1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with pyrroles in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 7 (21.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berridge, MV; Tan, AS | 1 |
| Ito, K; Nishimura, K; Ota, M | 1 |
| Pratt, MM; Salathe, M; Wanner, A | 1 |
| Iitaka, M; Ishii, J; Kitahama, S | 1 |
| Audesirk, G; Cabell, L | 1 |
| Goligorsky, MS; Malbon, CC; Wang, Hy | 1 |
| Ardenghi, P; Izquierdo, I; Izquierdo, LA; Medina, JH; Netto, CA; Quevedo, J; Schröder, N | 1 |
| Coleman, R; Roma, MG; Shaw, R; Stone, V | 1 |
| Day, BN; Green, KM; Kim, JH; Prather, RS; Wang, WH | 1 |
| Kamei, J; Ohsawa, M; Tanaka, S | 1 |
| Ito, Y; Marunaka, Y; Niisato, N | 1 |
| Izquierdo, I; Medina, JH; Netto, CA; Schröder, N | 1 |
| Ardenghi, P; Barros, DM; Izquierdo, I; Izquierdo, LA; Medinam, JH; Mello e Souza, T; Rodrigues, C; Sant'Anna, MK; Vianna, M | 1 |
| Gemba, M; Kohda, Y | 1 |
| Hirsh, JK; Silinsky, EM | 1 |
| Coleman, R; Elias, E; Milkiewicz, P; Roma, MG | 1 |
| Lan, C; Vollrath, B; Wickman, G | 1 |
| Blanquet, PR; Derer, P; Mariani, J | 1 |
| Abe, K; Misawa, M | 1 |
| Carlson, RR; Dudman, JT; Konradi, C; Macías, W | 1 |
| Huang, SH; Shen, WJ; Wang, SM; Yeo, HL | 1 |
| Kim, JO; Kofler, S; Methe, H; Nabauer, M; Weis, M | 1 |
| Shah, DI; Singh, M | 1 |
| Burns, N; Homma, N; Kraskauskas, D; McMurtry, IF; Morris, KG; Oka, M; Taraseviciene-Stewart, L; Voelkel, NF | 1 |
| Favre, G; Leveque, K; Sarrabayrouse, G; Synaeve, C; Tilkin-Mariamé, AF | 1 |
| Fukumoto, Y; Rashid, M; Seto, M; Shimokawa, H; Tawara, S; Yano, K | 1 |
| Alessi, DR; Deak, M; Dzamko, N; Hentati, F; Nichols, RJ; Prescott, AR; Reith, AD | 1 |
| Belcastro, V; Bosotti, R; Brunetti-Pierri, N; di Bernardo, D; Ferriero, R; Iorio, F; Isacchi, A; Mithbaokar, P; Murino, L; Scacheri, E; Tagliaferri, R | 1 |
| Feng, Y; Hirasawa, Y; Nagamatsu, T; Nagao, T; Nishiyama, T | 1 |
| Abe, K; Alzoubi, A; Gairhe, S; Matsumoto, Y; McMurtry, IF; O'Neill, KD; Oka, M; Oshima, K; Toba, M | 1 |
| Hui, L; Xiao-Ping, G; Yi, R | 1 |
| Chung, MH; Hahm, KB; Han, YM; Jeong, M; Ko, KH; Kwon, CI; Park, JM | 1 |
| Chen, L; Du, Y; Huang, S; Men, C; Qi, M; Wang, Z; Wu, C; Zhou, L | 1 |
2 trial(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and pyrroles
| Article | Year |
|---|---|
Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Atorvastatin; B7-1 Antigen; Bacterial Proteins; Bacterial Toxins; Cells, Cultured; Cytokines; Drug Interactions; Female; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; Monocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Protein Prenylation; Pyrroles; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4 | 2005 |
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Cross-Over Studies; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Leukocytes; Male; Pravastatin; Pyrroles; Quinolines; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2009 |
31 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and pyrroles
| Article | Year |
|---|---|
The protein kinase C inhibitor, calphostin C, inhibits succinate-dependent mitochondrial reduction of MTT by a mechanism that does not involve protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow; Carbazoles; Cell Division; Cell Line; Coloring Agents; DNA Replication; Indoles; Isoquinolines; Kinetics; Mice; Mice, Inbred C3H; Mitochondria; Naphthalenes; Oxidation-Reduction; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Succinates; Tetrazolium Salts; Thiazoles; Thymidine | 1992 |
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carbamates; Cromakalim; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Phenylephrine; Phosphatidylinositols; Piperazines; Protease Inhibitors; Pyrroles; Rats | 1991 |
Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Annexins; Carbazoles; Cell Fractionation; Cilia; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Erythrocytes; Indoles; Isoquinolines; Membrane Proteins; Movement; Phosphorylation; Phosphoserine; Phosphotyrosine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sheep; Tetradecanoylphorbol Acetate; Trachea; Tyrosine | 1993 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Dendrites; Female; Hippocampus; Imidazoles; Indoles; Isoquinolines; Naphthalenes; Neurites; Piperazines; Polycyclic Compounds; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Pyrroles; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1993 |
Temporal activation of Ca2+-calmodulin-sensitive protein kinase type II is obligate for adipogenesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Adipose Tissue; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Indoles; Mice; Pyrroles; Sulfonamides | 1997 |
Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining beta-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arousal; beta-Endorphin; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cosyntropin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fear; Hippocampus; Indoles; Injections, Intraperitoneal; Lypressin; Male; Mental Recall; Neural Pathways; Pyrroles; Rats; Rats, Wistar; Retention, Psychology | 1997 |
Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Antioxidants; Bile Canaliculi; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Leupeptins; Liver; Male; Microscopy, Electron, Scanning; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Tight Junctions; Vacuoles; Vasopressins | 1998 |
Effect of myosin light chain kinase, protein kinase A, and protein kinase C inhibition on porcine oocyte activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Carbazoles; Cell Nucleus; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytoplasmic Granules; Enzyme Inhibitors; Exocytosis; Female; Indoles; Microscopy, Electron; Myosin-Light-Chain Kinase; Oocytes; Protein Kinase C; Pyrroles; Swine; Wortmannin | 1999 |
Possible mechanisms for insulin-induced attenuation of the antinociceptive effect of [D-Ala2, N-MePhe4, Gly-ol5]enkephalin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Animals; Benzoquinones; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Hypoglycemic Agents; Indoles; Injections, Intraventricular; Insulin; Lactams, Macrocyclic; Male; Mice; Mice, Inbred ICR; Naphthalenes; Pain Measurement; Protein Kinase C; Pyrroles; Quinones; Rifabutin; Time Factors | 1999 |
Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Indoles; Isoquinolines; Myristic Acid; Pulmonary Alveoli; Pyrroles; Rats; Rats, Wistar; Sodium; Sodium Channels; Structure-Activity Relationship; Sulfonamides; Terbutaline | 1999 |
Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Amnesia, Retrograde; Animals; Avoidance Learning; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Environment; Enzyme Inhibitors; Hippocampus; Indoles; Injections; Male; Psychomotor Performance; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1999 |
Short- and long-term memory are differentially affected by metabolic inhibitors given into hippocampus and entorhinal cortex.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Animals; Avoidance Learning; Carbazoles; Entorhinal Cortex; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Hippocampus; Indoles; Inhibition, Psychological; Male; Memory; Memory, Short-Term; Phenols; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Sodium Chloride; Staurosporine | 2000 |
Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Carcinogens; Cephaloridine; Cephalosporins; Cyclic AMP; Enzyme Inhibitors; Free Radicals; Gluconeogenesis; In Vitro Techniques; Indoles; Kidney Cortex; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; p-Aminohippuric Acid; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Acetylcholine; Animals; Carbazoles; Carrier Proteins; Cell Membrane Permeability; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Neuromuscular Junction; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrroles; Staurosporine; Thionucleotides | 2002 |
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Bucladesine; Calcium; Carbazoles; Chelating Agents; Cholagogues and Choleretics; Cholestasis; Cholic Acids; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Indoles; Liver; Male; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Staurosporine; Taurochenodeoxycholic Acid; Taurolithocholic Acid | 2002 |
Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basilar Artery; Benzamides; Biological Transport; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Muscle, Smooth, Vascular; Oxyhemoglobins; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rabbits; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Vasoconstriction | 2003 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
Astrocyte stellation induced by Rho kinase inhibitors in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Astrocytes; Carbazoles; Cell Size; Cells, Cultured; Cerebral Cortex; Colchicine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gout Suppressants; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Phalloidine; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; rho-Associated Kinases | 2003 |
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 2003 |
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Animals; Benzylamines; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Glycerol; Hydroxycholesterols; Indoles; Lignans; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthalenes; Oleic Acid; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vacuoles | 2004 |
Involvement of Rho-kinase in experimental vascular endothelial dysfunction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Antibiotics, Antineoplastic; Aorta, Thoracic; Atorvastatin; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Endothelium, Vascular; Heptanoic Acids; Homocysteine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Intracellular Signaling Peptides and Proteins; Male; Nitrates; Nitrites; Oxidative Stress; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Streptozocin; Thiobarbituric Acid Reactive Substances; Vasodilation | 2006 |
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Disease Models, Animal; Disease Progression; Endothelin A Receptor Antagonists; Hypertension, Pulmonary; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Male; Myosin-Light-Chain Phosphatase; Organ Culture Techniques; Peptides, Cyclic; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Endothelial Growth Factor Receptor-2; Vasoconstriction; Vasodilator Agents | 2007 |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering | 2007 |
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 14-3-3 Proteins; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cells, Cultured; Cytoplasm; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Humans; Inclusion Bodies; Indoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Microscopy, Fluorescence; Middle Aged; Mutation; Parkinson Disease; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyrroles; Serine; Sunitinib; Swiss 3T3 Cells | 2010 |
Discovery of drug mode of action and drug repositioning from transcriptional responses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Algorithms; Antineoplastic Agents; Autophagy; Blotting, Western; Camptothecin; Cell Line, Tumor; Doxorubicin; Drug Discovery; Drug Screening Assays, Antitumor; Flavonoids; Fuzzy Logic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Irinotecan; Neoplasms; Oligonucleotide Array Sequence Analysis; Phosphorylation; Piperidines; Pyrazoles; Pyrroles; RNA Polymerase II | 2010 |
Involvement of protein kinase C in reduction of aggregated protein and phosphorylation of CREB in glomeruli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cattle; CREB-Binding Protein; Cyclic AMP; Enzyme Inhibitors; Kidney Glomerulus; Male; Mice; Mice, Inbred ICR; Oxidative Phosphorylation; Protein Kinase C; Pyrroles; Serum Albumin, Bovine | 2012 |
Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2014 |
Atorvastatin prevents angiotensin II-induced high permeability of human arterial endothelial cell monolayers via ROCK signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Arteries; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Lim Kinases; Permeability; Phosphorylation; Pyrroles; rho-Associated Kinases; Signal Transduction; Zonula Occludens-1 Protein | 2015 |
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Claudin-1; Deoxyguanosine; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Hyaluronan Receptors; Imidazoles; Lung Neoplasms; Matrix Metalloproteinases; Mice; Mice, Nude; NADPH Oxidases; Pancreatic Neoplasms; Pyrroles; rho-Associated Kinases; Signal Transduction; Transcription Factors; Vimentin; Xenograft Model Antitumor Assays; Zonula Occludens-1 Protein | 2017 |
Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Evoked Potentials; Glycine; Hippocampus; Leucine; Mice; Mice, Inbred ICR; Morpholines; Patch-Clamp Techniques; Protein Kinase C; Pyramidal Cells; Pyrroles; Receptors, Glycine; Signal Transduction; Strychnine; Sulfonamides; TRPV Cation Channels | 2018 |