1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with ro 31-8220 in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (56.52) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bacon, KB; Camp, RD | 1 |
| Abayasekara, RE; Flint, AP; Searle, MJ | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Lutz, EM; Mitchell, R; Simpson, J | 1 |
| Bershadsky, AD; Citi, S; Geiger, B; Volberg, T | 1 |
| Chopra, LC; Twort, CH; Ward, JP | 1 |
| Bonin, L; Chen, B; Griffith, OH; Hedberg, K; Mobley, PL | 1 |
| Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R; Thomson, FJ; Wolbers, WB | 1 |
| Mitchell, R; Thomson, FJ | 1 |
| Clegg, RA; Connor, K; Ison, AJ; Johnson, MS; MacEwan, DJ; Mitchell, R | 1 |
| Hall, N; Kelleher, D; Liskamp, RM; Long, A; O'Connell, MA; O'Neill, LA | 1 |
| Doherty, K; Paul, A; Plevin, R | 1 |
| Fischer, T; Mohaupt, MG; Schulze-Lohoff, E; Schwöbel, J; Sterzel, RB | 1 |
| Jope, RS; Pacheco, MA | 1 |
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Kamata, K; Suenaga, H | 1 |
| Hidaka, H; Hosoya, T; Ikenoya, M; Sasaki, Y; Suzuki, M; Yamamoto, N | 1 |
| Ito, K; Iwanaga, T; Nagumo, H; Nakamura, J; Sasaki, Y; Seto, M; Shimomura, E; Shindo, K; Shiraishi, M; Takuwa, Y | 1 |
| Bauer, J; Parekh, N | 1 |
| Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Brock, JA; Yeoh, M | 1 |
| Altmann, F; Baer, AS; Ffrench-Constant, C; Franklin, RJ; Kang, SU; Kotter, MR; Lubec, G; Mitteregger, D; Syed, YA; Vig, R | 1 |
23 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and ro 31-8220
| Article | Year |
|---|---|
Interleukin (IL)-8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Movement; Chemotactic Factors; Cholera Toxin; Cyclic AMP; Diglycerides; GTP-Binding Proteins; Humans; In Vitro Techniques; Indoles; Interleukin-8; Interleukins; Isoquinolines; Lymphocytes; Maleimides; Pertussis Toxin; Piperazines; Protein Kinase C; Sphingosine; Virulence Factors, Bordetella | 1990 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
A novel high molecular weight form of protein kinase C in anterior pituitary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Indoles; Isoenzymes; Isoquinolines; Kinetics; Molecular Weight; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Staurosporine | 1995 |
Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cadherins; Calcium; Carbazoles; Cell Adhesion; Cell Movement; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Indoles; Intercellular Junctions; Isoquinolines; Microfilament Proteins; Myosin Subfragments; Piperazines; Protein Kinase C; Talin; Vinculin | 1994 |
Differences in sensitivity to the specific protein kinase C inhibitor Ro31-8220 between small and large bronchioles of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bronchi; Bronchoconstriction; Carbachol; In Vitro Techniques; Indoles; Isoquinolines; Male; Maleimides; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Serotonin | 1994 |
Decreased phosphorylation of four 20-kDa proteins precedes staurosporine-induced disruption of the actin/myosin cytoskeleton in rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Animals, Newborn; Astrocytes; Azepines; Cells, Cultured; Cytoskeleton; Indoles; Isoquinolines; Myosin-Light-Chain Kinase; Myosins; Nerve Tissue Proteins; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine | 1994 |
The differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium | 1993 |
Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminobenzoates; Animals; Arachidonic Acid; Aristolochic Acids; Chlorobenzoates; Cinnamates; Cyclohexanones; Cycloheximide; Enzyme Activation; Female; Growth Hormone; Indoles; Ionomycin; Isoquinolines; Luteinizing Hormone; Melitten; ortho-Aminobenzoates; Phenanthrenes; Phenothiazines; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Piperazines; Pituitary Gland, Anterior; Proestrus; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Staurosporine | 1993 |
Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Indoles; Isoquinolines; Lung; Male; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes | 1993 |
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Muscle, Smooth, Vascular; Naphthalenes; Nitric Oxide Synthase; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Activation of purinergic P2Y2 receptors inhibits inducible NO synthase in cultured rat mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Indoles; Interferon-gamma; Lipopolysaccharides; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1998 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Alpha-adrenoceptor agonists produce Ca2+ oscillations in isolated rat aorta: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Signaling; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Verapamil | 2000 |
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Calcium-Binding Proteins; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glucosidases; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurons; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Substrate Specificity | 2002 |
Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Azepines; Calcium; Dinoprost; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Molecular Weight; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rabbits; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents | 2003 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction | 2005 |
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Carbazoles; Cell Differentiation; Demyelinating Diseases; Electrophoresis, Polyacrylamide Gel; Indoles; Maleimides; Myelin Sheath; Nerve Regeneration; Oligodendroglia; Protein Kinase C-alpha; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Stem Cells | 2009 |