Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and pyridoxal phosphate

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with pyridoxal phosphate in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's9 (90.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chessell, IP; Grahames, CB; Humphrey, PP; Michel, AD1
Barnard, EA; Chessell, IP; Humphrey, PP; Jones, CA; Michel, AD; Miller, KJ; Simon, J1
Chessell, IP; Humphrey, PP; Kaur, R; Michel, AD1
Hibell, AD; Humphrey, PP; Michel, AD; Thompson, KM; Xing, M1
Eschke, D; Hauschildt, S; Nieber, K; Wüst, M1
Kimura, J; Matsuoka, I; Watano, T1
Adinolfi, E; Baricordi, OR; Chiozzi, P; Di Virgilio, F; Morelli, A; Rizzo, R; Solini, A1
Hayato, R; Ohtubo, Y; Yoshii, K1
Chambers, LJ; Michel, AD; Walter, DS1
Clay, WC; Condreay, JP; Hall, M; Holbrook, J; Livermore, D; Michel, AD; Ng, SW; Roman, S; Senger, S; Thompson, K1

Other Studies

10 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and pyridoxal phosphate

ArticleYear
Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.
    British journal of pharmacology, 1999, Volume: 127, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cell Line; Enzyme Inhibitors; Humans; Interleukin-1; L-Lactate Dehydrogenase; Lipopolysaccharides; Monocytes; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7

1999
Functional characterization of the P2X(4) receptor orthologues.
    British journal of pharmacology, 2000, Volume: 129, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Axons; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Recombinant Proteins; Suramin

2000
Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1.
    British journal of pharmacology, 2000, Volume: 130, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Antibodies, Blocking; Benzoxazoles; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Fluorescent Dyes; Humans; Imidazoles; In Vitro Techniques; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Receptors, Purinergic P2X7; Stimulation, Chemical

2000
Complexities of measuring antagonist potency at P2X(7) receptor orthologs.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amiloride; Animals; Benzoxazoles; Buffers; Cations, Divalent; Cell Adhesion; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Ethidium; Fluorescent Dyes; Humans; Kinetics; Mice; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rosaniline Dyes; Serum Albumin, Bovine; Sodium Chloride; Species Specificity; Temperature

2001
Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique.
    Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 365, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cells, Cultured; Electrophysiology; Humans; Macrophages; Monocytes; Patch-Clamp Techniques; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rosaniline Dyes

2002
Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: unique antagonist sensitivity and lack of pore formation.
    Japanese journal of pharmacology, 2002, Volume: 88, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Benzoxazoles; Cations; Cell Membrane Permeability; Fluorescent Dyes; Mice; Patch-Clamp Techniques; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Suramin; Triazines; Tumor Cells, Cultured

2002
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Apoptosis; Apyrase; Autocrine Communication; Cell Shape; Cytidine Triphosphate; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Fibroblasts; Fibronectins; Gene Expression Regulation; Humans; Interleukin-6; Membrane Potentials; Paracrine Communication; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Uridine Diphosphate; Uridine Triphosphate

2004
Functional expression of ionotropic purinergic receptors on mouse taste bud cells.
    The Journal of physiology, 2007, Oct-15, Volume: 584, Issue:Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Signaling; Fluorescent Dyes; Immunohistochemistry; In Vitro Techniques; Isoquinolines; Membrane Potentials; Mice; Microscopy, Fluorescence; Patch-Clamp Techniques; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X7; Receptors, Purinergic P2Y1; Reverse Transcriptase Polymerase Chain Reaction; Taste; Taste Buds; Thionucleotides; Time Factors; Uridine Triphosphate

2007
Negative and positive allosteric modulators of the P2X(7) receptor.
    British journal of pharmacology, 2008, Volume: 153, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Allosteric Regulation; Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Ethidium; Glycine; Humans; Molecular Structure; Piperazines; Protein Conformation; Pyridoxal Phosphate; Quinolines; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Recombinant Proteins; Species Specificity; Time Factors; Transfection; Vanadates

2008
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.
    British journal of pharmacology, 2008, Volume: 155, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Dose-Response Relationship, Drug; Glycine; Humans; Imidazoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperazines; Plasmids; Polymorphism, Single Nucleotide; Protein Binding; Protein Structure, Tertiary; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridines; Pyridoxal Phosphate; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Sequence Alignment; Species Specificity; Transfection

2008