1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with simvastatin in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Danesh, FR; Kolavennu, V; Peng, H; Wang, Y; Zeng, L | 1 |
| Horiuchi, N; Maeda, T | 1 |
| Han, MK; Lapchak, PA | 1 |
| Blaheta, R; Henrich, D; Lehnert, M; Marzi, I; Meder, F; Relja, B; Wang, M | 1 |
| Caldwell, RB; Caldwell, RW; Chandra, S; Iddings, JA; Romero, MJ; Shatanawi, A; Umapathy, NS; Verin, AD | 1 |
| Chu, L; Du, R; Ji, E; Ma, Z; Zhang, J | 1 |
| Chen, XY; Lan, D; Li, T; Liu, LM; Tian, KL; Wu, Y; Yang, GM; Zhu, Y | 1 |
| Abdelsalam, RM; Ahmed, LA; Amin, HA; Darwish, HA | 1 |
| Austin, C; Awad, IA; Cao, Y; Gallione, C; Girard, R; Liao, JK; Lightle, R; Marchuk, DA; McDonald, DA; Moore, T; Pytel, P; Rorrer, A; Shenkar, R; Shi, C; Wu, M; Zeineddine, HA; Zhang, L | 1 |
| Domokos, D; Ducza, E; Gáspár, R | 1 |
| Fang, Q; Gan, Z; Gu, T; Niu, K; Yu, Q; Zhang, Y | 1 |
11 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and simvastatin
| Article | Year |
|---|---|
Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Collagen Type IV; Diabetic Nephropathies; Disease Progression; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Mesangial Cells; Mice; Mice, Inbred NOD; Protein Kinase Inhibitors; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin | 2008 |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin | 2009 |
Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticholesteremic Agents; Brain Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Fibrinolytic Agents; Male; Rabbits; rho-Associated Kinases; Simvastatin; Stroke; Time Factors; Tissue Plasminogen Activator | 2010 |
Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Adhesion; Cell Communication; Cell Proliferation; Cells, Cultured; Down-Regulation; Drug Evaluation, Preclinical; Endothelial Cells; Hep G2 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Integrins; Liver Neoplasms; Mevalonic Acid; rho-Associated Kinases; Simvastatin | 2011 |
Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginase; Boronic Acids; Cattle; Cell Line; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Simvastatin | 2011 |
Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Hypercholesterolemia; Inflammation Mediators; Lipid Metabolism; Lipids; Male; NF-kappa B; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; Simvastatin; Tunica Intima; Tunica Media | 2011 |
Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Connexins; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Drug Therapy, Combination; Female; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metformin; MicroRNAs; Muscle, Smooth, Vascular; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Renal Artery; rho-Associated Kinases; Simvastatin; Vasculitis | 2015 |
Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Behavior, Animal; Body Weight; Caspase 3; Corpus Striatum; Male; Membrane Potential, Mitochondrial; Mitochondria; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; Organ Size; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Propionates; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; rho-Associated Kinases; Simvastatin; Succinate Dehydrogenase; Tumor Necrosis Factor-alpha | 2016 |
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Neoplasms; Disease Models, Animal; Female; Hemangioma, Cavernous, Central Nervous System; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Transgenic; Protein Kinase Inhibitors; rho-Associated Kinases; Simvastatin | 2017 |
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Female; In Vitro Techniques; Muscle Contraction; Pregnancy; Pyridines; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Simvastatin | 2019 |
Time-dependently slow-released multiple-drug eluting external sheath for efficient long-term inhibition of saphenous vein graft failure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Coronary Artery Bypass; Drug Delivery Systems; Everolimus; Graft Rejection; Immunosuppressive Agents; Rabbits; Saphenous Vein; Simvastatin | 2019 |