Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and n-formylmethionine leucyl-phenylalanine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with n-formylmethionine leucyl-phenylalanine in 50 studies

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (46.00)	18.7374
1990's	25 (50.00)	18.2507
2000's	2 (4.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kobuchi, H; Li, MJ; Matsuno, T; Utsumi, K; Yasuda, T	1
Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T	1
Cronstein, BN; Haines, KA; Kolasinski, S; Reibman, J	1
Akimaru, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T; Yoshioka, T	1
Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A	1
Akimaru, K; Inoue, M; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T	1
Fujita, Y; Kataoka, S; Kobuchi, H; Tanimura, M; Utsumi, K; Utsumi, T; Yoshioka, T	1
Brown, GE; Lanser, ME; Reed, EB	1
Bonak, V; Casnellie, JE; Huang, CK; Laramee, GR	1
Huang, CK; Laramee, GR; Sha'afi, RI; Yamazaki, M	1
Abboud, CN; Lichtman, MA; Packman, CH; Sham, RL	1
Gay, JC; Stitt, ES	1
Jaswon, MS; Jones, HM; Khwaja, A; Linch, DC; Roberts, PJ; Yong, K	1
Badwey, JA; Heyworth, PG; Robinson, JM	1
Harvath, L	1
Becker, EL; Gomez-Cambronero, J; Mege, JL; Molski, TF; Sha'afi, RI	1
Bass, DA; Harvath, L; McCall, CE; McPhail, LC	1
Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI	1
Gerard, C; McCall, C; Salzer, W	1
Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI	1
Della Bianca, V; Dusi, S; Grzeskowiak, M; Rossi, F	1
Schächtele, C; Seifert, R	1
Gaudry, M; Hakim, J; Marquetty, C; Perianin, A	1
Justen, JM; Sam, LM; Smith, RJ	1
Berkow, RL; Dodson, MR	1
Anderson, R; Beyers, AD; Nel, AE; Savage, JE	1
Hirakawa, M; Okimasu, E; Tsuchiya, M; Ueda, W; Utsumi, K	1
Shibata, H; Shichijo, S; Shiotsuki, K; Shiraishi, M; Tsuboi, I; Tsunosue, R; Yokoyama, MM	1
Bass, DA; Gerard, C; Marfat, A; McCall, CE; McPhail, LC; Stimler-Gerard, NP	1
Huang, CK; Molski, TF; Naccache, PH; Sha'afi, RI	1
Ford, C; Molski, TF; Sha'afi, RI; Weisman, SJ	1
Fujita, I; Minakami, S; Takeshige, K	1
Hoffman, MD; Wright, CD	1
Berkow, RL; Dodson, RW; Kraft, AS	1
Matsumoto, T; Sha'afi, RI; Tao, W	1
Christensen, SB; Fujiki, H; Hirasawa, N; Ohuchi, K; Sugawara, T; Sugimura, T; Tsurufuji, S; Watanabe, M	1
Furuya, W; Grinstein, S	1
Bass, DA; Gerard, C; McCall, CE; McPhail, LC; Olbrantz, P; Wilson, J	1
Edashige, K; Kawada, M; Utsumi, K; Watanabe, Y; Yasuda, T	1
Komiyama, A; Miyabayashi, M; Tsuno, T; Yamazaki, M; Yasui, K	1
Combadière, C; el Benna, J; Hakim, J; Pedruzzi, E; Périanin, A	1
Arai, M; Nozawa, R; Sasaki, Y	1
Duprè, S; Fontana, M; Kodama, H; Sagara, Y; Sugahara, K; Zhang, J	1
Petersen, MM; Steadman, R; Williams, JD	1
Kodama, H; Kurashige, T; Masuoka, N; Ohta, J; Sagara, Y; Shimazaki, Y; Ubuka, T; Wakiguchi, H; Zhang, J	1
Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M	1
Kaihatsu, T; Maeda, T; Miwa, M; Watanabe, M	1
Andersson, T; Axelsson, L; Hellberg, C; Ydrenius, L	1
Badwey, JA; Ge, Q; Ohira, T; VanDyke, T; Zhan, Q	1
Klink, M; Sulowska, Z; Tchorzewski, H	1

Other Studies

50 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and n-formylmethionine leucyl-phenylalanine

Article	Year
Inhibition of neutrophil priming and tyrosyl phosphorylation by cepharanthine, a nonsteroidal antiinflammatory drug. Cell structure and function, 1992, Volume: 17, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Epidermal Growth Factor; Granulocyte Colony-Stimulating Factor; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Phosphorylation; Piperazines; Protein-Tyrosine Kinases; Respiratory Burst; Tumor Necrosis Factor-alpha	1992
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors. Archives of biochemistry and biophysics, 1992, Volume: 294, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan	1992
Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil. Blood, 1992, Aug-15, Volume: 80, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cell Membrane; Cyclic AMP; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Adrenergic, beta; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Purinergic; Signal Transduction; Superoxides	1992
Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors. Physiological chemistry and physics and medical NMR, 1992, Volume: 24, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Calcium; Dose-Response Relationship, Drug; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan	1992
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C. The Journal of cell biology, 1992, Volume: 116, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate	1992
Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor. Archives of biochemistry and biophysics, 1992, Nov-01, Volume: 298, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Blotting, Western; Cell Membrane; Cytosol; Genistein; Granulocyte Colony-Stimulating Factor; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine	1992
Neutrophil priming by granulocyte colony stimulating factor and its modulation by protein kinase inhibitors. Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cinnamates; Genistein; Granulocyte Colony-Stimulating Factor; Humans; Isoflavones; Isoquinolines; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfides; Superoxides	1992
Neutrophil CR3 expression and specific granule exocytosis are controlled by different signal transduction pathways. Journal of immunology (Baltimore, Md. : 1950), 1991, Aug-01, Volume: 147, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Azepines; Bucladesine; Calcimycin; Calcium; Calmodulin; Chlorpromazine; Exocytosis; Gelatinases; Gene Expression Regulation; Humans; In Vitro Techniques; Isoquinolines; Myosin-Light-Chain Kinase; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Neutrophils; Pepsin A; Piperazines; Protein Kinase Inhibitors; Receptors, Complement; Receptors, Complement 3b; Signal Transduction; Tetanus Toxin; Up-Regulation	1991
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils. The Biochemical journal, 1990, Jul-15, Volume: 269, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine	1990
Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation. Journal of cellular biochemistry, 1990, Volume: 44, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Detergents; Egtazic Acid; Enzyme Activation; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Octoxynol; Peritoneal Cavity; Piperazines; Polyethylene Glycols; Protamine Kinase; Protein Kinase C; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate	1990
Signal transduction and the regulation of actin conformation during myeloid maturation: studies in HL60 cells. Blood, 1991, Jan-15, Volume: 77, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Bryostatins; Calcium; Cell Differentiation; Dimethyl Sulfoxide; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Lactones; Macrolides; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1991
Chemotactic peptide enhancement of phorbol ester-induced protein kinase C activity in human neutrophils. Journal of leukocyte biology, 1990, Volume: 47, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cytochalasin B; Diglycerides; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1990
Isoquinolinesulfonamide protein kinase inhibitors H7 and H8 enhance the effects of granulocyte-macrophage colony-stimulating factor (GM-CSE) on neutrophil function and inhibit GM-CSF receptor internalization. Blood, 1990, Sep-01, Volume: 76, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antigens, CD; Colony-Stimulating Factors; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Hydrogen Peroxide; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Receptors, Cell Surface; Receptors, Colony-Stimulating Factor; Recombinant Proteins	1990
Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils. Biochimica et biophysica acta, 1990, Oct-15, Volume: 1055, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Models, Chemical; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate	1990
Regulation of neutrophil chemotaxis: correlations with actin polymerization. Cancer investigation, 1990, Volume: 8, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Chemotaxis, Leukocyte; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C	1990
Effect of granulocyte-macrophage colony-stimulating factor on superoxide production in cytoplasts and intact human neutrophils: role of protein kinase and G-proteins. Journal of leukocyte biology, 1989, Volume: 46, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Botulinum Toxins; Colony-Stimulating Factors; Cytoplasm; Cytoskeletal Proteins; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP-Binding Proteins; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella	1989
Inhibition of human neutrophil chemotaxis by the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine. Journal of immunology (Baltimore, Md. : 1950), 1987, Nov-01, Volume: 139, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Movement; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Humans; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Receptors, Formyl Peptide; Receptors, Immunologic	1987
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. Biochemical and biophysical research communications, 1987, Oct-14, Volume: 148, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles	1987
Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation. Biochemical and biophysical research communications, 1987, Oct-29, Volume: 148, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1987
Dissociation of the 47-kilodalton protein phosphorylation from degranulation and superoxide production in neutrophils. Journal of leukocyte biology, 1988, Volume: 43, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylglucosaminidase; Animals; Cytochalasin B; Cytoplasmic Granules; Drug Interactions; Hexosaminidases; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate	1988
Fluoride can activate the respiratory burst independently of Ca2+, stimulation of phosphoinositide turnover and protein kinase C translocation in primed human neutrophils. Biochemical and biophysical research communications, 1988, Feb-15, Volume: 150, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Calcium; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphatidylinositols; Piperazines; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella	1988
Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase. Biochemical and biophysical research communications, 1988, Apr-29, Volume: 152, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cytochalasin B; Enzyme Activation; Female; Humans; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1988
Negative effect of a protein kinase C inhibitor (H-7) on human polymorphonuclear neutrophil locomotion. Immunology, 1988, Volume: 63, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Cell Movement; Chemotaxis, Leukocyte; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Superoxides	1988
Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. Journal of leukocyte biology, 1988, Volume: 43, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzofurans; Calcium; Cytochalasin B; Cytoplasmic Granules; Diglycerides; Dose-Response Relationship, Drug; Exocytosis; Fura-2; Glycerides; Humans; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides	1988
Biochemical mechanisms involved in the priming of neutrophils by tumor necrosis factor. Journal of leukocyte biology, 1988, Volume: 44, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Piperazines; Protein Kinase C; Sodium; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella	1988
Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes. Biochemical pharmacology, 1988, Dec-15, Volume: 37, Issue:24 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Arachidonic Acid; Arachidonic Acids; Clofazimine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Superoxides	1988
Halothane, an inhalation anesthetic, activates protein kinase C and superoxide generation by neutrophils. FEBS letters, 1988, Dec-19, Volume: 242, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cytoplasm; Enzyme Activation; Guinea Pigs; Halothane; Histones; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphatidylserines; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate	1988
Human polymorphonuclear leukocyte activating factor isolated from Aleurites Fordii Hemsl. (Euphorbiaceae) seed. Journal of clinical & laboratory immunology, 1988, Volume: 27, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chemotactic Factors; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Interleukin-8; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptides; Pertussis Toxin; Piperazines; Quinacrine; Seeds; Superoxides; Virulence Factors, Bordetella	1988
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor. The Journal of clinical investigation, 1986, Volume: 77, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Complement C5; Complement C5a; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Oxygen Consumption; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1986
The inhibition of neutrophil responsiveness caused by phorbol esters is blocked by the protein kinase C inhibitor H7. Biochemical and biophysical research communications, 1986, May-29, Volume: 137, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcium; Cytosol; Exocytosis; Hexosaminidases; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phorbols; Phosphoproteins; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate	1986
Cell alkalinization is not necessary and increased sodium influx is not sufficient for stimulated superoxide production. FEBS letters, 1986, Jul-28, Volume: 203, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hydrogen-Ion Concentration; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Rabbits; Sodium; Superoxides; Tetradecanoylphorbol Acetate	1986
Inhibition of neutrophil superoxide formation by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and inhibitor of protein kinase-C. Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Cytoplasm; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1986
Comparison of the roles of calmodulin and protein kinase C in activation of the human neutrophil respiratory burst. Biochemical and biophysical research communications, 1987, Jan-15, Volume: 142, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate; Trifluoperazine	1987
The effect of a protein kinase C inhibitor, H-7, on human neutrophil oxidative burst and degranulation. Journal of leukocyte biology, 1987, Volume: 41, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Binding Proteins; Cells, Cultured; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1987
Demonstration of calcium-dependent phospholipase A2 activity in membrane preparation of rabbit neutrophils. Absence of activation by fMet-Leu-Phe, phorbol 12-myristate 13-acetate and A-kinase. The Biochemical journal, 1988, Mar-01, Volume: 250, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Membrane; Enzyme Activation; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Tetradecanoylphorbol Acetate	1988
Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages. British journal of pharmacology, 1988, Volume: 94, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Cytoplasm; In Vitro Techniques; Isoquinolines; Lyngbya Toxins; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Piperazines; Plant Extracts; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thapsigargin	1988
Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway. The Journal of biological chemistry, 1988, Feb-05, Volume: 263, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Membrane Permeability; Diglycerides; Ethers; Flow Cytometry; Humans; Ionomycin; Isoquinolines; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; NADP; Neutrophils; Oxygen Consumption; Phorbol Esters; Piperazines; Protein Kinase C	1988
Priming of the respiratory burst of neutrophils by diacylglycerol. Independence from activation or translocation of protein kinase C. The Journal of biological chemistry, 1987, May-15, Volume: 262, Issue:14 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cytosol; Diglycerides; Enzyme Activation; Glycerides; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate	1987
Increase in cell responses and protein phosphorylation of neutrophils induced by synthetic diacylglycerols. Physiological chemistry and physics and medical NMR, 1993, Volume: 25, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azides; Blood Proteins; Brain; Diglycerides; Guinea Pigs; Isoquinolines; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Rats; Sodium Azide; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate	1993
Signal transduction pathway in human polymorphonuclear leukocytes for chemotaxis induced by a chemotactic factor. Distinct from the pathway for superoxide anion production. Journal of immunology (Baltimore, Md. : 1950), 1994, Jun-15, Volume: 152, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chemotaxis, Leukocyte; Enzyme Activation; Humans; Hydroquinones; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoinositide Phospholipase C; Phospholipase D; Phosphoric Diester Hydrolases; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Superoxides	1994
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine. Blood, 1993, Nov-01, Volume: 82, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors	1993
Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochemical pharmacology, 1993, Oct-19, Volume: 46, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Enzyme Activation; Free Radicals; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate	1993
Effect of cystathionine ketimine on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors. Biochemical and biophysical research communications, 1996, Jan-05, Volume: 218, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cystathionine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Superoxides; Time Factors	1996
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity. The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates	1996
Different effect of diastereoisomers of L-cystathionine sulfoxide on the stimulus coupled responses of human neutrophils. Biochemical and biophysical research communications, 1998, Jun-18, Volume: 247, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Metabolism, Inborn Errors; Cystathionine; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase Inhibitors; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate	1998
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner. Archives of biochemistry and biophysics, 1999, Mar-01, Volume: 363, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine	1999
Ca2+/calmodulin-dependent protein kinase II inhibitors potentiate superoxide production in polymorphonuclear leukocytes. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Drug Interactions; Enzyme Inhibitors; In Vitro Techniques; Male; Mice; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sulfonamides; Superoxides; Tumor Necrosis Factor-alpha	1999
Disruption of beta(2)-integrin-cytoskeleton coupling abolishes the signaling capacity of these integrins on granulocytes. Biochemical and biophysical research communications, 1999, Volume: 265, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Calcium; CD18 Antigens; Cell Adhesion; Cytoskeleton; Cytosol; Granulocytes; HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Signal Transduction; Staurosporine	1999
Protein phosphorylation in neutrophils monitored with phosphospecific antibodies. Journal of immunological methods, 2003, Oct-01, Volume: 281, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies; Binding Sites; Blood Proteins; Guinea Pigs; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha	2003
Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases. Mediators of inflammation, 2003, Volume: 12, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Adhesion; Cells, Cultured; Enzyme Inhibitors; Genistein; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide Donors; Nitroprusside; Oxidation-Reduction; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate; Vasodilator Agents	2003