1-(5-isoquinolinesulfonyl)-2-methylpiperazine and phenylephrine

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbachol; Drug Interactions; Female; Isoquinolines; Muscle Contraction; Muscle, Smooth; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Rabbits; Urethra; Urinary Bladder

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carbamates; Cromakalim; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Phenylephrine; Phosphatidylinositols; Piperazines; Protease Inhibitors; Pyrroles; Rats

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calmodulin; Cells, Cultured; Gene Expression; Heart; Hydrolysis; Isoquinolines; Myocardium; Nifedipine; Phenylephrine; Phosphatidylinositols; Piperazines; Protein Kinase C; Rats; Sulfonamides

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cyclic AMP; Enzyme Activation; Estradiol; Female; Hypothalamus; Isoproterenol; Isoquinolines; Ovariectomy; Phenylephrine; Phospholipases A; Phospholipases A2; Piperazines; Preoptic Area; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Staurosporine; Type C Phospholipases

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Catecholamines; Epinephrine; Female; GTP-Binding Proteins; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred ICR; Motor Endplate; Motor Neurons; Nerve Endings; Norepinephrine; Phenylephrine; Piperazines; Protein Kinase Inhibitors; Receptors, Adrenergic, alpha; Signal Transduction; Sulfonamides

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Female; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Rabbits; Signal Transduction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Carbazoles; Cerebral Cortex; Cholera Toxin; GTP-Binding Proteins; In Vitro Techniques; Indole Alkaloids; Isoquinolines; Male; Neurosecretion; Norepinephrine; Ouabain; Pertussis Toxin; Phenylephrine; Piperazines; Polymyxin B; Potassium Chloride; Protein Kinase C; Rats; Veratridine; Virulence Factors, Bordetella

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Cell Line; Cell Movement; Enzyme Activation; Isoquinolines; Kinetics; Macrophages; Mice; Microscopy, Electron, Scanning; Phenylephrine; Piperazines; Protein Kinase C; Sphingosine; Trifluoperazine

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Calcium; Diltiazem; Endothelins; Endothelium, Vascular; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Phenylephrine; Phloretin; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine Vasopressin; Atrial Function; Atrial Natriuretic Factor; Bucladesine; Calmodulin; Dibutyryl Cyclic GMP; Heart; Heart Atria; Isoquinolines; Male; Phenylephrine; Physical Stimulation; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Diglycerides; Enzyme Activation; Ethanol; Fluorescent Dyes; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Type C Phospholipases

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Enzyme Activation; In Vitro Techniques; Isoquinolines; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Potassium; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Epidermal Growth Factor; Genistein; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Base Sequence; Calcium Channels; Cells, Cultured; Gene Expression Regulation; Genes, fos; Isoquinolines; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Diet; In Vitro Techniques; Isoquinolines; Isradipine; Magnesium Deficiency; Male; Nifedipine; Phenylephrine; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Embryo, Mammalian; Female; Isoquinolines; Organ Culture Techniques; Phenylephrine; Piperazines; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Signal Transduction; Situs Inversus

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Clonidine; Heart Atria; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Phenylephrine; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Stimulation, Chemical

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; beta-Adrenergic Receptor Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dogs; Down-Regulation; G-Protein-Coupled Receptor Kinase 3; Indomethacin; Phenylephrine; Prazosin; Protein Kinase C; Protein Serine-Threonine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Arteries; Endothelium, Vascular; Enzyme Inhibitors; Gadolinium; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Protein Kinase C; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Agonists; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Mixed Function Oxygenases; Multienzyme Complexes; Myocardium; Phenylephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; RNA Stability; RNA, Messenger; Sulfonamides; Transcription, Genetic

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Contractile Proteins; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Phenylephrine; Phosphorylation; Potassium; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Saphenous Vein; Vasoconstriction; Vasoconstrictor Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanethidine; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vas Deferens

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Chickens; Dose-Response Relationship, Drug; Male; Models, Biological; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Niacinamide; Oxygen; Peptides; Phenylephrine; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Autoreceptors; Biopterins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylephrine; Piperazines; Pyridines; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists; Time Factors; Tryptophan; Tryptophan Hydroxylase

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aorta, Thoracic; Dietary Fats; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptors, LDL; rho-Associated Kinases; Time Factors; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium; Calcium Channels, L-Type; Enzyme Inhibitors; Heart Ventricles; Inositol 1,4,5-Trisphosphate; Methoxamine; Muscle Cells; Phenylephrine; Prazosin; Propranolol; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Ventricular Function

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Heart Ventricles; Hypertrophy; Male; Membrane Potentials; Myocytes, Cardiac; Myosin Heavy Chains; Patch-Clamp Techniques; Peptides; Phenylephrine; Phosphorus Radioisotopes; Phosphorylation; Rats; Rats, Sprague-Dawley; Sarcolemma

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Ductus Arteriosus; Enzyme Activation; Enzyme Induction; Feedback, Physiological; Female; Fetal Heart; Gestational Age; Humans; Hydrogen Peroxide; Hypoplastic Left Heart Syndrome; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Mitochondria, Heart; Nifedipine; Organ Culture Techniques; Oxidation-Reduction; Oxygen; Partial Pressure; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Superoxides; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Accommodation, Ocular; Animals; Anterior Eye Segment; Aqueous Humor; Drug Therapy, Combination; Enzyme Inhibitors; Female; Iris; Macaca fascicularis; Male; Muscarinic Agonists; Phenylephrine; Pilocarpine; Protein Serine-Threonine Kinases; Pupil

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Benzophenanthridines; Calcium; Diabetes Mellitus, Experimental; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Streptozocin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Case-Control Studies; Coronary Artery Bypass; Coronary Artery Disease; Diabetes Mellitus; Female; Gene Expression Regulation, Enzymologic; Graft Occlusion, Vascular; Humans; Immunohistochemistry; Male; Mammary Arteries; Middle Aged; Phenylephrine; Protein Kinase Inhibitors; Radial Artery; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Saphenous Vein; Vascular Patency; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aorta, Thoracic; Arteriovenous Shunt, Surgical; Cardiac Volume; Heart Failure; Humans; Male; Models, Animal; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; rho-Associated Kinases; Urotensins; Vasoconstriction; Venae Cavae

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Electric Stimulation; Male; Muscle Contraction; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphorylation; Potassium Chloride; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Urethra

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-1 Receptor Agonists; Animals; Benzophenanthridines; Calcium Channel Agonists; Calcium Signaling; Carbenoxolone; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Gap Junctions; In Vitro Techniques; Male; Methacholine Chloride; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Pinacidil; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Riluzole; Ryanodine; Tetraethylammonium; Vasomotor System

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Cadaver; Hindlimb; Horses; NADPH Oxidases; Oxygen; Phenylephrine; Pyridines; Reactive Oxygen Species; rho-Associated Kinases; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Brain Stem; Chronic Disease; Consciousness; Enzyme Inhibitors; Heart; Heart Failure; Heart Rate; Male; Metoprolol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Rabbits; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Sympathetic Nervous System; Vagus Nerve

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Temperature Regulation; Calcium; Calcium Channel Blockers; Calcium Channels; Cold Temperature; Iliac Artery; Large-Conductance Calcium-Activated Potassium Channels; Male; Models, Animal; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Phosphorylation; Protein Phosphatase 1; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Drug Synergism; Lysophospholipids; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Pyridines; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents