Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and sildenafil citrate

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with sildenafil citrate in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guérin, P; Guilluy, C; Loirand, G; Pacaud, P; Rolli-Derkinderen, M; Sagan, C; Sauzeau, V1
de Boer, MA; Mouchaers, KT; Postmus, PE; Schalij, I; van der Laarse, WJ; van Hinsbergh, VW; van Nieuw Amerongen, GP; Vonk Noordegraaf, A1
Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J; Łuczak, A1
Elias-Al-Mamun, M; Fukumoto, Y; Miyata, S; Nergui, S; Satoh, K; Shimizu, T; Shimokawa, H; Tanaka, S1
Fukumoto, Y1
Connelly, KA; Desjardins, JF; Dhaliwal, R; Dunlop, K; Gosal, K; Ivanovska, J; Jain, A; Jankov, RP; Kantores, C; McNamara, PJ1

Reviews

1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and sildenafil citrate

ArticleYear
[Role of the Rho-kinase pathway in pulmonary arterial hypertension].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2014, Volume: 143, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bosentan; Drug Therapy, Combination; Epoprostenol; Humans; Hypertension, Pulmonary; Mice; Molecular Targeted Therapy; Piperazines; Protein Kinase Inhibitors; Purines; Rats; rho-Associated Kinases; Signal Transduction; Sildenafil Citrate; Sulfonamides; Sulfones; Vascular Resistance

2014

Other Studies

5 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and sildenafil citrate

ArticleYear
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.
    British journal of pharmacology, 2005, Volume: 146, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Carrier Proteins; Chronic Disease; Cytoskeleton; Guanine Nucleotide Dissociation Inhibitors; Hypertension, Pulmonary; Hypoxia; Male; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Phosphatase 1; Purines; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Sildenafil Citrate; Sulfones

2005
Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.
    The European respiratory journal, 2010, Volume: 36, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Familial Primary Pulmonary Hypertension; Heart Ventricles; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Piperazines; Pulmonary Artery; Purines; Rats; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents

2010
The beneficial impact of fasudil and sildenafil on monocrotaline-induced pulmonary hypertension in rats: a hemodynamic and biochemical study.
    Pharmacology, 2013, Volume: 91, Issue:3-4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cholesterol, HDL; Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Male; Monocrotaline; Natriuretic Peptide, Brain; Phosphodiesterase 5 Inhibitors; Piperazines; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; rho-Associated Kinases; Sildenafil Citrate; Sulfones; Vascular Endothelial Growth Factor A

2013
Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats.
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones

2014
Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.
    American journal of respiratory cell and molecular biology, 2015, Volume: 52, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Piperazines; Purines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Sildenafil Citrate; Sulfonamides; Vascular Resistance; Ventricular Dysfunction, Right

2015