1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with staurosporine in 424 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (4.01) | 18.7374 |
| 1990's | 372 (87.74) | 18.2507 |
| 2000's | 32 (7.55) | 29.6817 |
| 2010's | 3 (0.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Camps, M; Gumà, A; Muñoz, P; Palacín, M; Testar, X; Zorzano, A | 1 |
| Bloodgood, RA | 1 |
| Hemmings, BA; Monard, D; Stone, SR; Suidan, HS | 1 |
| Murata, Y; Shimizu, M; Shinohara, O | 1 |
| Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Fisher, J; Hankins, WD; Isaacs, MA; Spivak, JL | 1 |
| Cragoe, EJ; Haddad, P; Haman, A; Hoang, T; Rajotte, D | 1 |
| Corvol, P; Eckardt, KU; Fabbro, D; Kurtz, A; Pugh, C; Ratcliffe, P | 1 |
| Inoue, T; Morita, T; Okuhama, R; Sera, M; Tominaga, N; Ueki, H | 1 |
| Angenstein, F; Jork, R; Staak, S | 1 |
| Hegemann, L; Kurscheid-Reich, D; Wohlfeil, S | 1 |
| Hayashi, K | 1 |
| Hershkoviz, R; Lider, O; Miron, S; Schechter, Y; Tirosh, I; Yayun, A | 1 |
| Kiss, Z | 1 |
| Koyama, N; Morisaki, N; Saito, Y; Yoshida, S | 1 |
| Beermann, ML; Leli, U; Nixon, RA; Shea, TB | 1 |
| Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Chadee, K; Keller, K; Olivier, M | 1 |
| Desai, SN; Letts, GL; Myers, CL; Schembri-King, J; Wallace, RW | 1 |
| Diehl, H; Folch, H; Guarda, MI; Maldonado, C; Ojeda, F | 1 |
| Bandekar, JR; Castagna, R; Sultzer, BM | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Brown, EJ; Zheleznyak, A | 1 |
| Maeyama, K; Sakurai, E; Sasaki, M; Taguchi, Y; Watanabe, T; Yamatodani, A | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Fujita, Y; Kataoka, S; Kobuchi, H; Tanimura, M; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Yong, VW | 1 |
| Ishihara, M; Jiang, H; Kato, R; Nishikawa, K; Wang, JC; Yamamoto, S | 1 |
| Kobayashi, T | 1 |
| Pradines-Figueres, A; Raetz, CR | 1 |
| Ikeda, K; Kikuchi, T; Matsumoto, T; Morimoto, K; Nakano, T; Ogata, E; Okazaki, R; Sakamoto, A; Urakawa, K | 1 |
| Aumailley, M; Gimond, C | 1 |
| Benveniste, EN; Chung, IY; Kwon, J | 1 |
| Meltzer, M; Mufson, RA; Myers, C; Turpin, JA | 1 |
| Chrest, FJ; Gabrielson, EW; Lin, Y | 1 |
| Frangos, JA; Hsieh, HJ; Li, NQ | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI; Wang, E; Yamazaki, M | 1 |
| Fujii, T; Hashizume, T; Sato, T | 1 |
| Hallahan, DE; Mustafi, R; Panje, N; Schwartz, JL; Virudachalam, S; Weichselbaum, RR | 1 |
| Katayama, N; Komada, F; Minami, N; Nishikawa, M; Sekine, T; Shimizu, N; Shirakawa, S | 1 |
| Citi, S | 1 |
| Bouaboula, M; Casellas, P; d'Angeac, AD; Dornand, J; Favero, J; Shire, D | 1 |
| Hamilton, JR; Lembessis, P; MacLeod, RJ | 1 |
| Kelleher, D; Long, A | 1 |
| Felipo, V; Grisolía, S; Llopis, J; Miñana, MD; Romá, J; Romero, FJ | 1 |
| Gotlieb, AI; Yu, JC | 1 |
| Crews, FT; Guzman, NJ | 1 |
| Bergstrand, H; Edström, A; Ekström, PA | 1 |
| Asano, K; Iizuka, H; Ito, F; Takahashi, H; Tamura, T; Tsutsui, M | 1 |
| Cragoe, EJ; Gupta, S; Ruderman, NB; Sussman, I | 1 |
| Davis, PD; Nixon, JS; Sedgwick, AD; Wadsworth, J; Westmacott, D; Wilkinson, SE | 1 |
| Hartfield, PJ; Robinson, JM | 3 |
| Bryant, SH; Conte Camerino, D; Govoni, S; Tricarico, D | 1 |
| Fukazawa, H; Li, PM; Mizuno, S; Murakami, Y; Uehara, Y; Yamamoto, C | 1 |
| Ermel, B; Häring, HU; Kellerer, M; Mühlhöfer, A; Müller, HK; Obermaier-Kusser, B; Vogt, B | 1 |
| Gilfillan, AM; Welton, AF; Wiggan, GA | 1 |
| de Pont, JJ; Ederveen, AG; Van Emst-De Vries, SE; Willems, PH | 1 |
| Politis, AD; Vogel, SN | 1 |
| Arita, Y; Kimura, T; Nawata, H; Ogami, Y | 1 |
| Ewenstein, BM; Johnson, DR; Pober, JS; Ritchie, AJ | 1 |
| Bahrami, LH; Lenhard, LW; Pandol, SJ; Perkins, PS | 1 |
| Bryant, SH; Conte-Camerino, D | 1 |
| Cinotti, GA; Menè, P; Pugliese, F | 1 |
| Izawa, T; Komabayashi, T; Rubin, RP; Suda, K; Tsuboi, M; Yakata, A | 1 |
| Norman-O'Guin, K; Shafit-Zagardo, B; Sharma, N | 1 |
| Adeagbo, AS; Triggle, CR | 1 |
| Endou, M; Hattori, Y; Kanno, M; Nakaya, H | 1 |
| Kojima, I; Shibata, H | 1 |
| Bakouche, O; Lachman, LB; Moreau, JL | 1 |
| Spangler, R; Sytkowski, AJ | 1 |
| Alberola-Ila, J; Lozano, F; Places, L; Vives, J | 1 |
| Cao, XM; Guy, GR; Sukhatme, VP; Tan, YH | 1 |
| Barrett, KE; Dharmsathaphorn, K; Dinh, S; Kachintorn, U; Vajanaphanich, M; Vongkovit, P | 1 |
| Bitonti, AJ; Dumont, JA; Jones, WD | 1 |
| Gross, JL; Mochan, E; Newton, RC; Rommi, W; Uhl, J | 1 |
| Bernstein, SH; Kharbanda, SM; Kufe, DW; Sherman, ML; Stone, RM | 1 |
| Decker, K; Schulze-Specking, A; Weinhold, L | 1 |
| Barreau, P; Basset, M; Cost, H; Geny, B; Le Peuch, C | 1 |
| Caron, L; Grose, JH; Landry, J; Lebel, M | 1 |
| Arduino, C; Avanzi, GC; Brizzi, MF; Bussolino, F; Pegoraro, L | 1 |
| Asano, T; Koide, T; Matsui, T; Naitoh, S; Sugawa, M; Takato, M | 1 |
| Etgen, AM; Petitti, N | 1 |
| Endou, M; Hattori, Y; Kanno, M; Tohse, N | 1 |
| Balapure, AK; Brunswick, M; Feuerstein, N; Glazer, RI; June, CH; Mond, JJ; Witherspoon, K | 1 |
| Elliott, ME; Goodfriend, TL; Jones, HM; Tomasko, S | 1 |
| Badwey, JA; Curnutte, JT; Erickson, RW | 1 |
| Sauro, MD; Zorn, NE | 2 |
| Toi, M; Umezaza, K | 1 |
| Hasegawa-Sasaki, H; Sasaki, T; Yamashita, Y | 1 |
| Clark, WM; Kochhar, A; Madden, KP; Zivin, JA | 1 |
| Francis, J; Pon, DJ; Qu, Y; Sen, AK; Torchia, J | 1 |
| Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J | 1 |
| Chang, ZL; Novotney, M; Suzuki, T; Uchiyama, H | 1 |
| de Groot, RP; Herrmann-Erlee, MP; Koornneef, I; Kramer, YM; Kruijer, W; Slootweg, MC | 1 |
| Eguchi, S; Emori, T; Hirata, Y; Imai, T; Kanno, K; Marumo, F; Ohta, K; Shichiri, M | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Tai, HH; Tian, ZG; Xun, CQ | 1 |
| Asano, T; Johshita, H; Matsui, T; Takuwa, Y; Yamashita, K | 1 |
| Haystead, TA; Krebs, EG; Licciardi, KA; Meier, KE | 1 |
| Chuang, ST; Grunstein, MM; Pawlowski, NA; Schramm, CM | 1 |
| Kanaho, Y; Miura, K; Nozawa, Y; Yamada, K | 1 |
| Hendey, B; Mamrack, MD | 1 |
| Farley, J; Schuman, E | 1 |
| Harmody, D; Longley, RE | 1 |
| Bell, SC; Capetola, RJ; Goodman, MG; Gupta, S; Rosenthale, ME; Weigle, WO | 1 |
| Colussi, DJ; Merkel, LA; Perrone, MH; Rivera, LM | 1 |
| Martin, DB; Pek, SB; Thomas, TP | 1 |
| Moore, JJ; Moore, RM; Vander Kooy, D | 1 |
| Beermann, ML; Shea, TB | 1 |
| Bloodgood, RA; Salomonsky, NL | 1 |
| Hoffman, R; Newlands, ES | 1 |
| Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C | 1 |
| Barnett, NL; Broyden, NJ; Morris, NJ; Osborne, NN | 1 |
| Gimbrone, MA; Hrbolich, JK; Schafer, AI; Zavoico, GB | 1 |
| Crane, DL; Elliott, MS | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Bhalla, RC; Chiang, JJ; Loeber, CP; Potts, JD; Runyan, RB; Sharma, RV | 1 |
| Métézeau, P; Pérignon, JL; Selz, F; Thuillier, L | 1 |
| Aguet, M; Ballotti, R; Mao, C; Merlin, G; Metzler, M | 1 |
| Betts, CR; Garcia, JC; Martin, KJ; Pernalete, N | 1 |
| Berton, G; Laudanna, C; Miron, S; Rossi, F | 1 |
| Angeloni, A; Barile, G; Cirone, M; Faggioni, A; Frati, L; Torrisi, MR; Venanzoni, M; Zompetta, C | 1 |
| Kato, Y; Ogawa, K; Okuda, T; Sawada, H; Tashima, M; Ueda, T; Yumoto, Y | 1 |
| Badwey, JA; Heyworth, PG | 1 |
| Cragoe, EJ; Hara, M; Inagaki, C; Inoue, M; Omori, K; Otani, H; Uriu, T | 1 |
| Dinarello, CA; Morse, C; Zucali, JR | 1 |
| Fallon, RJ | 1 |
| Ito, N; Kawata, S; Shirai, Y; Takaishi, K; Tamura, S; Tarui, S | 1 |
| Badwey, JA; Heyworth, PG; Robinson, JM | 1 |
| Pfeffer, LM; Reich, NC | 1 |
| Keller, HU | 1 |
| Dailey, MO; Jung, TM | 1 |
| Brunsing, D; Hensel, G; Krönke, M; Meichle, A; Schütze, S | 1 |
| Buckley, DJ; Cooper, DR; Farese, RV; Hoffman, JM; Ishizuka, T; Pollet, RJ; Standaert, ML | 1 |
| Augereau, JM; Gleye, J; Herbert, JM; Maffrand, JP | 1 |
| Bonser, RW; Garland, LG; Randall, RW; Spacey, GD | 1 |
| Inui, N; Semba, M | 1 |
| Sandborg, RR; Smolen, JE | 1 |
| Boscá, L; Díaz-Guerra, MJ; Junco, M | 1 |
| Lieberman, AP; Pitha, PM; Shin, ML | 1 |
| Baines, AD; Ho, P | 1 |
| Davis, PD; Elliott, LH; Hill, CH; Lawton, G; Nixon, JS; Sedgwick, AD; Wilkinson, SE | 1 |
| Herbert, JM; Maffrand, JP; Seban, E | 1 |
| Kurtz, A; Scholz, H | 1 |
| Homonnai, ZT; Kalina, M; Naor, Z; Paz, GF; Rotem, R | 1 |
| Jhaveri, S; Laurence, J; Salmon, JE; Sikder, SK | 1 |
| Levin, EG; Marotti, KR; Santell, L | 1 |
| Hamamoto, Y; Hayashida, Y; Kobayashi, N; Kobayashi, S; Tamaoki, T; Yamamoto, N | 1 |
| Bedoy, CA; Mobley, PL | 1 |
| Murayama, T; Nomura, Y; Ui, M | 1 |
| Insel, PA; Slivka, SR; Weiss, BA | 1 |
| Jacobson, D; O'Flaherty, JT | 1 |
| Arese, P; Bussolino, F; Fischer, E; Kazatchkine, MD; Turrini, F | 1 |
| Auguet, M; Braquet, P; Chabrier, PE; Delaflotte, S | 1 |
| Lamkin, GE; Lane, TA; Wancewicz, E | 1 |
| Komada, F; Nishikawa, M; Shirakawa, S; Uemura, Y | 1 |
| Katayama, N; Minami, N; Nishikawa, M; Shirakawa, S | 1 |
| Kato, Y; Mochizuki, T; Okazaki, T; Sawada, H; Tashima, M; Uchino, H | 1 |
| Osswald, H; Schächtele, C; Seifert, R | 1 |
| Bollinger, DW; Toews, ML; Turner, JT | 1 |
| Isono, K; Magae, J; Osada, H; Watanabe, C | 1 |
| Hidaka, H; Nishikawa, M; Shirakawa, S | 1 |
| Aizu, E; Kato, R; Kiyoto, I; Yamamoto, S | 1 |
| Eling, TE; Hamasaki, Y | 1 |
| Cole, OF; Elder, MG; Seki, H; Sullivan, MH | 1 |
| Betz, H; Sato, K; Schloss, P | 1 |
| Denison, MS; Madhukar, BV; Schafer, MW; Swanson, HI; Tullis, K | 1 |
| Aiyar, J; Chandy, KG; Grissmer, S | 1 |
| Craven, PA; DeRubertis, FR; Studer, RK | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| de Prost, D; Hakim, J; Khechai, F; Ollivier, V; Ramani, M; Ternisien, C; Vu, T | 1 |
| Iitaka, M; Ishii, J; Kitahama, S | 1 |
| Grant, S; Jarvis, WD; Povirk, LF; Traylor, RS; Turner, AJ | 1 |
| Benishin, CG; Ren, J | 1 |
| Fukuzawa, K; Inoue, I; Minami, K | 1 |
| Dauer, WT; Fink, JS; Hamill, LK; Hyman, SE; Lewis, SE; Schwarzschild, MA | 1 |
| Hakomori, S | 1 |
| Carter, V; Gale, M; Parsons, M | 1 |
| Di Virgilio, F; Foresta, C; Rossato, M | 1 |
| Gukovskaya, AS; Pandol, SJ | 1 |
| Cutler, RL; Krystal, G; Liu, L | 1 |
| Azuma, Y; Ishimura, Y; Kizaki, H; Onishi, Y; Suzuki, K | 1 |
| Badolato, R; Johnston, JA; Kelvin, DJ; McVicar, D; Oppenheim, JJ; Wang, JM; Xu, LL | 1 |
| Goishi, K; Higashiyama, S; Ishikawa, M; Klagsbrun, M; Mekada, E; Nakano, N; Taniguchi, N; Umata, T | 1 |
| Nishio, I; Sasajima, H; Shima, H; Toyoda, Y | 1 |
| Chen, Y; Hanazawa, S; Kitano, S; Takeshita, A; Watanabe, A | 1 |
| Aarnoudse, C; Nibbering, PH; van Furth, R; Zheng, L; Zomerdijk, TP | 1 |
| Chida, K; Kuroki, T; Tagawa, T; Vogt, PK | 1 |
| DiBattista, JA; Iwata, K; Martel-Pelletier, J; Pelletier, JP; Zafarullah, M | 1 |
| Reich, H; Sei, Y | 1 |
| Brum, RL; Calixto, JB; Silva, AM | 1 |
| Brooks, BJ; Elliott, MS; Eriotou, P; Hart, KL; Kelly, DF; Morris, RC; Sagar, S | 1 |
| Ciudad, CJ; Noé, V | 1 |
| Kopp, UC; Smith, LA | 1 |
| Ibuki, Y; Imagawa, T; Suketa, Y | 1 |
| Atkins, KB; Troen, BR | 1 |
| Abayasekara, RE; Flint, AP; Searle, MJ | 1 |
| Jeoung, DI; Sonenberg, M; Tang, B | 1 |
| Bischer, P; Cantu, AR; Pavone, A; Reiners, JJ; Schöller, A | 1 |
| Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y | 1 |
| Niedbala, MJ; Stein-Picarella, M | 1 |
| Abraham, RT; Lutz, MP; Miller, LJ; Sutor, SL | 1 |
| Matsuura, M; Nakano, M; Nakano, Y; Saito, S; Shinomiya, H; Yamasu, H | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Alling, C; Larsson, C; Simonsson, P | 1 |
| Arai, T; Irino, S; Kawanishi, K; Kiuchi, H; Takahara, J; Tanaka, T; Taoka, T; Yamaoka, G | 1 |
| Fujimoto, T; McEver, RP | 1 |
| Evans, SW; Thompson, D; Whicher, JT | 1 |
| Dehaye, JP; Turner, RJ; Valdez, IH | 1 |
| Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ | 1 |
| Ha, H; Kim, KH; Yoon, SJ | 1 |
| Distler, A; Haller, H; Lindschau, C; Luft, FC; Quass, P | 1 |
| Honda, Z; Kurokawa, K; Shimizu, T; Waga, I; Watanabe, T | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Lutz, EM; Mitchell, R; Simpson, J | 1 |
| Black, JL; Yang, KX | 1 |
| Terrian, DM; Ways, DK | 1 |
| Basu, U; Bennett, GS; Hollander, BA; Quintana, R; Rodriguez, R | 1 |
| Chen, SP; Fu, WM; Wang, SM | 1 |
| Arthur, JM; Hartle, JE; Middleton, JP; Quarles, LD; Raymond, JR; Zhang, J | 1 |
| Burns, P; Chatterjee, S; Koga, J | 1 |
| Kawase, Y; Min, KR; Mue, S; Ohuchi, K; Tanabe, J; Watanabe, M | 1 |
| Gealy, R; Levitan, ES; Takimoto, K | 1 |
| Vietor, I; Vilcek, J | 1 |
| Dixon, SJ; Gallinaro, BJ; Reimer, WJ | 1 |
| Chiu, R; Evans, RM; Gachelin, G; Kitabayashi, I; Umesono, K; Yokoyama, K | 1 |
| Armstrong, DK; Davidson, NE; Ito, T; May, WS; Qatsha, KA; Tyler, PG | 1 |
| Benítez-King, G; Carbajal, ME; Meza, I; Santiago, A | 1 |
| Hirobe, T | 1 |
| Bernhard, EJ; Maity, A; McKenna, WG; Muschel, RJ | 1 |
| Onozuka, M; Watanabe, K | 1 |
| Huang, RW; Takatsuki, K; Tsuda, H | 1 |
| Takano, S | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Patel, MS; Sahai, A; Tannen, RL; Zavosh, AS | 1 |
| Arola, J; Heikkilä, P; Kahri, AI; Voutilainen, R | 1 |
| Burighel, P; Citi, S; Denisenko, N | 1 |
| Bonin, L; Chen, B; Griffith, OH; Hedberg, K; Mobley, PL | 1 |
| Bers, DM; Yuan, W | 1 |
| Abraham, I; Sampson, KE; Wolf, CL | 1 |
| Audette, M; Bouillon, M | 1 |
| Andersen, CB; Hansen, AB | 1 |
| Skoglund, G | 1 |
| Andersen, CB; Bouchelouche, PN; Giese, BN; Hansen, AB | 1 |
| Gabrielian, K; Hinton, DR; Ryan, SJ; Sakamoto, H; Sakamoto, T; Sheu, SJ | 1 |
| Chaki, S; Muramatsu, M; Otomo, S | 1 |
| ffrench-Mullen, JM; Plata-Salamán, CR | 1 |
| Terranova, PF; Zachow, RJ | 1 |
| Auger, EA; Chen, EY; Giaccia, AJ; Koong, AC | 1 |
| Black, SC; Chi, L; Fagbemi, SO; Friedrichs, GS; Lucchesi, BR | 1 |
| Kahri, A; Liu, J; Teppo, AM; Voutilainen, R | 1 |
| Kimura, I; Kimura, M; Nojima, H | 1 |
| Kubota, C; Murata, Y; Shinagawa, T; Shinohara, O | 1 |
| Hertelendy, F; Jamaluddin, M; Marrone, BL; Molnár, M | 1 |
| Kume, S; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Adamson, S; Coulam, C; Edwin, SS; LaMarche, S; Mitchell, MD; Silver, RM | 1 |
| Combadière, C; el Benna, J; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Larsen, TH; Lillehaug, JR; Myking, O; Saetersdal, T | 1 |
| Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB | 1 |
| Boniece, IR; Maiese, K; Skurat, K; Wagner, JA | 1 |
| Gali, RR; Khandelwal, RL; Pugazhenthi, S | 1 |
| Horio, T; Ikeda, M; Johchi, M; Kohno, M; Kurihara, N; Takeda, T; Yasunari, K | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Fox, WM; Korach, KS; Migliaccio, S; Washburn, TF; Wetsel, WC | 1 |
| Schrier, RW; Williams, B | 1 |
| Hosono, T; Ito, A; Mori, Y; Nagase, H; Ojima, Y; Sato, T; Takahashi, S | 1 |
| Johnson, MS; Mitchell, R; Simpson, J | 1 |
| Endoh, M; Kasai, H; Norota, I; Takanashi, M | 1 |
| Benistant, C; Gustavsson, L; Hoek, JB; Moehren, G; Rubin, R; Torres-Marquez, ME | 1 |
| Hakomori, S; Igarashi, Y; Mazurek, N; Megidish, T | 1 |
| Mitchell, MD; Pollard, JK | 1 |
| Pavlotsky, N; Tauber, AI; Wang, JS; Zaner, KS | 1 |
| Dana, R; Leto, TL; Levy, R; Malech, HL | 1 |
| Fukushima, D; Ishiura, S; Konishi, M; Maruyama, K; Miyamoto, T; Suzuki, K | 1 |
| Souhrada, JF; Souhrada, M | 1 |
| Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH | 1 |
| Cunningham, GR; House, FS; Stewart, SJ | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R | 1 |
| Collins, JL; Manning, K; Powell, CB | 1 |
| Abadie, A; Amirand, C; Dugas, B; Kolb, JP; Tran, PL | 1 |
| Aste, M; Calzetti, F; Cassatella, MA; Ceska, M; Constantin, G; Guasparri, I; Rossi, F | 1 |
| Haraoka, M; Kubo, S; Kumazawa, J; Matsumoto, T; Nagafuji, T; Ogata, N; Takahashi, K; Tanaka, M | 1 |
| Larsson, C; Simonsson, P | 1 |
| Ishikawa, Y; Ogawa, A; Sasakawa, S | 1 |
| Kim, HD; Lim, RW; Park, DJ | 1 |
| Garg, LC; Mohuczy-Dominiak, D; Saha, PK | 1 |
| Ayuso, MS; Butta, N; Ciprés, G; Manchón, CG; Parrilla, R; Requero, AM; Urcelay, E | 1 |
| Boniece, IR; Wagner, JA | 1 |
| Beppu, T; Hong, SK; Horinouchi, S; Matsumoto, A | 1 |
| Nozawa, Y; Sakai, N; Yamada, H; Zhang, W | 1 |
| Ginsberg, J; Matowe, W; Murray, PG | 1 |
| Carpentier, G; Climent, F; Lagord, C; Martelly, I; Moraczewski, J; Pons, G | 1 |
| Benzing, CF; Kono, T; Robinson, FW; Sumida, Y; Yano, Y | 1 |
| Bayat-Sarmadi, M; Houdebine, LM | 1 |
| Kitamura, Y; Miyazaki, A; Nomura, Y | 1 |
| Bousquet, C; Cassar, G; Colombies, P; Dastugue, N; Demur, C; Jaffrézou, JP; Laredo, J; Laurent, G; Muller, C; Saivin, S | 1 |
| Maurer, JA; McKay, DB; Wenger, BW | 1 |
| Greenwel, P; Hu, W; Kohanski, RA; Ramirez, F | 1 |
| Geberhiwot, T; Skoglund, G | 1 |
| Fleer, A; Mattsson, E; Rollof, J; Van Dijk, H; Van Kessel, K; Verhoef, J | 1 |
| Kubo, S; Kumazawa, J; Matsumoto, T; Nagafuji, T; Takahashi, K | 1 |
| DelValle, J; Osburn, J; Wang, L; Wilson, EJ | 1 |
| Jost, E; Leukel, M | 1 |
| Duty, L; Gorelik, E; Kim, M; Prezioso, JA; Tweardy, DJ; Wang, J | 1 |
| Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R | 1 |
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| Hakomori, S; Igarashi, Y; Sakakura, C; Shirahama, T; Sweeney, EA | 1 |
| Chalfant, ML; Civan, JM; Civan, MM; DiBona, DR; O'Brien, TG; Peterson-Yantorno, K | 1 |
| Chock, PB; Huang, CY; Tekle, E; Zhu, DM | 1 |
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| Nishizawa, S; Uemura, K; Yamamoto, S | 1 |
| Chang, B; Chang, WC; Jen, CJ; Lin, MT; Shi, GY; Tasi, CF; Wang, SJ; Wing, LY; Wu, HL | 1 |
| Chakravarthy, BR; Mealing, GA; Morley, P; Tsang, BK; Whitfield, JF | 1 |
| Moreland, RS; Rokolya, A; Walsh, MP | 1 |
| Frindt, G; Palmer, LG; Windhager, EE | 1 |
| Gerritsen, ME; Moatter, T | 1 |
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| Atabay, C; Cagnoli, CM; Kharlamov, E; Manev, H; Uz, T | 1 |
| Denger, S; Jahn, L; Kreuzer, J; Merten, M; Schmidts, A; von Hodenberg, E | 1 |
| Fujimoto, S; Satake, N; Shibata, S | 1 |
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| Itai, A; Takagi, A; Tomioka, N; Yamada Mizutani, M | 1 |
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| Aiuchi, T; Masuda, Y; Nakajo, S; Nakaya, K; Ohizumi, H; Watabe, M; Yoda, M | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Miyamoto, K; Nomura, M; Sugiura, N; Yamamoto, H | 1 |
| Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H | 1 |
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| Agranoff, BW; Heacock, AM | 1 |
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| McCaig, C; Rajnicek, A | 1 |
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| Chan, JS; Wang, TT; Wu, XH; Zhang, SL | 1 |
| Altura, BM; Altura, BT; Li, W; Zhang, A; Zheng, T | 1 |
| Kodama, H; Sagara, Y; Sugahara, K; Yasuda, K; Zhang, J | 1 |
| Eguchi, T; Ishida, H; Ishikawa, Y; Skowronski, MT | 1 |
| Sakurada, K; Sasaki, Y; Seto, M | 1 |
| Allert, N; Köller, H; Oel, D; Siebler, M; Stoll, G | 1 |
| Kandaswamy, V; Sen, S; Sil, P | 1 |
| Himmelreich, NH; Pozdnyakova, NG; Storchak, LG | 1 |
| Bergelson, LD; Krifuks, O; Schlesinger, M | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
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| Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS | 1 |
| Ciereszko, RE; Guan, Z; Ottobre, AC; Ottobre, JS; Petroff, BK; Stokes, BT | 1 |
| Cheng, CP; Little, WC; Ohte, N; Suzuki, M; Wang, ZM; Williams, DL | 1 |
| Gebert, CA; Park, SH; Waxman, DJ | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
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| Chong, YH; Lee, MJ | 2 |
| Andersson, T; Axelsson, L; Hellberg, C; Ydrenius, L | 1 |
| Greger, R; Henger, A; Mundel, P; Nitschke, R; Pavenstädt, H; Rüdiger, F | 1 |
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| Kim, JY; Lee, SH; Moon, CH; Woo, HG | 1 |
| Ardenghi, P; Barros, DM; Izquierdo, I; Izquierdo, LA; Medinam, JH; Mello e Souza, T; Rodrigues, C; Sant'Anna, MK; Vianna, M | 1 |
| Bhattacharya, A; Chandok, MR; Deswal, R; Pandey, GK; Sopory, SK; Yadav, N | 1 |
| Fukushima, A; Hashida, M; Kodama, H; Ueno, H; Zhang, J | 1 |
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| Böhmer, FD; Bosch, TC; Cardenas, M; Cerbon, J; Fabila, YV; Fujisawa, T; Salgado, LM; Wetzker, R; Yum, S | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Ferrer, I; López, E | 1 |
| Chen, H; Fetscher, C; Heusch, G; Michel, MC; Schäfers, RF; Wambach, G | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
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| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
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| Chung, IK; Jin, E; Kim, WT; Yang, SW | 1 |
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| Coleman, R; Elias, E; Milkiewicz, P; Roma, MG | 1 |
| Chang, YC; Hsieh, YS; Lai, CC; Liu, JY; Yang, SF | 1 |
| Gimbrone, MA; Masuda, J; Ochi, H | 1 |
| Clark, CL; Martin, RJ; Robertson, AP; Trailovic, SM | 1 |
| Bauer, J; Parekh, N | 1 |
| Chang, YC; Chou, MY; Hsieh, YS; Tsai, CH; Yang, SF | 1 |
| Bishop, GA; Haxhinasto, SA | 1 |
| Chandra, H; Chopra, P; D'Souza, RC; Gupta, PK; Meena, LS; Narayan, A; Pathak, M; Ramachandran, S; Sharma, K; Singh, Y | 1 |
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| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Chen, S; Dul, E; Hu, E; Khandekar, SS; Kirkpatrick, RB; Lee, D; Scott, GF; Smith, GK; Wright, LL; Yi, T | 1 |
| Ayalew, S; Chintagari, NR; Hartson, SD; Liu, L; Mishra, A; Su, L; Wang, Y | 1 |
| Chieng, YC; Hoon, LS; Hsum, YW; Mooi, LY; Soo, KK; Yew, WT | 1 |
| Barcomb, K; Bayer, KU; Coultrap, SJ | 1 |
1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and staurosporine
| Article | Year |
|---|---|
Intracellular protein phosphorylation in murine peritoneal macrophages in response to bacterial lipopolysaccharide (LPS): effects of kinase-inhibitors and LPS-induced tolerance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytoskeletal Proteins; Isoquinolines; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C3H; Microfilament Proteins; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Immunologic; Signal Transduction; Staurosporine | 1993 |
423 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and staurosporine
| Article | Year |
|---|---|
Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Insulin Antagonists; Isoquinolines; Lactates; Lactic Acid; Male; Muscles; Organ Culture Techniques; Piperazines; Polymyxin B; Protein Kinase C; Rats; Rats, Wistar; Receptor, Insulin; Staurosporine | 1992 |
Calcium-regulated phosphorylation of proteins in the membrane-matrix compartment of the Chlamydomonas flagellum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Chlamydomonas; Electrophoresis; Flagella; Isoquinolines; Membrane Glycoproteins; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine | 1992 |
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcimycin; Cyclic AMP; Egtazic Acid; Isoquinolines; Mice; Neurites; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface; Receptors, Thrombin; Staurosporine; Thrombin; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Endothelins; GTP-Binding Proteins; Isoquinolines; Male; Mice; Piperazines; Receptors, Cell Surface; Receptors, Endothelin; Staurosporine; Stem Cells | 1992 |
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Erythropoiesis; Erythropoietin; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinases; Protein Tyrosine Phosphatases; Signal Transduction; Staurosporine; Vanadates; Zinc | 1992 |
Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Carrier Proteins; Cell Death; Clone Cells; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Isoquinolines; Kinetics; Leukemia, Megakaryoblastic, Acute; Piperazines; Protein Kinase C; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoquinolines; Liver Neoplasms; Oxygen; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured | 1992 |
Stimulatory effect of vanadate on 3',5'-cyclic guanosine monophosphate-inhibited low Michaelis-Menten constant 3',5'-cyclic adenosine monophosphate phosphodiesterase activity in isolated rat fat pads.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Alkaloids; Amiloride; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Insulin; Isoquinolines; Kinetics; Male; Microsomes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Staurosporine; Vanadates | 1992 |
Phorbol ester-induced changes in rat hippocampal glycoprotein fucosylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Fucose; Glycoproteins; Hippocampus; In Vitro Techniques; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Rats; Staurosporine | 1992 |
Effect of protein kinase inhibitors on ACTH-stimulated aldosterone production in rat zona glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenocorticotropic Hormone; Aldosterone; Alkaloids; Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Staurosporine; Trifluoperazine; Zona Glomerulosa | 1992 |
Effect of protein kinase C inhibitors with different action mechanisms on Epstein-Barr virus replication.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; DNA, Viral; Herpesvirus 4, Human; Isoquinolines; Nucleic Acid Hybridization; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
Involvement of a protein kinase C and protein phosphatases in adhesion of CD4+ T cells to and detachment from extracellular matrix proteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; CD4 Antigens; Cell Adhesion; Cell Movement; Ethers, Cyclic; Fibronectins; Humans; Integrins; Isoquinolines; Laminin; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes | 1992 |
The long-term combined stimulatory effects of ethanol and phorbol ester on phosphatidylethanolamine hydrolysis are mediated by a phospholipase C and prevented by overexpressed alpha-protein kinase C in fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Enzyme Activation; Ethanol; Ethanolamines; Ethers, Cyclic; Fibroblasts; Hydrolysis; Isoenzymes; Isoquinolines; Mice; Mice, Inbred BALB C; Okadaic Acid; Phosphatidylethanolamines; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta, Thoracic; Biological Factors; Bucladesine; Cell Division; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fibronectins; Isoquinolines; Kinetics; Macromolecular Substances; Muscle, Smooth, Vascular; Pertussis Toxin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Wistar; Recombinant Proteins; Second Messenger Systems; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Virulence Factors, Bordetella | 1992 |
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Colforsin; Humans; Immunohistochemistry; Isoquinolines; Nervous System Neoplasms; Neurites; Neuroblastoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tumor Cells, Cultured | 1992 |
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida | 1992 |
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Alkaloids; Animals; Calcium; Carbohydrate Sequence; Cell Adhesion; Colon; Colonic Neoplasms; Entamoeba histolytica; Enzyme Activation; Humans; Intestinal Mucosa; Isoquinolines; Lectins; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Sequence Data; Mucins; Neoplasm Proteins; Piperazines; Protein Kinase C; Protozoan Proteins; Secretory Rate; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cell Adhesion Molecules; Cell Survival; Cytokines; Drug Synergism; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Ionomycin; Isoquinolines; Lipopolysaccharides; Piperazines; Protein Biosynthesis; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Role of protein kinase-C in thymocyte apoptosis induced by irradiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Death; DNA; DNA Damage; In Vitro Techniques; Interphase; Isoquinolines; Mice; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes | 1992 |
Roles of protein kinase C and G proteins in activation of murine resting B lymphocytes by endotoxin-associated protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Bacterial Proteins; DNA Replication; Dose-Response Relationship, Drug; Endotoxins; Female; GTP-Binding Proteins; Isoquinolines; Lipid A; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Pertussis Toxin; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA; Staurosporine; Sulfonamides; Virulence Factors, Bordetella | 1992 |
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Amino Acid Sequence; Biological Transport; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Eye Proteins; Humans; Immunoglobulin G; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; Naphthalenes; Phagocytosis; Phagosomes; Piperazines; Polycyclic Compounds; Protein Kinase C; Rod Opsins; Signal Transduction; Staurosporine; Sulfonamides | 1992 |
Effects of inhibitors of protein kinase C on the release and synthesis of histamine in rat basophilic leukemia cells (2H3).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basophils; Calcium; Histamine Release; Histidine Decarboxylase; Isoquinolines; Leukemia, Experimental; Piperazines; Protein Kinase C; Rats; Staurosporine; Tumor Cells, Cultured | 1992 |
Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzimidazoles; Calmodulin; Coronary Disease; Heart; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Naphthalenes; Piperazines; Polycyclic Compounds; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Trifluoperazine | 1992 |
Neutrophil priming by granulocyte colony stimulating factor and its modulation by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cinnamates; Genistein; Granulocyte Colony-Stimulating Factor; Humans; Isoflavones; Isoquinolines; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfides; Superoxides | 1992 |
Proliferation of human and mouse astrocytes in vitro: signalling through the protein kinase C pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Astrocytes; Cell Division; Cells, Cultured; Humans; Isoquinolines; Mice; Mitogens; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine | 1992 |
Protein kinase C-dependent and -independent actions of a potent protein kinase C inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epidermal Cells; Epidermis; Indomethacin; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
[Sulfolipids and glycolipid sulfotransferases in a human renal cell carcinoma cell line].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Renal Cell; Epidermal Growth Factor; Humans; Isoquinolines; Kidney Neoplasms; Lipid Metabolism; Lipids; Piperazines; Protein Kinase C; Staurosporine; Sulfotransferases; Sulfurtransferases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cysteine; Dose-Response Relationship, Drug; Endotoxins; Humans; Isoquinolines; Kinetics; Lipopolysaccharides; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Staurosporine; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Transcriptional activation of c-fos and c-jun protooncogenes by serum growth factors in osteoblast-like MC3T3-E1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Cell Differentiation; Cycloheximide; Dactinomycin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Growth Substances; Insulin-Like Growth Factor I; Isoquinolines; Mice; Osteoblasts; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Staurosporine; Transforming Growth Factor beta | 1992 |
Cellular interactions with the extracellular matrix are coupled to diverse transmembrane signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calmodulin; Cell Adhesion; Collagen; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Humans; Isoquinolines; Laminin; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1992 |
Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Base Sequence; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Interferon-gamma; Interleukin-1; Isoquinolines; Lipopolysaccharides; Molecular Sequence Data; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Second Messenger Systems; Staurosporine; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1992 |
Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cell Line; Cell Nucleus; Cells, Cultured; Enhancer Elements, Genetic; HIV-1; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; NF-kappa B; Oligonucleotide Probes; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
Reversible G1 arrest of a human lung epithelial cell line by staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; G1 Phase; Genistein; Humans; Isoflavones; Isoquinolines; Phenols; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides | 1992 |
Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Egtazic Acid; Endothelium, Vascular; Gene Expression Regulation; Guanosine Diphosphate; Humans; Ibuprofen; Indomethacin; Isoquinolines; Neomycin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Stress, Mechanical; Sulfonamides; Transcriptional Activation | 1992 |
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases | 1992 |
Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Survival; DNA; DNA Damage; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Radiation; Down-Regulation; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; Radiation-Sensitizing Agents; Staurosporine; Tumor Cells, Cultured | 1992 |
A role for protein kinase C in the growth of human erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bone Marrow Cells; Cell Division; Erythroid Precursor Cells; Erythropoiesis; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Recombinant Proteins; Staurosporine; Sulfonamides | 1992 |
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Azepines; Calcium; Cell Communication; Cell Line; Dogs; Egtazic Acid; Epithelium; Fluorescent Antibody Technique; Intercellular Junctions; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides | 1992 |
Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Interleukin-1; Interleukin-2; Interleukin-4; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured | 1992 |
Effect of protein kinase C inhibitors on Cl- conductance required for volume regulation after L-alanine cotransport.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Absorption; Alanine; Alkaloids; Animals; Anions; Biological Transport; Cells, Cultured; Chlorides; Diglycerides; Electric Conductivity; Intestinal Mucosa; Intestines; Isoquinolines; Microvilli; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine | 1992 |
Development and characterization of a protein kinase C beta-isozyme-deficient T-cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Flow Cytometry; Humans; Interleukin-2; Isoenzymes; Isoquinolines; Phenotype; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1992 |
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Enzyme Activation; Glutathione; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1992 |
Disruption of endothelial actin microfilaments by protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cell Count; Cells, Cultured; Endothelium, Vascular; Image Processing, Computer-Assisted; Isoquinolines; Phalloidine; Piperazines; Protein Kinase C; Rhodamines; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1992 |
Regulation of inositol transport by glucose and protein kinase C in mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport, Active; Cells, Cultured; Glomerular Mesangium; Glucose; Hyperglycemia; Inositol; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Effects of protein kinase inhibitors on regeneration in vitro of adult frog sciatic sensory axons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Alkaloids; Animals; Axons; Cell Division; Immunohistochemistry; In Vitro Techniques; Isoquinolines; Nerve Regeneration; Neurons, Afferent; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Rana temporaria; Schwann Cells; Sciatic Nerve; Staurosporine | 1992 |
Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Epidermis; Epinephrine; Histamine; Isoquinolines; Pertussis Toxin; Piperazines; Receptors, Adrenergic, beta; Receptors, Histamine; Skin; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Bumetanide; Carrier Proteins; Endothelins; Isoquinolines; Male; Membrane Proteins; Ouabain; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Rubidium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine | 1991 |
Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; CD4 Antigens; Cyclic AMP; Down-Regulation; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1991 |
ATP gamma S activates the respiratory burst in electropermeabilized neutrophils: the role of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Superoxides | 1991 |
Modulation of rat skeletal muscle chloride channels by activators and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Chloride Channels; Chlorides; Isoquinolines; Male; Membrane Proteins; Muscles; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetrahydropapaveroline | 1991 |
Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzoquinones; Cells, Cultured; Cyclic AMP; Cytoplasm; Fusion Proteins, bcr-abl; Isoquinolines; Lactams, Macrocyclic; Oncogene Protein pp60(v-src); Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine | 1991 |
Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Cells, Cultured; Glucose; Hypoglycemia; Insulin; Insulin Resistance; Isoquinolines; Male; Phosphorylation; Piperazines; Polymyxin B; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Survival; Histamine Release; Immunoglobulin E; Isoquinolines; Leukotrienes; Mast Cells; Piperazines; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cholecystokinin; In Vitro Techniques; Isoquinolines; Pancreas; Piperazines; Protein Kinase C; Rabbits; Secretory Rate; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Pharmacologic evidence for the requirement of protein kinase C in IFN-induced macrophage Fc gamma receptor and Ia antigen expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Differentiation; Calcium; Cells, Cultured; Histocompatibility Antigens Class II; Interferons; Isoquinolines; Macrophages; Mice; Mice, Inbred C3H; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Staurosporine | 1990 |
Effects of H7 and staurosporine on cytosolic free calcium and amylase secretion in rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Carbachol; Cytosol; Isoquinolines; Kinetics; Male; Pancreas; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Cell Compartmentation; E-Selectin; Endothelium, Vascular; Enzyme Activation; Histocompatibility Antigens Class I; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Phosphoproteins; Piperazines; Protein Biosynthesis; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcimycin; Carbachol; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzymes; Isoquinolines; Lipase; Nucleic Acid Hybridization; Pancreas; Pancreatic Elastase; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Chloride channel regulation in the skeletal muscle of normal and myotonic goats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Membrane Permeability; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Electric Conductivity; Female; Goats; Ion Channels; Isoquinolines; Male; Membrane Potentials; Muscles; Myotonia; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine; Tetrahydropapaveroline | 1991 |
Regulation of Na(+)-Ca2+ exchange in cultured human mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Calcium; Cell Line; Culture Media; Endothelins; Fura-2; Glomerular Mesangium; Gramicidin; Homeostasis; Humans; Insulin; Ionophores; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Sodium; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1991 |
Protein kinase C-dependent diacylglycerol formation is mediated via Ca2+/calmodulin in parotid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Calmodulin; Carbachol; Diglycerides; Isoquinolines; Lanthanum; Male; Parotid Gland; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Sulfonamides; Verapamil | 1991 |
Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Astrocytoma; Dactinomycin; Glial Fibrillary Acidic Protein; Humans; Isoquinolines; Piperazines; Protein Kinase C; RNA; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Effects of some inorganic divalent cations and protein kinase C inhibitors on endothelium-dependent relaxation in rat isolated aorta and mesenteric arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Alkaloids; Animals; Aorta, Thoracic; Calcium; Cations, Divalent; Endothelium, Vascular; Histamine; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Nitroprusside; Norepinephrine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine | 1991 |
Pharmacological analysis of the positive inotropic effect of endothelin-1 in guinea pig left atria.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atrial Function; Electric Stimulation; Endothelins; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Inositol; Isoquinolines; Male; Myocardial Contraction; Myocardium; Nifedipine; Phosphatidylinositols; Piperazines; Staurosporine; Stimulation, Chemical | 1991 |
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa | 1991 |
Secretion of IL-1: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Biological Transport; Cell Compartmentation; Cell Membrane; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Interleukin-1; Isoenzymes; Isoquinolines; Lipopolysaccharides; Liposomes; Monocytes; Piperazines; Protein Kinase C; Staurosporine | 1992 |
c-myc is an erythropoietin early response gene in normal erythroid cells: evidence for a protein kinase C-mediated signal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Erythroid Precursor Cells; Erythropoietin; Gene Expression; Genes, myc; Isoquinolines; Mice; Mice, Inbred C57BL; Phenylhydrazines; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; Signal Transduction; Spleen; Staurosporine; Transcription, Genetic | 1992 |
Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Concanavalin A; Cross-Linking Reagents; Diterpenes; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Isoquinolines; Kinetics; Lymphocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Phytohemagglutinins; Piperazines; Precipitin Tests; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Northern; Blotting, Western; DNA; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; HeLa Cells; Humans; Interferon-gamma; Isoquinolines; Kinetics; Mice; Phosphorylation; Piperazines; RNA, Messenger; Staurosporine; Sulfonamides; Thymidine; Tumor Necrosis Factor-alpha | 1992 |
Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Line; Chlorides; Colon; Humans; Intestinal Mucosa; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase Inhibitors; Rubidium; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Adhesion; Isoquinolines; Lung Neoplasms; Melanoma, Experimental; Membrane Proteins; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oxazoles; Oxazolone; Phosphorylation; Piperazines; Protein Kinase C; Pyridines; Staurosporine; Time Factors | 1992 |
Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Diterpenes; Fibroblasts; Humans; Interleukin-1; Isoquinolines; Lyngbya Toxins; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cell Line; Enzyme Activation; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Isoquinolines; Kinetics; Leukemia, Myeloid; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; RNA, Messenger; RNA, Neoplasm; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Signal transduction in endotoxin-stimulated synthesis of TNF-alpha and prostaglandin E2 by rat Kupffer cells. Role of extracellular calcium ions and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Dinoprostone; Egtazic Acid; Endotoxins; Interferon-gamma; Isoquinolines; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; Salmonella; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1991 |
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Membrane; Clone Cells; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Isoquinolines; Leukemia, Myeloid; Lipid Metabolism; Piperazines; Protein Kinase C; Staurosporine; Streptolysins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
Prostacyclin secretion and specific intracellular protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Heat-Shock Proteins; Hot Temperature; Isoquinolines; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Secretory Rate; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1991 |
GM-CSF and phorbol esters modulate GM-CSF receptor expression by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Down-Regulation; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Phorbol 12,13-diacetate-induced contraction of the canine basilar artery: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Cyclic GMP; Dinoprost; Dogs; Endothelins; Enzyme Activation; Female; Imidazoles; Isoquinolines; Male; Muscle Contraction; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Quinacrine; Serotonin; Staurosporine | 1991 |
Protein kinase C and phospholipase C mediate alpha 1- and beta-adrenoceptor intercommunication in rat hypothalamic slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cyclic AMP; Enzyme Activation; Estradiol; Female; Hypothalamus; Isoproterenol; Isoquinolines; Ovariectomy; Phenylephrine; Phospholipases A; Phospholipases A2; Piperazines; Preoptic Area; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Staurosporine; Type C Phospholipases | 1991 |
Protein kinase C is not involved in alpha 1-adrenoceptor-mediated positive inotropic effect.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electric Conductivity; Hydrolysis; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1991 |
Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Calcium; Enzyme Activation; Isoquinolines; Lymphocyte Activation; Mice; Mice, Inbred DBA; Phorbol 12,13-Dibutyrate; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperazines; Protein Kinase C; Staurosporine; Time Factors | 1991 |
Sphingosine inhibits angiotensin-stimulated aldosterone synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Angiotensin II; Animals; Bucladesine; Cattle; Cells, Cultured; Isoquinolines; Ouabain; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Zona Glomerulosa | 1991 |
Staurosporine inhibits the soluble and membrane-bound protein tyrosine kinases of human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Cytosol; Humans; Isoquinolines; Kinetics; Neutrophils; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine | 1991 |
Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Cyclosporins; DNA; Enzyme Activation; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Platelet-Derived Growth Factor; Prolactin; Protein Kinase C; Receptors, Prolactin; Sphingosine; Staurosporine; Thymidine; Tritium | 1991 |
[Inhibitors of growth factor functions, possible antineoplastic agents].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomyces; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Genistein; Isoflavones; Isoquinolines; Mice; Phenols; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine | 1991 |
Suppression by staurosporine of Ca(2+)-mobilization triggered by ligation of antigen-specific receptors on t and B lymphocytes. An essential role of protein tyrosine kinase in the signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Bombesin; Calcium; Cell Line; Dinoprost; Genistein; Humans; Isoflavones; Isoquinolines; Piperazines; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; T-Lymphocytes; Type C Phospholipases; Vasopressins | 1991 |
Effect of protein kinase C modulation on outcome of experimental CNS ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Diglycerides; Ischemia; Isoquinolines; Molecular Sequence Data; Piperazines; Prognosis; Protein Kinase C; Rabbits; Spinal Cord; Staurosporine | 1991 |
Carbachol-stimulated phosphorylation of a 170-kDa endogenous protein in avian salt gland cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Ducks; Ionomycin; Isoquinolines; Kinetics; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Proteins; Salt Gland; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Protein kinase C in tumoricidal activation of mouse macrophage cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cytotoxicity, Immunologic; Diglycerides; Enzyme Activation; Female; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Mast-Cell Sarcoma; Mice; Mice, Inbred BALB C; Phosphatidylserines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cells, Cultured; DNA-Binding Proteins; Fetus; Gene Expression; Growth Hormone; Isoquinolines; Mice; Molecular Sequence Data; Oligonucleotide Probes; Oncogene Protein p65(gag-jun); Oncogenes; Osteoblasts; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Recombinant Proteins; Retroviridae Proteins, Oncogenic; Signal Transduction; Staurosporine; Transcription Factors | 1991 |
Cellular mechanism of endothelin-1 release by angiotensin and vasopressin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Endothelins; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoquinolines; Neomycin; Nicardipine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Stimulation of synthesis de novo of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human promyelocytic leukaemia (HL-60) cells by phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Dimethyl Sulfoxide; Dinoprostone; Enzyme Activation; Enzyme Induction; Humans; Hydroxyprostaglandin Dehydrogenases; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; NAD; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Diglycerides; Dogs; Ischemic Attack, Transient; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Staurosporine; Vasodilation | 1991 |
Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Ethers, Cyclic; Glycogen Synthase Kinase 3; Isoquinolines; Mice; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Phosphoproteins; Piperazines; Protein Kinase C; Protein Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Role of endothelin 1 in regulating rabbit airway contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Dinoprostone; Endothelins; Epithelium; Epoprostenol; In Vitro Techniques; Indomethacin; Isometric Contraction; Isoquinolines; Kinetics; Muscle, Smooth; Piperazines; Protein Kinase Inhibitors; Rabbits; Reference Values; Staurosporine; Sulfonamides; Trachea | 1991 |
Antigen-induced phospholipase D activation in rat mast cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Helminth; Ascaris; Enzyme Activation; Enzyme Induction; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Mast Cells; Myristic Acid; Myristic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
WS-1 human fibroblasts contain distinct calcium and protein kinase C-mediated pathways for activation of Na+/H+ exchange: contrasting effects of thrombin and PMA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Biological Transport; Calcium; Cells, Cultured; DNA Replication; Enzyme Activation; Fibroblasts; Humans; Hydrogen; Hydrogen-Ion Concentration; Isoquinolines; Piperazines; Protein Kinase C; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Electric Stimulation; In Vitro Techniques; Isoquinolines; Microelectrodes; Nervous System Physiological Phenomena; Photoreceptor Cells; Piperazines; Protein Kinase C; Snails; Sphingosine; Staurosporine | 1991 |
A rapid colorimetric microassay to detect agonists/antagonists of protein kinase C based on adherence of EL-4.IL-2 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carcinogens; Cell Adhesion; Colorimetry; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Isoquinolines; Lactams; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Reproducibility of Results; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibody Formation; Antigens, CD; Cell Division; Concanavalin A; Dose-Response Relationship, Drug; Female; Guanosine; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunophenotyping; In Vitro Techniques; Isoquinolines; Lymphocytes; Male; Middle Aged; Piperazines; Pokeweed Mitogens; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Staurosporine | 1991 |
Protein kinase C and vascular smooth muscle contractility: effects of inhibitors and down-regulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Depression, Chemical; Dogs; Down-Regulation; Female; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Staurosporine; Vasoconstriction | 1991 |
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Protein kinase-C activation is required for oxytocin-induced prostaglandin production in human amnion cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Calcium; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Isoquinolines; Oxytocin; Phorbol Esters; Piperazines; Pregnancy; Protein Kinase C; RNA, Messenger; Staurosporine; Time Factors; Type C Phospholipases | 1991 |
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Axons; Cell Differentiation; Colchicine; Cycloheximide; Humans; Isoquinolines; Microtubules; Neuroblastoma; Neurons; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1991 |
Regulation of flagellar glycoprotein movements by protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Chlamydomonas; Flagella; Isoquinolines; Membrane Glycoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Staurosporine | 1991 |
Role of protein kinase C in adriamycin-induced erythroid differentiation of K562 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Division; Cell Line; Culture Techniques; Doxorubicin; Erythroid Precursor Cells; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Protein kinase C (alpha and beta) immunoreactivity in rabbit and rat retina: effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Aging; Alkaloids; Animals; Antibodies, Monoclonal; Cell Membrane; Cytosol; Fluorescent Antibody Technique; In Vitro Techniques; Isoenzymes; Isoquinolines; Kinetics; Phorbol Esters; Piperazines; Protein Kinase C; Quisqualic Acid; Rabbits; Rats; Retina; Sphingosine; Staurosporine | 1991 |
Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acids; Calcimycin; Cells, Cultured; Dinoprost; Dinoprostone; Endothelium, Vascular; Epoprostenol; Humans; Ionomycin; Isoquinolines; Phorbol Esters; Phospholipases A; Phospholipases A2; Piperazines; Platelet Activating Factor; Prostaglandin D2; Prostaglandins H; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Protein kinase C modulation of queuine uptake in cultured human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cells, Cultured; Diglycerides; Enzyme Activation; Fibroblasts; Growth Substances; Guanine; Humans; In Vitro Techniques; Isoquinolines; Male; Phorbol Esters; Phosphatidylserines; Piperazines; Protein Kinase C; Sphingosine; Staurosporine | 1990 |
Fluoride-mediated activation of the respiratory burst in electropermeabilized neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Cell Membrane Permeability; Fluorides; GTP-Binding Proteins; Guinea Pigs; Hydrogen Peroxide; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Signal transduction of a tissue interaction during embryonic heart development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Chick Embryo; Cholera Toxin; Endothelium; Enzyme Activation; Extracellular Matrix Proteins; Fetal Heart; Genistein; GTP-Binding Proteins; Isoflavones; Isoquinolines; Myocardium; Pertussis Toxin; Phenotype; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
The activation of protein kinase C is not necessary for the monoclonal antibody-induced modulation of CD3 and CD4 antigens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; CD4 Antigens; Down-Regulation; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Lymphocytes; Piperazines; Protein Kinase C; Receptors, Antigen, T-Cell; Staurosporine | 1990 |
Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Humans; In Vitro Techniques; Interferon-gamma; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinases; Receptors, Immunologic; Receptors, Interferon; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Inhibitors of protein kinase-C modulate desensitization of the parathyroid hormone receptor-adenylate cyclase system in opossum kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cells, Cultured; Cyclic AMP; Isoquinolines; Kidney; Opossums; Piperazines; Protein Kinase C; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Staurosporine | 1990 |
Tumor necrosis factor-alpha/cachectin activates the O2(-)-generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic acid.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acids; Bucladesine; Humans; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Kinetics; Neutrophils; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Superoxides; Theophylline; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 1990 |
Epstein-Barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, Differentiation, B-Lymphocyte; Antigens, Viral; Cell Line; Cell Transformation, Viral; Herpesvirus 4, Human; Humans; Infectious Mononucleosis; Isoquinolines; Piperazines; Receptors, Complement; Receptors, Complement 3d; Staurosporine | 1990 |
Effect of second-messenger modulators in K-562 cell differentiation: dual action of calcium/phospholipid-dependent protein kinase in the process of differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cell Differentiation; Cell Division; Cell Survival; Cytarabine; Diglycerides; Erythropoiesis; Globins; Hemin; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Guinea Pigs; Isoquinolines; Molecular Weight; Neutrophils; Oxygen; Phosphorus; Phosphorylation; Piperazines; Protein Kinase C; Staurosporine; Superoxides | 1990 |
Effects of inhibitors of protein kinase C and Na+/H+ exchange on alpha 1-adrenoceptor-mediated inotropic responses in the rat left ventricular papillary muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Animals; Heart Ventricles; Hydrogen; In Vitro Techniques; Ion Exchange; Isoquinolines; Male; Myocardial Contraction; Papillary Muscles; Piperazines; Prazosin; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sodium; Staurosporine | 1990 |
The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Bone Marrow Cells; Bucladesine; Calcium Channel Blockers; Calmodulin; Cell Line; Colforsin; Colony-Forming Units Assay; Colony-Stimulating Factors; Cyclic AMP; Fibroblasts; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Interleukin-1; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha | 1990 |
Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Asialoglycoprotein Receptor; Carcinoma, Hepatocellular; Cations, Divalent; Cell Membrane; Humans; Isoquinolines; Liver Neoplasms; Membrane Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Immunologic; Staurosporine; Tumor Cells, Cultured | 1990 |
Effects of phorbol ester on cell growth inhibition by transforming growth factor beta 1 in human hepatoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Cell Division; DNA; Epithelial Cells; Growth Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Liver Neoplasms; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Models, Chemical; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Evidence for involvement of protein kinase C in the cellular response to interferon alpha.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; DNA-Binding Proteins; Gene Expression; HeLa Cells; In Vitro Techniques; Interferon Type I; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Staurosporine; Transcription, Genetic; Vesicular stomatitis Indiana virus; Virus Replication | 1990 |
Diacylglycerols and PMA are particularly effective stimulators of fluid pinocytosis in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Chemotaxis, Leukocyte; Colchicine; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Nocodazole; Oligopeptides; Pinocytosis; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C. Receptor shedding due to accelerated proteolytic cleavage at the cell surface.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Surface; Cell Adhesion; Cell Membrane; Diglycerides; Down-Regulation; Flow Cytometry; Isoquinolines; Mice; Mice, Inbred Strains; Peptide Mapping; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Lymphocyte Homing; Solubility; Staurosporine | 1990 |
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; DNA, Viral; Down-Regulation; Enhancer Elements, Genetic; Enzyme Activation; H-2 Antigens; HIV-1; Humans; Isoquinolines; Leukemia; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha | 1990 |
Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Biological Transport; Cell Line; Cell Separation; Deoxyglucose; Hexoses; Insulin; Isoquinolines; Male; Muscles; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Chelerythrine is a potent and specific inhibitor of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibiotics, Antineoplastic; Benzophenanthridines; Binding, Competitive; Brain; Cell Transformation, Neoplastic; Isoquinolines; Kinetics; Leukemia L1210; Lymphoma; Phenanthridines; Piperazines; Protein Kinase C; Rats; Staurosporine; Tumor Cells, Cultured | 1990 |
Selectivity of protein kinase inhibitors in human intact platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Platelets; Carrier Proteins; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Tamoxifen | 1990 |
Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diglycerides; Drug Antagonism; Enzyme Activation; Glycerides; Isoquinolines; Methylcholanthrene; Mice; Palmitoylcarnitine; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Ca2(+)-induced secretion by electropermeabilized human neutrophils. The roles of Ca2+, nucleotides and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adult; Alkaloids; Calcium; Cell Membrane Permeability; Cytoplasmic Granules; Electric Stimulation; Glucuronidase; Humans; Isoquinolines; Kinetics; Lysosomes; Magnesium; Neutrophils; Piperazines; Proadifen; Protein Kinase C; Ribonucleotides; Staurosporine; Tetradecanoylphorbol Acetate; Transcobalamins | 1990 |
Substrate-dependent inhibition of protein kinase C by specific inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Chromatography, Affinity; Chromatography, Ion Exchange; Gossypol; Homeostasis; Isoquinolines; Kinetics; Ligands; Piperazines; Protein Kinase C; Quercetin; Rats; Sphingosine; Staurosporine; Substrate Specificity | 1990 |
Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amanitins; Animals; Astrocytes; Blotting, Northern; Cell Nucleus; Cell Transformation, Viral; Cells, Cultured; Diglycerides; Isoquinolines; Newcastle disease virus; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; RNA, Messenger; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha | 1990 |
Diacylglycerol and protein kinase mediated noradrenergic responses in perfused rat kidneys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glomerular Filtration Rate; Gluconeogenesis; Glycerides; In Vitro Techniques; Isoquinolines; Kidney; Kidney Tubules; Male; Norepinephrine; Perfusion; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Renal Circulation; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Vascular Resistance | 1990 |
K252a is a potent and selective inhibitor of phosphorylase kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carbazoles; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Kinetics; Muscles; Phosphorylase Kinase; Piperazines; Protein Kinase Inhibitors; Rabbits; Staurosporine; Structure-Activity Relationship | 1990 |
Characterization of specific binding sites for [3H]-staurosporine on various protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Carbazoles; Indole Alkaloids; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Sulfonamides | 1990 |
Role of protein kinase C in renal vasoconstriction caused by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil | 1990 |
Protein kinase C is present in human sperm: possible role in flagellar motility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibodies, Monoclonal; Humans; Immunohistochemistry; Isoquinolines; Kinetics; Male; Piperazines; Protein Kinase C; Reference Values; Sperm Motility; Spermatozoa; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: blockade by protein kinase inhibitors and relationship to tat-directed trans-activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Aminopurine; Adenine; Alkaloids; Cell Line; Clone Cells; Gene Products, tat; HIV-1; Humans; Idoxuridine; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Piperazines; Protein Kinase Inhibitors; Staurosporine; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Trans-Activators; Transcriptional Activation; Virus Replication | 1990 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
Comparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; CD4 Antigens; Cell Line; Down-Regulation; Flow Cytometry; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Viral Core Proteins; Virus Replication | 1989 |
Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Isoquinolines; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Enhancement of adenosine A2 and prostaglandin E1 receptor-mediated cAMP generation by prior exposure of Swiss 3T3 fibroblasts to Ca2+-mobilizing receptor agonists or phorbol ester. Activation of protein kinase C triggers increases in the receptor density
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Alkaloids; Animals; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Diglycerides; Enzyme Activation; Fibroblasts; Isoquinolines; Kinetics; Mice; Piperazines; Prostaglandins E; Protein Kinase C; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Purinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics | 1989 |
Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Azo Compounds; Cell Adhesion; Complement System Proteins; Diamide; Enzyme Activation; Erythrocytes; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Monocytes; Palmitoylcarnitine; Phagocytosis; Phosphorylation; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Complement; Sphingosine; Staurosporine; Structure-Activity Relationship | 1989 |
Comparative effects of endothelin and phorbol 12-13 dibutyrate in rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Calcium; Diltiazem; Endothelins; Endothelium, Vascular; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Phenylephrine; Phloretin; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction | 1989 |
Modulation of endothelial cell expression of intercellular adhesion molecule 1 by protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, Surface; Carcinogens; Cell Adhesion; Cell Adhesion Molecules; Diterpenes; Endothelium, Vascular; Enzyme Activation; Humans; Isoquinolines; Kinetics; Membrane Glycoproteins; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Alteration of intracellular actin levels induced by phorboldiester in human HL-60 leukemia cells susceptible or resistant to differentiation, and the effects of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Antibodies, Monoclonal; Antigen-Antibody Reactions; Cell Differentiation; Cell Line; Cytoplasm; Drug Resistance; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Macrophages; Neoplasm Proteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Putative involvement of protein kinase C in proliferation of human myeloid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Bone Marrow; Cell Division; Cell Line; Clone Cells; Colony-Forming Units Assay; Colony-Stimulating Factors; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Isoquinolines; Leukemia, Erythroblastic, Acute; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides | 1989 |
Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Calcitriol; Cell Differentiation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1988 |
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Diglycerides; Humans; Isoquinolines; Linoleic Acid; Linoleic Acids; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymyxin B; Polymyxins; Protein Kinase C; Staurosporine; Thrombin | 1988 |
Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Isoquinolines; Peptide PHI; Piperazines; Protein Kinase C; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Staurosporine; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1988 |
Rapid screening method for inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomycetales; Alkaloids; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Isoflavones; Isoquinolines; Leukemia, Myeloid; Lyngbya Toxins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1988 |
Possible involvement of direct stimulation of protein kinase C by unsaturated fatty acids in platelet activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acids; Aspirin; Blood Platelets; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Isoquinolines; Phosphorylation; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Time Factors | 1988 |
Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Enzyme Induction; Epidermis; In Vitro Techniques; Isoquinolines; Kinetics; Mice; Ornithine Decarboxylase; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1987 |
EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line, Transformed; Cinnamates; Dinoprostone; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; Isoquinolines; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Decidua; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Interleukin-1; Isoquinolines; Piperazines; Pregnancy; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Carrier Proteins; Cell Line; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Isoquinolines; Kidney; Kinetics; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Protein kinase C is not involved in Ah receptor transformation and DNA binding.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cytochrome P-450 Enzyme System; Cytosol; DNA; Enzyme Induction; Guinea Pigs; Isoquinolines; Liver; Male; Molecular Sequence Data; Naphthalenes; Piperazines; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Protein Binding; Protein Kinase C; Receptors, Aryl Hydrocarbon; Signal Transduction; Staurosporine | 1993 |
Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcineurin; Calmodulin-Binding Proteins; Charybdotoxin; Cloning, Molecular; Electric Stimulation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Membrane Potentials; Mice; Oocytes; Pertussis Toxin; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Potassium Channels; Protein Kinase C; Receptors, Serotonin; Recombinant Proteins; RNA, Complementary; Scorpion Venoms; Second Messenger Systems; Serotonin; Staurosporine; Transcription, Genetic; Virulence Factors, Bordetella; Xenopus laevis | 1993 |
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Amino Acid Oxidoreductases; Animals; Arginine; Calcimycin; Carbachol; Cyclic GMP; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kidney Glomerulus; Kinetics; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphates; Phosphorylation; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine; Thromboxane A2 | 1994 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Endotoxin-induced tissue factor in human monocytes is dependent upon protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Endotoxins; Enzyme Activation; Gene Expression Regulation; Humans; Isoquinolines; Monocytes; Naphthalenes; Naphthol AS D Esterase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin | 1993 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Benzophenanthridines; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA Damage; DNA, Neoplasm; Enzyme Inhibitors; Gossypol; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Naphthalenes; Perylene; Phenanthridines; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Time Factors; Tumor Cells, Cultured | 1994 |
Evidence that prostaglandin E2 can block calcium-activated 86Rb efflux from rat brain synaptosomes via a protein kinase C-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Calcium Channel Blockers; Charybdotoxin; Cyclic AMP; Dinoprostone; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Prosencephalon; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rubidium; Scorpion Venoms; Staurosporine; Sulfonamides; Synaptosomes; Thionucleotides | 1994 |
Regulation of a non-selective cation channel of cultured porcine coronary artery smooth muscle cells by tyrosine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cations; Cell Membrane; Cells, Cultured; Coronary Vessels; Genistein; Ion Channels; Isoflavones; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Swine | 1994 |
Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Blotting, Western; Carbazoles; Cell Line; Cells, Cultured; Ciliary Neurotrophic Factor; Cytokines; Growth Inhibitors; Indole Alkaloids; Interleukin-6; Isoquinolines; Leukemia Inhibitory Factor; Lymphokines; Nerve Growth Factors; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oncostatin M; Peptides; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; ras Proteins; Rats; RNA; RNA, Messenger; Staurosporine; Superior Cervical Ganglion; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
Novel endothelial cell activation factor(s) released from activated platelets which induce E-selectin expression and tumor cell adhesion to endothelial cells: a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Factors; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cells, Cultured; Colonic Neoplasms; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Kinetics; Lung Neoplasms; Melanoma, Experimental; Mice; Models, Biological; Naphthalenes; Neoplasms; Piperazines; Platelet Activation; Platelet Aggregation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Stomach Neoplasms; Tumor Cells, Cultured; Umbilical Veins | 1994 |
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins | 1994 |
Differential modulation by protein kinase C of progesterone-activated responses in human sperm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Membrane; Fluorescent Dyes; Fura-2; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Male; Membrane Potentials; Piperazines; Progesterone; Protein Kinase C; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Dual regulation of cGMP formation by calcium in pancreatic acinar cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Oxidoreductases; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Cyclic GMP; Cytosol; Guanylate Cyclase; Guinea Pigs; Homeostasis; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitric Oxide Synthase; Pancreas; Piperazines; Protein Kinase C; Staurosporine; Sulfonamides; Trifluoperazine | 1995 |
Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; In Vitro Techniques; Interleukin-3; Isoquinolines; Mice; Molecular Weight; Phosphorylation; Phosphotyrosine; Piperazines; Protein Serine-Threonine Kinases; Receptors, Erythropoietin; Receptors, Interleukin-3; Signal Transduction; Staurosporine; Tyrosine | 1995 |
Biphasic effect of staurosporine on thymocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Apoptosis; Bucladesine; Calcimycin; Carbazoles; Carcinogens; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Indole Alkaloids; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase Inhibitors; Radiation-Sensitizing Agents; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1995 |
Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cells, Cultured; Chemotaxis, Leukocyte; Desensitization, Immunologic; Enzyme Inhibitors; Humans; Isoquinolines; Macrophage Activation; Monocytes; Pertussis Toxin; Piperazines; Recombinant Proteins; Serum Amyloid A Protein; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1995 |
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acids; Animals; Anti-Bacterial Agents; Cell Membrane; Chlorocebus aethiops; Diphtheria Toxin; DNA; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Macrolides; Molecular Weight; Piperazines; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Staurosporine; Tetradecanoylphorbol Acetate; Vero Cells | 1995 |
Role of protein kinase C in relationship between Ca2+ and contractile elements in rat alpha-toxin-permeabilized mesenteric artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bacterial Toxins; Calcium; Cell Membrane Permeability; Enzyme Activation; Hemolysin Proteins; In Vitro Techniques; Isoquinolines; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1995 |
TGF-beta induces expression of monocyte chemoattractant JE/monocyte chemoattractant protein 1 via transcriptional factor AP-1 induced by protein kinase in osteoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Base Sequence; Chemokine CCL2; Chemotactic Factors; Cytokines; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Genes, fos; Genes, jun; Humans; Isoquinolines; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Osteoblasts; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta | 1995 |
Role of protein kinase C isozymes in Fc gamma receptor-mediated intracellular killing of Staphylococcus aureus by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Cross Reactions; Cross-Linking Reagents; Diglycerides; Humans; Isoenzymes; Isoquinolines; Molecular Sequence Data; Monocytes; Phagocytosis; Piperazines; Protein Kinase C; Reactive Oxygen Species; Receptors, IgG; Staphylococcus aureus; Staurosporine; Tetradecanoylphorbol Acetate; Translocation, Genetic; Type C Phospholipases | 1995 |
The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Biological Transport; Cell Cycle; Cell Nucleus; Cells, Cultured; Chick Embryo; Cytoplasm; Ethers, Cyclic; Fibroblasts; Isoquinolines; Molecular Sequence Data; Nuclear Localization Signals; Nuclear Proteins; Okadaic Acid; Oncogene Protein p65(gag-jun); Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperazines; Protein Kinases; Staurosporine | 1995 |
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Glycoproteins; Humans; Immunoenzyme Techniques; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Staurosporine; Synovial Membrane; Tetradecanoylphorbol Acetate; Thionucleotides; Tissue Inhibitor of Metalloproteinases; Up-Regulation | 1995 |
Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Calcimycin; Calcium; Calcium-Transporting ATPases; Cholera Toxin; Colforsin; Drug Synergism; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Isoquinolines; Leukemia-Lymphoma, Adult T-Cell; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; Endothelins; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Portal Vein; Potassium Chloride; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation | 1995 |
Activation of transfer RNA-guanine ribosyltransferase by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Buffers; Diphosphates; Enzyme Activation; Enzyme Reactivators; Enzyme Stability; Isoquinolines; Liver; Naphthalenes; Pentosyltransferases; Phosphoric Monoester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sphingosine; Staurosporine | 1995 |
Protein kinase C inhibitors reduce phorbol ester-induced resistance to methotrexate in Chinese hamster ovary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; CHO Cells; Colony-Forming Units Assay; Cricetinae; Drug Resistance; Glycyrrhetinic Acid; Isoquinolines; Methotrexate; Molecular Sequence Data; Naphthalenes; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine | 1995 |
A role for protein kinase C in bradykinin-mediated activation of renal pelvic sensory receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Enzyme Activation; Isoquinolines; Kidney Pelvis; Male; Naphthalenes; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Staurosporine | 1995 |
A role of protein kinase C in the alteration of renal glucose-6-phosphatase activity caused by fluoride.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Membrane; Cytosol; Down-Regulation; Fluorides; Glucose-6-Phosphatase; In Vitro Techniques; Isoquinolines; Kidney; Male; Microsomes; Naphthalenes; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1995 |
Phorbol ester stimulated cathepsin L expression in U937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cathepsin L; Cathepsins; Cell Differentiation; Cycloheximide; Cysteine Endopeptidases; Drug Interactions; Endopeptidases; Enzyme Induction; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Monocytes; Neoplasm Proteins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1995 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
Retinoic acid induces translocation of protein kinase C (PKC) and activation of nuclear PKC (nPKC) in rat splenocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Biological Transport; Cell Nucleus; Cytosol; Enzyme Activation; Isoquinolines; Lymphocytes; Male; Nuclear Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Sphingosine; Spleen; Staurosporine; Tretinoin | 1995 |
Induction of tumor suppressor p21 protein by kinase inhibitors in MCF-7 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Breast Neoplasms; Bucladesine; Cell Cycle; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Flow Cytometry; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1995 |
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoquinolines; Liver Neoplasms, Experimental; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction | 1993 |
Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Induction; Extracellular Matrix; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Naphthalenes; Oligodeoxyribonucleotides; Piperazines; Plasminogen Activator Inhibitor 1; Polycyclic Compounds; Protein Kinase C; RNA; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1993 |
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cells, Cultured; Cholecystokinin; Genistein; Isoflavones; Isoquinolines; Kinetics; Male; Pancreas; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Calcium; Cell Membrane Permeability; Diglycerides; Ethers, Cyclic; Humans; Isoenzymes; Isoquinolines; Molecular Sequence Data; Myelin Basic Protein; Neoplasm Proteins; Neuroblastoma; Okadaic Acid; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Polymyxin B; Protein Kinase C; Protein Phosphatase 2; Protein Processing, Post-Translational; Signal Transduction; Staurosporine; Substrate Specificity; Tumor Cells, Cultured | 1993 |
Alkaline phosphatase activity in the human promyelocytic leukemia cell line, HL-60, induced by retinoic acid and recombinant human granulocyte colony-stimulating factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Calcitriol; Cell Line; Enzyme Induction; Granulocyte Colony-Stimulating Factor; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Recombinant Proteins; Staurosporine; Tretinoin; Tumor Cells, Cultured | 1993 |
The cytoplasmic domain of P-selectin is phosphorylated on serine and threonine residues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Alprostadil; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; P-Selectin; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Platelet Membrane Glycoproteins; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins | 1993 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Beta-adrenergic stimulation and cAMP mobilize Ca2+ from an IP3-insensitive pool in rat submandibular granular ducts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Alkaloids; Animals; Atenolol; Atropine; Calcium; Carbachol; Cyclic AMP; Epinephrine; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoproterenol; Isoquinolines; Kinetics; Male; Phentolamine; Piperazines; Propanolamines; Propranolol; Protein Kinase C; Protein Kinase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Staurosporine; Submandibular Gland | 1993 |
The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Calcium; Calcium Channels; Dihydropyridines; Female; Growth Hormone; Ion Channel Gating; Isoquinolines; Luteinizing Hormone; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine | 1993 |
High glucose can induce lipid peroxidation in the isolated rat glomeruli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Glucose; In Vitro Techniques; Isoquinolines; Kidney Glomerulus; Lipid Peroxidation; Male; Oxidative Stress; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine | 1994 |
Nuclear calcium signaling is initiated by cytosolic calcium surges in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; Ionomycin; Isoquinolines; Kinetics; Microscopy, Confocal; Muscle, Smooth, Vascular; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Second Messenger Systems; Signal Transduction; Staurosporine; Terpenes; Thapsigargin | 1994 |
Prostaglandin F2 alpha stimulates formation of p21ras-GTP complex and mitogen-activated protein kinase in NIH-3T3 cells via Gq-protein-coupled pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Dinoprost; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Isoquinolines; Mice; Oncogene Protein p21(ras); Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine | 1995 |
A novel high molecular weight form of protein kinase C in anterior pituitary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Indoles; Isoenzymes; Isoquinolines; Kinetics; Molecular Weight; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Staurosporine | 1995 |
The involvement of protein kinase C in the contraction of human airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bronchi; Histamine; Humans; In Vitro Techniques; Indoles; Isoquinolines; Maleimides; Muscle Contraction; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Staurosporine | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Differential sensitivity to inhibitors discriminates between two types of kinases responsible for in vivo phosphorylation of different sites in the carboxy-terminal tail of chicken neurofilament-M.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Chick Embryo; Ganglia, Spinal; Indole Alkaloids; Isoquinolines; Lithium Chloride; Molecular Sequence Data; Neurofilament Proteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sphingosine; Staurosporine; Trifluoperazine | 1994 |
Pharmacological evidence for a lack of role for protein kinase C in staurosporine-induced morphological changes in embryonic Xenopus myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Alkaloids; Animals; Cell Membrane; Cell Size; Cells, Cultured; Electrophysiology; Embryo, Nonmammalian; Fluorescent Dyes; Isoquinolines; Muscle Proteins; Muscles; Patch-Clamp Techniques; Piperazines; Protein Kinase C; Staurosporine; Xenopus | 1994 |
Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Aluminum; Animals; Biological Transport; Calcium; Clone Cells; Cytosol; Diacylglycerol Kinase; DNA; Dogs; Gadolinium; Growth Substances; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neomycin; Osteoblasts; Phosphorus Radioisotopes; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Proteins; Receptors, Calcium-Sensing; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Herpesvirus 1, Human; Humans; Interferon Type I; Interferon-alpha; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Recombinant Proteins; Staurosporine; Tumor Cells, Cultured | 1995 |
Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Ketoprostaglandin F1 alpha; Alkaloids; Cells, Cultured; Endothelium, Vascular; Humans; Interleukin-1; Isoquinolines; Lipopolysaccharides; Lyngbya Toxins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Multiple protein kinases are required for basal Kv1.5 K+ channel gene expression in GH3 clonal pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Clone Cells; Gene Expression; Isoquinolines; Piperazines; Pituitary Gland; Potassium Channels; Protein Kinase Inhibitors; Rats; RNA, Messenger; Staurosporine; Transcription, Genetic | 1995 |
Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arsenites; Benzophenanthridines; Cell Line; Fibroblasts; Heat-Shock Proteins; Humans; Interleukin-1; Isoquinolines; Phenanthridines; Phosphorylation; Phosphotransferases; Piperazines; Sodium Compounds; Staurosporine; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Activation of protein kinase C inhibits ATP-induced [Ca2+]i elevation in rat osteoblastic cells: selective effects on P2Y and P2U signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Isoquinolines; Osteoblasts; Piperazines; Protein Kinase C; Rats; Receptors, Purinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
A novel pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptor-mediated trans-activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Differentiation; Genes, jun; Isoquinolines; Mice; Phosphoproteins; Piperazines; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Staurosporine; Teratocarcinoma; Time Factors; Transcriptional Activation; Tretinoin; Tumor Cells, Cultured | 1994 |
Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Bryostatins; Cells, Cultured; Cloning, Molecular; Erythropoietin; Hematopoietic Stem Cells; Interleukin-3; Isoquinolines; Lactones; Macrolides; Mice; Mitogens; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Piperazines; Precipitin Tests; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Staurosporine | 1994 |
Entamoeba histolytica: PKC transduction pathway activation in the trophozoite-fibronectin interaction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Entamoeba histolytica; Enzyme Activation; Fibronectins; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protozoan Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effects of activators (SC-9 and OAG) and inhibitors (staurosporine and H-7) of protein kinase C on the proliferation of mouse epidermal melanoblasts in serum-free culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Culture Media, Serum-Free; Diglycerides; Enzyme Activation; Humans; Infant, Newborn; Isoquinolines; Melanocytes; Mice; Mice, Inbred C57BL; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Stem Cells; Sulfonamides | 1994 |
Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Caffeine; Cell Cycle; Cyclins; Gene Expression; HeLa Cells; Humans; In Vitro Techniques; Isoquinolines; Piperazines; RNA, Messenger; Staurosporine | 1994 |
Glutamate elicits an outward K+ current which is normally suppressed by a Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alkaloids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cholera Toxin; Dose-Response Relationship, Drug; Ganglia, Invertebrate; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kynurenic Acid; Membrane Potentials; Neurons; Pertussis Toxin; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Snails; Staurosporine; Sulfonamides; Time Factors; Virulence Factors, Bordetella | 1994 |
Role of protein phosphorylation in EPO-mediated early signal transduction: analysis in the EPO-reactive cell line ELM-I-1 transfected with a c-fos-enhancer/promoter-luciferase reporter gene.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzoquinones; Cell Line; Erythropoietin; Genes, fos; Hydroquinones; In Vitro Techniques; Isoquinolines; Lactams, Macrocyclic; Luciferases; Mice; Phosphoproteins; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; Vanadates | 1994 |
Staurosporine inhibits STA2-induced platelet aggregation by inhibition of myosin light-chain phosphorylation in rabbit washed platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Blood Platelets; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Isoquinolines; Kinetics; Myosins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Staurosporine; Thromboxane A2 | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Chronic hypoxia impairs the differentiation of 3T3-L1 fibroblast in culture: role of sustained protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Differentiation; Cell Division; Cell Line; Enzyme Activation; Fibroblasts; Hypoxia; Isoquinolines; Mice; Phenotype; Piperazines; Protein Kinase C; Staurosporine | 1994 |
Protein kinase C signal transduction pathway in ACTH-induced growth effect of rat adrenocortical cells in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenocorticotropic Hormone; Alkaloids; Animals; Cell Division; Cells, Cultured; Corticosterone; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cadherins; Calcium; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Desmoplakins; Dogs; Epithelium; Intercellular Junctions; Isoquinolines; Kidney; Membrane Proteins; Phosphoproteins; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides; Zonula Occludens-1 Protein | 1994 |
Decreased phosphorylation of four 20-kDa proteins precedes staurosporine-induced disruption of the actin/myosin cytoskeleton in rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Animals, Newborn; Astrocytes; Azepines; Cells, Cultured; Cytoskeleton; Indoles; Isoquinolines; Myosin-Light-Chain Kinase; Myosins; Nerve Tissue Proteins; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine | 1994 |
Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electric Conductivity; Ferrets; Heart; Heart Ventricles; Isoquinolines; Myocardium; Peptide Fragments; Piperazines; Rabbits; Staurosporine; Sulfonamides | 1994 |
Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Drug Interactions; Drug Resistance; Gene Expression; Humans; Indole Alkaloids; Isoquinolines; KB Cells; Membrane Glycoproteins; Neoplasm Proteins; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Verapamil | 1993 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation; Glioma; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Selective inhibition by H7 and staurosporin of phorbol ester responses in U-937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Antigens, CD; Calcium; CD18 Antigens; Cell Adhesion; Drug Antagonism; Enzyme Activation; Humans; Isoquinolines; Macrophage-1 Antigen; Molecular Sequence Data; Monocytes; Neoplasm Proteins; Peptide Fragments; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Signal Transduction; SRS-A; Staurosporine; Tumor Cells, Cultured | 1993 |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Intercellular gap formation induced by thrombin in confluent cultured bovine retinal pigment epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Cattle; Cells, Cultured; Colforsin; Cytoskeleton; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Gap Junctions; Isoquinolines; Pigment Epithelium of Eye; Piperazines; Protein Kinase Inhibitors; Staurosporine; Thrombin; Time Factors; Vinculin | 1994 |
Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Alkaloids; Animals; Enzyme Activation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Pyridazines; Rats; Rats, Wistar; Serotonin; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1994 |
Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electrophysiology; GTP-Binding Proteins; Guanosine Diphosphate; Guinea Pigs; Hippocampus; Interleukin-1; Isoquinolines; Neurons; Pertussis Toxin; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Involvement of protein kinase C and protein tyrosine kinase pathways in tumor necrosis factor-alpha-induced clustering of ovarian theca-interstitial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstenedione; Animals; Benzophenanthridines; Benzylidene Compounds; Catechols; Cell Adhesion; Diglycerides; Enzyme Activation; Female; Hypophysectomy; Isoquinolines; Luteinizing Hormone; Nitriles; Phenanthridines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Theca Cells; Tumor Necrosis Factor-alpha; Tyrphostins | 1993 |
The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Carrier Proteins; Cell Hypoxia; Cells, Cultured; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gene Expression Regulation; Heat-Shock Proteins; Humans; Isoquinolines; Molecular Chaperones; Molecular Sequence Data; Oligodeoxyribonucleotides; Oxygen; Piperazines; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glyburide; Guanidines; Isoquinolines; Perfusion; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pinacidil; Piperazines; Protein Kinase C; Rabbits; Staurosporine; Ventricular Fibrillation | 1993 |
Regulation of parathyroid hormone gene expression and peptide secretion in human parathyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Alkaloids; Base Sequence; Blotting, Northern; Calcium; Cell Division; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hyperparathyroidism; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
The evidence of accelerative interaction between cAMP-dependent protein kinase and external calcium for the desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Hydroxybenzoates; Isoquinolines; Mice; Muscles; Piperazines; Receptors, Nicotinic; Staurosporine; Sulfonamides; Time Factors | 1994 |
Protein kinase C inhibitors enhance differentiation of rat adipocyte precursor cells in serum-free culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Glycerolphosphate Dehydrogenase; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Signal transduction in avian granulosa cells: effects of protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Chickens; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Female; Granulosa Cells; Inositol Phosphates; Isoquinolines; Piperazines; Progesterone; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85 alpha subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Platelets; Catechols; Enzyme Activation; Humans; Isoquinolines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Tyrphostins | 1994 |
Regulation of intrauterine prostaglandin biosynthesis: interactions between protein kinase C and interleukin 1 beta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Chorion; Decidua; Dinoprostone; Female; Humans; In Vitro Techniques; Interleukin-1; Isoquinolines; Obstetric Labor, Premature; Piperazines; Pregnancy; Protein Kinase C; Staurosporine; Uterus | 1994 |
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Inhibition and down-regulation of protein kinase C in cultured atrial myocytes: effects on distribution of specific granules and secretion of atrial natriuretic peptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cells, Cultured; Culture Media; Cycloheximide; Cytoplasmic Granules; Down-Regulation; Fluorescent Antibody Technique; Isoquinolines; Microscopy, Electron; Microtubules; Myocardium; Piperazines; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium | 1993 |
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Cell Death; Cell Hypoxia; Cells, Cultured; Dibutyryl Cyclic GMP; Hippocampus; Isoquinolines; Nerve Tissue Proteins; Nitric Oxide; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides | 1993 |
Reciprocal effects of the protein kinase C inhibitors staurosporine and H-7 on the regulation of glycogen synthase and phosphorylase in the primary culture of hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Glycogen; Glycogen Synthase; Isoquinolines; Liver; Male; Phosphorylases; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 1993 |
Interaction of PDGF and natriuretic peptides on mesangial cell proliferation and endothelin secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Atrial Natriuretic Factor; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Endothelins; Glomerular Mesangium; Isoquinolines; Kinetics; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Nitroprusside; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Thymidine; Transforming Growth Factor beta | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Animals; Blotting, Northern; Calcium; Cell Division; Enzyme Activation; Estradiol; Homeostasis; Isoquinolines; Kinetics; Osteoblasts; Osteosarcoma; Piperazines; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Arachidonic Acid; Cells, Cultured; Culture Media; Eicosanoids; Glomerular Mesangium; Glucose; Isoquinolines; Kinetics; Mannitol; Molecular Sequence Data; Oligopeptides; Phospholipases A; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Substrate Specificity; Thromboxane B2; Tritium | 1993 |
Involvement of protein kinase C in the interleukin 1 alpha-induced gene expression of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases (TIMP-1) in human uterine cervical fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Collagen; Dinoprostone; Down-Regulation; Extracellular Matrix; Female; Fibroblasts; Gene Expression Regulation; Glycoproteins; Guinea Pigs; Humans; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Precursors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Uterus | 1993 |
H7-resistant protein kinase C substrates in two-dimensional gels of proestrous rat anterior pituitary gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electrophoresis, Gel, Two-Dimensional; Estrus; Female; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substrate Specificity | 1993 |
Inotropic effects of staurosporine, NA 0345 and H-7, protein kinase C inhibitors, on rabbit ventricular myocardium: selective inhibition of the positive inotropic effect mediated by alpha 1-adrenoceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carbazoles; Heart Ventricles; Hydrolysis; Indoles; Isoquinolines; Male; Myocardial Contraction; Myocardium; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Prazosin; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha; Staurosporine | 1993 |
The role of cytosolic Ca2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Ethers, Cyclic; Glycerophospholipids; Isoquinolines; Liver; Male; Okadaic Acid; Phosphatidic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasopressins | 1994 |
Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoenzymes; Isoquinolines; Kinetics; Lysophospholipids; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Assembly dynamics of actin in adherent human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Calcium; Cell Adhesion; Deoxyribonuclease I; Enzyme Inhibitors; Fibronectins; Humans; Isoquinolines; Laminin; Neutrophils; Pertussis Toxin; Piperazines; Protein Kinase Inhibitors; Spectrometry, Fluorescence; Staurosporine; Virulence Factors, Bordetella | 1993 |
The requirement of p47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Proteins; Cell Membrane; Cytosol; Enzyme Activation; Humans; Ionomycin; Isoquinolines; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amyloid beta-Protein Precursor; Animals; Cell Line; Glioma; Humans; Isoquinolines; Kinetics; Molecular Weight; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Alkaloids; Amiloride; Animals; Carbazoles; Dose-Response Relationship, Drug; Furosemide; Guinea Pigs; Indoles; Isometric Contraction; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Piperazines; Protein Kinase C; Respiratory Muscles; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1993 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured | 1993 |
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Indoles; Isoquinolines; Lung; Male; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes | 1993 |
Interferon-alpha (IFN alpha) induces a cytolytic mechanism in ovarian carcinoma cells through a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Emetine; Female; Humans; Interferon alpha-2; Interferon-alpha; Isoquinolines; Ovarian Neoplasms; Piperazines; Protein Biosynthesis; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Intracellular signaling events associated with the induction of DNA synthesis in human B lymphocytes. I. Stimulation of PKC-dependent and -independent pathways by LMW-BCGF.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; B-Lymphocytes; Carrier Proteins; DNA; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Isoquinolines; Lymphokines; Mitosis; Neomycin; Piperazines; Protein Kinase C; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Type C Phospholipases | 1993 |
Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cytochrome b Group; Dexamethasone; Drug Synergism; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-8; Isoquinolines; NADPH Oxidases; Neutrophils; Piperazines; RNA, Messenger; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Enhancement of superoxide production of polymorphonuclear neutrophils by ofloxacin and the effects of the inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Isoquinolines; Luminescent Measurements; Neutrophils; Ofloxacin; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Superoxides | 1993 |
Desensitization of acetylcholine induced inositol 1,4,5-trisphosphate formation in neuroblastoma SH-SY5Y cells following repetitive acetylcholine stimulations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Alkaloids; Animals; Down-Regulation; Enzyme Activation; Humans; Inosine Triphosphate; Isoquinolines; Neuroblastoma; PC12 Cells; Phosphatidylinositols; Piperazines; Protein Kinase C; Second Messenger Systems; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Blood Platelets; Carbazoles; Carrier Proteins; Humans; Hydrogen; Indole Alkaloids; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine; Thrombin | 1993 |
Rapid induction of mouse virus-like (VL30) element transcripts by erythropoietin in murine erythroid progenitor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cloning, Molecular; Cycloheximide; DNA; DNA Transposable Elements; Erythroid Precursor Cells; Erythropoietin; Female; Friend murine leukemia virus; Gene Expression; Genistein; In Vitro Techniques; Isoflavones; Isoquinolines; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Staurosporine; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Cholinergic inhibition of Na-K-ATPase via activation of protein kinase C in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Cells, Cultured; Dogs; Enzyme Activation; Epithelium; Inositol Phosphates; Isoquinolines; Kidney; Naphthalenes; Parasympathomimetics; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Staurosporine; Sulfonamides | 1993 |
Role of protein kinase-C in the alpha 1-adrenoceptor-mediated responses of perfused rat liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Cell Membrane; Cytosol; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Liver; Male; Perfusion; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC, and protein synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anisomycin; Cell Hypoxia; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Fibroblast Growth Factor 2; Ischemia; Isoquinolines; Kinetics; Models, Biological; Neoplasm Proteins; Nerve Growth Factors; PC12 Cells; Phosphorylation; Piperazines; Protein Kinase C; Staurosporine; Time Factors | 1993 |
Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzoquinones; Carbazoles; Cell Differentiation; Fungal Proteins; Indole Alkaloids; Isoquinolines; Lactams, Macrocyclic; Manganese; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Streptomyces griseus | 1993 |
Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Dose-Response Relationship, Radiation; Glioma; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1993 |
Enhancement of thyrotropin-stimulated iodide organification in porcine thyroid cells after protein kinase-C inhibition.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Glyceryl Ethers; Iodides; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1993 |
Satellite cell myogenesis is highly stimulated by the kinase inhibitor iso-H7: comparison with HA1004 and staurosporine effects.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Differentiation; Cell Fusion; Cells, Cultured; Creatine Kinase; In Vitro Techniques; Isoquinolines; Muscles; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine; Sulfonamides | 1993 |
Primary sites of actions of staurosporine and H-7 in the cascade of insulin action to glucose transport in rat adipocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Binding Sites; Biological Transport; Cells, Cultured; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Isoquinolines; Male; Monosaccharide Transport Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Staurosporine | 1993 |
Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Alkaloids; Animals; Cells, Cultured; Epithelial Cells; Epithelium; Female; Gene Expression Regulation; Genistein; Isoflavones; Isoquinolines; Mammary Glands, Animal; Milk Proteins; Phenols; Phenylacetates; Piperazines; Polymyxin B; Pregnancy; Prolactin; Protein Kinase Inhibitors; Quercetin; Rabbits; Sphingosine; Staurosporine; Succinates | 1993 |
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1993 |
Effects of H-7 and staurosporine on proliferation and self-renewal of acute myeloid leukemia progenitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Alkaloids; Antineoplastic Agents; Cell Cycle; Cell Division; Child; Growth Inhibitors; Hematopoiesis; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Isoquinolines; Leukemia, Myeloid; Neoplastic Stem Cells; Piperazines; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity | 1996 |
Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Collagen; Enzyme Inhibitors; Ethers, Cyclic; Fetus; Fibroblasts; Gene Expression; Genistein; Humans; Isoflavones; Isoquinolines; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Skin; Staurosporine; Transcription, Genetic; Transforming Growth Factor beta; Vanadates | 1995 |
Ectoprotein kinase activities on non-differentiated and differentiated U-937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Calcium; Carcinogens; Cell Differentiation; Cyclic AMP; Enzyme Inhibitors; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Oligopeptides; Phosphorylation; Phosvitin; Piperazines; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Intracellular pathways involved in tumor necrosis factor-alpha release by human monocytes on stimulation with lipopolysaccharide or staphylococcal peptidoglycan are partly similar.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Antimalarials; Cell Communication; Chloroquine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; GTP-Binding Proteins; Humans; Isoquinolines; Lipopolysaccharides; Monocytes; Pentoxifylline; Peptidoglycan; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Staphylococcus epidermidis; Staurosporine; Sulfonamides; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1996 |
Effect of inhibitors of protein kinase C on enhanced superoxide production of human leucocytes by ofloxacin and fleroxacin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anti-Infective Agents; Enzyme Inhibitors; Fleroxacin; Humans; In Vitro Techniques; Isoquinolines; Luminescent Measurements; Neutrophils; Ofloxacin; Piperazines; Protein Kinase C; Staurosporine; Superoxides | 1995 |
Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminopyrine; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Acid; Inositol 1,4,5-Trisphosphate; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Sulfonamides | 1996 |
Two conserved serines in the nuclear localization signal flanking region are involved in the nuclear targeting of human lamin A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Phosphatase; Alkaline Phosphatase; Alkaloids; Amino Acid Sequence; Animals; Biological Transport; Cell Nucleus; Chick Embryo; Consensus Sequence; Enzyme Inhibitors; Humans; Isoquinolines; Kinetics; Lamin Type A; Lamins; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Protein Sorting Signals; Serine; Staurosporine | 1995 |
Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antineoplastic Agents; Arachidonic Acid; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Mice; Naphthalenes; Piperazines; Protein Kinase C; Staurosporine; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Anti-Idiotypic; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Immunoglobulins; Ionomycin; Isoquinolines; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Antigen, B-Cell; Signal Transduction; Staurosporine; Sulfonamides | 1996 |
Ca2+-dependent and Ca2+-independent regulation of the thyroid epithelial junction complex by protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Epithelium; Isoquinolines; Membrane Proteins; Phosphoproteins; Piperazines; Staurosporine; Swine; Thyroid Gland; Thyrotropin; Tight Junctions; Trypsin; Zonula Occludens-1 Protein | 1996 |
Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Differentiation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Sphingosine; Staurosporine; Suppression, Genetic; Tetradecanoylphorbol Acetate | 1996 |
Regulation of epithelial Na+ permeability by protein kinase C is tissue specific.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Amiloride; Animals; Benzophenanthridines; Biological Transport; Bufo marinus; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Organ Specificity; Phenanthridines; Piperazines; Protein Kinase C; Rana catesbeiana; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Urinary Bladder | 1996 |
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides | 1996 |
GH inhibition of lipogenesis and stimulation of lipolysis in sheep adipose tissue: involvement of protein serine phosphorylation and dephosphorylation and phospholipase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyl-CoA Carboxylase; Adipose Tissue; Alkaloids; Animals; Bridged-Ring Compounds; Culture Techniques; Ethers, Cyclic; Glycerol; Growth Hormone; Isoquinolines; Lipid Metabolism; Lipids; Lipolysis; Male; Norbornanes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Sheep; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Type C Phospholipases | 1996 |
Interrelation between protein kinase C and nitric oxide in the development of vasospasm after subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Basilar Artery; Cyclic GMP; Dogs; Enzyme Inhibitors; Female; In Vitro Techniques; Ischemic Attack, Transient; Isometric Contraction; Isoquinolines; Male; Models, Cardiovascular; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Piperazines; Protein Kinase C; Staurosporine; Subarachnoid Hemorrhage | 1996 |
Regulation of plasminogen activator inhibitor activity by plasmin in endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Fibrinolysin; Fibrinolysis; Gene Expression Regulation; GTP-Binding Proteins; Humans; Indomethacin; Isoquinolines; Lipoxygenase Inhibitors; Masoprocol; Pertussis Toxin; Phospholipases A; Phospholipases A2; Piperazines; Plasminogen Activator Inhibitor 1; Protein Kinase C; Quinacrine; Staurosporine; Tissue Plasminogen Activator; Umbilical Veins; Virulence Factors, Bordetella | 1996 |
Role of protein kinase C in the regulation of ATP-triggered intracellular Ca2+ oscillations in chicken granulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Chickens; Enzyme Activation; Female; Granulosa Cells; Intracellular Membranes; Naphthalenes; Osmolar Concentration; Protein Kinase C; Staurosporine | 1996 |
Calcium-and phorbol ester-dependent calponin phosphorylation in homogenates of swine carotid artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Calponins; Carotid Arteries; Electrophoresis; Enzyme Inhibitors; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine; Swine | 1996 |
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Feedback; Female; Kidney Tubules, Collecting; Male; Ouabain; Patch-Clamp Techniques; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Acidic fibroblast factor induction of cyclooxygenase II in rabbit cardiac muscle microvessel endothelial cells: mediation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Blotting, Northern; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fibroblast Growth Factor 1; Inositol Phosphates; Isoenzymes; Isoquinolines; Microcirculation; Myocardium; Naphthalenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rabbits; RNA, Messenger; Staurosporine; Sulfonamides | 1994 |
Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Clofibrate; Enzyme Inhibitors; Ethanolamine; Ethanolamines; Fibroblasts; Humans; Hypolipidemic Agents; Isoquinolines; Phosphatidylcholines; Phospholipids; Protein Kinase C; Skin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1996 |
Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Isoquinolines; Neurons; Okadaic Acid; Phosphoric Monoester Hydrolases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Sulfonamides | 1996 |
Fibrinogen promotes monocyte adhesion via a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Alkaloids; Cell Adhesion; Cells, Cultured; Fibrin; Fibrinogen; Humans; Isoquinolines; Monocytes; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
The potentiation of nitroglycerin-induced relaxation by PKG inhibition in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Potassium Channels; Protein Kinase C; Purinones; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Arachidonic Acid; Blood Platelets; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lysophospholipids; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Wortmannin | 1996 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzyme Inhibitors; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Maleimides; Neuroblastoma; Nickel; Phosphatidylinositols; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Gamma interferon induced increases in intracellular cathepsin B activity in PMA primed THP-1 cells are blocked by inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cathepsin B; Cytoplasm; Humans; Infant; Interferon-gamma; Leukemia, Monocytic, Acute; Phloretin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Production of C-type natriuretic peptide in human aortic endothelial cells induced by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aorta; Base Sequence; Cells, Cultured; Diglycerides; Endothelium; Enzyme Activation; Enzyme Inhibitors; Humans; Natriuretic Peptide, C-Type; Protein Biosynthesis; Protein Kinase C; Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Heart Rate; Isoquinolines; Male; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Relaxin; Staurosporine; Stimulation, Chemical; Sulfonamides | 1996 |
Inhibition mechanisms of staurosporine and H7 to cAMP-dependent protein kinase through docking study.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Crystallization; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Protein Conformation; Staurosporine | 1996 |
CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Curcumin; Enzyme Inhibitors; Fibroblasts; Gene Expression; Gingiva; Humans; Lactams, Macrocyclic; Lipopolysaccharide Receptors; Lipopolysaccharides; Monocytes; NF-kappa B; Porphyromonas gingivalis; Proline; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Signal Transduction; Staurosporine; Thiocarbamates; Transcription Factor AP-1 | 1996 |
Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cerebellum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Kinetics; Marine Toxins; Membrane Potentials; Nerve Fibers; Oxazoles; Purkinje Cells; Rats; Receptors, GABA-A; Signal Transduction; Staurosporine | 1996 |
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides | 1996 |
CD11b/CD18-dependent stimulation of leukotriene B4 synthesis by human neutrophils (PMN) is synergistically enhanced by tumour necrosis factor alpha and low dose diacylglycerol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Diglycerides; Humans; Leukotriene B4; Macrophage-1 Antigen; Neutrophils; Phagocytosis; Protein Kinase C; Staurosporine; Tumor Necrosis Factor-alpha; Up-Regulation; Zymosan | 1996 |
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates | 1996 |
Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; Base Sequence; Blood-Brain Barrier; Brain; Endothelium; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Glucose Transporter Type 1; Luciferases; Molecular Sequence Data; Monosaccharide Transport Proteins; Receptors for Activated C Kinase; Receptors, Cell Surface; RNA, Messenger; Staurosporine | 1996 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Cell Nucleus; Enzyme Inhibitors; Half-Life; Humans; Mutation; Neuroblastoma; Protein Kinase Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Diglycerides; Enzyme Inhibitors; Fatty Acids; Gallic Acid; Glycerides; Guinea Pigs; Male; Neutrophils; Phosphatidic Acids; Propranolol; Serum Albumin, Bovine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triglycerides | 1997 |
Fluorescence depolarization as an early measure of T lymphocyte stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Concanavalin A; Cytoplasm; Enzyme Inhibitors; Fluoresceins; Fluorescence Polarization; Humans; Lymphocyte Activation; Lymphocyte Count; Phosphatidylinositols; Phytohemagglutinins; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin | 1997 |
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Role of cytosolic Ca2+ and protein kinase C in developing myogenic contraction in isolated rat small arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Cytosol; Femoral Artery; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth, Vascular; Nifedipine; Protein Kinase C; Rats; Rats, Wistar; Second Messenger Systems; Staurosporine | 1997 |
Effect of protein kinase inhibitors on the growth, morphology, and infectivity of Leishmania promastigotes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Inhibitors; Leishmania; Leishmania major; Leishmaniasis; Leishmaniasis, Cutaneous; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Serine-Threonine Kinases; Protozoan Proteins; Staurosporine | 1997 |
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Apoptosis; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Mice; Neoplasm Proteins; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Female; Intercellular Adhesion Molecule-1; Isoquinolines; Liver Neoplasms, Experimental; Lymphocyte Function-Associated Antigen-1; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Reorganization of the cortical actin cytoskeleton during maturation division in the Tubifex egg: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Calcimycin; Calcium; Cell Size; Chelating Agents; Cytoskeleton; Egtazic Acid; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Meiosis; Microinjections; Microscopy, Fluorescence; Oligochaeta; Oocytes; Protein Kinase C; Spectrophotometry; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Epoprostenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Osmolar Concentration; Peptides, Cyclic; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Vasoconstrictor Agents | 1997 |
Calmodulin-dependent protein kinases mediate calcium-induced slow motility of mammalian outer hair cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Auditory, Outer; Ionomycin; Ionophores; Isoquinolines; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Staurosporine; Sulfonamides | 1997 |
Induction of neutrophil chemotactic factor production by staurosporine in rat peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Dose-Response Relationship, Drug; Growth Substances; Intercellular Signaling Peptides and Proteins; Male; Neutrophils; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Possible involvement of protein kinase C in the modulation of inotropic and chronotropic effects induced by ouabain in rat right atrial muscles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Function; Enzyme Inhibitors; Heart Atria; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Ouabain; Phorbol Esters; Protein Kinase C; Rats; Staurosporine | 1997 |
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Goldfish; Indole Alkaloids; Nerve Crush; Neurites; Okadaic Acid; Optic Nerve; Protein Kinase C; Protein Kinase Inhibitors; Retina; Sphingosine; Staurosporine | 1997 |
Involvement of different transduction pathways in NF-kappa B activation by several inducers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Antioxidants; Base Sequence; Binding Sites; Cell Line; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Kinetics; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Protein Kinase Inhibitors; Reactive Oxygen Species; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Guidance of CNS growth cones by substratum grooves and ridges: effects of inhibitors of the cytoskeleton, calcium channels and signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytochalasin B; Cytoskeleton; Embryo, Mammalian; Embryo, Nonmammalian; Enzyme Inhibitors; Gadolinium; GTP-Binding Proteins; Hippocampus; Indoles; Isoquinolines; Maleimides; Microtubules; Neurites; Neurons; Nocodazole; Paclitaxel; Pertussis Toxin; Protein Kinase Inhibitors; Rats; Spinal Cord; Staurosporine; Sulfonamides; Virulence Factors, Bordetella; Xenopus laevis | 1997 |
Parthenogenetic activation of pig eggs by exposure to protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Meiosis; Microscopy, Electron; Ovary; Ovum; Parthenogenesis; Protein Kinase Inhibitors; Staurosporine; Swine | 1997 |
Facilitation of L-type calcium current in thalamic neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Electrophysiology; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Okadaic Acid; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Staurosporine; Thalamic Nuclei; Thionucleotides; Time Factors | 1998 |
Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Enzyme Activation; Half-Life; Humans; Indoles; Maleimides; Nasopharyngeal Neoplasms; Protein Kinase C; Protein Synthesis Inhibitors; Sphingosine; Staurosporine; Telomerase; Tumor Cells, Cultured | 1997 |
Protein kinase C regulation of organic anion transport in renal proximal tubule.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Enzyme Inhibitors; Epithelial Cells; Fluorescein; Homeostasis; Kidney Tubules, Proximal; Killifishes; Models, Biological; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antimetabolites; Carcinogens; Cells, Cultured; Cyclic AMP; Deoxyglucose; Diuretics, Osmotic; Enzyme Inhibitors; Estrenes; Gene Expression; Glucose; Growth Hormone; Kidney; Mannitol; Opossums; Phosphodiesterase Inhibitors; Phospholipases A; Pyrrolidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1998 |
Staurosporine and H7 attenuate ethanol-induced elevation in [Ca2+]i in cultured canine cerebral vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium; Dogs; Enzyme Inhibitors; Ethanol; Muscle, Smooth, Vascular; Protein Kinase C; Staurosporine | 1998 |
The effects of serum iminodipeptides and prednisolone on superoxide generation and tyrosyl phosphorylation of proteins in neutrophils from a patient with prolidase deficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Proteins; Dipeptidases; Dipeptides; Enzyme Inhibitors; Genistein; Humans; Imines; Neutrophils; Phosphorylation; Prednisolone; Proline; Protein-Tyrosine Kinases; Staurosporine; Superoxides | 1998 |
Acetylcholine acts on M3 muscarinic receptors and induces the translocation of aquaporin5 water channel via cytosolic Ca2+ elevation in rat parotid glands.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aquaporin 5; Aquaporins; Atropine; Calcimycin; Calcium; Calcium Channel Blockers; Cytosol; Diamines; Enzyme Inhibitors; Gallic Acid; Ion Channels; Ionophores; Male; Membrane Proteins; Parasympatholytics; Parotid Gland; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Muscarinic; Staurosporine | 1998 |
Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Aorta; Azepines; Blotting, Western; Cell Line; Dinoprost; Enzyme Inhibitors; Kinetics; Mice; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Staurosporine; Wortmannin | 1998 |
TNF alpha induces a protein kinase C-dependent reduction in astroglial K+ conductance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Barium; Brain; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Membrane Potentials; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Increased protein kinase C activity in myotrophin-induced myocyte growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Animals; Antisense Elements (Genetics); Cell Fractionation; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation; Genistein; Growth Substances; Intercellular Signaling Peptides and Proteins; Isoenzymes; Muscle Fibers, Skeletal; Myocardium; Myosin Heavy Chains; Pregnancy; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Signal Transduction; Staurosporine | 1998 |
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes | 1998 |
Arachidonic acid activates NADPH oxidase by a direct, calmodulin-regulated mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; NADPH Oxidases; Neutrophils; Nitric Oxide Synthase; Onium Compounds; Spectrophotometry; Staurosporine; Sulfonamides; Superoxides; Vasodilator Agents | 1998 |
The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; CD4 Antigens; CD4-Positive T-Lymphocytes; Down-Regulation; Enzyme Inhibitors; G(M1) Ganglioside; Gangliosides; Genistein; Humans; In Vitro Techniques; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphoprotein Phosphatases; Phytohemagglutinins; Protein Kinase Inhibitors; Staurosporine; Vanadates | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Benzoquinones; Cadaverine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytochalasin B; Endocytosis; Endosomes; Enzyme Activation; Enzyme Inhibitors; Kupffer Cells; Lactams, Macrocyclic; Lipopolysaccharides; Macrolides; Male; Nisoldipine; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Signal Transduction; Staurosporine; Stimulation, Chemical | 1998 |
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic | 1998 |
Assessment of the mechanism by which prolactin stimulates progesterone production by early corpora lutea of pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Cells, Cultured; Corpus Luteum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Ionomycin; Ionophores; Lipoproteins, LDL; Luteal Phase; Phorbol 12,13-Dibutyrate; Progesterone; Prolactin; Protein Kinase C; Staurosporine; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1998 |
Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Anti-Arrhythmia Agents; Calcium; Cardiotonic Agents; Cell Size; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Heart Failure; Hemodynamics; Isoproterenol; Male; Myocardial Contraction; Myocardium; Peptides, Cyclic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sodium-Hydrogen Exchangers; Staurosporine | 1998 |
Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; Electrophoresis; Female; Genistein; Growth Hormone; Growth Inhibitors; Janus Kinase 2; Leupeptins; Liver; Male; Milk Proteins; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Involvement of phospholipase A2 activation in anthrax lethal toxin-induced cytotoxicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminobenzoic Acid; Acetophenones; Aminobenzoates; Animals; Anthrax; Antigens, Bacterial; Antioxidants; Apoptosis; Bacterial Toxins; Cells, Cultured; Dehydroepiandrosterone; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Macrophages, Peritoneal; Melatonin; Mice; Mice, Inbred ICR; Nitric Oxide; para-Aminobenzoates; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Protein Kinase Inhibitors; Quinacrine; Reactive Oxygen Species; Staurosporine; Terpenes | 1999 |
Expression and characterization of protein kinase C in isolated rabbit parietal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminopyrine; Animals; Calcium; Cimetidine; Enzyme Inhibitors; Histamine; In Vitro Techniques; Isoenzymes; Male; Parietal Cells, Gastric; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protons; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Enzyme Inhibitors; Genistein; Osteoblasts; Parathyroid Hormone; Protein Kinase C; Staurosporine; Thrombin | 1999 |
Endothelin-induced prostacyclin production in rat aortic endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Arachidonic Acid; Cells, Cultured; Eicosanoids; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Indomethacin; Male; Protein Kinase C; Rats; Staurosporine | 1999 |
Involvement of calmodulin and protein kinase C in the regulation of K+ transport by carbachol across the rat distal colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbachol; Cholinergic Agonists; Colon; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Transport; Potassium; Protein Kinase C; Rats; Rats, Wistar; Rubidium Radioisotopes; Staurosporine | 1999 |
Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Muscle, Smooth, Vascular; Naphthalenes; Necrosis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reactive Oxygen Species; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-Erk signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Embryonal; Cell Differentiation; Ciliary Neurotrophic Factor; Cytokines; DNA-Binding Proteins; Flavonoids; Genes, Reporter; Growth Inhibitors; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Nerve Tissue Proteins; Neurons; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Signal Transduction; STAT3 Transcription Factor; Staurosporine; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Tyrphostins | 1999 |
K+ channels of Cf-9 transgenic tobacco guard cells as targets for Cladosporium fulvum Avr9 elicitor-dependent signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cladosporium; Electric Conductivity; Fungal Proteins; Ion Channel Gating; Kinetics; Membrane Glycoproteins; Membrane Potentials; Nicotiana; Patch-Clamp Techniques; Phosphorylation; Plant Diseases; Plant Proteins; Plants, Genetically Modified; Plants, Toxic; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Channels, Tandem Pore Domain; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine | 1999 |
Effect of HIV-1 gp41 peptides on secretion of beta-amyloid precursor protein in human astroglial cell line, T98G.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; AIDS Dementia Complex; Amyloid beta-Protein Precursor; Astrocytes; Carcinogens; Cell Line; Culture Media, Conditioned; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation, Viral; HIV Envelope Protein gp41; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; Staurosporine | 1999 |
Disruption of beta(2)-integrin-cytoskeleton coupling abolishes the signaling capacity of these integrins on granulocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Calcium; CD18 Antigens; Cell Adhesion; Cytoskeleton; Cytosol; Granulocytes; HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Signal Transduction; Staurosporine | 1999 |
Polycations induce calcium signaling in glomerular podocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Benzoquinones; Calcium Signaling; Cells, Cultured; DEAE-Dextran; Heparin; Kidney Glomerulus; Lactams, Macrocyclic; Marine Toxins; Mice; Muramidase; Oxazoles; Protamines; Quinones; Rifabutin; Staurosporine; Thapsigargin | 1999 |
Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Interleukin-1; Naphthalenes; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Staurosporine; Time Factors | 2000 |
Radiation augments a sequential program of differentiation in PKC inhibitor- pretreated mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Keratinocytes; Mice; Mice, Inbred BALB C; Protein Kinase C; Staurosporine | 1999 |
Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Reductase; Animals; Benzothiazoles; Cell Line; Drug Synergism; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phthalazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles | 1999 |
Short- and long-term memory are differentially affected by metabolic inhibitors given into hippocampus and entorhinal cortex.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Animals; Avoidance Learning; Carbazoles; Entorhinal Cortex; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Hippocampus; Indoles; Inhibition, Psychological; Male; Memory; Memory, Short-Term; Phenols; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Sodium Chloride; Staurosporine | 2000 |
Expression of complement inhibitor protein CD59 in human neuronal and glial cell lines treated with HIV-1 gp41 peptides.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; CD59 Antigens; Cell Line; Complement Inactivator Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HIV Envelope Protein gp41; Humans; Immunodominant Epitopes; Lipopolysaccharides; Neuroglia; Neurons; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C; RNA, Messenger; Staurosporine | 2000 |
A novel protein kinase from Brassica juncea stimulated by a protozoan calcium binding protein. Purification and partial characterization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brassica; Calcium; Calcium Signaling; Calcium-Binding Proteins; Calmodulin; Chelating Agents; Egtazic Acid; Entamoeba histolytica; Histones; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Peptides; Phosphorylation; Phosphoserine; Plant Proteins; Protein Kinases; Protein Processing, Post-Translational; Protozoan Proteins; Recombinant Fusion Proteins; Staurosporine; Sulfonamides | 2000 |
Involvement of superoxide generated by polymorphonuclear leukocytes in endotoxin-induced uveitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Male; Neutrophil Activation; Neutrophils; Protein Kinase C; Rats; Rats, Inbred Lew; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Uveitis, Anterior | 2000 |
Stimulation of Ca(2+)-independent exocytosis in rat pituitary gonadotrophs by G-protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum Compounds; Animals; Calcium; Calcium-Transporting ATPases; Cyclic AMP; Cytoplasmic Granules; Cytosol; Egtazic Acid; Enzyme Inhibitors; Exocytosis; Fluorides; Fluorometry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Male; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Anterior; Protein Kinase C; Rats; Staurosporine | 2000 |
Purification and in vitro activity of Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Baculoviridae; Catalytic Domain; Cattle; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Staurosporine | 2000 |
Selective protein kinase inhibitors block head-specific differentiation in hydra.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoquinones; Carrier Proteins; Cell Cycle; Humans; Hydra; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Protein Kinase C; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Sphingosine; Staurosporine | 2000 |
Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Calcimycin; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Extracellular Space; Female; Imidazoles; Intracellular Fluid; Ionophores; Isradipine; Potassium; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Staurosporine; Zona Glomerulosa | 2001 |
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Blotting, Western; Caspase 2; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Neuroblastoma; Neurons; Proteins; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2000 |
Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction | 2001 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Regulation of SERCA Ca2+ pump expression by cytoplasmic Ca2+ in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blotting, Northern; Calcimycin; Calcium; Calcium-Transporting ATPases; Carrier Proteins; Cells, Cultured; Cytoplasm; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Gene Expression; Heat-Shock Proteins; Homeostasis; Ionophores; Male; Molecular Chaperones; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Staurosporine; Thapsigargin | 2001 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Involvement of intracellular Ca2+ in the regulation of bovine leukemia virus expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Viral; Ionophores; Kidney; Leukemia Virus, Bovine; NF-kappa B; Protein Kinase C; Signal Transduction; Staurosporine; Terminal Repeat Sequences; Transcription, Genetic | 2001 |
Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Carbachol; Carcinogens; Cell Communication; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Acid; Interleukin-1; Parietal Cells, Gastric; Phenanthridines; Protein Kinase C; Rabbits; Sphingomyelin Phosphodiesterase; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Bucladesine; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycosphingolipids; Leishmania donovani; Leishmaniasis, Visceral; Lipopolysaccharides; Macrophages; Mice; Okadaic Acid; Ornithine Decarboxylase; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Protein kinase inhibitors and the dynamics of tight junction opening and closing in A6 cell monolayers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carrier Proteins; Cell Line; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Phosphoproteins; Plant Proteins; Protein Kinase C; Staurosporine; Tight Junctions; Xenopus; Xenopus Proteins; Zonula Occludens-1 Protein | 2001 |
Cell cycle-dependent regulation of telomerase activity by auxin, abscisic acid and protein phosphorylation in tobacco BY-2 suspension culture cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2,4-Dichlorophenoxyacetic Acid; Abscisic Acid; Cantharidin; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Indoleacetic Acids; Nicotiana; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Plant Growth Regulators; Protein Phosphatase 2; Staurosporine; Telomerase; Telomere; Time Factors | 2002 |
Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Acetylcholine; Animals; Carbazoles; Carrier Proteins; Cell Membrane Permeability; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Neuromuscular Junction; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrroles; Staurosporine; Thionucleotides | 2002 |
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Bucladesine; Calcium; Carbazoles; Chelating Agents; Cholagogues and Choleretics; Cholestasis; Cholic Acids; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Indoles; Liver; Male; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Staurosporine; Taurochenodeoxycholic Acid; Taurolithocholic Acid | 2002 |
Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aggregatibacter actinomycetemcomitans; Cells, Cultured; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Matrix Metalloproteinase 2; Periodontal Diseases; Periodontal Ligament; Porphyromonas gingivalis; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2002 |
Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Membrane; Cells, Cultured; Culture Media; Cycloheximide; DNA-Binding Proteins; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; GTP-Binding Proteins; Imidazoles; Intercellular Adhesion Molecule-1; Interferon Regulatory Factor-1; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-1; Interleukin-13; Interleukin-4; NF-kappa B; Okadaic Acid; Osmosis; Phosphoproteins; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Staurosporine; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2002 |
Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amino Acid Sequence; Animals; Ascaris suum; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Genistein; Levamisole; Membrane Potentials; Molecular Sequence Data; Patch-Clamp Techniques; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptors, Nicotinic; Staurosporine; Vasodilator Agents | 2002 |
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents | 2003 |
Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Squamous Cell; Cell Culture Techniques; Down-Regulation; Enzyme Inhibitors; Humans; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mouth Mucosa; Mouth Neoplasms; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2003 |
A novel interaction between protein kinase D and TNF receptor-associated factor molecules regulates B cell receptor-CD40 synergy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; CD40 Antigens; Cell Line; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Mice; Mice, Inbred C57BL; Protein Binding; Protein Kinase C; Proteins; Receptors, Antigen, B-Cell; Receptors, Tumor Necrosis Factor; Signal Transduction; Staurosporine; TNF Receptor-Associated Factor 1; TNF Receptor-Associated Factor 2; TNF Receptor-Associated Factor 3; Up-Regulation | 2003 |
PknH, a transmembrane Hank's type serine/threonine kinase from Mycobacterium tuberculosis is differentially expressed under stress conditions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acids; Adaptation, Physiological; Bacterial Proteins; Cloning, Molecular; Enzyme Inhibitors; Escherichia coli; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Histones; Hot Temperature; Membrane Proteins; Mycobacterium tuberculosis; Myelin Basic Protein; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Signal Transduction; Staurosporine | 2004 |
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Gallopamil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Indoles; Magnesium; Memantine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nifedipine; Protein Kinase C; Pyridines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Staurosporine; Sulfonamides; Tetrodotoxin | 2004 |
Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Active Transport, Cell Nucleus; Adenoviridae; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Fluorescence Recovery After Photobleaching; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Histone Deacetylases; Kinetics; MEF2 Transcription Factors; Mice; Mice, Inbred Strains; Microscopy, Confocal; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Myogenic Regulatory Factors; Recombinant Fusion Proteins; Staurosporine; Time Factors; Transcription Factors | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Amino Acid Sequence; Animals; Humans; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Molecular Weight; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; Spodoptera; Staurosporine | 2006 |
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Hydrogen-Ion Concentration; Macrolides; Male; Membrane Microdomains; Organelles; Protein Kinase C; Protein Subunits; Proteomics; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; RNA Interference; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staurosporine; Vacuolar Proton-Translocating ATPases | 2010 |
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Anticarcinogenic Agents; Benzopyrans; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Oleanolic Acid; Precursor Cells, B-Lymphoid; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2012 |
Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Female; Glutamic Acid; HEK293 Cells; Humans; Male; Neurons; Phosphorylation; Protein Binding; Protein Subunits; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine; Synapses | 2013 |