Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and sphingosine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with sphingosine in 110 studies

Research

Studies (110)

TimeframeStudies, this research(%)All Research%
pre-199023 (20.91)18.7374
1990's79 (71.82)18.2507
2000's6 (5.45)29.6817
2010's2 (1.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chase, HS; Lindeman, RP; Luo, H1
Engler, D; Funder, JW; Liu, JP; Robinson, PJ1
Considine, RV; Sherwin, JR; Simpson, LL1
Fröhlich, O; Wallert, MA1
Fujita, Y; Sugiya, H1
Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A1
Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P1
Chao, R; Hannun, YA; Khan, W1
Pradines-Figueres, A; Raetz, CR1
Faraci, FM; Heistad, DD; Murray, MA2
Betto, R; Fachechi-Cassano, G; Sabbadini, RA; Salviati, G; Teresi, A1
Fujii, T; Hashizume, T; Sato, T1
Joyce, NC; Meklir, B1
Felipo, V; Grisolía, S; Llopis, J; Miñana, MD; Romá, J; Romero, FJ1
Chedrese, PJ; Ly, H; Murphy, BD; Rajkumar, K1
Frizzell, RA; Worrell, RT1
Kojima, I; Shibata, H1
Barrett, KE; Dharmsathaphorn, K; Dinh, S; Kachintorn, U; Vajanaphanich, M; Vongkovit, P1
Anwyl, R; McGuinness, N; Rowan, M1
Celada, A; Maki, RA1
Elliott, ME; Goodfriend, TL; Jones, HM; Tomasko, S1
Raymond, JR1
Sauro, MD; Zorn, NE2
Agopyan, I; Agopyan, N1
Bell, RM; Hannun, YA; Merrill, AH1
Suen, CS; Wilk, S1
Grove, DS; Mastro, AM1
Farley, J; Schuman, E1
Bell, SC; Capetola, RJ; Goodman, MG; Gupta, S; Rosenthale, ME; Weigle, WO1
Martin, DB; Pek, SB; Thomas, TP1
Barnett, NL; Broyden, NJ; Morris, NJ; Osborne, NN1
Bement, WM; Capco, DG1
Crane, DL; Elliott, MS1
Akiyama, SK; Asseffa, A; Breton, P; Cha, JK; Grzegorzewski, K; Olden, K; White, SL1
Kitaoka, M; Kojima, I; Ogata, E1
Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S1
Ballou, LR; Barker, SC; Kang, AH; Postlethwaite, AE1
Buzilã, L; Laky, M; Moraru, II; Popescu, LM; Stãnescu, T1
Bacon, KB; Camp, RD1
Fisher, TE; Kaczmarek, LK1
Buckley, NE; Gibson, K; Spiegel, S; Zhang, H1
Buckley, AR; Crowe, PD; Farese, RV; Hadden, EM; Laird, HE; Russell, DH; Sauro, MD; Zorn, NE1
Boscá, L; Díaz-Guerra, MJ; Junco, M1
Cline, HT; Constantine-Paton, M1
Baines, AD; Ho, P1
Homonnai, ZT; Kalina, M; Naor, Z; Paz, GF; Rotem, R1
Hansen, HS; Jensen, B; Linnebjerg, H1
Krebs, B; Kurrle, R; Rehermann, B; Resch, K; Szamel, M1
Petty, HR1
Bedoy, CA; Mobley, PL1
Insel, PA; Slivka, SR; Weiss, BA1
Jacobson, D; O'Flaherty, JT1
Beattie, LL; Cragoe, EJ; Gerrard, JM; Israels, SJ; Lint, D; McNicol, A; Park, J1
Bixby, JL1
Boner, G; Gbarah, A; Mhashilkar, AM; Sharon, N1
Arese, P; Bussolino, F; Fischer, E; Kazatchkine, MD; Turrini, F1
Aizu, E; Kato, R; Nakadate, T; Nishikawa, K; Yamamoto, S1
Corradetti, R; Pugliese, AM; Ropert, N1
Hsu, T; Simpson, RU; Taylor, JM; Wendt, MD1
Kaever, V; Pfannkuche, HJ; Resch, K; Wessel, K1
Gemsa, D; Kaever, V; Pfannkuche, HJ; Resch, K1
Gilchrest, BA; Gordon, PR1
Dougherty, RW; Niedel, JE; Rider, LG1
Badwey, JA; Horn, W; Karnovsky, MJ; Karnovsky, ML; Robinson, JM; Soberman, RJ1
Insel, PA; Meier, KE; Slivka, SR1
Madison, DV; Malinow, R; Tsien, RW1
Conn, PJ; Kaczmarek, LK; Strong, JA1
Bloom, BR; Fan, XD; Goldberg, M1
Gershengorn, MC; Winicov, I1
Kachra, Z; Posner, BI; Yang, CR1
Brooks, BJ; Elliott, MS; Eriotou, P; Hart, KL; Kelly, DF; Morris, RC; Sagar, S1
Terrian, DM; Ways, DK1
Basu, U; Bennett, GS; Hollander, BA; Quintana, R; Rodriguez, R1
Abita, JP; Chedeville, A; Gespach, C; Zimber, A1
Larivée, P; Levine, SJ; Logun, C; Martinez, A; Shelhamer, JH; Wu, T1
Andersen, CB; Hansen, AB1
Andersen, CB; Bouchelouche, PN; Giese, BN; Hansen, AB1
Blobe, GC; Hannun, YA; Khan, WA; Richards, AL1
Hayashi, K; Niwayama, S1
Ishihara, H; Nagaki, M; Sasaki, H; Shimura, S; Takishima, T1
Boniece, IR; Maiese, K; Skurat, K; Wagner, JA1
Hara, A; Taketomi, T; Uemura, K1
Hakomori, S; Igarashi, Y; Mazurek, N; Megidish, T1
Cunningham, GR; House, FS; Stewart, SJ1
Crow, T; Forrester, J2
Ishikawa, Y; Ogawa, A; Sasakawa, S1
Bayat-Sarmadi, M; Houdebine, LM1
Hakomori, S; Igarashi, Y; Sakakura, C; Shirahama, T; Sweeney, EA1
Jarvis, WD; Spangelo, BL1
Hashizume, T; Nakao, M; Sato, T1
Papp, A1
Cagnoli, CM; Manev, H1
Agranoff, BW; Heacock, AM1
Cheng, AJ; Ku, WC; Wang, TC1
Himmelreich, NH; Pozdnyakova, NG; Storchak, LG1
Carpio, LC; Dziak, R1
Kawano, Y; Matsui, N; Miyakawa, I; Narahara, H; Nasu, K; Sugano, T1
Jett, M; Yan, Z; Yang, DC1
Abend, M; Frombeck, S; Van Beuningen, D1
Arima, K; Fujisawa, K; Miyakawa, I; Narahara, H; Nasu, K; Sugano, T1
Böhmer, FD; Bosch, TC; Cardenas, M; Cerbon, J; Fabila, YV; Fujisawa, T; Salgado, LM; Wetzker, R; Yum, S1
Choi, MR; Suh, HW; Won, JS1
Harvey, KA; Paranavitana, CN; Siddiqui, RA; Zaloga, GP1
Kaneko, S; Okamoto, Y; Sugimoto, N; Takamura, M; Takashima, S; Takata, S; Takuwa, N; Takuwa, Y; Yoshioka, K1
Adachi, S; Hanai, Y; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Mizutani, J; Otsuka, T; Takai, S; Tokuda, H1
Chieng, YC; Hoon, LS; Hsum, YW; Mooi, LY; Soo, KK; Yew, WT1
Balogh, A; Benyó, Z; Dancs, PT; Fülöp, Á; Kerék, M; Móré, D; Offermanns, S; Panta, CR; Proia, RL; Ruisanchez, É; Tigyi, GJ1

Reviews

1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and sphingosine

ArticleYear
The regulation of excitability by second messengers and protein kinases in peptidergic neurons of Aplysia.
    Advances in second messenger and phosphoprotein research, 1990, Volume: 24

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Aplysia; Calcium; Calcium Channels; Enzyme Activation; Ion Channel Gating; Isoquinolines; Neurons; Neuropeptides; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinases; Protein Processing, Post-Translational; Second Messenger Systems; Sphingosine; Tetradecanoylphorbol Acetate

1990

Other Studies

109 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and sphingosine

ArticleYear
Participation of protein kinase C in desensitization to bradykinin and to carbachol in MDCK cells.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Calcium; Carbachol; Cell Line; Cell Membrane; Dogs; Epithelium; Isoquinolines; Kidney; Kinetics; Microscopy, Fluorescence; Piperazines; Protein Kinase C; Receptors, Cell Surface; Sphingosine; Tetradecanoylphorbol Acetate

1992
Evidence that the stimulation by arginine vasopressin of the release of adrenocorticotropin from the ovine anterior pituitary involves the activation of protein kinase C.
    Molecular and cellular endocrinology, 1992, Volume: 87, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Cells, Cultured; Corticotropin-Releasing Hormone; Enzyme Activation; Female; Isoquinolines; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Protein Kinase Inhibitors; Retinaldehyde; Sheep; Sphingosine; Tetradecanoylphorbol Acetate

1992
Role of protein kinase C in short-term transmission at the mammalian neuromuscular junction.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Botulinum Toxins; Calcium; Isoquinolines; Neuroblastoma; Neuromuscular Blocking Agents; Neuromuscular Junction; Piperazines; Protein Kinase C; Sphingosine; Synaptic Transmission; Tumor Cells, Cultured

1992
Alpha 1-adrenergic stimulation of Na-H exchange in cardiac myocytes.
    The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Carrier Proteins; Hydrogen-Ion Concentration; Isoquinolines; Myocardium; Norepinephrine; Piperazines; Protein Kinase C; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate

1992
Sphingosine inhibits muscarinic cholinergic receptor binding in rat parotid acinar cells.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1992, Volume: 103, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Calcium; Isoquinolines; Male; Parotid Gland; Piperazines; Protein Kinase C; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sphingosine

1992
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
    The Journal of cell biology, 1992, Volume: 116, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1992
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate

1992
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
    The Journal of biological chemistry, 1992, Nov-25, Volume: 267, Issue:33

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cell Division; Cell Line; Ceramides; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Humans; Ionomycin; Isomerism; Isoquinolines; Molecular Weight; Naphthalenes; Okadaic Acid; Phosphorylation; Piperazines; Polycyclic Compounds; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate

1992
Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.
    The Journal of biological chemistry, 1992, Nov-15, Volume: 267, Issue:32

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cysteine; Dose-Response Relationship, Drug; Endotoxins; Humans; Isoquinolines; Kinetics; Lipopolysaccharides; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Staurosporine; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1992
Effect of protein kinase C inhibitors on endothelin- and vasopressin-induced constriction of the rat basilar artery.
    The American journal of physiology, 1992, Volume: 263, Issue:6 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine Vasopressin; Basilar Artery; Endothelins; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Sphingosine; Vasoconstriction

1992
Role of protein kinase C in constrictor responses of the rat basilar artery in vivo.
    The Journal of physiology, 1992, Volume: 445

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Dinoprost; Dose-Response Relationship, Drug; Enzyme Activation; Ergolines; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Sphingosine; Vasoconstriction

1992
Sphingosine inhibits calcium release from sarcoplasmic reticulum membranes.
    Advances in experimental medicine and biology, 1992, Volume: 311

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium; In Vitro Techniques; Isoquinolines; Kinetics; Muscles; Piperazines; Protein Kinase Inhibitors; Rabbits; Sarcoplasmic Reticulum; Sphingosine

1992
Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.
    The Biochemical journal, 1992, Feb-15, Volume: 282 ( Pt 1)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cell Membrane; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Piperazines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Thrombin; Type C Phospholipases

1992
Protein kinase C activation during corneal endothelial wound repair.
    Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Cell Movement; Cells, Cultured; Endothelium, Corneal; Enzyme Activation; Epidermal Growth Factor; Fluorescent Antibody Technique; Fluorescent Dyes; Isoquinolines; Male; Phalloidine; Piperazines; Protein Kinase C; Rabbits; Rhodamines; Sphingosine; Tetradecanoylphorbol Acetate; Wound Healing

1992
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
    FEBS letters, 1992, May-25, Volume: 303, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Enzyme Activation; Glutathione; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tumor Cells, Cultured

1992
Protein kinase C, an endogenous regulator of hormone-induced cyclic AMP induction in porcine luteal cells.
    The Journal of endocrinology, 1991, Volume: 130, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Colistin; Corpus Luteum; Cyclic AMP; Female; Isoquinolines; Luteinizing Hormone; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Swine; Tetradecanoylphorbol Acetate

1991
CaMKII mediates stimulation of chloride conductance by calcium in T84 cells.
    The American journal of physiology, 1991, Volume: 260, Issue:4 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Chloride Channels; Colon; Imidazoles; Ion Channels; Ionomycin; Isoquinolines; Kinetics; Membrane Proteins; Peptide Fragments; Phloretin; Piperazines; Protein Kinase C; Protein Kinases; Sphingosine; Trifluoperazine

1991
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
    Endocrinologia japonica, 1991, Volume: 38, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa

1991
Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.
    The American journal of physiology, 1992, Volume: 262, Issue:1 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Line; Chlorides; Colon; Humans; Intestinal Mucosa; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase Inhibitors; Rubidium; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors

1992
Inhibition of an N-methyl-D-aspartate induced short-term potentiation in the rat hippocampal slice.
    Brain research, 1991, Oct-25, Volume: 562, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoquinolines; N-Methylaspartate; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase Inhibitors; Rats; Sphingosine; Time Factors

1991
IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 1991, Jan-01, Volume: 146, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Calcimycin; Calmodulin; Gene Expression Regulation; Histocompatibility Antigens Class II; Interferon-gamma; Ionomycin; Isoquinolines; Macrophages; Major Histocompatibility Complex; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Trifluoperazine; Tumor Necrosis Factor-alpha

1991
Sphingosine inhibits angiotensin-stimulated aldosterone synthesis.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 38, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Angiotensin II; Animals; Bucladesine; Cattle; Cells, Cultured; Isoquinolines; Ouabain; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Zona Glomerulosa

1991
Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor.
    The Journal of biological chemistry, 1991, Aug-05, Volume: 266, Issue:22

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Affinity Labels; Animals; Cell Line; Cell Membrane; Cloning, Molecular; Cricetinae; Cricetulus; Humans; Isoquinolines; Phosphorylation; Photochemistry; Piperazines; Precipitin Tests; Protein Kinase C; Receptors, Serotonin; Sphingosine; Tetradecanoylphorbol Acetate

1991
Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism.
    Journal of cellular physiology, 1991, Volume: 148, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Division; Cells, Cultured; Cyclosporins; DNA; Enzyme Activation; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Platelet-Derived Growth Factor; Prolactin; Protein Kinase C; Receptors, Prolactin; Sphingosine; Staurosporine; Thymidine; Tritium

1991
Effects of protein kinase C activators and inhibitors on membrane properties, synaptic responses, and cholinergic actions in CA1 subfield of rat hippocampus in situ and in vitro.
    Synapse (New York, N.Y.), 1991, Volume: 7, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Cell Membrane; Enzyme Activation; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Methacholine Chloride; Parasympathomimetics; Phorbol Esters; Piperazines; Protein Kinase C; Pyramidal Tracts; Rats; Rats, Inbred Strains; Sphingosine; Synapses

1991
Use of sphingosine as inhibitor of protein kinase C.
    Methods in enzymology, 1991, Volume: 201

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine

1991
Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester.
    Endocrinology, 1990, Volume: 127, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Epinephrine; Eye Neoplasms; Humans; Immune Sera; Immunoblotting; Isoquinolines; Kinetics; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Pyroglutamyl-Peptidase I; Retinoblastoma; Sphingosine; Tetradecanoylphorbol Acetate

1990
Differential activation and inhibition of lymphocyte proliferation by modulators of protein kinase C: diacylglycerols, "rationally designed" activators and inhibitors of protein kinase C.
    Experimental cell research, 1991, Volume: 193, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cattle; Diglycerides; Down-Regulation; Enzyme Activation; Genistein; Indole Alkaloids; Isoflavones; Isoquinolines; Lymphocyte Activation; Piperazines; Protease Inhibitors; Protein Kinase C; Sphingosine; Sulfonamides; Type C Phospholipases

1991
Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Mar-01, Volume: 88, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Electric Stimulation; In Vitro Techniques; Isoquinolines; Microelectrodes; Nervous System Physiological Phenomena; Photoreceptor Cells; Piperazines; Protein Kinase C; Snails; Sphingosine; Staurosporine

1991
Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency.
    Clinical immunology and immunopathology, 1991, Volume: 59, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibody Formation; Antigens, CD; Cell Division; Concanavalin A; Dose-Response Relationship, Drug; Female; Guanosine; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunophenotyping; In Vitro Techniques; Isoquinolines; Lymphocytes; Male; Middle Aged; Piperazines; Pokeweed Mitogens; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Staurosporine

1991
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
    Diabetes, 1991, Volume: 40, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil

1991
Protein kinase C (alpha and beta) immunoreactivity in rabbit and rat retina: effect of phorbol esters and transmitter agonists on immunoreactivity and the translocation of the enzyme from cytosolic to membrane compartments.
    Journal of neurochemistry, 1991, Volume: 57, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Aging; Alkaloids; Animals; Antibodies, Monoclonal; Cell Membrane; Cytosol; Fluorescent Antibody Technique; In Vitro Techniques; Isoenzymes; Isoquinolines; Kinetics; Phorbol Esters; Piperazines; Protein Kinase C; Quisqualic Acid; Rabbits; Rats; Retina; Sphingosine; Staurosporine

1991
Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.
    Cell regulation, 1990, Volume: 1, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Egtazic Acid; Exocytosis; Interphase; Isoquinolines; Oocytes; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Xenopus laevis

1990
Protein kinase C modulation of queuine uptake in cultured human fibroblasts.
    Biochemical and biophysical research communications, 1990, Aug-31, Volume: 171, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cells, Cultured; Diglycerides; Enzyme Activation; Fibroblasts; Growth Substances; Guanine; Humans; In Vitro Techniques; Isoquinolines; Male; Phorbol Esters; Phosphatidylserines; Piperazines; Protein Kinase C; Sphingosine; Staurosporine

1990
Swainsonine modulation of protein kinase C activity in murine peritoneal macrophages.
    Cancer communications, 1990, Volume: 2, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Cycloheximide; Dose-Response Relationship, Drug; Female; Immunoblotting; Isoquinolines; Macrophage Activation; Macrophages; Mannosidases; Mice; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine; Swainsonine

1990
Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells.
    The Journal of biological chemistry, 1990, Oct-05, Volume: 265, Issue:28

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Diglycerides; Glucose; Glycerol; Inositol; Insecticides; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Phosphates; Piperazines; Protein Kinase Inhibitors; Pyrethrins; Sphingosine; Tetradecanoylphorbol Acetate

1990
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
    Biochemical pharmacology, 1990, Oct-01, Volume: 40, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1990
Sphingosine potentiates IL-1-mediated prostaglandin E2 production in human fibroblasts.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Dec-15, Volume: 145, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Drug Synergism; Enzyme Activation; Fibroblasts; Humans; In Vitro Techniques; Interleukin-1; Isoquinolines; Phorbol Esters; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Time Factors

1990
Protein kinase C controls Fc gamma receptor-mediated endocytosis in human neutrophils.
    FEBS letters, 1990, Nov-12, Volume: 274, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation; Cells, Cultured; Endocytosis; Humans; Immunoglobulin G; Isoquinolines; Kinetics; Neutrophils; Palmitoylcarnitine; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Signal Transduction; Sphingosine; Tamoxifen

1990
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C.
    Biochemical and biophysical research communications, 1990, Jun-29, Volume: 169, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Movement; Chemotactic Factors; Cholera Toxin; Cyclic AMP; Diglycerides; GTP-Binding Proteins; Humans; In Vitro Techniques; Indoles; Interleukin-8; Interleukins; Isoquinolines; Lymphocytes; Maleimides; Pertussis Toxin; Piperazines; Protein Kinase C; Sphingosine; Virulence Factors, Bordetella

1990
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
    The Journal of biological chemistry, 1990, Jan-05, Volume: 265, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; DNA; Down-Regulation; Drug Synergism; Fibroblasts; Growth Substances; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1990
Prolactin and known modulators of rat splenocytes activate nuclear protein kinase C.
    European journal of pharmacology, 1990, Mar-13, Volume: 188, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cell Nucleus; Cyclosporins; Glycerol; Isoquinolines; Lipid Metabolism; Male; Microscopy, Electron; Phospholipids; Phosphorylation; Piperazines; Prolactin; Protein Kinases; Rats; Rats, Inbred Strains; Sphingosine; Spleen; T-Lymphocytes

1990
Substrate-dependent inhibition of protein kinase C by specific inhibitors.
    FEBS letters, 1990, Apr-09, Volume: 263, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Chromatography, Affinity; Chromatography, Ion Exchange; Gossypol; Homeostasis; Isoquinolines; Kinetics; Ligands; Piperazines; Protein Kinase C; Quercetin; Rats; Sphingosine; Staurosporine; Substrate Specificity

1990
The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system.
    Neuron, 1990, Volume: 4, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Horseradish Peroxidase; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Polyvinyls; Protein Kinase Inhibitors; Rana pipiens; Retina; Retinal Ganglion Cells; Sphingosine; Superior Colliculi; Visual Pathways

1990
Diacylglycerol and protein kinase mediated noradrenergic responses in perfused rat kidneys.
    Canadian journal of physiology and pharmacology, 1990, Volume: 68, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glomerular Filtration Rate; Gluconeogenesis; Glycerides; In Vitro Techniques; Isoquinolines; Kidney; Kidney Tubules; Male; Norepinephrine; Perfusion; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Renal Circulation; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Vascular Resistance

1990
Protein kinase C is present in human sperm: possible role in flagellar motility.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:18

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibodies, Monoclonal; Humans; Immunohistochemistry; Isoquinolines; Kinetics; Male; Piperazines; Protein Kinase C; Reference Values; Sperm Motility; Spermatozoa; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1990
Inhibition by amiloride and by Na+-depletion of A23187-stimulated arachidonic acid and histamine release from rat mast cells.
    FEBS letters, 1988, Nov-21, Volume: 240, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Carrier Proteins; Histamine Release; In Vitro Techniques; Isoquinolines; Mast Cells; Piperazines; Protein Kinase C; Rats; Sodium; Sodium-Hydrogen Exchangers; Sphingosine

1988
Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C.
    Journal of immunology (Baltimore, Md. : 1950), 1989, Nov-01, Volume: 143, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cells, Cultured; Diglycerides; DNA; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Indomethacin; Interleukin-2; Ionomycin; Isoquinolines; Linoleic Acid; Linoleic Acids; Lymphocyte Activation; Lymphocytes; Masoprocol; Membrane Lipids; Phospholipids; Piperazines; Protein Kinase C; Receptors, Antigen, T-Cell; Sphingosine

1989
Regulation of RAW264 macrophage morphology and spreading: studies with protein kinase C activators, inhibitors and a cyclic AMP analog.
    Biochimica et biophysica acta, 1989, Aug-15, Volume: 1012, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Cell Line; Cell Movement; Enzyme Activation; Isoquinolines; Kinetics; Macrophages; Mice; Microscopy, Electron, Scanning; Phenylephrine; Piperazines; Protein Kinase C; Sphingosine; Trifluoperazine

1989
Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors.
    Brain research, 1989, Jun-26, Volume: 490, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Isoquinolines; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1989
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
    Molecular pharmacology, 1989, Volume: 36, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1989
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
    Biochemical and biophysical research communications, 1989, Sep-29, Volume: 163, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics

1989
A role for protein kinase C in the membrane fusion necessary for platelet granule secretion.
    Blood, 1989, Nov-15, Volume: 74, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Blood Platelets; Calcimycin; Carrier Proteins; Cytoplasmic Granules; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Membrane Fusion; Membrane Potentials; Phosphoproteins; Piperazines; Platelet Aggregation; Protein Kinase C; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate

1989
Protein kinase C is involved in laminin stimulation of neurite outgrowth.
    Neuron, 1989, Volume: 3, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Chick Embryo; Concanavalin A; Cyclic AMP; Extracellular Matrix; Ganglia, Parasympathetic; Isoquinolines; Laminin; Motor Neurons; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1989
Involvement of protein kinase C in activation of human granulocytes and peritoneal macrophages by type 1 fimbriated (mannose specific) Escherichia coli.
    Biochemical and biophysical research communications, 1989, Dec-29, Volume: 165, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carbazoles; Escherichia coli; Fimbriae, Bacterial; Granulocytes; Indole Alkaloids; Isoquinolines; Luminescent Measurements; Macrophage Activation; Macrophages; Mannose; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1989
Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1).
    The Journal of biological chemistry, 1989, Dec-25, Volume: 264, Issue:36

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Azo Compounds; Cell Adhesion; Complement System Proteins; Diamide; Enzyme Activation; Erythrocytes; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Monocytes; Palmitoylcarnitine; Phagocytosis; Phosphorylation; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Complement; Sphingosine; Staurosporine; Structure-Activity Relationship

1989
H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells.
    Molecular pharmacology, 1989, Volume: 36, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Epidermis; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1989
The protein kinase C inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) disinhibits CA1 pyramidal cells in rat hippocampal slices.
    British journal of pharmacology, 1989, Volume: 98, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Calcium Channel Blockers; Electric Stimulation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Piperazines; Protein Kinase C; Pyramidal Tracts; Rats; Rats, Inbred Strains; Sphingosine; Sulfonamides

1989
1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C.
    The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Cell Differentiation; Cell Line; Cell Nucleus; Ethanol; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured

1989
Regulation of eicosanoid synthesis in mouse peritoneal macrophages by protein kinase C.
    Agents and actions, 1989, Volume: 26, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acids; Diglycerides; Dinoprostone; Isoquinolines; Macrophages; Mice; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1989
Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages.
    The Biochemical journal, 1989, Jun-01, Volume: 260, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Acylglycerophosphocholine O-Acyltransferase; Acyltransferases; Animals; Arachidonic Acids; Cells, Cultured; Dinoprostone; Isoquinolines; Macrophages; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; Sphingosine

1989
Human melanogenesis is stimulated by diacylglycerol.
    The Journal of investigative dermatology, 1989, Volume: 93, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Cycloheximide; Dactinomycin; Diglycerides; Enzyme Activation; Glycerides; Humans; Isoquinolines; Melanins; Piperazines; Protein Kinase C; Skin Pigmentation; Sphingosine

1989
Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.
    Journal of immunology (Baltimore, Md. : 1950), 1988, Jan-01, Volume: 140, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chlorpromazine; Diglycerides; Ethers; Glycerides; Glyceryl Ethers; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Neutrophils; Piperazines; Protein Kinase C; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate

1988
Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.
    The Journal of biological chemistry, 1988, Feb-25, Volume: 263, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cations, Divalent; Drug Synergism; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Isoquinolines; Neutrophils; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Sphingosine; Sulfonamides; Superoxides

1988
Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.
    The Journal of biological chemistry, 1988, Sep-05, Volume: 263, Issue:25

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cell Membrane; Cytosol; Diglycerides; Dogs; Enzyme Activation; Epinephrine; Hydrolysis; Isoquinolines; Kidney; Kinetics; Neomycin; Phosphatidylcholines; Phosphorylcholine; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Sphingosine

1988
Persistent protein kinase activity underlying long-term potentiation.
    Nature, 1988, Oct-27, Volume: 335, Issue:6193

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Calcium; Calmodulin; Electrophysiology; Enzyme Activation; Hippocampus; Isoquinolines; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sphingosine; Synapses; Synaptic Transmission

1988
Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Abdomen; Action Potentials; Animals; Aplysia; Calcium; Electrophysiology; Ganglia; Isoquinolines; Neurons; Neuropeptides; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate

1989
Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:14

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Cell Membrane; HLA-DR Antigens; Humans; Interferon-gamma; Isoquinolines; Kinetics; Macrophages; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic

1988
Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C.
    The Journal of biological chemistry, 1988, Sep-05, Volume: 263, Issue:25

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cell Membrane; Isoquinolines; Kinetics; Piperazines; Pituitary Gland; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone

1988
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
    Endocrinology, 1994, Volume: 134, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1994
Activation of transfer RNA-guanine ribosyltransferase by protein kinase C.
    Nucleic acids research, 1995, Jul-11, Volume: 23, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; Buffers; Diphosphates; Enzyme Activation; Enzyme Reactivators; Enzyme Stability; Isoquinolines; Liver; Naphthalenes; Pentosyltransferases; Phosphoric Monoester Hydrolases; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Fluoride; Sphingosine; Staurosporine

1995
Retinoic acid induces translocation of protein kinase C (PKC) and activation of nuclear PKC (nPKC) in rat splenocytes.
    International journal of immunopharmacology, 1995, Volume: 17, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Biological Transport; Cell Nucleus; Cytosol; Enzyme Activation; Isoquinolines; Lymphocytes; Male; Nuclear Proteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Sphingosine; Spleen; Staurosporine; Tretinoin

1995
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
    Journal of neurochemistry, 1995, Volume: 64, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine

1995
Differential sensitivity to inhibitors discriminates between two types of kinases responsible for in vivo phosphorylation of different sites in the carboxy-terminal tail of chicken neurofilament-M.
    Molecular and cellular neurosciences, 1994, Volume: 5, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Carbazoles; Chick Embryo; Ganglia, Spinal; Indole Alkaloids; Isoquinolines; Lithium Chloride; Molecular Sequence Data; Neurofilament Proteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sphingosine; Staurosporine; Trifluoperazine

1994
Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro.
    International journal of cancer, 1994, Oct-01, Volume: 59, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Cell Cycle; Cell Differentiation; Cell Division; Chenodeoxycholic Acid; Deoxycholic Acid; Flow Cytometry; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Lithocholic Acid; Monocytes; Piperazines; Protein Kinase C; Sphingosine; Tretinoin; Tumor Cells, Cultured

1994
Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes.
    American journal of respiratory cell and molecular biology, 1994, Volume: 11, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cats; Cell Fractionation; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Enzyme Activation; Epithelium; Isoenzymes; Isoquinolines; Kinetics; Molecular Weight; Mucins; Piperazines; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Trachea

1994
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
    Virchows Archiv. B, Cell pathology including molecular pathology, 1993, Volume: 63, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1993
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1993, Volume: 101, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
    The Journal of biological chemistry, 1994, Apr-01, Volume: 269, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Platelets; Blotting, Western; Calcium; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Diglycerides; Durapatite; Enzyme Activation; Humans; Isoquinolines; Kinetics; Oleic Acid; Oleic Acids; Phorbol 12,13-Dibutyrate; Phospholipids; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sphingosine; Substrate Specificity

1994
Effects of gangliosides on the growth of herpes simplex virus type 1-infected cells derived from neurons and on viral replication.
    Intervirology, 1993, Volume: 36, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA, Viral; Gangliosides; Herpesvirus 1, Human; Humans; Hybrid Cells; Isoquinolines; Neurons; Piperazines; Protein Kinase C; Sphingosine; Virus Replication

1993
A stimulatory role of protein kinase C in feline tracheal submucosal gland secretion.
    Respiration physiology, 1993, Volume: 93, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cats; Glycoconjugates; Glycoproteins; Isoquinolines; Methacholine Chloride; Mucous Membrane; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sodium; Sodium Radioisotopes; Sphingosine; Tetradecanoylphorbol Acetate; Trachea; Tritium

1993
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
    Journal of neuroscience research, 1993, Sep-01, Volume: 36, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Cell Death; Cell Hypoxia; Cells, Cultured; Dibutyryl Cyclic GMP; Hippocampus; Isoquinolines; Nerve Tissue Proteins; Nitric Oxide; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides

1993
Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine.
    Journal of biochemistry, 1993, Volume: 114, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Blood; Culture Media; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Swine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
    Biochemical and biophysical research communications, 1994, Jan-14, Volume: 198, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoenzymes; Isoquinolines; Kinetics; Lysophospholipids; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate

1994
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
    Cellular signalling, 1993, Volume: 5, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Protein kinase inhibitors do not block the expression of established enhancement in identified Hermissenda B-photoreceptors.
    Brain research, 1993, Jun-04, Volume: 613, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Conditioning, Classical; Evoked Potentials; Isoquinolines; Photic Stimulation; Photoreceptor Cells; Piperazines; Protein Kinase C; Sphingosine; Time Factors

1993
Na+/H+ exchange activity induced by thrombin is not inhibited by protein kinase inhibitors, staurosporine, K-252a, H-7 and sphingosine, in human platelets.
    Thrombosis research, 1993, Apr-15, Volume: 70, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Blood Platelets; Carbazoles; Carrier Proteins; Humans; Hydrogen; Indole Alkaloids; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Staurosporine; Thrombin

1993
Down-regulation of protein kinase C and kinase inhibitors dissociate short- and long-term enhancement produced by one-trial conditioning of Hermissenda.
    Journal of neurophysiology, 1993, Volume: 69, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brachyura; Conditioning, Classical; Down-Regulation; Isoquinolines; Neuronal Plasticity; Photic Stimulation; Photoreceptor Cells; Piperazines; Protein Kinase C; Serotonin; Sphingosine; Tetradecanoylphorbol Acetate

1993
Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
    Molecular and cellular endocrinology, 1993, Volume: 92, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Alkaloids; Animals; Cells, Cultured; Epithelial Cells; Epithelium; Female; Gene Expression Regulation; Genistein; Isoflavones; Isoquinolines; Mammary Glands, Animal; Milk Proteins; Phenols; Phenylacetates; Piperazines; Polymyxin B; Pregnancy; Prolactin; Protein Kinase Inhibitors; Quercetin; Rabbits; Sphingosine; Staurosporine; Succinates

1993
Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
    FEBS letters, 1996, Jan-29, Volume: 379, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Differentiation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Sphingosine; Staurosporine; Suppression, Genetic; Tetradecanoylphorbol Acetate

1996
Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro.
    Endocrinology, 1996, Volume: 137, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Cells, Cultured; Enzyme Inhibitors; Interleukin-1; Interleukin-6; Lysophosphatidylcholines; Male; Phenanthridines; Phosphorylcholine; Pituitary Gland, Anterior; Platelet Activating Factor; Prolactin; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine

1996
Sphingosine enhances phosphatidylinositol 4-kinase activity in rabbit platelets.
    Journal of biochemistry, 1996, Volume: 120, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Arachidonic Acid; Blood Platelets; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lysophospholipids; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rabbits; Sphingosine; Staurosporine; Wortmannin

1996
Presynaptic modification of synaptic transmission at identified Aplysia central synapses, induced by changes in protein kinase C activity.
    Neurobiology (Budapest, Hungary), 1996, Volume: 4, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Evoked Potentials; Ganglia, Invertebrate; Glycerol; In Vitro Techniques; Naphthalenes; Neurons; Phorbol Esters; Presynaptic Terminals; Protein Kinase C; Sphingosine; Sulfonamides; Synapses; Synaptic Transmission

1996
Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common?
    Neurochemistry international, 1997, Volume: 31, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cells, Cultured; Enzyme Inhibitors; Isoquinolines; Neurons; Rats; Sphingosine; Sulfonamides

1997
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina.
    Neurochemical research, 1997, Volume: 22, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Goldfish; Indole Alkaloids; Nerve Crush; Neurites; Okadaic Acid; Optic Nerve; Protein Kinase C; Protein Kinase Inhibitors; Retina; Sphingosine; Staurosporine

1997
Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
    Biochemical and biophysical research communications, 1997, Dec-29, Volume: 241, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Enzyme Activation; Half-Life; Humans; Indoles; Maleimides; Nasopharyngeal Neoplasms; Protein Kinase C; Protein Synthesis Inhibitors; Sphingosine; Staurosporine; Telomerase; Tumor Cells, Cultured

1997
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
    Neuroscience, 1998, Volume: 85, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes

1998
Phosphatidic acid effects on cytosolic calcium and proliferation in osteoblastic cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 59, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Division; Cells, Cultured; Cytoplasm; Epidermal Growth Factor; Osteoblasts; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Rats; Rats, Sprague-Dawley; Skull; Sphingosine; Thapsigargin; Verapamil

1998
Expression of hepatocyte growth factor in cultured human endometrial stromal cells is induced through a protein kinase C-dependent pathway.
    Biology of reproduction, 1999, Volume: 60, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endometrium; Enzyme Inhibitors; Female; Hepatocyte Growth Factor; Humans; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Stromal Cells

1999
Cholera toxin induces tumor necrosis factor alpha production in human monocytes.
    Molecular cell biology research communications : MCBRC, 1999, Volume: 2, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate; Benzamides; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoquinolines; Lymphocytes; Monocytes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha; Type C Phospholipases

1999
Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells.
    International journal of radiation biology, 1999, Volume: 75, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aurintricarboxylic Acid; Benzhydryl Compounds; Bromodeoxyuridine; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Electrophoresis, Gel, Pulsed-Field; Endonucleases; Enzyme Inhibitors; Fibrosarcoma; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Proliferating Cell Nuclear Antigen; Protein Kinase C; Spermine; Sphingosine; Teniposide; Topoisomerase II Inhibitors; Transcription, Genetic; Tumor Cells, Cultured

1999
Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.
    Placenta, 2000, Volume: 21, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Blotting, Northern; Choriocarcinoma; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Pregnancy; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uterine Neoplasms

2000
Selective protein kinase inhibitors block head-specific differentiation in hydra.
    Cellular signalling, 2000, Volume: 12, Issue:9-10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoquinones; Carrier Proteins; Cell Cycle; Humans; Hydra; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Protein Kinase C; Quinones; Receptor Protein-Tyrosine Kinases; Rifabutin; Sphingosine; Staurosporine

2000
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
    Brain research, 2001, Jun-08, Volume: 903, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1

2001
Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.
    Journal of cellular physiology, 2007, Volume: 211, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Cell Differentiation; Cell Line; Cell Lineage; Cell Shape; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Activation; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Laminin; Lung; Lysophospholipids; Morphogenesis; Phenotype; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteoglycans; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Time Factors; Transfection; Transforming Growth Factor beta1

2007
G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.
    Cardiovascular research, 2008, Sep-01, Volume: 79, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Animals; Botulinum Toxins; Calcium; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Lysophospholipids; Male; Muscle, Smooth, Vascular; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrazoles; Pyridines; rac GTP-Binding Proteins; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Lysosphingolipid; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Sphingosine; Transfection

2008
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
    International journal of molecular medicine, 2009, Volume: 24, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Line; HSP27 Heat-Shock Proteins; Lysophospholipids; Mice; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Sphingosine

2009
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Anticarcinogenic Agents; Benzopyrans; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Oleanolic Acid; Precursor Cells, B-Lymphoid; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid

2012
Sphingosine-1-Phosphate Enhances α
    International journal of molecular sciences, 2019, Dec-17, Volume: 20, Issue:24

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Drug Synergism; Lysophospholipids; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Pyridines; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2019