Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and nimodipine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with nimodipine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (57.14)18.2507
2000's4 (28.57)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Das, KP; Hong, JS; Hudson, PM; McMillian, MK; Suh, HW; Wilson, BC; Wu, GC1
Asano, T; Hidaka, H; Ikegaki, I; Satoh, S; Shibuya, M; Suzuki, Y1
Ha, TS; Kim, YH; Song, DK; Suh, HW; Wie, MB1
Choi, SR; Huh, SO; Kim, YH; Song, DK; Suh, HW2
Algra, A; Feigin, VL; Rinkel, GJ; van Gijn, J; Vermeulen, M1
Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS1
Choi, MR; Huh, SO; Kim, YH; Lee, JK; Song, DK; Suh, HW1
Asano, T; Hitomi, A; Ikegaki, I; Satoh, S; Shibuya, M; Suzuki, Y1
Damaj, MI1
Guo, J; Ren, Z; Wang, R; Wang, S; Xu, B; Zhao, J; Zhou, D; Zhou, L1
Jung, SR; Reed, BJ; Sweet, IR1
Guo, J; Mao, Y; Ren, Z; Wang, R; Wang, S; Xu, B; Zhang, X; Zhang, Y; Zhao, J; Zhao, K; Zhou, D; Zhou, L1

Reviews

1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and nimodipine

ArticleYear
Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage: a systematic review.
    Neurology, 1998, Volume: 50, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium Channel Blockers; Humans; Intracranial Aneurysm; Nimodipine; Subarachnoid Hemorrhage

1998

Trials

2 trial(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and nimodipine

ArticleYear
Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.
    Neurologia medico-chirurgica, 2006, Volume: 46, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Brain Ischemia; Female; Humans; Male; Middle Aged; Nimodipine; Protein Kinase Inhibitors; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilator Agents; Vasospasm, Intracranial

2006
Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Female; Humans; Male; Middle Aged; Nimodipine; Subarachnoid Hemorrhage; Vasodilator Agents; Vasospasm, Intracranial; Young Adult

2011

Other Studies

11 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and nimodipine

ArticleYear
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cholinergic Antagonists; DNA Probes; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Isoquinolines; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Nimodipine; Piperazines; Protein Precursors; RNA, Messenger; Transcription, Genetic

1995
Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils.
    British journal of pharmacology, 1996, Volume: 118, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Water; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Cell Death; Embolism; Enzyme Inhibitors; Gerbillinae; Male; Methacrylates; Neurons; Neuroprotective Agents; Nimodipine; Protein Kinase Inhibitors; Rats; Thromboxane-A Synthase

1996
Molecular mechanisms underlying the regulation of proenkephalin gene expression in cultured spinal cord cells.
    Neuropeptides, 1996, Volume: 30, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mollusk Venoms; Nimodipine; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate

1996
Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mous
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; beta-Endorphin; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; omega-Conotoxin GVIA; Peptides; Spinal Cord

1997
Effects of intrathecal injection of nimodipine, omega-conotoxin GVIA, calmidazolium, and KN-62 on the antinociception induced by cold water swimming stress in the mouse.
    Brain research, 1997, Aug-29, Volume: 767, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesia; Animals; Calcium Channel Blockers; Cold Temperature; Enzyme Inhibitors; Imidazoles; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Mollusk Venoms; Nimodipine; omega-Conotoxin GVIA; Pain Measurement; Peptides; Stress, Physiological; Swimming

1997
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
    Brain research. Molecular brain research, 1998, Oct-01, Volume: 60, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic

1998
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
    Neuroscience letters, 1999, Nov-26, Volume: 276, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Calmodulin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; Isoquinolines; Nimodipine; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured

1999
Hemorheological abnormalities in experimental cerebral ischemia and effects of protein kinase inhibitor on blood fluidity.
    Life sciences, 2000, Sep-08, Volume: 67, Issue:16

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterial Occlusive Diseases; Blood Viscosity; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Hematocrit; Hemodilution; Ischemic Attack, Transient; Male; Methacrylates; Middle Cerebral Artery; Nimodipine; Protein Kinase Inhibitors; Rats; Rats, Wistar; Thromboxane-A Synthase

2000
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Nicotine; Nicotinic Agonists; Nimodipine; Pain Measurement; Reaction Time; Spinal Cord; Verapamil

2005
A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 297, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Energy Metabolism; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Models, Biological; Nimodipine; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley

2009