1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with potassium chloride in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.25) | 18.7374 |
| 1990's | 24 (50.00) | 18.2507 |
| 2000's | 12 (25.00) | 29.6817 |
| 2010's | 9 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Day, RW; Ignarro, LJ; Klitzner, TS; Lai, WW | 1 |
| Ikeda, K; Machida, J; Nishi, K; Sakiyama, H; Ueda, S; Yoshida, M | 1 |
| O'Brian, CA; Ward, NE | 1 |
| Iwasaki, T; Miyata, S; Morita, S; Nagai, K; Shibata, R | 1 |
| Bast, A; Leurs, R; Timmerman, H | 1 |
| Guitart, X; Marsal, J; Solsona, C | 1 |
| Ari, IL; Atlas, D; Schwarz, L | 1 |
| Souhrada, JF; Souhrada, M | 1 |
| Ishii, K; Kato, R; Sasakawa, N; Yamamoto, S | 1 |
| Daniel, EE; Kwan, CY; Loke, JC; Low, AM | 1 |
| Barber, LE; Lu, M; Renfro, JL | 1 |
| Homma, I; Inazu, M; Sakai, Y; Shamoto, A; Zhu, B | 1 |
| Clegg, JM; McKenna, TM; Williams, TJ | 1 |
| Brum, RL; Calixto, JB; Silva, AM | 1 |
| Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y | 1 |
| Distler, A; Haller, H; Lindschau, C; Luft, FC; Quass, P | 1 |
| Nishio, A; Sakaguchi, H | 1 |
| Cantabrana, B; Fernandez, AI; Hidalgo, A | 1 |
| Cortijo, J; De Diego, A; Esplugues, J; Morcillo, EJ; Perpiñá, M; Villagrasa, V | 1 |
| Cui, ZJ; Dannies, PS; Hidaka, H | 1 |
| Cortijo, J; de Diego, A; Morcillo, EJ; Perpina, M; Villagrasa, V | 1 |
| Gault, LM; Siegel, RE | 1 |
| Albrecht, J; Faff, L; Reichenbach, A | 1 |
| Paradiso, AM | 1 |
| Cinquanta, M; Frittoli, E; Gobbi, M; Mennini, T | 1 |
| Himmelreich, NH; Pozdnyakova, NG; Storchak, LG | 1 |
| Behar, J; Biancani, P; Chen, Q; Harnett, K; Xiao, Z; Yu, P | 1 |
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Jin, N; Li, L; Rhoades, RA; Swartz, DR; Wang, Z; Yancey, KW; Zhang, D | 1 |
| Büyükafşar, K; Levent, A | 2 |
| Ark, M; Büyükafşar, K; Levent, A | 1 |
| Kim, W; Lee, CJ; Nam, RH | 1 |
| Arikan, O; Ark, M; Büyükafsar, K; Korkmaz, B; Kubat, H; Ozveren, E; Songu-Mize, E; Yazici, G | 1 |
| Frazier, EP; Mathy, MJ; Michel, MC; Peters, SL | 1 |
| Busch, AE; Ivashchenko, Y; Löhn, M; Plettenburg, O; Rütten, H; Steioff, K | 1 |
| Shimoda, LA; Sylvester, JT; Weigand, L | 1 |
| Chen, J; Cheng, Z; Guo, L; He, Z; Huang, L; Li, H; Li, Q | 1 |
| Kamai, T; Masuda, A; Mizuno, T; Tatsumiya, K; Watanabe, M; Yamanishi, T; Yoshida, K | 1 |
| Blanco, CE; Villamor, E; Zoer, B | 1 |
| Huang, WJ; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Cole, WC; Hollywood, M; McHale, N; Sergeant, G; Thornbury, K; Walsh, MP | 1 |
| Bednarek, ML; Miner, AS; Ratz, PH; Speich, JE | 1 |
| Alvarez, SM; Browne, BM; Clelland, LJ; Miner, AS; Ratz, PH | 1 |
| Greenwood, JA; Ma, L; Schachner, M | 1 |
| Henderson, S; Klausner, AP; Ratz, PH; Southern, JB; Speich, JE; Wilson, CW | 1 |
| Astarci, E; Aydinoglu, F; Balli, E; Ergurhan Kiroglu, O; Ogulener, N | 1 |
| Chen, YC; Du, GH; Fang, LH; Li, L; Niu, ZR; Wang, DS; Yuan, TY; Zhang, HF | 1 |
48 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and potassium chloride
| Article | Year |
|---|---|
Oxygen-mediated regulation of neonatal and adult rabbit aortic tension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Aorta; Arginine; Endothelium, Vascular; Enzyme Activation; In Vitro Techniques; Isoquinolines; Muscle Contraction; Muscle Development; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxygen; Piperazines; Potassium Chloride; Protein Kinase C; Rabbits | 1992 |
Effects of phorbol ester on lower urinary tract smooth muscles in rabbits.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Drug Interactions; Female; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rabbits; Urethra; Urinary Bladder | 1992 |
The intrinsic ATPase activity of protein kinase C is catalyzed at the active site of the enzyme.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetates; Acetic Acid; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Binding Sites; Binding, Competitive; Brain; Calcium; Catalysis; Isoenzymes; Isoquinolines; Kinetics; Phosphatidylserines; Phosphorylation; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Sodium Chloride; Substrate Specificity | 1992 |
Effects of H-7 (protein kinase inhibitor) and phorbol ester on aortic strips from spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Calcimycin; Calcium; Dinoprost; Hypertension; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1990 |
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Catechols; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine; Indomethacin; Isoindoles; Isoquinolines; Lung; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Organoselenium Compounds; Piperazines; Potassium Chloride; Selenium; Thiazoles | 1990 |
Phorbol esters induce neurotransmitter release in cholinergic synaptosomes from Torpedo electric organ.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Botulinum Toxins; Dose-Response Relationship, Drug; Electric Organ; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase C; Synaptosomes; Tetradecanoylphorbol Acetate; Torpedo | 1990 |
Cholinergic-induced [3H] noradrenaline release in rat brain cortical slices is mediated via a pertussis toxin sensitive GTP binding protein and involves activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Carbazoles; Cerebral Cortex; Cholera Toxin; GTP-Binding Proteins; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Male; Neurosecretion; Norepinephrine; Ouabain; Pertussis Toxin; Phenylephrine; Piperazines; Polymyxin B; Potassium Chloride; Protein Kinase C; Rats; Veratridine; Virulence Factors, Bordetella | 1989 |
The role of protein kinase-C in sensitization and antigen response of airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Antibody Specificity; Antigens; Carbazoles; Guinea Pigs; Histamine; Immunization; Immunoglobulin G; Indoles; Indomethacin; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Ovalbumin; Piperazines; Potassium Chloride; Protein Kinase C; Tetradecanoylphorbol Acetate; Trachea | 1989 |
Differential effects of protein kinase C activators on carbamylcholine- and high K+-induced rises in intracellular free calcium concentration in cultured adrenal chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Animals; Calcium; Carbachol; Cattle; Chromaffin Granules; Chromaffin System; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Piperazines; Potassium; Potassium Chloride; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Calcium; Guinea Pigs; Hypertonic Solutions; In Vitro Techniques; Indomethacin; Isoquinolines; Male; Mannitol; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Nicardipine; Phentolamine; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar | 1994 |
Renal transepithelial phosphate secretion: luminal membrane voltage and Ca2+ dependence.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Charybdotoxin; Electrophysiology; Epithelium; Flounder; In Vitro Techniques; Isoquinolines; Kidney; Kinetics; Mannitol; Membrane Potentials; Models, Biological; Phorbol Esters; Phosphates; Phosphorus Radioisotopes; Piperazines; Potassium Chloride; Protein Kinase C; Scorpion Venoms; Sulfonamides; Terpenes; Thapsigargin; Time Factors; Verapamil | 1994 |
Contractile hyperreactivity and alteration of PKC activity in gastric fundus smooth muscle of diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium Channels; Cell Membrane; Diabetes Mellitus, Experimental; Gastric Fundus; In Vitro Techniques; Isoquinolines; Isradipine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C is a mediator of lipopolysaccharide-induced vascular suppression in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Cell Membrane; Citrulline; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Kinetics; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonamides | 1994 |
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; Endothelins; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Portal Vein; Potassium Chloride; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation | 1995 |
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction | 1993 |
Nuclear calcium signaling is initiated by cytosolic calcium surges in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; Ionomycin; Isoquinolines; Kinetics; Microscopy, Confocal; Muscle, Smooth, Vascular; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Second Messenger Systems; Signal Transduction; Staurosporine; Terpenes; Thapsigargin | 1994 |
Mechanisms of the enhanced contractile response to phenylephrine in thoracic aorta isolated from rats with dietary magnesium deficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Diet; In Vitro Techniques; Isoquinolines; Isradipine; Magnesium Deficiency; Male; Nifedipine; Phenylephrine; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction | 1994 |
Effects of phorbol 12,13-dibutyrate and H-7 in extravascular smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Female; Isoquinolines; Muscle, Smooth; Oxytocin; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rats; Rats, Wistar; Uterine Contraction | 1993 |
Effects of phorbol 12,13-diacetate and its influence on spasmogenic responses in normal and sensitized guinea-pig trachea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Diuretics; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase C; Serotonin; Trachea; Vasodilator Agents; Verapamil | 1995 |
KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Female; Isoquinolines; Kinetics; Piperazines; Pituitary Gland, Anterior; Potassium; Potassium Chloride; Prolactin; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Time Factors | 1996 |
H-7, a protein kinase C inhibitor, inhibits spontaneous tone and spasmogenic responses in normal and sensitized guinea pig trachea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Chloride; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Histamine; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth; Piperazines; Potassium Chloride; Protein Kinase C; Trachea | 1995 |
Expression of the GABAA receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Chelating Agents; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Macromolecular Substances; Membrane Potentials; Neurons; Nifedipine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sulfonamides; Tetrodotoxin; Time Factors; Transcription, Genetic | 1997 |
Two modes of stimulation by ammonia of taurine release from cultured rabbit Müller cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Ammonia; Animals; Buffers; Calcium; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Guanylate Cyclase; Methylene Blue; Potassium Chloride; Protein Kinase Inhibitors; Rabbits; Retina; Taurine | 1997 |
ATP-activated basolateral Na+/H+ exchange in human normal and cystic fibrosis airway epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adolescent; Adult; Ammonium Chloride; Cell Membrane; Cell Polarity; Cells, Cultured; Child; Cystic Fibrosis; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Nasal Mucosa; Nigericin; Potassium Chloride; Reference Values; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1997 |
Further evidence of Ca(2+)-dependent, exocytotic-like serotonin release induced by D-fenfluramine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Exocytosis; Fenfluramine; Hippocampus; In Vitro Techniques; Male; Polymyxin B; Potassium Chloride; Rats; Rats, Inbred Strains; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptosomes | 1997 |
Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Biological Transport; Brain Chemistry; Calcium; Carbon Radioisotopes; Enzyme Inhibitors; gamma-Aminobutyric Acid; Male; Potassium Chloride; Rats; Sphingosine; Spider Venoms; Staurosporine; Sulfonamides; Synaptosomes | 1998 |
Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calmodulin; Cats; Cell Membrane; Cholecystokinin; Diglycerides; Egtazic Acid; Female; Gallbladder; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phospholipase C beta; Potassium Chloride; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents | 2001 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2003 |
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanethidine; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vas Deferens | 2003 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Long-Term Potentiation; Magnesium; Nifedipine; Potassium Chloride; Receptors, N-Methyl-D-Aspartate; Telencephalon; Time Factors; Valine; Zebrafish | 2004 |
Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Biophysics; Calcium; Dose-Response Relationship, Drug; Humans; Models, Biological; Nifedipine; Potassium Chloride; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Serotonin; Umbilical Arteries | 2004 |
Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine; Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Potassium Chloride; Rats; Signal Transduction; Urinary Bladder | 2005 |
Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aorta, Thoracic; Dietary Fats; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptors, LDL; rho-Associated Kinases; Time Factors; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Azepines; Endothelin-1; Enzyme Inhibitors; Genistein; Hypoxia; Indoles; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Maleimides; Myosin-Light-Chain Kinase; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Staurosporine; Vasoconstriction | 2006 |
Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Hippocampus; Hypoxia; Intracellular Space; Ischemia; Neurons; Potassium Chloride; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2009 |
Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Chloride; Protein Kinase Inhibitors; rho-Associated Kinases; Swine; Urinary Bladder; Urothelium | 2009 |
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction | 2010 |
Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Agents; Coumarins; Cytochalasin D; Enzyme Inhibitors; Furocoumarins; Glutamic Acid; Hippocampus; Ionomycin; Male; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Synapsins; Synaptic Vesicles | 2010 |
Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Electric Stimulation; Male; Muscle Contraction; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphorylation; Potassium Chloride; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Urethra | 2011 |
Active tension adaptation at a shortened arterial muscle length: inhibition by cytochalasin-D.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Calcium Channels; Cytochalasin D; Femoral Artery; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Myosin Light Chains; Nifedipine; Phosphorylation; Potassium Chloride; Rabbits; rho-Associated Kinases; Thiazolidines | 2011 |
Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cardiovascular Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escin; Female; Femoral Artery; Indoles; Male; Maleimides; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Octoxynol; Organ Culture Techniques; Permeability; Potassium Chloride; Rabbits; rho-Associated Kinases; Surface-Active Agents | 2011 |
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chelating Agents; Chlorocebus aethiops; CREB-Binding Protein; Cystatins; Dendrites; Egtazic Acid; Embryo, Mammalian; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Growth Cones; Hippocampus; Male; Microscopy, Confocal; Neurites; Neurons; Nifedipine; Potassium Chloride; Pseudopodia; Rats; RNA, Messenger; RNA, Small Interfering; Transfection; Up-Regulation; Valine | 2011 |
Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Cholinergic Agonists; Dinoprostone; Enzyme Inhibitors; Female; Male; Mice; Muscle Contraction; Muscle, Smooth; Potassium Chloride; rho-Associated Kinases; Urinary Bladder; Urinary Bladder Neck Obstruction | 2012 |
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2015 |
Fasudil evokes vasodilatation of rat mesenteric vascular bed via Ca(2+) channels and Rho/ROCK pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Calcium Channels; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mesenteric Arteries; Myosin Light Chains; Phosphorylation; Potassium Chloride; Protein Phosphatase 1; Rats; rho-Associated Kinases; Vasodilation | 2016 |