1-(5-isoquinolinesulfonyl)-2-methylpiperazine and ng-nitroarginine methyl ester

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Aorta; Arginine; Endothelium, Vascular; Enzyme Activation; In Vitro Techniques; Isoquinolines; Muscle Contraction; Muscle Development; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxygen; Piperazines; Potassium Chloride; Protein Kinase C; Rabbits

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Cell Membrane; Citrulline; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoquinolines; Kinetics; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Piperazines; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfonamides

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Animals; Arginine; Arteries; Base Sequence; Cattle; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Gene Expression Regulation; Humans; Isoquinolines; Molecular Sequence Data; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Piperazines; Protein Kinase C; RNA, Messenger; Stress, Mechanical; Veins

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acids; Arginine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chorionic Gonadotropin; Dinoprost; Female; In Vitro Techniques; Isoquinolines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovary; Ovulation; Perfusion; Piperazines; Progesterone; Rabbits; Signal Transduction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Blotting, Northern; Chronic Disease; Cyclic AMP-Dependent Protein Kinases; Enzyme Induction; Hypoxia; Isoenzymes; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Area Under Curve; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Serine-Threonine Kinases; Rats; Rats, Inbred WKY; rho-Associated Kinases

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Death; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Enzyme Inhibitors; Fetus; Kinetics; Membrane Potentials; Neurons; NG-Nitroarginine Methyl Ester; Nifedipine; Nitriles; Pyrethrins; Rats; Sulfonamides; Tacrolimus; Trifluoperazine; Veratridine

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blood Pressure; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitroprusside; Penis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Brain Ischemia; Cerebrovascular Circulation; Down-Regulation; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia, Brain; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Laser-Doppler Flowmetry; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Rats; rho-Associated Kinases; Stimulation, Chemical; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Androstadienes; Animals; Apoptosis; Cardiotonic Agents; Coronary Circulation; Cytoskeletal Proteins; Enzyme Activation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Microfilament Proteins; Multiprotein Complexes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Wortmannin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Resistance; Vasoconstriction; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Carbazoles; Cyclic GMP; Cyclic N-Oxides; Female; Grasshoppers; Guanylate Cyclase; Imidazoles; Indoles; Muscles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oviposition; Penicillamine; Protein Kinases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aorta; Disease Models, Animal; Hemodynamics; Hypertension, Portal; Liver; Liver Cirrhosis, Biliary; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phosphorylation; Portal Pressure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcimycin; Cells, Cultured; Coronary Vessels; Down-Regulation; Endothelial Cells; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Nitrite; Triazenes

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Angiotensin II; Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Heart Rate; Hypoxia; Injections, Intravenous; Isradipine; Lung; Male; NG-Nitroarginine Methyl Ester; Protein Kinase Inhibitors; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vascular Resistance; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Collagen Type I; Collagen Type III; Drug Interactions; Enzyme Inhibitors; Hypertension, Renal; Intercellular Adhesion Molecule-1; Kidney; Male; NADPH Oxidases; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Superoxides; Transforming Growth Factor beta

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Bone Morphogenetic Protein 2; Bone Remodeling; Carrier Proteins; Cell Differentiation; Cell Line; Enzyme Activation; Histocytochemistry; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Osteoblasts; Osteocalcin; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Ribonucleotides; RNA, Messenger

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aged; Aging; Blood Flow Velocity; Blood Pressure; Blood Vessels; Body Temperature Regulation; Cold Temperature; Female; Forearm; Humans; Laser-Doppler Flowmetry; Male; Microdialysis; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Protein Kinase Inhibitors; Reflex; Regional Blood Flow; rho-Associated Kinases; Skin; Vasoconstriction; Vasodilator Agents; Young Adult

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Dehydrogenase; Allopurinol; Animals; Blood Pressure; Cyanamide; Dose-Response Relationship, Drug; Male; Mitochondria; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Vasodilator Agents; Xanthine Dehydrogenase

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Topical; Animals; Blood Flow Velocity; Blood Pressure; Endothelin-1; Evoked Potentials, Visual; Infusions, Intravenous; Intraocular Pressure; Laser-Doppler Flowmetry; Male; NG-Nitroarginine Methyl Ester; Optic Disk; Protein Kinase Inhibitors; Rabbits; Regional Blood Flow; rho-Associated Kinases

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-1 Receptor Agonists; Animals; Benzophenanthridines; Calcium Channel Agonists; Calcium Signaling; Carbenoxolone; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Gap Junctions; In Vitro Techniques; Male; Methacholine Chloride; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Pinacidil; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Riluzole; Ryanodine; Tetraethylammonium; Vasomotor System

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Angiography; Animals; Endothelium, Vascular; Enzyme Inhibitors; Hypertension, Pulmonary; Lung; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Rats, Sprague-Dawley; Regional Blood Flow; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Brain Stem; Chronic Disease; Consciousness; Enzyme Inhibitors; Heart; Heart Failure; Heart Rate; Male; Metoprolol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Rabbits; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Sympathetic Nervous System; Vagus Nerve

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Actins; Animals; Carotid Arteries; Endothelium, Vascular; Female; Male; Mice; Mice, Inbred C57BL; Myosin Light Chains; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Protein Kinase Inhibitors; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Apoptosis; Cholesterol; Coronary Vessels; Hypercholesterolemia; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; rho-Associated Kinases; Wortmannin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcium Channel Blockers; Cardiotonic Agents; Drug Synergism; Enzyme Inhibitors; Fluorobenzenes; Heart; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Ventricular Function, Left

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cerebral Angiography; Cerebral Arteries; Cerebral Hemorrhage; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hyperglycemia; Infarction, Middle Cerebral Artery; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Organ Size; Rats, Sprague-Dawley; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Cardiomegaly; Endothelin-1; Endothelium, Vascular; Hypertension; Male; Mice, Inbred C57BL; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilator Agents

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alzheimer Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Memory Disorders; Neuroprotective Agents; NF-kappa B; NG-Nitroarginine Methyl Ester; Nootropic Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats, Wistar; Streptozocin; Wortmannin