1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with morphine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kavaliers, M; Ossenkopp, KP; Tysdale, DM | 1 |
| Feng, Y; Ho, IK; Hoskins, B; Makimura, M; Narita, M | 1 |
| Bernstein, RN; Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z | 1 |
| Arden, J; Sadée, W; Wang, Z | 1 |
| Garbay, C; Maldonado, R; Roques, BP; Valverde, O | 1 |
| Hanoune, J; Maldonado, R; Roques, BP; Tzavara, E; Valverde, O | 1 |
| Fukuda, H; Iwai, M; Makimura, M; Sugimoto, H | 1 |
| Choi, SR; Huh, SO; Kim, YH; Song, DK; Suh, HW | 1 |
| Franki, N; Gibbons, N; Kapasi, A; Sharma, P; Singhal, PC; Wagner, JD | 1 |
| Bilecki, W; Höllt, V; Przewłocki, R | 1 |
| Ho, IK; Tokuyama, S; Yamamoto, T | 1 |
| Ceng, X; Liu, D; Lu, L; Zeng, S | 1 |
| Cadet, P; Goldman, S; Payne, M; Stefano, GB; Touma, S; Weeks, BS | 1 |
| Harada, S; Kobori, T; Nakamoto, K; Tokuyama, S | 1 |
| Holloway, AC; Nurse, CA; Salman, S | 1 |
| He, Z; Li, M; Li, Z; Wang, J; Wang, P; Zha, Y | 1 |
16 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and morphine
| Article | Year |
|---|---|
Evidence for the involvement of protein kinase C in the modulation of morphine-induced 'analgesia' and the inhibitory effects of exposure to 60-Hz magnetic fields in the snail, Cepaea nemoralis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesia; Animals; Enzyme Activation; Hot Temperature; Isoquinolines; Magnetics; Morphine; Naloxone; Piperazines; Protein Kinase C; Snails; Sulfonamides | 1991 |
A protein kinase inhibitor, H-7, inhibits the development of tolerance to opioid antinociception.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butorphanol; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; Isoquinolines; Male; Morphine; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1994 |
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analgesics, Opioid; Animals; Drug Tolerance; Enzyme Inhibitors; Isoquinolines; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Peptide Fragments; Peptides; Piperazines; Protein Kinase C; Receptors, Opioid, mu; Somatostatin | 1996 |
Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Opioid, mu | 1996 |
Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminosalicylic Acids; Animals; Enzyme Inhibitors; Isoquinolines; Locus Coeruleus; Male; Morphine; Naloxone; Piperazines; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1995 |
Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Enzyme Inhibitors; Injections; Isoquinolines; Male; Morphine; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1996 |
Effect of NMDA receptor antagonists on protein kinase activated by chronic morphine treatment.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Enzyme Activation; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Morphine; Naloxone; Norepinephrine; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mous
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; beta-Endorphin; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; omega-Conotoxin GVIA; Peptides; Spinal Cord | 1997 |
Effect of morphine on renomedullary interstitial cell proliferation and matrix accumulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antimetabolites; Bromodeoxyuridine; Cell Division; Cells, Cultured; Collagen; Enzyme Inhibitors; Extracellular Matrix; Kidney Medulla; Mitosis; Morphine; Narcotics; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; RNA | 1997 |
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics, Opioid; Blotting, Western; Calmodulin; Cell Line; Cyclic AMP Response Element-Binding Protein; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Humans; Isoquinolines; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, Opioid, delta; Time Factors | 2000 |
A protein kinase inhibitor, H-7, blocks naloxone-precipitated changes in dopamine and its metabolites in the brains of opioid-dependent rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Butorphanol; Cerebral Cortex; Corpus Striatum; Dopamine; Enzyme Inhibitors; Homovanillic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Limbic System; Male; Mesencephalon; Morphine; Naloxone; Opioid-Related Disorders; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley | 2000 |
Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Conditioning, Psychological; Enzyme Inhibitors; Hippocampus; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2000 |
Morphine inhibits indolactam V-induced U937 cell adhesion and gelatinase secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Adhesion; Cell Aggregation; Drug Antagonism; Enzyme Inhibitors; Extracellular Matrix Proteins; Gelatinases; Humans; Indoles; Lactams; Monocytes; Morphine; Protein Kinase C; Receptors, Opioid, mu; RNA, Messenger; U937 Cells | 2001 |
Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesia; Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytoskeletal Proteins; Drug Interactions; Etoposide; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ileum; Membrane Proteins; Mice; Microfilament Proteins; Morphine; Protein Kinase Inhibitors; Pyrimidines; rho-Associated Kinases; rhoA GTP-Binding Protein; Rosuvastatin Calcium; Signal Transduction; Sulfonamides; Up-Regulation | 2013 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2014 |
Inhibition of the lateral habenular CaMKⅡ abolishes naloxone-precipitated conditioned place aversion in morphine-dependent mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Avoidance Learning; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Classical; Habenula; Male; Mice, Inbred C57BL; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Substance Withdrawal Syndrome | 2017 |