Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and propranolol

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with propranolol in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's7 (50.00)18.2507
2000's4 (28.57)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jin, N; Packer, CS; Rhoades, RA1
Cragoe, EJ; Hori, M; Iwakura, K; Kamada, T; Kitabatake, A; Watanabe, Y; Yoshida, H1
Myers, LM; Sumners, C1
Dehaye, JP; Turner, RJ; Valdez, IH1
Hayakawa, T; Minamino, H; Moriyama, T; Tokumura, A; Tsukatani, H1
Bever, CT; Li, Q; Milo, R; Panitch, H1
Carpio, LC; Dziak, R1
Konishi, S; Mitoma, H1
Antunes-Rodrigues, J; Martins, MC; Udrisar, DP; Wanderley, MI1
Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V1
Hirano, Y; Hiraoka, M; Lin, J; Zhang, S1
Flavahan, NA; Holowatz, LA; Kenney, WL; Thompson-Torgerson, CS1
Ballarini, F; Frey, JU; Martinez, MC; Moncada, D; Viola, H1
Beil, M; Danhof, M; Fu, F; Luttringer, O; Ploeger, BA; Rigel, DF; Snelder, N; Stanski, DR1

Trials

1 trial(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and propranolol

ArticleYear
Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Body Temperature Regulation; Cold Temperature; Female; Humans; Intracellular Signaling Peptides and Proteins; Laser-Doppler Flowmetry; Male; Norepinephrine; Propranolol; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases; Skin; Skin Temperature; Vasoconstriction; Vasoconstrictor Agents; Yohimbine

2007

Other Studies

13 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and propranolol

ArticleYear
Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms.
    Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Phentolamine; Piperazines; Propranolol; Pulmonary Artery; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Verapamil; Xanthine Oxidase

1991
Alpha 1-adrenoceptor stimulation increases intracellular pH and Ca2+ in cardiomyocytes through Na+/H+ and Na+/Ca2+ exchange.
    European journal of pharmacology, 1990, Sep-04, Volume: 186, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amiloride; Animals; Calcium; Fluorescent Dyes; Heart; Hydrogen; Hydrogen-Ion Concentration; Ion Exchange; Isoquinolines; Male; Myocardium; Norepinephrine; Phentolamine; Piperazines; Prazosin; Propranolol; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Sodium; Yohimbine

1990
Regulation of angiotensin II binding sites in neuronal cultures by catecholamines.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Animals, Newborn; Brain; Carbachol; Cells, Cultured; Isoquinolines; Kinetics; Neurons; Norepinephrine; Phosphatidylinositols; Piperazines; Propranolol; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Yohimbine

1989
Beta-adrenergic stimulation and cAMP mobilize Ca2+ from an IP3-insensitive pool in rat submandibular granular ducts.
    The American journal of physiology, 1993, Volume: 265, Issue:5 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Alkaloids; Animals; Atenolol; Atropine; Calcium; Carbachol; Cyclic AMP; Epinephrine; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoproterenol; Isoquinolines; Kinetics; Male; Phentolamine; Piperazines; Propanolamines; Propranolol; Protein Kinase C; Protein Kinase Inhibitors; Putrescine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Staurosporine; Submandibular Gland

1993
Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms.
    Biochimica et biophysica acta, 1997, Jan-07, Volume: 1344, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Diglycerides; Enzyme Inhibitors; Fatty Acids; Gallic Acid; Glycerides; Guinea Pigs; Male; Neutrophils; Phosphatidic Acids; Propranolol; Serum Albumin, Bovine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triglycerides

1997
Effect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cells.
    Immunopharmacology and immunotoxicology, 1998, Volume: 20, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Cell Line; Cytokines; Diglycerides; HLA-DQ Antigens; HLA-DR Antigens; Humans; Interferon-beta; Interferon-gamma; Monocytes; Propranolol; Protein Kinase C

1998
Phosphatidic acid effects on cytosolic calcium and proliferation in osteoblastic cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 59, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Division; Cells, Cultured; Cytoplasm; Epidermal Growth Factor; Osteoblasts; Phosphatidic Acids; Phospholipase D; Propranolol; Protein Kinase C; Rats; Rats, Sprague-Dawley; Skull; Sphingosine; Thapsigargin; Verapamil

1998
Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses.
    Neuroscience, 1999, Volume: 88, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebellum; Colforsin; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Methiothepin; Neuronal Plasticity; Norepinephrine; Propranolol; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA; Serotonin; Sulfonamides; Synapses; Synaptic Transmission; Tetrodotoxin; Thionucleotides

1999
Propranolol stimulates histone phosphorylation by a putative PK-C in partially purified homogenate of rat testicular interstitial cells. A possible mechanism for increased testosterone secretion by propranolol.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chromatography, Agarose; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Histones; Leydig Cells; Male; Phorbol 12,13-Dibutyrate; Phosphorylation; Propranolol; Protein Kinase C; Rats; Rats, Wistar; Testis; Testosterone; Tritium

2000
Regulation of glutamatergic neurotransmission in the striatum by presynaptic adenylyl cyclase-dependent processes.
    Neurochemistry international, 2003, Volume: 42, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Calcium; Calmodulin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Feedback; Female; Glutamic Acid; Imidazoles; Imines; Isoenzymes; Isoproterenol; Isoquinolines; Kainic Acid; Male; Mice; N-Methylaspartate; Nerve Tissue Proteins; Propranolol; Receptors, Adrenergic, beta; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Presynaptic; Second Messenger Systems; Sulfonamides; Synaptic Transmission; Trifluoperazine

2003
Modulation of ICa-L by alpha1-adrenergic stimulation in rat ventricular myocytes.
    Canadian journal of physiology and pharmacology, 2005, Volume: 83, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium; Calcium Channels, L-Type; Enzyme Inhibitors; Heart Ventricles; Inositol 1,4,5-Trisphosphate; Methoxamine; Muscle Cells; Phenylephrine; Prazosin; Propranolol; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Ventricular Function

2005
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Aug-02, Volume: 108, Issue:31

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; Animals; Avoidance Learning; Benzazepines; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dobutamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Memory, Long-Term; Memory, Short-Term; Neuronal Plasticity; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, N-Methyl-D-Aspartate

2011
Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling.
    British journal of pharmacology, 2014, Volume: 171, Issue:22

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Amlodipine; Animals; Atropine; Enalapril; Hemodynamics; Hydrochlorothiazide; Hypertension; Male; Models, Biological; Prazosin; Propranolol; Rats, Inbred SHR; Rats, Inbred WKY

2014