1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with staurosporine aglycone in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 16 (72.73) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gordon, PB; Holen, I; Seglen, PO | 1 |
| Grove, DS; Mastro, AM | 1 |
| Davis, PD; Elliott, LH; Hill, CH; Lawton, G; Nixon, JS; Sedgwick, AD; Wilkinson, SE | 1 |
| Herbert, JM; Maffrand, JP; Seban, E | 1 |
| Putney, JW; Sugiya, H | 1 |
| Ari, IL; Atlas, D; Schwarz, L | 1 |
| Shen, SS | 1 |
| Boner, G; Gbarah, A; Mhashilkar, AM; Sharon, N | 1 |
| Dauer, WT; Fink, JS; Hamill, LK; Hyman, SE; Lewis, SE; Schwarzschild, MA | 1 |
| Borosky, SA; Boxer, PA; Coughenour, LL; Hajimohammadreza, I; Marcoux, FW; Probert, AW; Wang, KK | 1 |
| Azuma, Y; Ishimura, Y; Kizaki, H; Onishi, Y; Suzuki, K | 1 |
| Basu, U; Bennett, GS; Hollander, BA; Quintana, R; Rodriguez, R | 1 |
| Kondoh, S; Mue, S; Ohuchi, K; Tanabe, J; Watanabe, M | 1 |
| Abraham, I; Sampson, KE; Wolf, CL | 1 |
| Ishikawa, Y; Ogawa, A; Sasakawa, S | 1 |
| Beppu, T; Hong, SK; Horinouchi, S; Matsumoto, A | 1 |
| Kitamura, Y; Miyazaki, A; Nomura, Y | 1 |
| Maurer, JA; McKay, DB; Wenger, BW | 1 |
| Agranoff, BW; Heacock, AM | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Lankisch, TO; Mitamura, K; Nozu, F; Owyang, C; Tsunoda, Y; Yoshida, H | 1 |
| Chaby, R; Girard, R; Pedron, T | 1 |
22 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and staurosporine aglycone
| Article | Year |
|---|---|
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Cytoskeleton; Ethers, Cyclic; Indole Alkaloids; Indoles; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Raffinose; Rats; Rats, Inbred Strains; Sulfonamides; Tritium | 1992 |
Differential activation and inhibition of lymphocyte proliferation by modulators of protein kinase C: diacylglycerols, "rationally designed" activators and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cattle; Diglycerides; Down-Regulation; Enzyme Activation; Genistein; Indole Alkaloids; Isoflavones; Isoquinolines; Lymphocyte Activation; Piperazines; Protease Inhibitors; Protein Kinase C; Sphingosine; Sulfonamides; Type C Phospholipases | 1991 |
K252a is a potent and selective inhibitor of phosphorylase kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carbazoles; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Kinetics; Muscles; Phosphorylase Kinase; Piperazines; Protein Kinase Inhibitors; Rabbits; Staurosporine; Structure-Activity Relationship | 1990 |
Characterization of specific binding sites for [3H]-staurosporine on various protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Carbazoles; Indole Alkaloids; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Sulfonamides | 1990 |
Protein kinase C-dependent and -independent mechanisms regulating the parotid substance P receptor as revealed by differential effects of protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Indole Alkaloids; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Sugar Phosphates | 1988 |
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Carbazoles; Cerebral Cortex; Cholera Toxin; GTP-Binding Proteins; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Male; Neurosecretion; Norepinephrine; Ouabain; Pertussis Toxin; Phenylephrine; Piperazines; Polymyxin B; Potassium Chloride; Protein Kinase C; Rats; Veratridine; Virulence Factors, Bordetella | 1989 |
Na+-H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Carbazoles; Carrier Proteins; Female; Fertilization; Indole Alkaloids; Isoquinolines; Kinetics; Ovum; Piperazines; Protein Kinase C; Sea Urchins; Sodium-Hydrogen Exchangers; Sulfonamides; Tetradecanoylphorbol Acetate | 1989 |
Involvement of protein kinase C in activation of human granulocytes and peritoneal macrophages by type 1 fimbriated (mannose specific) Escherichia coli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carbazoles; Escherichia coli; Fimbriae, Bacterial; Granulocytes; Indole Alkaloids; Isoquinolines; Luminescent Measurements; Macrophage Activation; Macrophages; Mannose; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Blotting, Western; Carbazoles; Cell Line; Cells, Cultured; Ciliary Neurotrophic Factor; Cytokines; Growth Inhibitors; Indole Alkaloids; Interleukin-6; Isoquinolines; Leukemia Inhibitory Factor; Lymphokines; Nerve Growth Factors; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oncostatin M; Peptides; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; ras Proteins; Rats; RNA; RNA, Messenger; Staurosporine; Superior Cervical Ganglion; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Genistein; Imidazoles; Indole Alkaloids; Isoflavones; Isoquinolines; Kinetics; N-Methylaspartate; Naphthalenes; Neurons; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrin | 1995 |
Biphasic effect of staurosporine on thymocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Apoptosis; Bucladesine; Calcimycin; Carbazoles; Carcinogens; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Indole Alkaloids; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase Inhibitors; Radiation-Sensitizing Agents; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1995 |
Differential sensitivity to inhibitors discriminates between two types of kinases responsible for in vivo phosphorylation of different sites in the carboxy-terminal tail of chicken neurofilament-M.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Chick Embryo; Ganglia, Spinal; Indole Alkaloids; Isoquinolines; Lithium Chloride; Molecular Sequence Data; Neurofilament Proteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sphingosine; Staurosporine; Trifluoperazine | 1994 |
Possible roles of protein kinases in neutrophil chemotactic factor production by leucocytes in allergic inflammation in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cells, Cultured; Chemotactic Factors; Culture Media, Conditioned; Cycloheximide; Depression, Chemical; Dexamethasone; Genistein; Hypersensitivity; Indole Alkaloids; Inflammation; Isoelectric Focusing; Isoflavones; Isoquinolines; Leukocytes; Male; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1994 |
Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Drug Interactions; Drug Resistance; Gene Expression; Humans; Indole Alkaloids; Isoquinolines; KB Cells; Membrane Glycoproteins; Neoplasm Proteins; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Verapamil | 1993 |
Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Blood Platelets; Carbazoles; Carrier Proteins; Humans; Hydrogen; Indole Alkaloids; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine; Thrombin | 1993 |
Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Benzoquinones; Carbazoles; Cell Differentiation; Fungal Proteins; Indole Alkaloids; Isoquinolines; Lactams, Macrocyclic; Manganese; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinones; Rifabutin; Staurosporine; Streptomyces griseus | 1993 |
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1993 |
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity | 1996 |
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Goldfish; Indole Alkaloids; Nerve Crush; Neurites; Okadaic Acid; Optic Nerve; Protein Kinase C; Protein Kinase Inhibitors; Retina; Sphingosine; Staurosporine | 1997 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
A possible role for Ca(2+)/calmodulin-dependent protein kinase IV during pancreatic acinar stimulus-secretion coupling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Immunoblotting; Indole Alkaloids; Male; Myosin-Light-Chain Kinase; Pancreas; Phosphotransferases; Rats; Rats, Sprague-Dawley; Sincalide; Sulfonamides | 2000 |
Protein phosphorylation pathways involved during lipopolysaccharide-induced expression of CD14 in mouse bone marrow granulocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bone Marrow Cells; Carbazoles; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Flavonoids; Flow Cytometry; Granulocytes; Immunoblotting; Indole Alkaloids; Indoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases | 2000 |