1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with tetrodotoxin in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 15 (55.56) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kojo, T | 1 |
| Del Bianco, E; Geppetti, P; Maggi, CA; Patacchini, R; Santicioli, P; Tramontana, M | 1 |
| Yau, WM | 1 |
| Dorsett, JA; Parr, EL; Yau, WM | 1 |
| Agopyan, N; Krnjević, K; Leblond, J | 1 |
| Kobayashi, H; Mochida, S | 1 |
| Hirai, H; Okada, Y | 1 |
| Sontheimer, H; Thio, CL | 1 |
| Behar, J; Biancani, P; De Petris, G; Harnett, KM; Yu, P | 1 |
| Barnes, NM; Brown, DC; Bruton, RK; Ge, J; Steward, LJ; Stokes, PR; Stowe, RL | 1 |
| Gault, LM; Siegel, RE | 1 |
| Ayajiki, K; Okamura, T; Toda, N | 1 |
| Chiu, LM; Guarneros, A; Peña, F; Sitges, M | 1 |
| Chakder, S; Rattan, S | 1 |
| Krnjević, K; Liu, PL; McArdle, JJ; Ren, J; Ye, JH | 1 |
| Konishi, S; Mitoma, H | 1 |
| Alroy, G; Su, H; Yaari, Y | 1 |
| Chen, YZ; Xing, BR; Zhu, BG | 1 |
| Blandizzi, C; Colucci, R; Del Tacca, M; Tognetti, M | 1 |
| Higo, A; Katsura, M; Mohri, Y; Ohkuma, S; Shuto, K; Takesue, M; Tarumi, C; Tsujimura, A | 1 |
| Kaneishi, K; Kato, M; Kobayashi, H; Sakuma, Y | 1 |
| Hackman, JC; Holohean, AM | 1 |
| Büyükafsar, K; Levent, A | 1 |
| Gao, C; Gao, N; Hu, HZ; Liu, S; Wood, JD; Xia, Y | 1 |
| Honda, M; Ishikawa, T; Nakayama, K; Suzuki, M | 1 |
| Mody, I; Sokolova, IV | 1 |
| Carbonetto, S; Tremblay, M; Vezina-Audette, R | 1 |
27 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and tetrodotoxin
| Article | Year |
|---|---|
[A pharmacological study on the mechanism of the endothelin-induced contraction of the bovine cerebral artery].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cerebral Arteries; Endothelins; Female; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Quinacrine; Sarcoplasmic Reticulum; Sodium Channels; Tetrodotoxin; Vasoconstriction | 1991 |
Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acids; Animals; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Guinea Pigs; Hydrogen-Ion Concentration; Indomethacin; Isoquinolines; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Neurosecretion; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperazines; Potassium; Ruthenium Red; Tetrodotoxin; Urinary Bladder | 1991 |
Mode of stimulation of gallbladder contraction by substance K.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; Female; Gallbladder; Guinea Pigs; Isoquinolines; Kinetics; Muscle Contraction; Muscle, Smooth; Neurokinin A; Piperazines; Tetrodotoxin | 1990 |
Characterization of acetylcholine release from enzyme-dissociated myenteric ganglia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Colforsin; Deoxyribonuclease I; Female; Guinea Pigs; Isoquinolines; L-Lactate Dehydrogenase; Microbial Collagenase; Microscopy, Electron; Microscopy, Electron, Scanning; Myenteric Plexus; Neuropeptides; Peptide Hydrolases; Piperazines; Potassium; Protein Kinase C; Serotonin; Tetrodotoxin; Veratrine | 1989 |
Mediation of acetylcholine's excitatory actions in central neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Cyclic GMP; Hippocampus; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Rats; Rats, Inbred Strains; Tetrodotoxin | 1989 |
Protein kinase C activators mimic the M2-muscarinic receptor-mediated effects on the action potential in isolated sympathetic neurons of rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adrenergic Fibers; Animals; Calcium; Diglycerides; Glycerides; In Vitro Techniques; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Rabbits; Receptors, Muscarinic; Tetrodotoxin | 1988 |
Adenosine facilitates glutamate release in a protein kinase-dependent manner in superior colliculus slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Calcium; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Superior Colliculi; Tetrodotoxin | 1994 |
Differential modulation of TTX-sensitive and TTX-resistant Na+ channels in spinal cord astrocytes following activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Enzyme Activation; Isoquinolines; Mathematics; Membrane Potentials; Models, Neurological; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channels; Spinal Cord; Tetradecanoylphorbol Acetate; Tetrodotoxin | 1993 |
Interaction between signal transduction pathways contributing to gallbladder tonic contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cats; Diglycerides; Female; Gallbladder; In Vitro Techniques; Inositol; Inositol 1,4,5-Trisphosphate; Isoquinolines; Male; Models, Biological; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Phosphorylation; Piperazines; Protein Kinase C; Signal Transduction; Strontium; Sulfonamides; Tetrodotoxin | 1993 |
Ability of 5-HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Corpus Striatum; Dopamine; Female; In Vitro Techniques; Microdialysis; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Agents; Tetrodotoxin | 1996 |
Expression of the GABAA receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Chelating Agents; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Macromolecular Substances; Membrane Potentials; Neurons; Nifedipine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sulfonamides; Tetrodotoxin; Time Factors; Transcription, Genetic | 1997 |
Effect of Ca2+/calmodulin-dependent protein kinase II inhibitors on the neurogenic cerebroarterial relaxation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Arteries; Coronary Vessels; Cyclic GMP; Dinoprost; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Norepinephrine; Oxytocics; Phosphorylation; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Tetrodotoxin; Vasoconstrictor Agents | 1997 |
Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Okadaic Acid; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sodium; Sodium Channels; Synaptosomes; Tetrodotoxin; Veratridine | 1998 |
Mechanisms and sites of action of endothelins 1 and 2 on the opossum internal anal sphincter smooth muscle tone in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Agents; Anal Canal; Animals; Atropine; Calcium Channel Blockers; Calmodulin; Cyclooxygenase Inhibitors; Endothelin-1; Endothelin-2; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Indomethacin; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; omega-Conotoxin GVIA; Opossums; Peptides; Polymethacrylic Acids; Protein Kinase C; Substance P; Sulfonamides; Tachyphylaxis; Tetrodotoxin | 1999 |
Cocaine decreases the glycine-induced Cl- current of acutely dissociated rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anesthetics, Local; Animals; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Glycine Agents; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Strychnine; Sulfonamides; Tetrodotoxin | 1999 |
Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebellum; Colforsin; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Methiothepin; Neuronal Plasticity; Norepinephrine; Propranolol; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA; Serotonin; Sulfonamides; Synapses; Synaptic Transmission; Tetrodotoxin; Thionucleotides | 1999 |
Protein kinase C mediates muscarinic block of intrinsic bursting in rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Atropine; Carbachol; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyramidal Cells; Rats; Receptors, Muscarinic; Signal Transduction; Tetraethylammonium; Tetrodotoxin | 1999 |
Effect of calcium on the uptake of glutamate by synaptosomes: possible involvement of two different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cerebral Cortex; Chelating Agents; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Synaptosomes; Tetrodotoxin; Trifluoperazine | 1999 |
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Calcium; Colforsin; Dose-Response Relationship, Drug; Ethylmaleimide; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle, Smooth; Myenteric Plexus; Nifedipine; Norepinephrine; omega-Conotoxins; Pertussis Toxin; Phenols; Receptors, Histamine H3; Rolipram; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetrodotoxin; Virulence Factors, Bordetella; Yohimbine | 2000 |
Mechanism for increase in expression of cerebral diazepam binding inhibitor mRNA by nicotine: involvement of L-type voltage-dependent calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Local; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dibucaine; Enzyme Inhibitors; Gene Expression; Hexamethonium; Lidocaine; Membrane Potentials; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; omega-Agatoxin IVA; omega-Conotoxin GVIA; Platelet Aggregation Inhibitors; Procainamide; RNA, Messenger; Sulfonamides; Tetrodotoxin; Tritium | 2000 |
3',5'-cyclic adenosine monophosphate augments intracellular Ca2+ concentration and gonadotropin-releasing hormone (GnRH) release in immortalized GnRH neurons in an Na+ -dependent manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Calcium; Cell Line, Transformed; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Isoquinolines; Neurons; Protein Kinase C; Sodium; Sulfonamides; Tetrodotoxin | 2002 |
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Gallopamil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Indoles; Magnesium; Memantine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nifedipine; Protein Kinase C; Pyridines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Staurosporine; Sulfonamides; Tetrodotoxin | 2004 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Boron Compounds; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Indoles; Male; Maleimides; Norepinephrine; Phenethylamines; Pyrrolidinones; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Submucous Plexus; Synaptic Transmission; Tetrodotoxin; Theophylline; Triazines; Triazoles | 2007 |
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amides; Anesthetics, Local; Animals; Blood Pressure; Blood Vessels; Body Temperature Regulation; Clonidine; Cold Temperature; Heart Rate; Intracellular Signaling Peptides and Proteins; Isoquinolines; Laser-Doppler Flowmetry; Male; Mice; Naphthyridines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Quinolizines; Receptors, Adrenergic, alpha-2; Reflex; Regional Blood Flow; rho-Associated Kinases; Skin; Skin Temperature; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction | 2007 |
Silencing-induced metaplasticity in hippocampal cultured neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Analysis of Variance; Animals; Calcium Channel Blockers; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Mice; Mice, Inbred C57BL; Neural Inhibition; Neuronal Plasticity; Neurons; Nifedipine; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Valine | 2008 |
Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Agrin; Animals; Benzoquinones; Bungarotoxins; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cell Line; Gene Expression; Lactams, Macrocyclic; Laminin; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Protein Aggregates; Receptors, Cholinergic; Sodium Channel Blockers; Sodium Channels; Staining and Labeling; Tetrodotoxin; Verapamil | 2017 |