatidic Acids; Phosphatidylserines; Phosphotransferases; Piperazines; Pyrimidinones; Signal Transduction; Thiazoles | 1992 |
The protein kinase C inhibitor, calphostin C, inhibits succinate-dependent mitochondrial reduction of MTT by a mechanism that does not involve protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow; Carbazoles; Cell Division; Cell Line; Coloring Agents; DNA Replication; Indoles; Isoquinolines; Kinetics; Mice; Mice, Inbred C3H; Mitochondria; Naphthalenes; Oxidation-Reduction; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Succinates; Tetrazolium Salts; Thiazoles; Thymidine | 1992 |
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Catechols; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine; Indomethacin; Isoindoles; Isoquinolines; Lung; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Organoselenium Compounds; Piperazines; Potassium Chloride; Selenium; Thiazoles | 1990 |
A central role for phosphoinositide hydrolysis in activating the lytic mechanism of human natural killer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cytosol; Cytotoxicity, Immunologic; Diacylglycerol Kinase; Humans; Hydrolysis; Inositol Phosphates; Isoquinolines; Killer Cells, Natural; Neomycin; Phosphatidylinositols; Phosphotransferases; Piperazines; Protein Kinase C; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Role of protein kinase C in chick embryo skeletal myoblast fusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Calcium; Cell Fusion; Chick Embryo; Diglycerides; Enzyme Activation; Isoquinolines; Muscles; Piperazines; Protein Kinase C; Protein Kinases; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles | 1987 |
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Diterpenes; Drug Synergism; Humans; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1987 |
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Immunoblotting; Immunosorbent Techniques; Insulin Resistance; Isoquinolines; Kinetics; Phosphorylation; Phosphotyrosine; Piperazines; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine | 1994 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antimetabolites; Bucladesine; Cell Division; Cells, Cultured; Cholagogues and Choleretics; Cyclic AMP; Dideoxyadenosine; Drug Interactions; Enzyme Inhibitors; Fibroblasts; Humans; Pentoxifylline; Platelet-Derived Growth Factor; Stimulation, Chemical; Taurochenodeoxycholic Acid; Tetrazolium Salts; Thiazoles; Ursodeoxycholic Acid | 1998 |
Acto-myosin drug effects and aqueous outflow function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aqueous Humor; Bridged Bicyclo Compounds, Heterocyclic; Cell Size; Cell Survival; Cells, Cultured; Diacetyl; Microscopy, Fluorescence; Myosins; Swine; Thiazoles; Thiazolidines; Trabecular Meshwork | 1999 |
Protein kinase C-dependent anti-apoptotic mechanism that is associated with high sensitivity to anti-Fas antibody in ovarian cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Apoptosis; Calcimycin; Cell Division; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Female; Flow Cytometry; Humans; Isoquinolines; Ovarian Neoplasms; Protein Kinase C; Signal Transduction; Sphingomyelin Phosphodiesterase; Sulfonamides; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Reductase; Animals; Benzothiazoles; Cell Line; Drug Synergism; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phthalazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles | 1999 |
Requirement of cortical actin organization for bombesin, endothelin, and EGF receptor internalization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Actins; Animals; Bombesin; Bridged Bicyclo Compounds, Heterocyclic; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gastrin-Releasing Peptide; GTP-Binding Proteins; Iodine Radioisotopes; Kinetics; Mice; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Receptors, Bombesin; Receptors, Endothelin; Signal Transduction; Thiazoles; Thiazolidines | 2000 |
Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bombesin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoblotting; Indoles; Maleimides; Marine Toxins; Mice; Microscopy, Fluorescence; Myosin-Light-Chain Phosphatase; Nucleic Acid Synthesis Inhibitors; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Thiazoles; Thiazolidines; Time Factors | 2001 |
N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Phosphatase; Apoptosis; Bone and Bones; Bone Diseases, Metabolic; Caspase 3; Caspases; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Isoenzymes; Models, Chemical; NF-kappa B; Osteoblasts; Osteoclasts; Piperazines; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Tartrate-Resistant Acid Phosphatase; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspase Inhibitors; Caspases; Cell Membrane; Chlorocebus aethiops; COS Cells; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Heterocyclic Compounds, 4 or More Rings; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Myosins; PC12 Cells; Phagocytosis; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Rats; rho-Associated Kinases; RNA, Small Interfering; Thiazoles; Thiazolidines | 2006 |
Effect of H-7 and Lat-B on retinal physiology.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Dark Adaptation; Electroretinography; Enzyme Inhibitors; Fluorescein Angiography; Fluorophotometry; Injections; Macaca fascicularis; Macaca mulatta; Marine Toxins; Photic Stimulation; Retina; Retinal Vessels; Thiazoles; Thiazolidines; Vitreous Body | 2006 |
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Benzoxazoles; HEK293 Cells; Humans; Macaca mulatta; Membrane Potentials; Molecular Sequence Data; Patch-Clamp Techniques; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Pyridines; Quinolinium Compounds; Receptors, Purinergic P2X7; Single-Cell Analysis; Tetrazoles; Thiazoles | 2011 |
Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate/P2X7 receptor activation in human periodontal ligament cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Benzenesulfonates; Calcium Channel Blockers; Calcium Signaling; Cell Culture Techniques; Cell Survival; Cells, Cultured; Coloring Agents; Dactinomycin; Homeostasis; Humans; Interleukin-1beta; Luminescent Measurements; Periodontal Ligament; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA, Small Interfering; Signal Transduction; Stress, Mechanical; Suramin; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2013 |
The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Biomarkers; Calcium; Cell Adhesion; Cell Differentiation; Cell Surface Extensions; Extracellular Space; Gene Knockdown Techniques; Human Embryonic Stem Cells; Humans; Ion Channel Gating; Models, Biological; Purinergic P2X Receptor Antagonists; rac GTP-Binding Proteins; Receptors, Purinergic P2X7; rho GTP-Binding Proteins; Thiazoles; Time-Lapse Imaging | 2017 |
Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Allosteric Site; Amides; Binding Sites; Humans; Imidazoles; Indoles; Models, Molecular; Molecular Docking Simulation; Point Mutation; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Rosaniline Dyes; Thiazoles | 2019 |
Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Breast Neoplasms; Colon; Drug Screening Assays, Antitumor; Female; Gastrointestinal Microbiome; Humans; Lipid Peroxidation; Mammary Neoplasms, Experimental; MCF-7 Cells; Rats, Sprague-Dawley; rho-Associated Kinases; Thiazoles | 2021 |