Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide in 108 studies

Research

Studies (108)

TimeframeStudies, this research(%)All Research%
pre-199012 (11.11)18.7374
1990's90 (83.33)18.2507
2000's6 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jung, T; Lee, C; Moor, RM1
Hake, SS; Morelli, JG; Murphy, RC; Norris, DA1
Bloodgood, RA1
Schultz, RM; Schwartz, DA1
Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S1
Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S1
Amano, S; Hanazawa, S; Kitami, H; Kitano, S; Murakami, Y; Ohta, K; Takeshita, A1
Ballard, PL; Duffy, DM; Goldfien, A; Roberts, JM1
Katabami, T; Nemoto, K; Ogura, M; Ohira, K; Okano, K; Shimizu, M; Suzuki, S; Tsukamoto, T; Yamada, Y; Yano, Y1
Fredholm, BB; Jondal, M; Kontny, E; Kvanta, A; Okret, S1
Arakaki, N; Daikuhara, Y; Hara, H; Hirono, S; Ishii, T; Kawakami, S; Tsubouchi, H1
Citi, S1
Bright, EC; Hess, AD2
Fusamoto, H; Hayashi, N; Kamada, T; Kasahara, A; Katayama, K; Sasaki, Y; Takehara, T; Towata, T1
Kumegawa, M; Oshima, T; Tanabe, T; Yamamoto, S; Yokoyama, C; Yoshimoto, T1
Kojo, T1
Hamazaki, M; Higashigawa, M; Ido, M; Nagao, Y; Sakurai, M; Shibata, T; Taniguchi, K1
Chipkin, SR; Goodman, HM; Tai, LR1
Politis, AD; Vogel, SN1
Dorf, ME; Jayaraman, S; Mensi, N; Webb, DR1
Hashioka, T; Kato, M1
Autieri, MV; Coffman, FD; Cohen, S; Fresa, KL; Katz, ME1
Spangler, R; Sytkowski, AJ1
Chang, F; Cohen, IS; DiFrancesco, D; Rosen, MR; Tromba, C1
Hasegawa-Sasaki, H; Sasaki, T; Yamashita, Y1
el Touny, S; Hannun, YA; Khan, W1
Anwer, K; Hovington, JA; Sanborn, BM1
Logan, CY; Manejwala, FM; Schultz, RM1
Bloodgood, RA; Salomonsky, NL1
AbuBakar, S; Albrecht, T; Boldogh, I1
Kato, Y; Ogawa, K; Okuda, T; Sawada, H; Tashima, M; Ueda, T; Yumoto, Y1
Rao, MC; Toskulkao, C1
Khandelwal, RL; Mantha, SV; Pugazhenthi, S1
Teitelbaum, I1
Jaswon, MS; Jones, HM; Khwaja, A; Linch, DC; Roberts, PJ; Yong, K1
Pfeffer, LM; Reich, NC1
Browning, MD; Dunwiddie, TV; Hahner, LD; Harris, RA; Leidenheimer, NJ1
Boulis, NM; Davis, M1
Cha, T; Ikegami, H; Noma, Y; Ogihara, T; Shima, K; Tahara, Y; Yamato, E; Yoneda, H1
Baglioni, C; Johnson, SE1
Herbert, JM; Maffrand, JP; Seban, E1
Clark, EA; Meier, KE; Rossie, S; Valentine, MA1
Dileepan, KN; Stechschulte, DJ; Suzuki, T; Yamada, A1
Sasakawa, S; Tamura-Nishimura, M1
Poueymirou, WT; Schultz, RM1
Berg, KL; Foster, DA; Joseph, C; Qureshi, SA; Spangler, R1
Manejwala, FM; Schultz, RM1
Agopyan, N; Krnjević, K; Leblond, J1
Devenyi, ZJ; Holian, A; Jordan, MK; Nguyen, HV1
Adamo, S; Cavallo, G; Frati, L; Gismondi, A; Paolini, R; Piccoli, M; Procopio, AD; Santoni, A1
Cosgrove, JM; Howcroft, TK; Lindquist, RR; Tatum, SM1
Mittag, TW; Podos, SM; Yoshimura, N1
Rush, JS; Waechter, CJ1
Evans, DL; Jaso-Friedmann, L; Leary, JH1
Adachi, S; Akiyama, Y; Hirota, H; Kubota, M; Kuwakado, K; Lin, YW; Matsubara, K; Okuda, A; Wakazono, Y1
Heike, T; Jung, EY; Katamura, K; Mayumi, M; Ohshima, Y; Shintaku, N; Sumimoto, S1
Walters, JD; Wojcik, MS1
Carter, V; Gale, M; Parsons, M1
Ijichi, A; Sakuma, S; Tofilon, PJ1
DiBattista, JA; Iwata, K; Martel-Pelletier, J; Pelletier, JP; Zafarullah, M1
Fusamoto, H; Hayashi, N; Horimoto, M; Ito, T; Kamada, T; Kaneko, A; Sasaki, Y; Tanaka, Y1
Burnside, B; Liepe, BA1
Evans, SW; Thompson, D; Whicher, JT1
Arai, S; Chowdhury, MI; Koyanagi, Y; Munakata, T; Yamamoto, N1
Aloyo, VJ1
Deng, ZW; Denkinger, DJ; Deuel, TF; Kawahara, RS1
Erickson, RP; Gatlin, LA; Heiman, SA; Schiffman, SS; Stagner, WC; Suggs, MS1
Losee, ML; Schiffman, SS; Suggs, MS1
Kaku, K; Kaneko, T; Nagasaka, Y; Nakamura, K1
Burighel, P; Citi, S; Denisenko, N1
Hasegawa, T1
Berns, CM; Corry, PM; Erdos, G; Lee, YJ1
Boniece, IR; Maiese, K; Skurat, K; Wagner, JA1
Cha, T; Fujioka, Y; Fukuda, M; Ikegami, H; Kawaguchi, Y; Noma, Y; Ogihara, T; Shima, K; Tahara, Y; Yamato, E1
Albrecht, T; Boldogh, I; Fons, MP1
Aksamit, TR; Hunninghake, GW; Monick, MM1
Cunningham, GR; House, FS; Stewart, SJ1
Collins, JL; Manning, K; Powell, CB1
Hinko, A; Soloff, MS1
Lewis, CE; McGee, JO; Pusztai, L1
Garg, LC; Mohuczy-Dominiak, D; Saha, PK1
Burnham, K; Hudson, J; Pickard, S; Voss, T1
Beezhold, DH; Chang, ZL; Personius, CD; Shen, ZL1
Kahan, BD; Kerman, RH; Kimball, P; Williams, J1
Maurer, JA; McKay, DB; Wenger, BW1
Feng, Y; Ho, IK; Tokuyama, S; Wakabayashi, H1
Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z1
Atabay, C; Cagnoli, CM; Manev, H1
Arden, J; Sadée, W; Wang, Z1
Bossemeyer, D; Engh, RA; Girod, A; Huber, R; Kinzel, V1
Atabay, C; Cagnoli, CM; Kharlamov, E; Manev, H; Uz, T1
Burke, JP; Hablitz, JJ1
Hanoune, J; Maldonado, R; Roques, BP; Tzavara, E; Valverde, O1
Cagnoli, CM; Manev, H1
Copenhagen, DR; Dixon, DB1
Braun, C; Plattner, H; Purvee, J; Van Houten, JL; Yang, WQ1
Aliño, SF; Blaya, C; Crespo, A; Crespo, J1
Adler, MR; Botsford, SA; Gronau, RT; Light, DB; Ter Beest, JK1
Burnham, K; Johnson, J; Kuschel, L; Richins, M; Shankar, G1
Bajorath, J; Godden, JW; Stahura, F1
Ito, Y; Marunaka, Y; Niisato, N1
Bilecki, W; Höllt, V; Przewłocki, R1
Colston, VL; Wheeler, TJ1
Johnson, SW; Shen, KZ1
Aikawa, T; Hirose, T; Matsumoto, I; Shimada, T1
Linsdell, P; McDonald, TF; Missan, S1
Anderson, JM; Macewan, SR; McNally, AK1

Trials

1 trial(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide

ArticleYear
In vivo administration of granulocyte colony-stimulating factor promotes neutrophil survival in vitro.
    European journal of haematology, 1994, Volume: 53, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Burkitt Lymphoma; Cell Survival; Child; Child, Preschool; Female; Granulocyte Colony-Stimulating Factor; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Male; Neuroblastoma; Neutrophils; Osteosarcoma; Piperazines; Protein Kinase C; Recombinant Proteins; Time Factors; Tumor Cells, Cultured

1994

Other Studies

107 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide

ArticleYear
Effects of protein kinase inhibitors on pig oocyte maturation in vitro.
    Reproduction, nutrition, development, 1992, Volume: 32, Issue:5-6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Isoquinolines; Oocytes; Phosphorylation; Piperazines; Protein Biosynthesis; Protein Kinase C; Protein Kinase Inhibitors; Sulfonamides; Swine

1992
Leukotriene B4-induced human melanocyte pigmentation and leukotriene C4-induced human melanocyte growth are inhibited by different isoquinolinesulfonamides.
    The Journal of investigative dermatology, 1992, Volume: 98, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cells, Cultured; Humans; Isoquinolines; Leukotriene B4; Melanocytes; Pigmentation; Piperazines; Protein Kinase C; SRS-A

1992
Calcium-regulated phosphorylation of proteins in the membrane-matrix compartment of the Chlamydomonas flagellum.
    Experimental cell research, 1992, Volume: 198, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Chlamydomonas; Electrophoresis; Flagella; Isoquinolines; Membrane Glycoproteins; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine

1992
Zygotic gene activation in the mouse embryo: involvement of cyclic adenosine monophosphate-dependent protein kinase and appearance of an AP-1-like activity.
    Molecular reproduction and development, 1992, Volume: 32, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aphidicolin; Cleavage Stage, Ovum; Cyclic AMP; Gene Expression Regulation; Isoquinolines; Mice; Microinjections; Oocytes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation

1992
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.
    Journal of assisted reproduction and genetics, 1992, Volume: 9, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida

1992
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.
    Journal of assisted reproduction and genetics, 1992, Volume: 9, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate

1992
Porphyromonas gingivalis fimbriae induce expression of the neutrophil chemotactic factor KC gene of mouse peritoneal macrophages: role of protein kinase C.
    Infection and immunity, 1992, Volume: 60, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Dose-Response Relationship, Drug; Fimbriae, Bacterial; Gene Expression Regulation, Bacterial; Interleukin-8; Isoquinolines; Macrophages; Mice; Mice, Inbred BALB C; Neutrophils; Piperazines; Porphyromonas gingivalis; Protein Kinase C; RNA; Sulfonamides; Tetradecanoylphorbol Acetate

1992
Cyclic adenosine 3',5'-monophosphate increases beta-adrenergic receptor concentration in cultured human fetal lung explants and type II cells.
    Endocrinology, 1992, Volume: 131, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Culture Techniques; Cyclic AMP; Fetal Organ Maturity; Humans; Isoquinolines; Lung; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Adrenergic, beta

1992
Intracellular signal transduction for interleukin-1 beta-induced endothelin production in human umbilical vein endothelial cells.
    Biochemical and biophysical research communications, 1992, Oct-30, Volume: 188, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Endothelins; Endothelium, Vascular; Genistein; Humans; Indomethacin; Interleukin-1; Isoflavones; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; Signal Transduction; Sulfonamides; Umbilical Veins

1992
Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity.
    Cellular signalling, 1992, Volume: 4, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Concanavalin A; Gene Expression Regulation; Humans; Isoquinolines; Lectins; Phorbol Esters; Phytohemagglutinins; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; T-Lymphocytes; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1992
Effects of protein kinase inhibitors on the mitogenic activity of human hepatocyte growth factor on rat hepatocytes in primary culture.
    Biochemical and biophysical research communications, 1992, May-29, Volume: 185, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cells, Cultured; Genistein; Growth Substances; Hepatocyte Growth Factor; Isoflavones; Isoquinolines; Liver; Male; Mitogens; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sulfonamides

1992
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
    The Journal of cell biology, 1992, Volume: 117, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Azepines; Calcium; Cell Communication; Cell Line; Dogs; Egtazic Acid; Epithelium; Fluorescent Antibody Technique; Intercellular Junctions; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides

1992
The effect of the CD28 activation pathway on the immunosuppressive action of cyclosporine.
    Transplantation, 1991, Volume: 51, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bryostatins; CD28 Antigens; CD3 Complex; Cyclosporins; Humans; In Vitro Techniques; Interleukin-2; Isoquinolines; Lactones; Lymphocyte Activation; Macrolides; Piperazines; Protein Kinases; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; T-Lymphocytes

1991
Signal transduction pathways in the induction of HLA class I antigen expression on Huh 6 cells by interferon-gamma.
    Biochemical and biophysical research communications, 1991, Jun-14, Volume: 177, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Carcinoma, Hepatocellular; Cell Line; Cyclic CMP; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Liver Neoplasms; Piperazines; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1991
cAMP-dependent induction of fatty acid cyclooxygenase mRNA in mouse osteoblastic cells (MC3T3-E1).
    The Journal of biological chemistry, 1991, Jul-25, Volume: 266, Issue:21

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Blotting, Western; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Dinoprostone; Enzyme Induction; Epinephrine; Gene Expression; Isoquinolines; Mice; Osteoblasts; Piperazines; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides

1991
[A pharmacological study on the mechanism of the endothelin-induced contraction of the bovine cerebral artery].
    Nihon seirigaku zasshi. Journal of the Physiological Society of Japan, 1991, Volume: 53, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cattle; Cerebral Arteries; Endothelins; Female; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Quinacrine; Sarcoplasmic Reticulum; Sodium Channels; Tetrodotoxin; Vasoconstriction

1991
Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.
    British journal of cancer, 1991, Volume: 64, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Division; Cell Membrane; Cell Survival; Cytosol; Doxorubicin; Drug Resistance; Etoposide; Isoquinolines; Leukemia P388; Membrane Glycoproteins; Mice; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Tumor Cells, Cultured; Vincristine

1991
The isoquinoline sulfonamide inhibitors of protein phosphorylation, H-7, H-8, and HA-1004, also inhibit RNA synthesis: studies on responses of adipose tissue to growth hormone.
    Endocrinology, 1990, Volume: 126, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Animals; Growth Hormone; Insulin; Isoquinolines; Lipolysis; Male; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; RNA; Sulfonamides

1990
Pharmacologic evidence for the requirement of protein kinase C in IFN-induced macrophage Fc gamma receptor and Ia antigen expression.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Dec-01, Volume: 145, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Differentiation; Calcium; Cells, Cultured; Histocompatibility Antigens Class II; Interferons; Isoquinolines; Macrophages; Mice; Mice, Inbred C3H; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Staurosporine

1990
Involvement of protein kinase C in competence induction of macrophages to generate T suppressor cells.
    Journal of immunology (Baltimore, Md. : 1950), 1991, Jun-15, Volume: 146, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Epitopes; Histocompatibility Antigens Class II; Immunocompetence; Interferon-gamma; Interleukin-1; Interleukin-6; Isoquinolines; Macrophages; Mice; Piperazines; Protein Kinase C; Protein Kinases; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate

1991
Effects of inhibitors of intracellular messenger systems on amylase release from rat parotid gland.
    Aichi-Gakuin dental science, 1990, Volume: 3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Azepines; Calmodulin; Exocytosis; Isoquinolines; Male; Myosin-Light-Chain Kinase; Parotid Gland; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Second Messenger Systems; Sulfonamides

1990
Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase.
    Cell regulation, 1990, Volume: 1, Issue:13

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Amino Acid Sequence; Aprotinin; Cell Nucleus; Gene Expression Regulation, Enzymologic; Humans; Isoquinolines; Leukemia, Lymphoid; Lymphocytes; Membrane Proteins; Membranes; Peptides; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein Precursors; Serine Endopeptidases; Signal Transduction; Subcellular Fractions; Sulfonamides

1990
c-myc is an erythropoietin early response gene in normal erythroid cells: evidence for a protein kinase C-mediated signal.
    Blood, 1992, Jan-01, Volume: 79, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Erythroid Precursor Cells; Erythropoietin; Gene Expression; Genes, myc; Isoquinolines; Mice; Mice, Inbred C57BL; Phenylhydrazines; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; Signal Transduction; Spleen; Staurosporine; Transcription, Genetic

1992
Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f).
    The Journal of physiology, 1991, Volume: 440

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Colforsin; Dogs; Electrophysiology; In Vitro Techniques; Ion Channel Gating; Isoproterenol; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Purkinje Fibers

1991
Cyclosporine inhibits T-cell activation at two distinct levels: role of the CD 28 activation pathway.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; CD3 Complex; Cyclosporins; Humans; In Vitro Techniques; Interleukin-2; Isoquinolines; Lymphocyte Activation; Piperazines; Protein Kinase Inhibitors; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; T-Lymphocytes

1991
Suppression by staurosporine of Ca(2+)-mobilization triggered by ligation of antigen-specific receptors on t and B lymphocytes. An essential role of protein tyrosine kinase in the signal transduction.
    FEBS letters, 1991, Aug-19, Volume: 288, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; B-Lymphocytes; Bombesin; Calcium; Cell Line; Dinoprost; Genistein; Humans; Isoflavones; Isoquinolines; Piperazines; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; Staurosporine; T-Lymphocytes; Type C Phospholipases; Vasopressins

1991
Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C.
    FEBS letters, 1991, Nov-04, Volume: 292, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Blood Platelets; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Isoquinolines; Peptide Mapping; Phosphorylation; Piperazines; Precipitin Tests; Protein Kinase C; Substrate Specificity

1991
Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium.
    Biology of reproduction, 1990, Volume: 43, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cyclic AMP; Female; Inositol Phosphates; Isoproterenol; Isoquinolines; Myometrium; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Relaxin; Tetradecanoylphorbol Acetate; Thionucleotides

1990
Regulation of hsp70 mRNA levels during oocyte maturation and zygotic gene activation in the mouse.
    Developmental biology, 1991, Volume: 144, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amanitins; Animals; Base Sequence; Cleavage Stage, Ovum; Cycloheximide; Gene Expression; Heat-Shock Proteins; Isoquinolines; Mice; Molecular Sequence Data; Oligonucleotides; Oocytes; Phosphoproteins; Piperazines; Polymerase Chain Reaction; Protein Kinase Inhibitors; RNA, Messenger

1991
Regulation of flagellar glycoprotein movements by protein phosphorylation.
    European journal of cell biology, 1991, Volume: 54, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Chlamydomonas; Flagella; Isoquinolines; Membrane Glycoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Staurosporine

1991
Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C.
    Biochemical and biophysical research communications, 1990, Jan-30, Volume: 166, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Diacylglycerol Kinase; Humans; In Vitro Techniques; Isoquinolines; Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Piperazines; Protein Kinase C; Quinacrine; Tetracaine; Tetradecanoylphorbol Acetate

1990
Effect of second-messenger modulators in K-562 cell differentiation: dual action of calcium/phospholipid-dependent protein kinase in the process of differentiation.
    Journal of cellular physiology, 1990, Volume: 143, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cell Differentiation; Cell Division; Cell Survival; Cytarabine; Diglycerides; Erythropoiesis; Globins; Hemin; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1990
Identification of a 50-kDa Ca-, cAMP-, and cGMP-dependent epithelial phosphoprotein as a cAMP regulatory protein.
    The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Cyclic AMP; Cyclic AMP Receptor Protein; Cyclic GMP; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epithelium; Flounder; Intestinal Mucosa; Isoquinolines; Kinetics; Molecular Weight; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Second Messenger Systems; Subcellular Fractions

1990
Inhibitory effect of H-7, H-8 and polymyxin B on liver protein kinase C-induced phosphorylation of endogenous substrates.
    Biochemistry international, 1990, Volume: 20, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cytosol; Diglycerides; Enzyme Activation; Histones; Isoquinolines; Liver; Male; Molecular Weight; Phosphatidylserines; Phosphoproteins; Phosphorylation; Piperazines; Polymyxin B; Polymyxins; Protein Kinase C; Rats; Rats, Inbred Strains

1990
Cyclic adenosine monophosphate and diacylglycerol. Mutually inhibitory second messengers in cultured rat inner medullary collecting duct cells.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cyclic AMP; Diglycerides; Dinoprostone; Epidermal Growth Factor; Glycerides; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Piperazines; Protein Kinase Inhibitors; Rats; Signal Transduction; Type C Phospholipases

1990
Isoquinolinesulfonamide protein kinase inhibitors H7 and H8 enhance the effects of granulocyte-macrophage colony-stimulating factor (GM-CSE) on neutrophil function and inhibit GM-CSF receptor internalization.
    Blood, 1990, Sep-01, Volume: 76, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antigens, CD; Colony-Stimulating Factors; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Hydrogen Peroxide; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Receptors, Cell Surface; Receptors, Colony-Stimulating Factor; Recombinant Proteins

1990
Evidence for involvement of protein kinase C in the cellular response to interferon alpha.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:22

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; DNA-Binding Proteins; Gene Expression; HeLa Cells; In Vitro Techniques; Interferon Type I; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Staurosporine; Transcription, Genetic; Vesicular stomatitis Indiana virus; Virus Replication

1990
Phosphorylation-independent effects of second messenger system modulators on gamma-aminobutyric acidA receptor complex function.
    Molecular pharmacology, 1990, Volume: 38, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chlorides; Colforsin; Cyclic AMP; Edetic Acid; Isoquinolines; Mice; Mice, Inbred ICR; Muscimol; Phosphorylation; Piperazines; Protein Kinases; Pyridazines; Receptors, GABA-A; Second Messenger Systems

1990
Blockade of the spinal excitatory effect of cAMP on the startle reflex by intrathecal administration of the isoquinoline sulfonamide H-8: comparison to the protein kinase C inhibitor H-7.
    Brain research, 1990, Aug-20, Volume: 525, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cyclic AMP; Dose-Response Relationship, Drug; Injections, Spinal; Isoquinolines; Male; Piperazines; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Reference Values; Reflex, Startle; Spinal Cord

1990
Role of protein kinase C in the regulation of glucagon gene expression by arginine.
    Biochemical and biophysical research communications, 1990, Sep-14, Volume: 171, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine; Cells, Cultured; Gene Expression Regulation; Glucagon; Islets of Langerhans; Isoquinolines; Kinetics; Male; Piperazines; Proglucagon; Protein Kinase C; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger

1990
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
    The Journal of biological chemistry, 1990, Apr-25, Volume: 265, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoquinolines; Kinetics; Melanoma; Phorbol 12,13-Dibutyrate; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Pregnancy; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1990
Characterization of specific binding sites for [3H]-staurosporine on various protein kinases.
    Biochemical and biophysical research communications, 1990, Aug-31, Volume: 171, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Carbazoles; Indole Alkaloids; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Staurosporine; Sulfonamides

1990
Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. Regulation by protein kinase C.
    The Journal of biological chemistry, 1989, Jul-05, Volume: 264, Issue:19

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Humans; Immunoglobulin M; Isoquinolines; Lymphocyte Activation; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Antigen, B-Cell; Sulfonamides; Tetradecanoylphorbol Acetate; Trypsin

1989
Regulation of Fc gamma 2a receptor-mediated phagocytosis by a murine macrophage-like cell line, P388D1: involvement of casein kinase II activity associated with Fc gamma 2a receptor.
    The Journal of molecular and cellular immunology : JMCI, 1989, Volume: 4, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigen-Antibody Complex; Antigens, Differentiation; Casein Kinases; Cell Line; Cytoplasmic Granules; Cytoskeletal Proteins; Down-Regulation; Heparin; Immunoglobulin G; Isoquinolines; Macrophages; Mast Cells; Mice; Phagocytosis; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Fc; Receptors, IgG; Sulfonamides

1989
The roles of protein kinase C and cyclic nucleotide dependent kinase in signal transduction in human interferon gamma induction by poly I:poly C.
    FEBS letters, 1989, May-08, Volume: 248, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cyclic AMP; Cytosol; Drug Synergism; Enzyme Activation; Enzyme Induction; Humans; Interferon-gamma; Isoquinolines; Leukocytes, Mononuclear; Phorbol Esters; Piperazines; Poly I-C; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction

1989
Regulation of mouse preimplantation development: inhibition of synthesis of proteins in the two-cell embryo that require transcription by inhibitors of cAMP-dependent protein kinase.
    Developmental biology, 1989, Volume: 133, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amanitins; Animals; Blastocyst; Carrier Proteins; Cyclic AMP; DNA; Female; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Phosphoproteins; Piperazines; Pregnancy; Protein Biosynthesis; Protein Kinase Inhibitors; Stereoisomerism; Transcription, Genetic

1989
Evidence that v-src and v-fps gene products use a protein kinase C-mediated pathway to induce expression of a transformation-related gene.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:18

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Calcium Channel Blockers; Cell Transformation, Neoplastic; Chick Embryo; Gene Products, gag; Isoquinolines; Kinetics; Oncogene Protein pp60(v-src); Oncogenes; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Retroviridae Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Transcription, Genetic

1989
Blastocoel expansion in the preimplantation mouse embryo: stimulation of sodium uptake by cAMP and possible involvement of cAMP-dependent protein kinase.
    Developmental biology, 1989, Volume: 136, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Blastocyst; Cyclic AMP; Embryonic Development; Extracellular Space; Female; In Vitro Techniques; Isoquinolines; Mice; Piperazines; Pregnancy; Protein Kinase Inhibitors; Protein Kinases; Sodium

1989
Mediation of acetylcholine's excitatory actions in central neurons.
    EXS, 1989, Volume: 57

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Carbachol; Cyclic GMP; Hippocampus; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Rats; Rats, Inbred Strains; Tetrodotoxin

1989
Inhibition of macrophage activation by isoquinolinesulfonamides, phenothiazines, and a napthalenesulfonamide.
    Journal of cellular physiology, 1988, Volume: 137, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Fluphenazine; Guinea Pigs; Isoquinolines; Macrophage Activation; Macrophages; Male; Naphthalenes; Phenothiazines; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Pulmonary Alveoli; Sulfonamides; Superoxides; Trifluoperazine

1988
Effects of protein kinase C (PK-C) activators and inhibitors on human large granular lymphocytes (LGL): role of PK-C on natural killer (NK) activity.
    Cellular immunology, 1989, Volume: 118, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Diglycerides; Enzyme Activation; Ethers; Humans; Immunity, Innate; Ionomycin; Isoquinolines; Killer Cells, Natural; Molecular Weight; Phosphoproteins; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate

1989
Protein kinase C (PKC) inhibitors inhibit primary (1-0) but not secondary (1-1) or cloned cytotoxic T lymphocytes.
    Biochemical and biophysical research communications, 1988, Aug-15, Volume: 154, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Clone Cells; Cytotoxicity, Immunologic; Isoquinolines; Mice; Piperazines; Protein Kinase C; Sulfonamides; T-Lymphocytes, Cytotoxic

1988
Analysis of protein kinase activities in rabbit ciliary processes: identification and characterization using exogenous substrates.
    Experimental eye research, 1987, Volume: 45, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Casein Kinases; Chromatography, DEAE-Cellulose; Ciliary Body; Heparin; Isoquinolines; Molecular Weight; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rabbits

1987
Inhibitors of protein kinase C block activation of B lymphocytes by bacterial lipopolysaccharide.
    Biochemical and biophysical research communications, 1987, Jun-30, Volume: 145, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cells, Cultured; DNA Replication; Female; Isoquinolines; Kinetics; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; Transcription, Genetic

1987
Pathways of signaling in nonspecific cytotoxic cells: effects of protein kinase and phosphatase inhibitors and evidence for membrane tyrosine phosphorylation.
    Cellular immunology, 1994, Volume: 153, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Catfishes; Cell Membrane; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Isoquinolines; Male; Phosphoprotein Phosphatases; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sulfonamides; Tyrosine

1994
Effects of cyclic AMP on expression of LFA-1, Mac-1, and VLA-4 and eosinophilic differentiation of a human leukemia cell line, EoL-1.
    European journal of haematology, 1994, Volume: 53, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Bucladesine; Butyrates; Cell Differentiation; Cell Division; Cyclic AMP; Eosinophils; Fluorescent Antibody Technique; Granulocyte Colony-Stimulating Factor; Humans; Integrin beta1; Integrins; Isoquinolines; Leukemia; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1994
Polyamine transport in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
    Leukemia research, 1994, Volume: 18, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Genistein; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoflavones; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Neutrophils; Piperazines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Sulfonamides; Temperature; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1994
Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei.
    Journal of cell science, 1994, Volume: 107 ( Pt 7)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Catechols; Cell Cycle; Cell Division; Cycloheximide; DNA; Enzyme Induction; Ethers, Cyclic; Flow Cytometry; Genistein; Isoflavones; Isoquinolines; Molecular Weight; Nitriles; Okadaic Acid; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Denaturation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; S Phase; Staurosporine; Trypanosoma brucei brucei; Tyrosine; Tyrphostins

1994
Hypoxia-induced vascular endothelial growth factor expression in normal rat astrocyte cultures.
    Glia, 1995, Volume: 14, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Base Sequence; Benzoquinones; Blotting, Northern; Cells, Cultured; Deferoxamine; Endothelial Growth Factors; Endothelium, Vascular; Hemeproteins; Hypoxia; Isoquinolines; Lactams, Macrocyclic; Lymphokines; Molecular Sequence Data; Oxygen; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Siderophores; Signal Transduction; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1995
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
    Journal of cellular biochemistry, 1995, Volume: 57, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Glycoproteins; Humans; Immunoenzyme Techniques; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Staurosporine; Synovial Membrane; Tetradecanoylphorbol Acetate; Thionucleotides; Tissue Inhibitor of Metalloproteinases; Up-Regulation

1995
Activation of Na+/H+ exchanger by hepatocyte growth factor in hepatocytes.
    Hepatology (Baltimore, Md.), 1995, Volume: 22, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Cells, Cultured; Genistein; Hepatocyte Growth Factor; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides

1995
Cyclic nucleotide regulation of teleost rod photoreceptor inner segment length.
    The Journal of general physiology, 1993, Volume: 102, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Actins; Animals; Cyclic AMP; Cyclic GMP; Cytoskeleton; Darkness; Ethers, Cyclic; In Vitro Techniques; Isoquinolines; Light; Okadaic Acid; Peptide Chain Elongation, Translational; Perciformes; Phosphoprotein Phosphatases; Photoreceptor Cells; Piperazines; Protein Kinase Inhibitors

1993
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
    Immunopharmacology and immunotoxicology, 1993, Volume: 15, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Mycoplasma stimulates HIV-1 expression from acutely- and dormantly-infected promonocyte/monoblastoid cell lines.
    Archives of virology, 1994, Volume: 139, Issue:3-4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acholeplasma laidlawii; Cell Line; HIV Core Protein p24; HIV-1; Humans; Isoquinolines; Macrophages; Monocytes; Mycoplasma; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Virus Replication

1994
Modulation of mu opioid binding by protein kinase inhibitors.
    Biochemical pharmacology, 1995, Jan-06, Volume: 49, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Receptors, Opioid, mu; Sulfonamides; Tritium

1995
Role of serine/threonine protein kinases in the induction of JE, a platelet-derived growth factor inducible gene.
    Biochemical and biophysical research communications, 1994, Sep-30, Volume: 203, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Cell Nucleus; Chemokine CCL2; Chemotactic Factors; Culture Media; Cytokines; Ethers, Cyclic; Gene Expression; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Okadaic Acid; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription, Genetic

1994
Modulators of the adenylate cyclase system can alter electrophysiological taste responses in gerbil.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cell Membrane Permeability; Colforsin; Cyclic AMP; Electrophysiology; Female; Gerbillinae; GTP Phosphohydrolases; GTP-Binding Proteins; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Sodium Fluoride; Taste

1994
Effect of modulators of the adenylate cyclase system on sweet electrophysiological taste responses in gerbil.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Chorda Tympani Nerve; Colforsin; Dimethylformamide; Electrophysiology; Female; Gerbillinae; Isoquinolines; Ketamine; Piperazines; Protein Kinase C; Signal Transduction; Sodium Chloride; Taste; Tongue

1994
cAMP inhibits the insulin-stimulated mitogen-activated protein kinase pathway in rat hepatoma H4EII cells.
    Biochemical and biophysical research communications, 1994, Jul-29, Volume: 202, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Cyclic AMP; Enzyme Activation; Glycerophosphates; Insulin; Isoquinolines; Liver Neoplasms, Experimental; Manganese; Phosphorylation; Piperazines; Rats; Receptor, Insulin; Sodium Fluoride; Thionucleotides; Tumor Cells, Cultured

1994
Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites.
    Journal of cell science, 1994, Volume: 107 ( Pt 4)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cadherins; Calcium; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Desmoplakins; Dogs; Epithelium; Intercellular Junctions; Isoquinolines; Kidney; Membrane Proteins; Phosphoproteins; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides; Zonula Occludens-1 Protein

1994
Production of a unique antibody specific for membrane ruffles and its use to characterize the behavior of two distinct types of ruffles.
    The Journal of cell biology, 1993, Volume: 120, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Antigens, Surface; Calmodulin; Cell Membrane; Chick Embryo; Culture Media, Serum-Free; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoquinolines; Kinetics; Membrane Proteins; Molecular Weight; Nocodazole; Paclitaxel; Piperazines; Protein Kinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors

1993
Effect of isoquinolinesulfonamides on heat shock gene expression during heating at 41 degrees C in human carcinoma cell lines.
    Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Breast Neoplasms; Cyclic AMP-Dependent Protein Kinases; Female; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Hot Temperature; Humans; Isoquinolines; Kinetics; Leucine; Male; Piperazines; Prostatic Neoplasms; Protein Kinase C; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured

1994
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
    Journal of neuroscience research, 1993, Sep-01, Volume: 36, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Cell Death; Cell Hypoxia; Cells, Cultured; Dibutyryl Cyclic GMP; Hippocampus; Isoquinolines; Nerve Tissue Proteins; Nitric Oxide; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides

1993
Cellular mechanism of glyburide-induced insulin gene expression in isolated rat islets.
    Biochemical and biophysical research communications, 1993, Dec-15, Volume: 197, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; DNA Probes; Gene Expression; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Kinetics; Male; Piperazines; Proinsulin; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger

1993
Increased levels of sequence-specific DNA-binding proteins in human cytomegalovirus-infected cells.
    Biochemical and biophysical research communications, 1993, Dec-30, Volume: 197, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cell Nucleus; Cell Transformation, Viral; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cytomegalovirus; DNA-Binding Proteins; Humans; Isoquinolines; Kinetics; Lung; NF-kappa B; Piperazines; Protein Kinase C; Time Factors

1993
Protein kinase C modulates the amounts of IL-1 receptor mRNA in human lung fibroblasts.
    Journal of immunology (Baltimore, Md. : 1950), 1993, Jul-01, Volume: 151, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cells, Cultured; Dinoprostone; Fibroblasts; Gene Expression; Humans; In Vitro Techniques; Interleukin-1; Isoquinolines; Lung; Piperazines; Protein Kinase C; Receptors, Interleukin-1; RNA, Messenger

1993
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
    Cellular signalling, 1993, Volume: 5, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Interferon-alpha (IFN alpha) induces a cytolytic mechanism in ovarian carcinoma cells through a protein kinase C-dependent pathway.
    Gynecologic oncology, 1993, Volume: 50, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Emetine; Female; Humans; Interferon alpha-2; Interferon-alpha; Isoquinolines; Ovarian Neoplasms; Piperazines; Protein Biosynthesis; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'-monophosphate.
    Endocrinology, 1993, Volume: 132, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amnion; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; Drug Synergism; Female; Isoquinolines; Oxytocin; Piperazines; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Receptors, Angiotensin; Receptors, Oxytocin; Tetradecanoylphorbol Acetate; Up-Regulation

1993
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.
    British journal of cancer, 1993, Volume: 67, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Division; DNA, Neoplasm; Ethers, Cyclic; Humans; Isoquinolines; Okadaic Acid; Piperazines; Protein Kinase C; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1993
Cholinergic inhibition of Na-K-ATPase via activation of protein kinase C in Madin-Darby canine kidney cells.
    Journal of the American Society of Nephrology : JASN, 1993, Volume: 4, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Cells, Cultured; Dogs; Enzyme Activation; Epithelium; Inositol Phosphates; Isoquinolines; Kidney; Naphthalenes; Parasympathomimetics; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Staurosporine; Sulfonamides

1993
Requirements for Langerhans' cell depletion following in vitro exposure of murine skin to ultraviolet-B.
    Immunology, 1993, Volume: 79, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Animals; Cholera Toxin; GTP-Binding Proteins; Guanosine Triphosphate; Isoquinolines; Langerhans Cells; Mice; Pertussis Toxin; Piperazines; Protein Biosynthesis; Protein Kinase Inhibitors; Skin; Ultraviolet Rays; Virulence Factors, Bordetella

1993
Fibronectin cell-binding domain triggered transmembrane signal transduction in human monocytes.
    Journal of leukocyte biology, 1993, Volume: 53, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Division; Cells, Cultured; Chymotrypsin; Dactinomycin; Fibronectins; Humans; Isoquinolines; Kinetics; L Cells; Lipopolysaccharides; Mice; Monocytes; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha

1993
Cyclosporine and rapamycin block protein kinase C-mediated induction of the activation signal, activator of DNA replication, in cell-free assay.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell-Free System; Cyclosporine; DNA Replication; Enzyme Induction; Humans; Immunosuppressive Agents; Isoquinolines; Lymphocyte Activation; Lymphocytes; Piperazines; Polyenes; Protein Kinase C; Sirolimus

1993
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
    Journal of neurochemistry, 1996, Volume: 66, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity

1996
Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8.
    European journal of pharmacology, 1995, Sep-15, Volume: 284, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Butorphanol; Cytosol; Enzyme Inhibitors; Isoquinolines; Male; Medulla Oblongata; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Piperazines; Pons; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

1995
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analgesics, Opioid; Animals; Drug Tolerance; Enzyme Inhibitors; Isoquinolines; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Peptide Fragments; Peptides; Piperazines; Protein Kinase C; Receptors, Opioid, mu; Somatostatin

1996
Protective action of isoquinolinesulfonamides in in vitro models of neuronal apoptosis.
    Life sciences, 1996, Volume: 58, Issue:19

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Enzyme Inhibitors; Isoquinolines; Neurons; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides

1996
Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent.
    FEBS letters, 1996, May-27, Volume: 387, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Opioid, mu

1996
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
    The Journal of biological chemistry, 1996, Oct-18, Volume: 271, Issue:42

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites; Casein Kinase II; Casein Kinases; Cattle; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glycine; Isoquinolines; Myosin-Light-Chain Kinase; Protein Conformation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Sulfonamides

1996
Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9.
    Journal of molecular neuroscience : MN, 1996,Spring, Volume: 7, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Isoquinolines; Neurons; Okadaic Acid; Phosphoric Monoester Hydrolases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Sulfonamides

1996
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
    Neuroscience, 1996, Volume: 75, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides

1996
Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.
    The European journal of neuroscience, 1996, Volume: 8, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Enzyme Inhibitors; Injections; Isoquinolines; Male; Morphine; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Substance Withdrawal Syndrome

1996
Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common?
    Neurochemistry international, 1997, Volume: 31, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cells, Cultured; Enzyme Inhibitors; Isoquinolines; Neurons; Rats; Sphingosine; Sulfonamides

1997
Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Dec-01, Volume: 17, Issue:23

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Aminobutyrates; Animals; Atrial Natriuretic Factor; Benzoates; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Glycine; Ictaluridae; Ion Channel Gating; Isoquinolines; Models, Neurological; Patch-Clamp Techniques; Photoreceptor Cells; Potassium Channels; Receptors, Metabotropic Glutamate; Second Messenger Systems; Thionucleotides

1997
Cyclic nucleotides in glutamate chemosensory signal transduction of Paramecium.
    Journal of cell science, 1997, Volume: 110 ( Pt 20)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Ammonium Chloride; Animals; Chemotactic Factors; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Inosine Monophosphate; Intracellular Fluid; Isoquinolines; Paramecium tetraurelia; Potassium Acetate; Quisqualic Acid; Second Messenger Systems; Signal Transduction

1997
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
    European journal of pharmacology, 1998, Jul-31, Volume: 354, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma, Lewis Lung; Cell Division; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Disease Progression; Enzyme Inhibitors; Indomethacin; Isoquinolines; Leukocytes, Mononuclear; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Spleen

1998
Protein kinase C and regulatory volume decrease in mudpuppy red blood cells.
    The Journal of membrane biology, 1998, Nov-15, Volume: 166, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Size; Enzyme Inhibitors; Erythrocytes; Gramicidin; Hematocrit; Hypotonic Solutions; Indoles; Ion Channel Gating; Ion Transport; Isoquinolines; Maleimides; Models, Biological; Necturus; Osmotic Fragility; Osmotic Pressure; Patch-Clamp Techniques; Phenanthridines; Potassium Channels; Protein Kinase C; Sulfonamides

1998
Protein-kinase-specific inhibitors block Langerhans' cell migration by inhibiting interleukin-1alpha release.
    Immunology, 1999, Volume: 96, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Enterotoxins; Enzyme Inhibitors; Female; Interferon Inducers; Interleukin-1; Isoquinolines; Langerhans Cells; Mice; Mice, Inbred BALB C; Protein Kinase C; Staphylococcus aureus

1999
Evaluation of docking strategies for virtual screening of compound databases: cAMP-dependent serine/threonine kinase as an example.
    Journal of molecular graphics & modelling, 1998, Volume: 16, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Computer Graphics; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Databases, Factual; Enzyme Inhibitors; Evaluation Studies as Topic; Humans; Isoquinolines; Molecular Structure; Protein Conformation; Sulfonamides

1998
Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms.
    Life sciences, 1999, Volume: 65, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Indoles; Isoquinolines; Myristic Acid; Pulmonary Alveoli; Pyrroles; Rats; Rats, Wistar; Sodium; Sodium Channels; Structure-Activity Relationship; Sulfonamides; Terbutaline

1999
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
    European journal of pharmacology, 2000, Feb-25, Volume: 390, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors

2000
Stimulation of cardiac glucose transport by inhibitors of oxidative phosphorylation.
    Life sciences, 2001, Oct-05, Volume: 69, Issue:20

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-O-Methylglucose; Animals; Azides; Biological Transport; Cell Fractionation; Cell Membrane; Dose-Response Relationship, Drug; Drug Interactions; Genistein; Glucose Transporter Type 4; Heart; In Vitro Techniques; Isoquinolines; Male; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Oxidative Phosphorylation; Perfusion; Phenols; Polymyxin B; Rats; Rats, Sprague-Dawley; Rotenone; Uncoupling Agents

2001
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
    The Journal of physiology, 2003, Dec-01, Volume: 553, Issue:Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes

2003
Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms.
    The Journal of endocrinology, 2005, Volume: 184, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcimycin; Calcium; Colforsin; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Drug Synergism; Enzyme Activation; Guinea Pigs; Hydrocortisone; Ionophores; Isoquinolines; Male; Perfusion; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyridinium Compounds; Receptors, G-Protein-Coupled; Secretory Rate

2005
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.
    Biochimica et biophysica acta, 2006, Volume: 1758, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cytochalasin D; Cytoskeleton; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoquinolines; KCNQ1 Potassium Channel; Maleimides; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins

2006
Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.
    Experimental and molecular pathology, 2008, Volume: 84, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Benzopyrans; Carbazoles; Cell Fusion; Cells, Cultured; Enzyme Inhibitors; Giant Cells, Foreign-Body; Humans; Indoles; Isoenzymes; Isoquinolines; Macrophages; Maleimides; Monocytes; Naphthalenes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Signal Transduction

2008