Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and okadaic acid

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with okadaic acid in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	60 (80.00)	18.2507
2000's	14 (18.67)	29.6817
2010's	1 (1.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Emoto, S; Ichikawa, A; Imanishi, N; Kawai, H; Ohgoh, M; Ohmori, E; Yatsunami, K	1
Badwey, JA; Ding, J	1
Artalejo, CR; Fox, AP; Perlman, RL; Rossie, S	1
Gordon, PB; Holen, I; Seglen, PO	2
Hershkoviz, R; Lider, O; Miron, S; Schechter, Y; Tirosh, I; Yayun, A	1
Kiss, Z	1
Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S	1
Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S	1
Chao, R; Hannun, YA; Khan, W	1
Candeo, P; Favaron, M; Lengyel, I; Manev, H; Manev, RM; Rimland, JM	1
Datta, R; Hass, R; Kharbanda, S; Kufe, D; Nakamura, T; Rubin, E	1
Kono, T; Robinson, FW; Shibata, H; Soderling, TR	1
de Groot, RP; de Laat, SW; de Vries, C; Koornneef, I; Kramer, IM; Kruijer, W; van den Eijnden-van Raaij, AJ	1
Casillas, T; Delicado, EG; Miras-Portugal, MT; Sen, RP	1
Haystead, TA; Krebs, EG; Licciardi, KA; Meier, KE	1
Carter, V; Gale, M; Parsons, M	1
Chida, K; Kuroki, T; Tagawa, T; Vogt, PK	1
Aggarwal, BB; Chan, H; Higuchi, M; Singh, S	1
Falcone, DJ; Garcia, M; Haimovitz-Friedman, A; McCaffrey, TA	1
Bertrand, R; Jenkins, J; Pommier, Y; Solary, E	1
Alling, C; Larsson, C; Simonsson, P	1
Burnside, B; Liepe, BA	1
Doris, R; Houslay, MD; Kilgour, E; Thompson, GE; Vernon, RG	1
Terrian, DM; Ways, DK	1
Deng, ZW; Denkinger, DJ; Deuel, TF; Kawahara, RS	1
Wood, PL	1
Abe, H; Asakuno, K; Hidaka, K; Kohno, K; Kuwano, M; Tanimura, H; Uchida, Y; Uchiumi, T	1
Firestone, GL; Singer, KL; Stevenson, BR; Woo, PL	1
Benistant, C; Gustavsson, L; Hoek, JB; Moehren, G; Rubin, R; Torres-Marquez, ME	1
Colucci, WS; Izzo, NJ; Tulenko, TN	1
Brubaker, JH; Chin, WW; Jones, KE	1
Dwen, P; Mayrand, SH; Pederson, T	1
Lewis, CE; McGee, JO; Pusztai, L	1
Kim, KT; Lin, LF; Westhead, EW	1
Greenwel, P; Hu, W; Kohanski, RA; Ramirez, F	1
Heimerl, P; Hofer, HW; Stader, C; Willmann, R	1
Dussault, JH; Etongue-Mayer, P; Puymirat, J	1
Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R	1
Ejiri, S; Hidaka, S; Kagaya, Y; Nakamura, H; Satoh, W; Tsutsumi, K	1
Chock, PB; Huang, CY; Tekle, E; Zhu, DM	1
Vernon, RG	1
Chandok, MR; Sopory, SK	2
Atabay, C; Cagnoli, CM; Kharlamov, E; Manev, H; Uz, T	1
Geelen, MJ; Guzmán, M; Velasco, G; Zammit, VA	1
Casey, ML; Devora, GA; MacDonald, PC; Mibe, M; Morimoto, T	1
Agranoff, BW; Heacock, AM	1
Castrucci, AM; da Silva, MA; Josefsson, L; Nery, LE	1
Jones, SW; Kammermeier, PJ	1
Nishiyama, I; Ogiso, M; Oota, T; Seki, T	1
Chiu, LM; Guarneros, A; Peña, F; Sitges, M	1
Reinach, PS; Torres-zamorano, V; Wu, X; Yang, H	1
Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T	1
Hernández, ML; Martínez, MJ; Ochoa, B	1
Collin, T	1
Doris, RA; Houslay, MD; Kilgour, E; Vernon, RG	1
Chik, CL; Ho, AK; Karpinski, E; Li, B	1
Bisht, D; Chakraborti, PK; Rana, S	1
Espinos, E; Le Van Thaï, A; Pomiès, C; Weber, MJ	1
Aggarwal, BB; Manna, SK	1
Chaudhuri, S; Raha, S	1
Barnes, S; Kourennyi, DE	1
Hishinuma, S; Ogura, K	1
Bontron, S; Eder-Colli, L; Pahud, G	1
Bennecib, M; Gong, CX; Grundke-Iqbal, I; Iqbal, K	1
Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D	1
Courjaret, R; Lapied, B	1
Collins, JF; Ghishan, FK; Hines, ER; Kiela, PR	1
Balaraman, S; Kapoor, P; Madhubala, R; Raj, VS; Saxena, S	1
Chung, IK; Jin, E; Kim, WT; Yang, SW	1
Gimbrone, MA; Masuda, J; Ochi, H	1
Reiser, G; Tulapurkar, ME; Zündorf, G	1
Ashizawa, K; Katayama, S; Narumi, K; Ranasinghe, AR; Takano, D; Tsuzuki, Y; Wishart, GJ	1
Balezina, OP; Bogatcheva, PO	1

Other Studies

75 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and okadaic acid

Article	Year
Synergistic effects of 12-O-tetradecanoylphorbol-13-acetate and dexamethasone on de novo synthesis of histidine decarboxylase in mouse mastocytoma P-815 cells. Biochimica et biophysica acta, 1992, Jan-13, Volume: 1133, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Dexamethasone; Diglycerides; Drug Synergism; Enzyme Activation; Ethers, Cyclic; Histidine Decarboxylase; Isoquinolines; Mast-Cell Sarcoma; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1992
Effects of antagonists of protein phosphatases on superoxide release by neutrophils. The Journal of biological chemistry, 1992, Mar-25, Volume: 267, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Calcium; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Guinea Pigs; Isoquinolines; Magnesium; Marine Toxins; Models, Biological; Neutrophils; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Piperazines; Superoxides; Tetradecanoylphorbol Acetate	1992
Voltage-dependent phosphorylation may recruit Ca2+ current facilitation in chromaffin cells. Nature, 1992, Jul-02, Volume: 358, Issue:6381 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenal Medulla; Animals; Calcium; Calcium Channels; Cattle; Ethers, Cyclic; In Vitro Techniques; Ion Channel Gating; Isoquinolines; Membrane Potentials; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Phosphatase 2	1992
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity. The Biochemical journal, 1992, Jun-15, Volume: 284 ( Pt 3) Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Cytoskeleton; Ethers, Cyclic; Indole Alkaloids; Indoles; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Raffinose; Rats; Rats, Inbred Strains; Sulfonamides; Tritium	1992
Involvement of a protein kinase C and protein phosphatases in adhesion of CD4+ T cells to and detachment from extracellular matrix proteins. Cellular immunology, 1992, Oct-01, Volume: 144, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; CD4 Antigens; Cell Adhesion; Cell Movement; Ethers, Cyclic; Fibronectins; Humans; Integrins; Isoquinolines; Laminin; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes	1992
The long-term combined stimulatory effects of ethanol and phorbol ester on phosphatidylethanolamine hydrolysis are mediated by a phospholipase C and prevented by overexpressed alpha-protein kinase C in fibroblasts. European journal of biochemistry, 1992, Oct-01, Volume: 209, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Enzyme Activation; Ethanol; Ethanolamines; Ethers, Cyclic; Fibroblasts; Hydrolysis; Isoenzymes; Isoquinolines; Mice; Mice, Inbred BALB C; Okadaic Acid; Phosphatidylethanolamines; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases	1992
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida. Journal of assisted reproduction and genetics, 1992, Volume: 9, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida	1992
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation. Journal of assisted reproduction and genetics, 1992, Volume: 9, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate	1992
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. The Journal of biological chemistry, 1992, Nov-25, Volume: 267, Issue:33 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cell Division; Cell Line; Ceramides; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Humans; Ionomycin; Isomerism; Isoquinolines; Molecular Weight; Naphthalenes; Okadaic Acid; Phosphorylation; Piperazines; Polycyclic Compounds; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate	1992
Pathological phosphorylation causes neuronal death: effect of okadaic acid in primary culture of cerebellar granule cells. Journal of neurochemistry, 1992, Volume: 59, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cells, Cultured; Cerebellum; Ethers, Cyclic; Granulocytes; Isoquinolines; Neurons; Okadaic Acid; Phosphorylation; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate	1992
Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1992, Volume: 3, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Division; Cycloheximide; Dactinomycin; Ethers, Cyclic; Gene Expression Regulation, Leukemic; Genes, jun; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Male; Monocytes; Neoplasm Proteins; Neoplastic Stem Cells; Okadaic Acid; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured	1992
Effects of okadaic acid on insulin-sensitive cAMP phosphodiesterase in rat adipocytes. Evidence that insulin may stimulate the enzyme by phosphorylation. The Journal of biological chemistry, 1991, Sep-25, Volume: 266, Issue:27 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Animals; Biological Transport; Cells, Cultured; Enzyme Activation; Ethers, Cyclic; Glucose; Insulin; Isoproterenol; Isoquinolines; Lipolysis; Okadaic Acid; Phosphorylation; Piperazines; Rats; Rats, Inbred Strains	1991
Phosphorylation of nuclear protein is an early event in TGF beta 1 action. Biochemical and biophysical research communications, 1991, Mar-29, Volume: 175, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Line; DNA-Binding Proteins; Ethers, Cyclic; Isoquinolines; Lung; Mink; Nuclear Proteins; Okadaic Acid; Phosphates; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA; Transcription Factors; Transforming Growth Factor beta	1991
Control of nucleoside transport in neural cells. Effect of protein kinase C activation. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adrenal Medulla; Animals; Biological Transport; Calcimycin; Caprylates; Cells, Cultured; Diglycerides; Dinucleoside Phosphates; Enzyme Activation; Ethers, Cyclic; Isoquinolines; Kinetics; Okadaic Acid; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Triglycerides	1991
Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. The Journal of biological chemistry, 1991, Jan-25, Volume: 266, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Ethers, Cyclic; Glycogen Synthase Kinase 3; Isoquinolines; Mice; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Phosphoproteins; Piperazines; Protein Kinase C; Protein Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured	1991
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei. Journal of cell science, 1994, Volume: 107 ( Pt 7) Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins	1994
The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal. The Journal of cell biology, 1995, Volume: 130, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Biological Transport; Cell Cycle; Cell Nucleus; Cells, Cultured; Chick Embryo; Cytoplasm; Ethers, Cyclic; Fibroblasts; Isoquinolines; Molecular Sequence Data; Nuclear Localization Signals; Nuclear Proteins; Okadaic Acid; Oncogene Protein p65(gag-jun); Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperazines; Protein Kinases; Staurosporine	1995
Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation. Blood, 1995, Sep-15, Volume: 86, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Base Sequence; Cell Differentiation; Cycloheximide; Cytotoxicity, Immunologic; DNA Damage; Ethers, Cyclic; Gene Expression Regulation, Leukemic; Humans; Isoquinolines; Leukemia, Myeloid; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Okadaic Acid; Piperazines; Protease Inhibitors; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1995
Transforming growth factor-beta 1 stimulates macrophage urokinase expression and release of matrix-bound basic fibroblast growth factor. Journal of cellular physiology, 1993, Volume: 155, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Macroglobulins; Animals; Cell Line; Dactinomycin; Drug Synergism; Ethers, Cyclic; Extracellular Matrix; Fibroblast Growth Factor 2; Gene Expression; Humans; Isoquinolines; Macrophages; Methylamines; Mice; Microcystins; Okadaic Acid; Peptides, Cyclic; Piperazines; Plasminogen Activator Inhibitor 1; Protein Kinase C; RNA, Messenger; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator	1993
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. Experimental cell research, 1993, Volume: 207, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc	1993
An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells. Cellular signalling, 1993, Volume: 5, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Calcium; Cell Membrane Permeability; Diglycerides; Ethers, Cyclic; Humans; Isoenzymes; Isoquinolines; Molecular Sequence Data; Myelin Basic Protein; Neoplasm Proteins; Neuroblastoma; Okadaic Acid; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Polymyxin B; Protein Kinase C; Protein Phosphatase 2; Protein Processing, Post-Translational; Signal Transduction; Staurosporine; Substrate Specificity; Tumor Cells, Cultured	1993
Cyclic nucleotide regulation of teleost rod photoreceptor inner segment length. The Journal of general physiology, 1993, Volume: 102, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Actins; Animals; Cyclic AMP; Cyclic GMP; Cytoskeleton; Darkness; Ethers, Cyclic; In Vitro Techniques; Isoquinolines; Light; Okadaic Acid; Peptide Chain Elongation, Translational; Perciformes; Phosphoprotein Phosphatases; Photoreceptor Cells; Piperazines; Protein Kinase Inhibitors	1993
Modulation of adenosine signalling in sheep adipose tissue by growth hormone. Biochemical Society transactions, 1995, Volume: 23, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adipose Tissue; Animals; Cattle; Cells, Cultured; Ethers, Cyclic; Growth Hormone; Isoproterenol; Isoquinolines; Kinetics; Lipolysis; Okadaic Acid; Phenylisopropyladenosine; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Recombinant Proteins; Sheep; Signal Transduction	1995
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly. Journal of neurochemistry, 1995, Volume: 64, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine	1995
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. The Journal of biological chemistry, 1995, Mar-17, Volume: 270, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Autophagy; Cells, Cultured; Dose-Response Relationship, Drug; Endocytosis; Ethers, Cyclic; Flavanones; Flavonoids; Genistein; Isoflavones; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Wistar	1995
Role of serine/threonine protein kinases in the induction of JE, a platelet-derived growth factor inducible gene. Biochemical and biophysical research communications, 1994, Sep-30, Volume: 203, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Cell Nucleus; Chemokine CCL2; Chemotactic Factors; Culture Media; Cytokines; Ethers, Cyclic; Gene Expression; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Okadaic Acid; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription, Genetic	1994
Differential regulation of IL-1 alpha and TNF alpha release from immortalized murine microglia (BV-2). Life sciences, 1994, Volume: 55, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Diterpenes; Ethers, Cyclic; Interleukin-1; Isoquinolines; Lipopolysaccharides; Mice; Microglia; Nerve Tissue Proteins; Okadaic Acid; Pentoxifylline; Phosphorylation; Piperazines; Terpenes; Tumor Necrosis Factor-alpha	1994
Involvement of protein kinase in environmental stress-induced activation of human multidrug resistance 1 (MDR1) gene promoter. FEBS letters, 1993, Jul-12, Volume: 326, Issue:1-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Carrier Proteins; Chloramphenicol O-Acetyltransferase; DNA; Drug Resistance; Ethers, Cyclic; Ethyl Methanesulfonate; Fluorouracil; Gene Expression; Humans; Isoquinolines; Membrane Glycoproteins; Okadaic Acid; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinases; Stress, Physiological; Tumor Cells, Cultured; Ultraviolet Rays	1993
Relationship of serine/threonine phosphorylation/dephosphorylation signaling to glucocorticoid regulation of tight junction permeability and ZO-1 distribution in nontransformed mammary epithelial cells. The Journal of biological chemistry, 1994, Jun-10, Volume: 269, Issue:23 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cadherins; Cell Compartmentation; Cell Membrane Permeability; Dexamethasone; Electric Impedance; Epithelial Cells; Epithelium; Ethers, Cyclic; Intercellular Junctions; Isoquinolines; Mammary Glands, Animal; Membrane Proteins; Mice; Mifepristone; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Zonula Occludens-1 Protein	1994
The role of cytosolic Ca2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes. The Journal of biological chemistry, 1994, Jan-14, Volume: 269, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Ethers, Cyclic; Glycerophospholipids; Isoquinolines; Liver; Male; Okadaic Acid; Phosphatidic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasopressins	1994
Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells. The Journal of biological chemistry, 1994, Jan-21, Volume: 269, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Bradykinin; Cells, Cultured; Diglycerides; Down-Regulation; Ethers, Cyclic; Inositol Phosphates; Isoquinolines; Kinetics; Models, Biological; Muscle, Smooth, Vascular; Norepinephrine; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha-1; RNA, Messenger; Tetradecanoylphorbol Acetate	1994
Evidence that phosphorylation events participate in thyroid hormone action. Endocrinology, 1994, Volume: 134, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cell Line; Chickens; Ethers, Cyclic; Gene Expression; Isoquinolines; Molecular Sequence Data; Muramidase; Okadaic Acid; Oligodeoxyribonucleotides; Phosphorylation; Piperazines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Kinases; Protein Tyrosine Phosphatases; Rats; Receptors, Thyroid Hormone; Repetitive Sequences, Nucleic Acid; Transcription, Genetic; Transfection; Triiodothyronine	1994
Serine/threonine phosphorylation regulates binding of C hnRNP proteins to pre-mRNA. Proceedings of the National Academy of Sciences of the United States of America, 1993, Aug-15, Volume: 90, Issue:16 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2,3-Diphosphoglycerate; Adenosine Triphosphate; Cell Nucleus; Diphosphoglyceric Acids; Ethers, Cyclic; Guanosine Triphosphate; HeLa Cells; Heterogeneous-Nuclear Ribonucleoproteins; Homeostasis; Humans; Isoquinolines; Okadaic Acid; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quercetin; Ribonucleoproteins; RNA Precursors; RNA, Heterogeneous Nuclear	1993
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction. British journal of cancer, 1993, Volume: 67, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Division; DNA, Neoplasm; Ethers, Cyclic; Humans; Isoquinolines; Okadaic Acid; Piperazines; Protein Kinase C; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	1993
Protein phosphorylation at a postreceptor site can block desensitization and induce potentiation of secretion in chromaffin cells. Journal of neurochemistry, 1993, Volume: 60, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Animals; Cattle; Chromaffin System; Drug Synergism; Enzyme Activation; Ethers, Cyclic; Isoquinolines; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface	1993
Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression. Molecular and cellular biology, 1995, Volume: 15, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Collagen; Enzyme Inhibitors; Ethers, Cyclic; Fetus; Fibroblasts; Gene Expression; Genistein; Humans; Isoflavones; Isoquinolines; Nuclear Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Skin; Staurosporine; Transcription, Genetic; Transforming Growth Factor beta; Vanadates	1995
Phorbol ester-dependent regulation of nuclear protein tyrosine phosphatase in situ. Cellular signalling, 1995, Volume: 7, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Nucleus; Enzyme Inhibitors; Ethers, Cyclic; Immunoblotting; Isoquinolines; Lymphocytes; Molecular Weight; Nuclear Proteins; Okadaic Acid; Phosphorylation; Piperazines; Protein Kinase C; Protein Tyrosine Phosphatases; Spleen; Swine; Tetradecanoylphorbol Acetate; Time Factors	1995
Thyroid hormones stabilize acetylcholinesterase mRNA in neuro-2A cells that overexpress the beta 1 thyroid receptor. The Journal of biological chemistry, 1995, Dec-22, Volume: 270, Issue:51 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholinesterase; Animals; Cell Line; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Ethers, Cyclic; Humans; Isoquinolines; Kinetics; Mice; Naphthalenes; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Thyroid Hormone; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Triiodothyronine; Tumor Cells, Cultured	1995
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets. FEBS letters, 1996, Mar-04, Volume: 381, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin	1996
Genomic structure of the rice aldolase isozyme C-1 gene and its regulation through a Ca 2+ -mediated protein kinase-phosphatase pathway. Plant molecular biology, 1996, Volume: 30, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Base Sequence; Calcium; Calcium-Transporting ATPases; Ethers, Cyclic; Fructose-Bisphosphate Aldolase; Gene Expression Regulation, Enzymologic; Genes, Plant; Isoenzymes; Isoquinolines; Molecular Sequence Data; Okadaic Acid; Oryza; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sequence Homology, Amino Acid; Signal Transduction; Terpenes; Thapsigargin	1996
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase. Biochemistry, 1996, Jun-04, Volume: 35, Issue:22 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides	1996
GH inhibition of lipogenesis and stimulation of lipolysis in sheep adipose tissue: involvement of protein serine phosphorylation and dephosphorylation and phospholipase C. The Journal of endocrinology, 1996, Volume: 150, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyl-CoA Carboxylase; Adipose Tissue; Alkaloids; Animals; Bridged-Ring Compounds; Culture Techniques; Ethers, Cyclic; Glycerol; Growth Hormone; Isoquinolines; Lipid Metabolism; Lipids; Lipolysis; Male; Norbornanes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Sheep; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Type C Phospholipases	1996
Phosphorylation/dephosphorylation steps are key events in the phytochrome-mediated enhancement of nitrate reductase mRNA levels and enzyme activity in maize. Molecular & general genetics : MGG, 1996, Jul-19, Volume: 251, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Darkness; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation, Plant; Isoquinolines; Light; Nitrate Reductase; Nitrate Reductases; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phytochrome; Piperazines; Protein Kinase C; RNA, Messenger; RNA, Plant; Signal Transduction; Tetradecanoylphorbol Acetate; Zea mays	1996
Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9. Journal of molecular neuroscience : MN, 1996,Spring, Volume: 7, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Isoquinolines; Neurons; Okadaic Acid; Phosphoric Monoester Hydrolases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Sulfonamides	1996
Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes. The Biochemical journal, 1997, Jan-01, Volume: 321 ( Pt 1) Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carnitine O-Palmitoyltransferase; Enzyme Activation; Enzyme Inhibitors; L-Lactate Dehydrogenase; Liver; Male; Okadaic Acid; Phosphorylation; Rats; Rats, Wistar	1997
Parathyroid hormone-related protein and human myometrial cells: action and regulation. Molecular and cellular endocrinology, 1997, Apr-25, Volume: 129, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Chorionic Gonadotropin; Colforsin; Corticotropin-Releasing Hormone; Female; Gene Expression Regulation; Humans; Muscle Relaxation; Myometrium; Okadaic Acid; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Pregnancy; Proteins; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate	1997
Protein kinase inhibitors block neurite outgrowth from explants of goldfish retina. Neurochemical research, 1997, Volume: 22, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Goldfish; Indole Alkaloids; Nerve Crush; Neurites; Okadaic Acid; Optic Nerve; Protein Kinase C; Protein Kinase Inhibitors; Retina; Sphingosine; Staurosporine	1997
Cellular signalling of PCH-induced pigment aggregation in the crustacean Macrobrachium potiuna erythrophores. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1997, Volume: 167, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chromatophores; Colforsin; Cyclosporine; In Vitro Techniques; Invertebrate Hormones; Neomycin; Okadaic Acid; Oligopeptides; Palaemonidae; Pigments, Biological; Pyrrolidonecarboxylic Acid; Signal Transduction; Trifluoperazine	1997
Facilitation of L-type calcium current in thalamic neurons. Journal of neurophysiology, 1998, Volume: 79, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Electrophysiology; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Okadaic Acid; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Staurosporine; Thalamic Nuclei; Thionucleotides; Time Factors	1998
A protein kinase inhibitor H-7 induces process extrusion in fetal rat thyroid C-cells in vitro. Zoological science, 1997, Volume: 14, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcitonin; Embryonic and Fetal Development; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Neural Cell Adhesion Molecules; Neural Crest; Okadaic Acid; Phenotype; Protein Kinases; Rats; Rats, Wistar; Thyroid Gland	1997
Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels. Neurochemistry international, 1998, Volume: 32, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Okadaic Acid; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sodium; Sodium Channels; Synaptosomes; Tetrodotoxin; Veratridine	1998
ETA receptor mediated inhibition of intracellular pH regulation in cultured bovine corneal epithelial cells. Experimental eye research, 1998, Volume: 66, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arsenicals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclosporine; Diuretics; Egtazic Acid; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epithelium, Corneal; Hydrogen-Ion Concentration; Immunosuppressive Agents; Intracellular Fluid; Naphthalenes; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Endothelin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate	1998
ZmcPKC70, a protein kinase C-type enzyme from maize. Biochemical characterization, regulation by phorbol 12-myristate 13-acetate and its possible involvement in nitrate reductase gene expression. The Journal of biological chemistry, 1998, Jul-24, Volume: 273, Issue:30 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chromatography, Gel; Diglycerides; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Histones; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lipid Metabolism; Nitrate Reductase; Nitrate Reductases; Okadaic Acid; Phosphatidylserines; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Zea mays	1998
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Sep-15, Volume: 18, Issue:18 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides	1998
The okadaic acid induced ACAT activation is prevented by a specific inhibitor of the Ca2+/calmodulin protein kinase II. Biochemical Society transactions, 1998, Volume: 26, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Kinetics; Liver; Maleimides; Naphthalenes; Okadaic Acid; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase	1998
Serotonin induces an increase in D-myo-inositol (1,4,5)-trisphosphate 3-kinase activity in rat brainstem slices. Neuroscience letters, 1998, Oct-16, Volume: 255, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzylamines; Brain Stem; Calcium-Calmodulin-Dependent Protein Kinases; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Indophenol; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Sulfonamides	1998
Regulation of the GTP-binding protein-based antilipolytic system of sheep adipocytes by growth hormone. The Journal of endocrinology, 1998, Volume: 158, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adrenergic beta-Agonists; Analysis of Variance; Animals; Cell Membrane; Colforsin; Culture Techniques; Enzyme Inhibitors; Growth Hormone; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Isomerism; Isoproterenol; Lipolysis; Male; Models, Biological; Okadaic Acid; Pertussis Toxin; Phenylisopropyladenosine; Protein Binding; Receptors, Purinergic P1; Sheep; Stimulation, Chemical; Virulence Factors, Bordetella	1998
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation. Journal of neurochemistry, 1999, Volume: 72, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics	1999
Synergistic activation of yeast-expressed rat androgen receptor by modulators of protein kinase-A. Journal of molecular biology, 1999, Feb-26, Volume: 286, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Androgens; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyproterone; Dihydrotestosterone; Enzyme Inhibitors; Flutamide; Gene Expression Regulation; Genes, Reporter; Metribolone; Okadaic Acid; Rats; Receptors, Androgen; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Saccharomyces cerevisiae; Signal Transduction; Transcriptional Activation; Transformation, Genetic	1999
Cooperation between phosphorylation and acetylation processes in transcriptional control. Molecular and cellular biology, 1999, Volume: 19, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylation; Acetyltransferases; Adenovirus E1A Proteins; Anti-Bacterial Agents; Butyrates; Cell Cycle; Cell Cycle Proteins; Cell Line; Choline O-Acetyltransferase; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Okadaic Acid; p300-CBP Transcription Factors; Peptides; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Transcription Factors; Transcriptional Activation; Transfection	1999
Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester. FEBS letters, 2000, May-04, Volume: 473, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Ceramides; DNA Probes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Humans; Hydrogen Peroxide; I-kappa B Proteins; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Organ Specificity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin	2000
Inhibition and stimulation of growth of Entamoeba histolytica in culture: association with PKC activity and protein phosphorylation. Experimental parasitology, 2000, Volume: 95, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Culture Media; Down-Regulation; Entamoeba histolytica; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Threonine	2000
Depolarization-induced calcium channel facilitation in rod photoreceptors is independent of G proteins and phosphorylation. Journal of neurophysiology, 2000, Volume: 84, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Ambystoma; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Electric Stimulation; Enzyme Inhibitors; GTP-Binding Proteins; Membrane Potentials; Okadaic Acid; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Retinal Rod Photoreceptor Cells	2000
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. Journal of neurochemistry, 2000, Volume: 75, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclosporine; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Okadaic Acid; Piperidines; Pyrilamine; Ranitidine; Receptors, Histamine H1; Sulfonamides; Tacrolimus; Tumor Cells, Cultured	2000
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma. Neurochemistry international, 2001, Volume: 38, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Choline O-Acetyltransferase; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Mice; Neoplasm Proteins; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Processing, Post-Translational; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured	2001
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. FEBS letters, 2001, Feb-09, Volume: 490, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation	2001
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases. Cell biology and toxicology, 2000, Volume: 16, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction	2000
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons). Molecular pharmacology, 2001, Volume: 60, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adenylyl Imidodiphosphate; Animals; Bungarotoxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Imidazoles; Insecta; Insecticides; Isoquinolines; Median Nerve; Neonicotinoids; Neurons; Niacin; Nitro Compounds; Okadaic Acid; Permeability; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Nicotinic; Signal Transduction; Sulfonamides	2001
Regulation of the rat NHE3 gene promoter by sodium butyrate. American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 281, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butyrates; Caco-2 Cells; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Volatile; Genes, Reporter; Humans; Hydroxamic Acids; Okadaic Acid; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transcription, Genetic; Vanadates	2001
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages. The Journal of parasitology, 2001, Volume: 87, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Bucladesine; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycosphingolipids; Leishmania donovani; Leishmaniasis, Visceral; Lipopolysaccharides; Macrophages; Mice; Okadaic Acid; Ornithine Decarboxylase; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors	2001
Cell cycle-dependent regulation of telomerase activity by auxin, abscisic acid and protein phosphorylation in tobacco BY-2 suspension culture cells. The Plant journal : for cell and molecular biology, 2002, Volume: 29, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2,4-Dichlorophenoxyacetic Acid; Abscisic Acid; Cantharidin; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Indoleacetic Acids; Nicotiana; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Plant Growth Regulators; Protein Phosphatase 2; Staurosporine; Telomerase; Telomere; Time Factors	2002
Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity. European journal of immunology, 2002, Volume: 32, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Membrane; Cells, Cultured; Culture Media; Cycloheximide; DNA-Binding Proteins; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; GTP-Binding Proteins; Imidazoles; Intercellular Adhesion Molecule-1; Interferon Regulatory Factor-1; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-1; Interleukin-13; Interleukin-4; NF-kappa B; Okadaic Acid; Osmosis; Phosphoproteins; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Staurosporine; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	2002
Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II. Journal of neurochemistry, 2006, Volume: 96, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Drug Interactions; Endocytosis; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Okadaic Acid; Protein Transport; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Time Factors; Transfection	2006
Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A. Reproduction (Cambridge, England), 2006, Volume: 131, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome Reaction; Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cells, Cultured; Chickens; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Signal Transduction; Sperm Motility; Spermatozoa; Stimulation, Chemical; Sulfonamides; Vitelline Membrane	2006
Multidirectional effects of calmodulin kinase II on transmitter release in mature and newly formed mouse motor synapses. Bulletin of experimental biology and medicine, 2013, Volume: 154, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Mice; Motor Endplate; Neurotransmitter Agents; Nitrendipine; Okadaic Acid; Phosphoric Monoester Hydrolases; Sulfonamides; Synapses; Synaptic Transmission	2013