1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with kn 62 in 380 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 174 (45.79) | 18.2507 |
| 2000's | 149 (39.21) | 29.6817 |
| 2010's | 55 (14.47) | 24.3611 |
| 2020's | 2 (0.53) | 2.80 |
| Authors | Studies |
|---|---|
| Hayakawa, T; Hidaka, H; Ishiguro, H; Kitagawa, M; Kondo, T; Nakae, Y; Sakai, Y; Shibata, T; Sobajima, H; Tanikawa, M | 1 |
| Fox, LM; Funasaka, M; Goldenring, JR; Hidaka, H; Modlin, IM; Tsunoda, Y | 1 |
| Hagiwara, M; Hidaka, H; Kato, M | 1 |
| Gordon, PB; Holen, I; Seglen, PO | 2 |
| Hidaka, H; Li, G; Wollheim, CB | 1 |
| Easom, RA; Hidaka, H; Landt, M; Walters, SM; Wenham, RM | 1 |
| Glembotski, CC; Hidaka, H; Irons, CE; Sei, CA | 1 |
| Hidaka, H; Nakamura, J; Nomura, Y; Tohda, M | 1 |
| Hidaka, H; Kobayashi, R; Watanabe, M | 1 |
| Hidaka, H; Ishii, A; Kiuchi, K; Kobayashi, R; Nagatsu, T; Sumi, M | 1 |
| Hidaka, H; Hoshino, T; Mizutani, A; Shimizu, S; Yamane, T | 1 |
| Hidaka, H; Ito, I; Sugiyama, H | 1 |
| Hidaka, H; Kobayashi, R | 2 |
| Hidaka, H; Ishikawa, T; Tokumitsu, H | 1 |
| Chijiwa, T; Hagiwara, M; Hidaka, H; Mizutani, A; Terasawa, M; Tokumitsu, H | 1 |
| Hidaka, H; Tokumitsu, H; Watanabe, M | 1 |
| Hashiba, Y; Hidaka, H; Ishikawa, N | 1 |
| Hidaka, H; Kikkawa, F; Maeda, O; Obata, NH; Okazaki, K; Tomoda, Y | 1 |
| Boddeke, H; Figurov, A; Muller, D | 1 |
| Glembotski, CC; McDonough, PM; Stella, SL | 1 |
| Basavappa, S; Liddle, RA; Mangel, AW; Prpic, V | 1 |
| Huang, CK; Liang, L | 1 |
| Borosky, SA; Boxer, PA; Coughenour, LL; Hajimohammadreza, I; Marcoux, FW; Probert, AW; Wang, KK | 1 |
| Baltas, LG; Karczewski, P; Krause, EG | 1 |
| Hinds, TR; Storm, DR; Wayman, GA | 1 |
| Sanderson, MJ; Schweitzer, ES; Wasterlain, CG | 1 |
| Doherty, P; Mittal, B; Walsh, FS; Williams, EJ | 1 |
| Chiu, LM; Dunkley, PR; Sitges, M | 1 |
| Dharmarajan, AM; Kugu, K; Preutthipan, S; Wallach, EE | 1 |
| Itoh, M; Joh, T; Kato, T; Miyamoto, T; Moriyama, A; Okayama, N; Suzuki, T; Takeuchi, T | 1 |
| Impey, S; Storm, DR; Wayman, GA | 1 |
| Golombek, DA; Ralph, MR | 2 |
| Audesirk, G; Cabell, L | 1 |
| Ganguly, A; Haxton, M; Li, L | 1 |
| Mercier, AJ; Noronha, KF | 1 |
| Blanchard, DK; Djeu, JY; Hoffman, SL | 1 |
| Couraud, F; Dargent, B; Jullien, F | 1 |
| Terrian, DM; Ways, DK | 1 |
| Giebisch, G; Kubokawa, M; McNicholas, CM; Wang, W | 1 |
| Audette, M; Bouillon, M | 1 |
| Goshima, K; Hidaka, H; Inui, M; Ishikawa, T; Okamoto, T; Okazaki, K; Tada, M | 1 |
| Imai, S; Nagata, K; Onozuka, M; Watanabe, K | 1 |
| Onozuka, M; Watanabe, K | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Jonas, JC; Li, G; Palmer, M; Weller, U; Wollheim, CB | 1 |
| Ruskoaho, H; Taskinen, P; Tóth, M | 2 |
| Barrett, PQ; Fern, RJ; Lu, HK; Nee, JJ | 1 |
| Bers, DM; Hove-Madsen, L; Mattiazzi, A | 1 |
| Bianchin, M; Da Silva, RC; Dias, M; Fin, C; Izquierdo, I; Medina, JH; Schmitz, PK; Wolfman, C | 1 |
| Bers, DM; Yuan, W | 1 |
| Kano, M; Nakabayashi, Y; Satoh, R | 1 |
| Hidaka, H; Inoue, S; Minami, H | 1 |
| Dunlop, J; Ennis, C; Minchin, MC; Rossiter, J | 1 |
| Kamm, KE; Luby-Phelps, K; Stull, JT; Tansey, MG | 1 |
| Ammälä, C; Ashcroft, FM; Bokvist, K; Eliasson, L; Larsson, O; Rorsman, P | 1 |
| Baden, JM; Fujinaga, M; Hoffman, BB | 1 |
| Kimura, I; Kimura, M; Nojima, H | 1 |
| Boniece, IR; Maiese, K; Skurat, K; Wagner, JA | 1 |
| Grabié, V; Scemama, JL; Seidel, ER | 1 |
| Fährmann, M; Hidaka, H; Mayer, P; Möhlig, M; Pfeiffer, A; Rochlitz, H; Schatz, H; Seidler, U | 1 |
| Grabie, V; Robertson, JB; Scemama, JL; Seidel, ER | 1 |
| Hidaka, H; Iguchi, A; Niki, A; Niki, H; Niki, I; Okazaki, K; Saitoh, M; Tamagawa, T | 1 |
| Hidaka, H; Ito, T; Mochizuki, H | 1 |
| Maurer, JA; McKay, DB; Wenger, BW | 1 |
| Das, KP; Hong, JS; Hudson, PM; McMillian, MK; Suh, HW; Wilson, BC; Wu, GC | 1 |
| Pearson, HA; Sihra, TS | 1 |
| Ekokoski, E; Törnquist, K | 1 |
| Cui, ZJ; Dannies, PS; Hidaka, H | 1 |
| Cooper, E; De Koninck, P | 1 |
| Phelps, SH; Porter, RA; Williams, CL | 2 |
| Rothstein, TL; Wang, Z; Xie, H | 1 |
| Fukunaga, K; Izumi, F; Kuroiwa, A; Minami, K; Miyamoto, E; Nakashima, Y; Tsutsui, M; Yanagihara, N | 1 |
| Benz, D; Möller, K; Perrin, D; Söling, HD | 1 |
| Marley, PD; Thomson, KA | 1 |
| Bennett, P; Gibbs, ME; Ng, KT; Rickard, N; Sedman, GL; Zhao, WQ | 1 |
| Chock, PB; Huang, CY; Tekle, E; Zhu, DM | 1 |
| Chang, JP; Jobin, RM; Neumann, CM | 1 |
| McCullough, LA; Westfall, TC | 1 |
| Amano, H; Ito, M; Tomono, M; Toyoshima, K | 1 |
| Moreland, RS; Rokolya, A; Walsh, MP | 1 |
| Frindt, G; Palmer, LG; Windhager, EE | 1 |
| Hidaka, H; Yokokura, H | 1 |
| Bristow, DR; Zamani, MR | 1 |
| Ikeuchi, Y; Nishizaki, T; Okada, Y | 1 |
| Fergus, A; Jin, Y; Kassell, NF; Lee, KS; Thai, QA | 1 |
| Gage, AT; Stanton, PK | 1 |
| Fukunaga, K; Kano, M; Konnerth, A | 1 |
| Brittis, PA; Doherty, P; Silver, J; Walsh, FS | 1 |
| Ha, TS; Kim, YH; Song, DK; Suh, HW; Wie, MB | 1 |
| Adachi, M; Imai, K; Minami, Y; Miyazaki, T; Reed, JC; Sekiya, M; Takayama, S; Taniguchi, T; Torigoe, T | 1 |
| Ganapathi, R; Grabowski, D; Hidaka, H; Kawamura, K; Krivacic, K | 1 |
| Hashimoto, Y; Higashihara, M; Kurokawa, K; Satoh, H; Sunaga, S; Togo, M; Watanabe, T | 1 |
| Bockaert, J; Lafon-Cazal, M; Rodriguez-Alvarez, J | 1 |
| Goligorsky, MS; Malbon, CC; Wang, Hy | 1 |
| Geelen, MJ; Guzmán, M; Velasco, G; Zammit, VA | 1 |
| Gault, LM; Siegel, RE | 1 |
| Liang, KC; Tan, SE | 1 |
| Aussel, C; Breittmayer, JP; Dumaurier, MJ; Marhaba, R; Pelassy, C | 1 |
| Ikeuchi, Y; Matsuoka, T; Nishizaki, T; Sumikawa, K | 1 |
| Gargett, CE; Wiley, JS | 1 |
| Chen, YH; Fu, WM; Lee, KF; Liou, JC | 1 |
| Aronstam, RS; Puhl, HL; Raman, PS; Williams, CL | 1 |
| Fukushima, T; Hamada, T; Ono, M; Shibata, S; Shimazoe, T; Watanabe, A; Watanabe, S | 1 |
| Barria, A; Derkach, V; Griffith, LC; Muller, D; Soderling, TR | 1 |
| Baxter, DA; Byrne, JH; Eskin, A; Nakanishi, K; Zhang, F | 1 |
| Hirata, C; Kizaki, H; Onishi, Y; Sakurai, Y; Tanimoto, Y; Yamada, T | 1 |
| Choi, SR; Huh, SO; Kim, YH; Song, DK; Suh, HW | 2 |
| Puschner, B; Schacht, J | 1 |
| Cinquanta, M; Frittoli, E; Gobbi, M; Mennini, T | 1 |
| Ardenghi, P; Izquierdo, I; Izquierdo, LA; Medina, JH; Netto, CA; Quevedo, J; Schröder, N | 1 |
| Hidaka, H; Iida, Y; Matsukawa, Y; Miyazaki, JI; Niki, I; Nimura, Y; Onoda, K; Sakaguchi, H; Senda, T | 1 |
| Kumatoriya, K; Nomura, T; Yamauchi, T; Yoshimura, Y | 1 |
| Cornish, JE; Gargett, CE; Wiley, JS | 1 |
| de Leij, LF; Gringhuis, SI; Tokumitsu, H; Vellenga, E; Wayman, GA | 1 |
| Inagaki, N; Iwahashi, K; Kitai, H; Kuji, N; Nakatogawa, N; Suzuki, S; Yoshimura, Y | 1 |
| Block, MR; Bouvard, D; Molla, A | 1 |
| Arreola, J; Begenisich, T; Melvin, JE | 1 |
| Ayajiki, K; Okamura, T; Toda, N | 1 |
| Akaboshi, S; Higaki, K; Katsumoto, T; Ohno, K; Sakuraba, H; Sato, M; Tai, T; Taniguchi, M | 1 |
| Chiu, LM; Guarneros, A; Peña, F; Sitges, M | 1 |
| Carré, DA; Civan, MM; McGlinn, AM; Mitchell, CH; Stone, RA | 1 |
| Chen, PL; Harms, PG; McArthur, NH; Moreno, PA; Waters, WW | 1 |
| Kasahara, J; Sugiyama, H | 1 |
| Reinach, PS; Torres-zamorano, V; Wu, X; Yang, H | 1 |
| Dubyak, GR; Humphreys, BD; Rice, J; Surprenant, A; Virginio, C | 1 |
| Liu, L | 1 |
| Fährmann, M; Möhlig, M; Pfeiffer, A; Schatz, H | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Su, JY; Toda, H | 1 |
| Dubyak, GR; Ganapathi, R; Grabowski, DR; Hidaka, H; Rybicki, L | 1 |
| Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS | 1 |
| Hernández, ML; Martínez, MJ; Ochoa, B | 1 |
| Hidaka, H; Naito, Y | 1 |
| Gondal, JA; Grundke-Iqbal, I; Iqbal, K; Sironi, JJ; Wu, Q; Yen, SH | 1 |
| Collin, T | 1 |
| Bixby, JL; Holt, CE; Höpker, V; Lom, B; McFarlane, S | 1 |
| Barros, DM; Izquierdo, I; Izquierdo, LA; McGaugh, JL; Medina, JH; Quevedo, J; Sant'Anna, MK | 1 |
| Best, JD; Hastings, MH; McNulty, S; Schurov, IL; Sloper, PJ | 1 |
| Bilato, C; Crow, MT; Curto, KA; Lundberg, MS; Monticone, RE | 1 |
| Fernando, KC; Gargett, CE; Wiley, JS | 1 |
| Fukuda, K; Ishida, H; Kodama, H; Koura, T; Miyoshi, S; Murata, M; Nakazawa, HK; Ogawa, S | 1 |
| Krnjević, K; Liu, PL; McArdle, JJ; Ren, J; Ye, JH | 1 |
| Bianchin, M; Izquierdo, I; Medina, JH; Mello e Souza, T | 1 |
| Brozinick, JT; Cartee, G; Cushman, SW; Dean, D; Reynolds, TH | 1 |
| Kobayashi, K; Manabe, T; Takahashi, T | 1 |
| Hiruma, H; Hoka, S; Katakura, T; Kawakami, T; Maruyama, H; Nishida, S; Simada, ZB; Takenaka, T | 1 |
| Collingridge, GL; Kilpatrick, IC; Palmer, MJ; Schnabel, R | 1 |
| Hatton, WJ; Kenyon, JL; Koh, SD; Perrino, BA; Sanders, KM | 1 |
| Chen, J; Hoffman, BB; Hu, ZW; Lin, R | 1 |
| Kaihatsu, T; Maeda, T; Miwa, M; Watanabe, M | 1 |
| Chalecka-Franaszek, E; Chen, H; Chuang, DM | 1 |
| Fan, GH; Ma, L; Pei, G; Qiu, HC; Wang, LZ | 1 |
| Chen, YZ; Xing, BR; Zhu, BG | 1 |
| Famulski, KS; Paterson, MC | 1 |
| Perkinton, MS; Sihra, TS; Williams, RJ | 1 |
| Gadea, A; López-Colomé, AM | 1 |
| Diener, M; Heinke, B; Ribeiro, R | 1 |
| Chartier, D; Leblanc, N; Ledoux, J | 1 |
| Hafner, M; Kox, WJ; Petzelt, C; Schmehl, W; Taschenberger, G | 1 |
| Chessell, IP; Grahames, CB; Humphrey, PP; Michel, AD | 1 |
| Izquierdo, I; Medina, JH; Netto, CA; Schröder, N | 1 |
| Jope, RS; Pacheco, MA | 1 |
| Greger, R; Henger, A; Mundel, P; Nitschke, R; Pavenstädt, H; Rüdiger, F | 1 |
| Fährmann, M; Jacob, P; Möhlig, M; Osterhoff, M; Pfeiffer, A; Seidler, U | 1 |
| Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M | 1 |
| Choi, MR; Huh, SO; Kim, YH; Lee, JK; Song, DK; Suh, HW | 1 |
| Chan, JY; Chan, SH; Chang, JW | 1 |
| Barnard, EA; Chessell, IP; Humphrey, PP; Jones, CA; Michel, AD; Miller, KJ; Simon, J | 1 |
| Ardenghi, P; Barros, DM; Izquierdo, I; Izquierdo, LA; Medinam, JH; Mello e Souza, T; Rodrigues, C; Sant'Anna, MK; Vianna, M | 1 |
| Arbabi, S; Garcia, I; Maier, RV; Rosengart, MR | 1 |
| Dunwiddie, TV; Thümmler, S | 1 |
| Baraldi, PG; di Virgilio, F; Falzoni, S; Romagnoli, R; Tabrizi, MA | 1 |
| Jope, RS; Song, L; Zhang, L | 1 |
| Izquierdo, I; Izquierdo, LA; Schröder, N; Wolfman, C | 1 |
| Dong, XP; Wang, DS; Xu, TL | 1 |
| Aikawa, R; Hayashi, D; Komuro, I; Kudoh, S; Mizukami, M; Nagai, R; Shibasaki, F; Shiojima, I; Toko, H; Yazaki, Y; Zhu, W; Zou, Y | 1 |
| Chessell, IP; Humphrey, PP; Kaur, R; Michel, AD | 1 |
| Bhattacharya, A; Chandok, MR; Deswal, R; Pandey, GK; Sopory, SK; Yadav, N | 1 |
| Ikegami, K; Koike, T | 1 |
| Lankisch, TO; Mitamura, K; Nozu, F; Owyang, C; Tsunoda, Y; Yoshida, H | 1 |
| Hishinuma, S; Ogura, K | 1 |
| Dryer, SE; Lhuillier, L | 1 |
| Carlier, E; Couraud, F; Dargent, B; De Waard, M | 1 |
| Bontron, S; Eder-Colli, L; Pahud, G | 1 |
| Carmines, PK; Hall, DA; Ma, R; Sansom, SC | 1 |
| Ceng, X; Liu, D; Lu, L; Zeng, S | 1 |
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Katayama, T; Kuroda, H; Kyan, H; Murakami, N; Nakashima, M; Rahayu, EY | 1 |
| Higo, A; Katsura, M; Mohri, Y; Ohkuma, S; Shuto, K; Takesue, M; Tarumi, C; Tsujimura, A | 1 |
| Ferrier, GR; Zhu, J | 1 |
| Bhatt, HS; Conner, BP; Easom, RA; Prasanna, G; Yorio, T | 1 |
| Chiozzi, P; Di Virgilio, F; Dichmann, S; Ferrari, D; Idzko, M; Luttmann, W; Norgauer, J; Purlis, D; Virchow, C | 1 |
| Davis, J; Schiebinger, R; Yingst, DR | 1 |
| Mikoshiba, K; Muto, Y; Nagao, T; Urushidani, T; Yamada, M | 1 |
| Aoyama, M; Bukowski, RM; Ganapathi, MK; Ganapathi, R; Grabowski, DR; Holmes, KA; Rybicki, LA | 1 |
| Bennecib, M; Gong, CX; Grundke-Iqbal, I; Iqbal, K | 1 |
| Hibell, AD; Humphrey, PP; Michel, AD; Thompson, KM; Xing, M | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Boland, R; Buitrago, C; de Boland, AR; Morelli, S | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Gao, C; Zhang, GY | 1 |
| Baldi, E; Bielavska, E; Sacchetti, B; Tassoni, G | 1 |
| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
| Honma, Y; Kasukabe, T; Okabe-Kado, J; Yamamoto-Yamaguchi, Y | 1 |
| Choi, MR; Suh, HW; Won, JS | 1 |
| Katoh, Y; Kawamura, T; Morimoto-Ishizuka, T; Niimi, M; Sawada, M; Takemori, H; Yamamoto, Y; Yamatodani, A | 1 |
| Courjaret, R; Lapied, B | 1 |
| Nakajima, Y; Nakanishi, S; Shinohara, Y | 1 |
| Di Virgilio, F; Dichmann, S; Ferrari, D; Herouy, Y; Idzko, M; Luttmann, W; Norgauer, J; Panther, E; Virchow , C | 1 |
| Conigrave, AD; Fernando, KC; Gu, B; Luttrell, BM; Tasevski, V; Wiley, JS; Zhang, W | 1 |
| Abe, K; Egawa, T; Fujii, M; Fujiwara, M; Inada, K; Iwasaki, K; Matsumoto, Y; Mishima, K; Tsukikawa, H | 1 |
| Basavappa, S; Chang, CB; Huang, CC; Lim, PH; Liu, JY | 1 |
| Fährmann, M; Heinzmann, A; Seidler, U | 1 |
| Eschke, D; Hauschildt, S; Nieber, K; Wüst, M | 1 |
| Arbogast, LA | 1 |
| Baraldi, PG; Di Virgilio, F; Falzoni, S; Makaeva, R; Moro, S; Nuñez, Mdel C; Pavani, MG; Romagnoli, R; Spalluto, G | 1 |
| Choe, ES; Wang, JQ | 1 |
| Kalenderova, S; Mitev, V; Miteva, L; Poumay, Y; Praskova, M | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Fukunaga, K; Furuya, K; Hiraoka, H; Ikuhara, T; Kato, H; Matsumura, F; Matsuo, YI; Miyamoto, E; Nagumo, H; Naito, Y; Sakurada, K; Sasaki, Y; Yamakita, Y | 1 |
| Hasegawa, H; Iida, Y; Kojima, M; Nakanishi, N; Oguro, K; Sawabe, K | 1 |
| Kotak, VC; Sanes, DH | 1 |
| Haralambieva, I; Iankov, I; Mitev, V; Mitov, I | 1 |
| Kawamoto, T; Negishi, M; Yamamoto, Y | 1 |
| Fukushi, H; Morishima, Y; Shirasaki, Y; Takano, H | 1 |
| Grinkevich, LN; Lisachev, PD; Merkulova, TI | 1 |
| Abe, K; Egashira, N; Fujiwara, M; Inada, K; Iwasaki, K; Matsumoto, Y; Mishima, K; Miura, I; Tsukikawa, H | 1 |
| Allen, JC; Kahn, AM; Kone, BC; Yang, Y; Zhang, S | 1 |
| Bok, J; Devaiah, AK; Green, SH; Hansen, MR; Zha, XM | 1 |
| Baraldi, PG; del Carmen Nuñez, M; Di Virgilio, F; Falzoni, S; Morelli, A; Romagnoli, R | 1 |
| Blanquet, PR; Derer, P; Mariani, J | 1 |
| Kalluri, HS; Ticku, MK | 1 |
| Carlson, RR; Dudman, JT; Konradi, C; Macías, W | 1 |
| Guo, J; Meng, F; Song, B; Yan, X; Zhang, G | 1 |
| El-Armouche, A; Eschenhagen, T; Jäckel, E; Marx, M; Zolk, O | 1 |
| Barnes, BR; Craig, BW; Fick, CA; Lim, K; Olesen, JB; Wright, DC | 1 |
| Höfler, S; Mühl, H; Pfeilschifter, J | 1 |
| Fu, XZ; Meng, FJ; Zhang, GY; Zhang, QG | 1 |
| Han, DH; Holloszy, JO; Hucker, KA; Wright, DC | 1 |
| Morgan, NG; Scarpello, JH; Smith, SA; Tadayyon, M; Welters, HJ | 1 |
| Guo, J; Meng, FJ; Song, B; Yan, XB; Zhang, GY | 1 |
| Agostino, PV; Ferreyra, GA; Golombek, DA; Murad, AD; Watanabe, Y | 1 |
| Huang, SH; Shen, WJ; Wang, SM; Yeo, HL | 1 |
| Bauer, EP; Farb, CR; LeDoux, JE; Rodrigues, SM; Schafe, GE | 1 |
| Duncan, M; Elssner, A; Gavrilin, M; Wewers, MD | 1 |
| Meng, FJ; Song, B; Yan, XB; Zhang, GY | 1 |
| Adinolfi, E; Baricordi, OR; Chiozzi, P; Di Virgilio, F; Morelli, A; Rizzo, R; Solini, A | 1 |
| Hübner, K; Phi-van, L | 1 |
| Barden, JA; Shemon, AN; Sluyter, R; Wiley, JS | 1 |
| Hackman, JC; Holohean, AM | 1 |
| Adinolfi, E; Baricordi, R; Di Virgilio, F; Falzoni, S; Ferrari, D; Forchap, S; Minelli, M; Pizzirani, C; Sitta, B; Turchet, L | 1 |
| Hirst, DG; Ruddock, MW | 1 |
| Leclerc, I; Rutter, GA | 1 |
| Baraldi, PG; Di Virgilio, F; Romagnoli, R | 1 |
| Markwardt, F; Schmalzing, G; Seyffert, C | 1 |
| Haralambieva, IH; Iankov, ID; Ivanova, PV; Mitev, V; Mitov, IG | 1 |
| Jiang, L; Kang, J; Kang, N; Nedergaard, M; Xu, J | 1 |
| Liu, Y; Randall, WR; Schneider, MF | 1 |
| Aghajanian, GK; Lambe, EK; Liu, RJ | 1 |
| Miao, B; Pei, DS; Yin, XH; Zhang, GY; Zhang, QG | 1 |
| Cameron, P; Kanke, T; Macfarlane, SR; McKenzie, RC; Plevin, R; Sloss, CM | 1 |
| Bliss, SP; Clay, CM; Farmerie, TA; Navratil, AM; Roberson, MS; Wolfe, MW; Xie, J | 1 |
| du Lac, S; Gittis, AH; Nelson, AB | 1 |
| Burnstock, G; Butler, PE; White, N | 1 |
| Kometani, K; Shiroma, S; Yamaguchi, T | 1 |
| Kalil, K; Tang, F | 1 |
| Aromolaran, AA; Blatter, LA | 1 |
| Damaj, MI | 2 |
| Christopherson, RI; Fuller, SJ; Georgiou, JG; Martin, CJ; Skarratt, KK; Sluyter, R; Wiley, JS | 1 |
| Guan, QH; Hao, ZB; Pei, DS; Zhang, GY | 1 |
| Baraldi, PG; Bianchini, E; Gambari, R; Lambertini, E; Penolazzi, L; Piva, R; Romagnoli, R | 1 |
| Hwang, SJ; Kaang, BK; Kim, JH; Kim, YS; Lee, JA; Park, CH; Son, H; Song, YM | 1 |
| Reiser, G; Tulapurkar, ME; Zündorf, G | 1 |
| Cohen, EB; Korngreen, A; Kuzin, L; Ma, W; Priel, A; Silberberg, SD; Weil, S | 1 |
| Craveiro, RB; Ferreira, AT; França, JP; Oshiro, ME; Paredes-Gamero, EJ; Pesquero, JB | 1 |
| De Lorenzi, M; Dehaye, JP; Devleeschouwer, M; Garcia-Marcos, M; Marino, A; Pochet, S; Querriére, S; Tandel, S; Tre-Hardy, M; Vandenbranden, M | 1 |
| Cuevas, J; Henning, RJ | 1 |
| Collins, SJ; Mueller, L; Schuler, AD; Si, J; Simon, JA | 1 |
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| Clay, WC; Condreay, JP; Hall, M; Holbrook, J; Livermore, D; Michel, AD; Ng, SW; Roman, S; Senger, S; Thompson, K | 1 |
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| Hou, X; Wang, X; Yang, B; Yu, G; Zhang, L; Zhou, J | 1 |
| Basile, G; Benvenuto, F; Bruzzone, S; De Flora, A; Fiorese, F; Moreschi, I; Nobbio, L; Schenone, A; Sturla, L; Usai, C; Zocchi, E | 1 |
| Jung, SR; Reed, BJ; Sweet, IR | 1 |
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| Gadeock, S; Georgiou, JG; Jalilian, I; Sluyter, R; Taylor, RM; Tran, JN; Wiley, JS | 1 |
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| Berglund, E; Bränström, R; Farnebo, LO; Höög, A; Larsson, C; Lu, M | 1 |
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| Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S | 1 |
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| Boubali, S; Dimitracopoulos, G; Liopeta, K; Mavrothalassitis, G; Paliogianni, F; Thyphronitis, G; Virgilio, L | 1 |
| Hernández-Ochoa, EO; Liu, Y; Randall, WR; Schneider, MF | 1 |
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| Aguiar, AS; Bettio, LE; Budni, J; Cunha, MP; Machado, DG; Martins, DF; Oliveira, Á; Pazini, FL; Rodrigues, AL; Santos, AR | 1 |
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| Cao, Y; Liu, R; Qu, L; Wang, P; Wang, W; Wang, X; Wang, Y; Yu, J; Yue, W; Zhang, Q | 1 |
| Artalejo, AR; Bustillo, D; Marín-García, P; Miras-Portugal, MT; Olivos-Oré, LA; Sánchez-Nogueiro, J | 1 |
| Cho, JH; Hien, TT; Kang, KW; Kim, S; Kim, YC; Kim, YG; Ko, H; Lee, GE; Lee, SD; Lim, SC; Park, JH; Yang, JW | 1 |
| Chebolu, S; Darmani, NA; Hutchinson, TE; Wilson, SM; Zhong, W | 1 |
| Al-Qudah, M; Anderson, CD; Grider, JR; Kendig, DM; Mahavadi, S; Murthy, KS | 1 |
| Di, JH; Han, D; Han, M; Li, PP; Qi, DS; Song, YJ; Wang, M; Ye, JS; Yu, HM; Zhang, F; Zhang, GY; Zhou, C; Zhou, XY | 1 |
| Konishi, S; Ono, Y; Saitow, F | 1 |
| Corrêa, G; Coutinho-Silva, R; de A Lindenberg, C; F Kubelka, C; Fernandes-Santos, C; Gandini, M; Petitinga Paiva, F | 1 |
| Harley, CW; McLean, JH; Modarresi, S; Mukherjee, B; Yuan, Q | 1 |
| Abbott, TB; Chung, L; Colangelo, CM; Gulcicek, EE; Lam, TT; Nairn, AC; Rich, MT; Stone, KL; Taylor, JR; Torregrossa, MM | 1 |
| Wang, C; Yu, S; Zhao, Y; Zhu, J; Zhu, L | 1 |
| Carbonetto, S; Tremblay, M; Vezina-Audette, R | 1 |
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| Chen, L; Du, Y; Huang, S; Men, C; Qi, M; Wang, Z; Wu, C; Zhou, L | 1 |
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| Borczyk, M; Nowacka, A; Radwanska, K; Salamian, A; Wójtowicz, T; Włodarczyk, J | 1 |
| Dai, L; Feng, F; Liu, H; Wang, L; Xiao, Y | 1 |
5 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and kn 62
| Article | Year |
|---|---|
[Molecular pharmacology of intracellular calcium signaling].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Cyclic AMP; Humans; Isoquinolines; Muscle Contraction; Muscle, Smooth; Myosins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Second Messenger Systems; Sulfonamides | 1990 |
Protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Humans; Isoquinolines; Myosin-Light-Chain Kinase; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases | 1994 |
Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein kinase II (CaM kinase II) inhibitor, KN-62, and proposal of CaM kinase phosphorylation cascades.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cardiovascular System; Dihydroxyphenylalanine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Islets of Langerhans; Molecular Sequence Data; Molecular Structure; Muscle, Smooth; Myosin Light Chains; Neurons; Pancreas; Phosphorylation; Protein Kinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Tyrosine 3-Monooxygenase | 1996 |
[Inhibitor of calmodulin and calmodulin dependent enzyme].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Myosin-Light-Chain Kinase; Naphthalenes; Naphthalenesulfonates; Phenothiazines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Sulfonamides; Vinca Alkaloids | 1998 |
Agonists and antagonists acting at P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Humans; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Structure-Activity Relationship | 2004 |
375 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and kn 62
| Article | Year |
|---|---|
Effects of calmodulin inhibitors on amylase secretion from rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Calcium; Calmodulin; Isoquinolines; Male; Pancreas; Piperazines; Protein Kinase Inhibitors; Rats; Second Messenger Systems; Sulfonamides | 1992 |
An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Separation; Colforsin; Gastric Acid; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase Inhibitors; Protein Kinases | 1992 |
Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay (RBA).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Calmodulin-Binding Proteins; Chromatography, Affinity; Cytosol; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Substrate Specificity; Sulfonamides | 1992 |
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Cytoskeleton; Ethers, Cyclic; Indole Alkaloids; Indoles; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Raffinose; Rats; Rats, Inbred Strains; Sulfonamides; Tritium | 1992 |
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Membrane Permeability; Colforsin; Cricetinae; Diphosphonates; Drug Synergism; Insulin; Insulin Secretion; Insulinoma; Ion Channel Gating; Isoquinolines; Manganese; Membrane Potentials; Mitochondria; Piperazines; Protein Kinase Inhibitors; Stimulation, Chemical; Tumor Cells, Cultured | 1992 |
Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Kinetics; Myosin-Light-Chain Kinase; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rats | 1992 |
Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Natriuretic Factor; Cells, Cultured; Endothelins; Heart; Heart Atria; Isoquinolines; Kinetics; Myocardium; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sulfonamides | 1992 |
Inhibitory effects of KN-62, a specific inhibitor of Ca/calmodulin-dependent protein kinase II, on serotonin-evoked C1-current and 36-C1-efflux in Xenopus oocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Chlorides; Isoquinolines; Male; Membrane Proteins; Oocytes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Serotonin; Xenopus | 1991 |
Properties and use of H-series compounds as protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Isoquinolines; Kinetics; PC12 Cells; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides | 1991 |
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Gland Neoplasms; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dihydroxyphenylalanine; Enzyme Activation; Isoquinolines; Kinetics; Molecular Weight; Pheochromocytoma; Phosphorylation; Piperazines; Potassium; Protein Kinase Inhibitors; Rats; Tyrosine 3-Monooxygenase | 1991 |
Calcium ion regulates the release of lipase of Fusarium oxysporum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calmodulin; Fusarium; Isoquinolines; Kinetics; Lipase; Piperazines; Protein Kinase Inhibitors; Subcellular Fractions; Sulfonamides | 1991 |
Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Piperazines; Protein Kinase Inhibitors; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
[Calmodulin dependent regulation of smooth muscle contraction].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Calmodulin; Isoquinolines; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Piperazines; Sulfonamides; Thyroxine | 1990 |
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites; Binding, Competitive; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Chickens; Chromatography, Affinity; Cyclic AMP; Gizzard, Avian; Isoquinolines; Kinetics; Myosin-Light-Chain Kinase; Myosins; Pheochromocytoma; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Tumor Cells, Cultured | 1990 |
Search for the functional substrate proteins of protein kinases and their selective inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Gland Neoplasms; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Cell Differentiation; Isoquinolines; Neoplasm Proteins; Pheochromocytoma; Phosphorylation; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Rats; Second Messenger Systems; Substrate Specificity; Sulfonamides; Tumor Cells, Cultured | 1990 |
Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Calmodulin; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Heart Rate; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfonamides; Vasodilator Agents | 1990 |
Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Cystadenocarcinoma; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Glutathione Transferase; Humans; Isoquinolines; Kinetics; Ovarian Neoplasms; Piperazines; Tumor Cells, Cultured | 1995 |
Enhancement of AMPA-mediated synaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Magnesium; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Synaptic Transmission | 1993 |
Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Analysis of Variance; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzophenanthridines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytoplasm; Endothelins; Fluorescent Dyes; Heart; Heart Atria; Indoles; Isoquinolines; Kinetics; Myocardial Contraction; Myocardium; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phosphoproteins; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1994 |
Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholecystokinin; Cyclic AMP; Diltiazem; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Mice; Phenylalanine; Piperazines; Secretory Rate | 1994 |
Activation of multiple protein kinases induced by cross-linking of Fc gamma RII in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Cross-Linking Reagents; Egtazic Acid; Enzyme Activation; Genistein; Humans; Isoflavones; Isoquinolines; Molecular Sequence Data; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Receptors, IgG; Superoxides | 1995 |
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Genistein; Imidazoles; Indole Alkaloids; Isoflavones; Isoquinolines; Kinetics; N-Methylaspartate; Naphthalenes; Neurons; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrin | 1995 |
The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Antibodies; Autoradiography; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Heart Ventricles; Isoenzymes; Isoquinolines; Kinetics; Myocardium; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Protein Kinases; Rats; Sarcoplasmic Reticulum; Swine | 1995 |
Hormone stimulation of type III adenylyl cyclase induces Ca2+ oscillations in HEK-293 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoproterenol; Isoquinolines; Kidney; Kinetics; Models, Biological; Oscillometry; Phosphatidylinositols; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Signal Transduction; Time Factors | 1995 |
Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Dopamine Antagonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Isoquinolines; Kinetics; Membrane Potentials; Norepinephrine; PC12 Cells; Piperazines; Protein Kinase C; Rats; Trifluoperazine | 1995 |
A Ca2+/calmodulin kinase inhibitor, KN-62, inhibits neurite outgrowth stimulated by CAMs and FGF.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cells, Cultured; Cerebellum; Cholera Toxin; Dose-Response Relationship, Drug; Fibroblasts; Isoquinolines; Neurites; Neurons; Piperazines; Rats; Receptors, Fibroblast Growth Factor | 1995 |
A role for calcium/calmodulin kinase(s) in the regulation of GABA exocytosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Exocytosis; gamma-Aminobutyric Acid; Isoquinolines; Membrane Potentials; Mice; Nerve Endings; Piperazines; Potassium | 1995 |
Role of calcium/calmodulin-dependent protein kinase II in gonadotrophin-induced ovulation in in vitro perfused rabbit ovaries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acids; Arginine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chorionic Gonadotropin; Dinoprost; Female; In Vitro Techniques; Isoquinolines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovary; Ovulation; Perfusion; Piperazines; Progesterone; Rabbits; Signal Transduction | 1995 |
Mediation of pepsinogen secretion from guinea pig chief cells by Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Gastric Mucosa; Guinea Pigs; Immunohistochemistry; Ionomycin; Isoquinolines; Male; Pepsinogens; Phosphorylation; Piperazines | 1995 |
Ca2+ inhibition of type III adenylyl cyclase in vivo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Line; Cell Membrane; Embryo, Mammalian; Gene Library; Glucagon; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Isoenzymes; Isoproterenol; Isoquinolines; Kidney; Kinetics; Piperazines; Receptors, Glucagon; Recombinant Proteins; Transfection | 1995 |
Circadian responses to light: the calmodulin connection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Circadian Rhythm; Cricetinae; Cyclic AMP Response Element-Binding Protein; Immunohistochemistry; Isoquinolines; Light; Male; Mesocricetus; Phosphorylation; Piperazines; Sulfonamides; Suprachiasmatic Nucleus | 1995 |
Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Dendrites; Female; Hippocampus; Imidazoles; Indoles; Isoquinolines; Naphthalenes; Neurites; Piperazines; Polycyclic Compounds; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Pyrroles; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of angiotensin II- and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca(2+)-calmodulin dependent protein kinase II in aldosterone secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Isoquinolines; Kinetics; Piperazines; Potassium; Sulfonamides; Zona Glomerulosa | 1995 |
A role for calcium/calmodulin-dependent protein kinase in mediating synaptic modulation by a neuropeptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astacoidea; Cyclic Nucleotide Phosphodiesterases, Type 1; Evoked Potentials; FMRFamide; Isoquinolines; Neuropeptides; Phosphoric Diester Hydrolases; Piperazines; Synaptic Transmission; Time Factors | 1995 |
Inhibition of extracellular ATP-mediated lysis of human macrophages by calmodulin antagonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium; Calmodulin; Cell Death; Cells, Cultured; Cytosol; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Isoquinolines; Kinetics; Macrophages; Membrane Potentials; Piperazines | 1995 |
Internalization of voltage-dependent sodium channels in fetal rat brain neurons: a study of the regulation of endocytosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chloroquine; Electrophysiology; Endocytosis; Isoquinolines; Neurons; Piperazines; Protein Kinases; Protein-Tyrosine Kinases; Rats; Sodium Channels | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
KN-62, an inhibitor of Ca2+/calmodulin kinase II, attenuates circadian responses to light.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Circadian Rhythm; Cricetinae; Isoquinolines; Male; Mesocricetus; Models, Neurological; Motor Activity; Photic Stimulation; Piperazines; Signal Transduction; Visual Pathways | 1994 |
Role of Ca2+/CaMK II in Ca(2+)-induced K+ channel inhibition in rat CCD principal cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electrophysiology; Female; Indoles; Isoquinolines; Kidney Cortex; Kidney Tubules, Collecting; Male; Maleimides; Piperazines; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1995 |
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Autophagy; Cells, Cultured; Dose-Response Relationship, Drug; Endocytosis; Ethers, Cyclic; Flavanones; Flavonoids; Genistein; Isoflavones; Isoquinolines; Kinetics; Liver; Male; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Wistar | 1995 |
Retinoic acid-stimulated intercellular adhesion molecule-1 expression on SK-N-SH cells: calcium/calmodulin-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Adhesion Molecules; Enzyme Activation; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Sulfonamides; Terpenes; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1994 |
KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cells, Cultured; Heart; Heart Rate; Isoquinolines; Mice; Mice, Inbred ICR; Myocardium; Phosphorylation; Piperazines; Rabbits; Sarcoplasmic Reticulum | 1994 |
Involvement of a Ca2+/calmodulin-dependent protein kinase II-associated mechanism in the induction of an outward potassium current by quisqualate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Electric Stimulation; Electrophysiology; Isoquinolines; Neurons; Piperazines; Potassium Channels; Quisqualic Acid; Signal Transduction; Snails; Tetraethylammonium Compounds | 1994 |
Glutamate elicits an outward K+ current which is normally suppressed by a Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alkaloids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cholera Toxin; Dose-Response Relationship, Drug; Ganglia, Invertebrate; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kynurenic Acid; Membrane Potentials; Neurons; Pertussis Toxin; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Snails; Staurosporine; Sulfonamides; Time Factors; Virulence Factors, Bordetella | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Dynamics of Ca2+ and guanosine 5'-[gamma-thio]triphosphate action on insulin secretion from alpha-toxin-permeabilized HIT-T15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Insulin; Insulin Secretion; Isoquinolines; Kinetics; Piperazines; Staphylococcus aureus; Type C Phospholipases | 1994 |
Effects of genistein on cardiac contractile force and atrial natriuretic peptide secretion in the isolated perfused rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Diltiazem; Drug Interactions; Genistein; Hemodynamics; Isoflavones; Isoquinolines; Male; Myocardial Contraction; Perfusion; Piperazines; Protein-Tyrosine Kinases; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1994 |
Ca(2+)-dependent activation of T-type Ca2+ channels by calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Electrophysiology; Isoquinolines; Piperazines; Zona Glomerulosa | 1994 |
Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Biological Transport; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Isoquinolines; Myocardium; Piperazines; Protein Kinase Inhibitors; Rabbits; Sarcoplasmic Reticulum; Sulfonamides | 1994 |
Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amnesia, Retrograde; Amygdala; Animals; Avoidance Learning; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; Isoquinolines; Male; Piperazines; Rats; Rats, Wistar; Retention, Psychology | 1994 |
Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electric Conductivity; Ferrets; Heart; Heart Ventricles; Isoquinolines; Myocardium; Peptide Fragments; Piperazines; Rabbits; Staurosporine; Sulfonamides | 1994 |
Ca2+/calmodulin-dependent regulation of the density of Na+ channels in embryonic chick skeletal muscle cells during their development in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Chick Embryo; Electrophysiology; Isoquinolines; Muscles; Piperazines; Sodium Channels; Sulfonamides | 1994 |
The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Humans; In Vitro Techniques; Isoquinolines; Leukemia, Erythroblastic, Acute; Piperazines; Tumor Cells, Cultured | 1994 |
The effect of 3 calmodulin antagonists on K(+)-stimulated neurotransmitter release from rat cortical slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Potassium; Rats; Serotonin; Sulfonamides; Trifluoperazine | 1993 |
Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Egtazic Acid; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Isoquinolines; Kinetics; Microscopy, Fluorescence; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Peptide Fragments; Phosphorylation; Piperazines; Rhodamines; Trachea | 1994 |
Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Electric Stimulation; Endocytosis; Exocytosis; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Isoquinolines; Mice; Piperazines | 1993 |
Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Embryo, Mammalian; Female; Isoquinolines; Organ Culture Techniques; Phenylephrine; Piperazines; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Signal Transduction; Situs Inversus | 1994 |
The evidence of accelerative interaction between cAMP-dependent protein kinase and external calcium for the desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Hydroxybenzoates; Isoquinolines; Mice; Muscles; Piperazines; Receptors, Nicotinic; Staurosporine; Sulfonamides; Time Factors | 1994 |
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Cell Death; Cell Hypoxia; Cells, Cultured; Dibutyryl Cyclic GMP; Hippocampus; Isoquinolines; Nerve Tissue Proteins; Nitric Oxide; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides | 1993 |
Characterization of univectorial polyamine transport in duodenal crypt cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Azepines; Biological Transport; Calmodulin; Cell Line; Duodenum; Epithelium; Humans; Imidazoles; Isoquinolines; Kinetics; Naphthalenes; Piperazines; Protein Kinase Inhibitors; Putrescine; Spermidine; Sulfonamides | 1993 |
Characterization of gamma- and delta-subunits of Ca2+/calmodulin-dependent protein kinase II in rat gastric mucosal cell populations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Gastric Mucosa; Isoquinolines; Male; Molecular Sequence Data; Molecular Weight; Phosphorylation; Piperazines; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Substrate Specificity | 1994 |
Paraquat uptake in the cultured gastrointestinal epithelial cell line, IEC-6.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Calmodulin; Cell Count; Cell Line; Intestinal Mucosa; Isoquinolines; Paraquat; Piperazines; Putrescine; Rats; Spermidine; Sulfonamides | 1993 |
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Immunoblotting; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Kinetics; Male; Myosin-Light-Chain Kinase; Myosins; Phosphates; Phosphorus Radioisotopes; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Female; Isoquinolines; Male; Molecular Sequence Data; Peptides; Phosphorylation; Piperazines; Rats; Rats, Wistar; Substrate Specificity | 1993 |
Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Catecholamines; Cattle; Cells, Cultured; Enzyme Inhibitors; Indole Alkaloids; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Staurosporine; Substrate Specificity | 1996 |
Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cholinergic Antagonists; DNA Probes; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Isoquinolines; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Nimodipine; Piperazines; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1995 |
Ca/calmodulin-dependent kinase II inhibitor KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channels; Calmodulin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Isoquinolines; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Synaptosomes; Time Factors | 1995 |
Inhibition of agonist-mediated calcium entry by calmodulin antagonists and by the Ca2+/calmodulin kinase II inhibitor KN-62. Studies with thyroid FRTL-5 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Barium; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Calmodulin; Cell Line; Depression, Chemical; Fluphenazine; Imidazoles; Isoquinolines; Membrane Potentials; Phenoxybenzamine; Piperazines; Rats; Sulfonamides; Terpenes; Thapsigargin; Thyroid Gland | 1996 |
KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Female; Isoquinolines; Kinetics; Piperazines; Pituitary Gland, Anterior; Potassium; Potassium Chloride; Prolactin; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Time Factors | 1996 |
Differential regulation of neuronal nicotinic ACh receptor subunit genes in cultured neonatal rat sympathetic neurons: specific induction of alpha 7 by membrane depolarization through a Ca2+/calmodulin-dependent kinase pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Animals, Newborn; Bungarotoxins; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Choline; Electrophysiology; Ganglia, Sympathetic; Gene Expression Regulation; Isoquinolines; Neurons; Piperazines; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Transcription, Genetic | 1995 |
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cel
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Small Cell; Cell Division; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoquinolines; Lung Neoplasms; Piperazines; Tumor Cells, Cultured | 1996 |
Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Anti-Idiotypic; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Immunoglobulins; Ionomycin; Isoquinolines; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Antigen, B-Cell; Signal Transduction; Staurosporine; Sulfonamides | 1996 |
Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Adrenal Medulla; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Catecholamines; Cattle; Chromaffin System; Enzyme Inhibitors; Humans; Ion Channels; Isoquinolines; Nicotinic Agonists; Piperazines; Sodium; Tyrosine 3-Monooxygenase | 1996 |
The role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amylases; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Immunoblotting; Isoproterenol; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Binding; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
The Ca++/calmodulin-dependent protein kinase II inhibitors KN62 and KN93, and their inactive analogues KN04 and KN92, inhibit nicotinic activation of tyrosine hydroxylase in bovine chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Line; Chromaffin Granules; Enzyme Activation; Isoquinolines; Nicotine; Piperazines; Sulfonamides; Tyrosine 3-Monooxygenase | 1996 |
The involvement of Ca2+/calmodulin-dependent protein kinase in memory formation in day-old chicks.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Avoidance Learning; Brain Mapping; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Isoquinolines; Mental Recall; Piperazines; Prosencephalon; Retention, Psychology | 1996 |
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides | 1996 |
Roles of calcium and calmodulin in the mediation of acute and sustained GnRH-stimulated gonadotropin secretion from dispersed goldfish pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cobalt; Culture Media; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Pituitary Gland | 1996 |
Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Ion Channel Gating; Isoquinolines; Neuropeptide Y; Nifedipine; omega-Conotoxin GVIA; PC12 Cells; Peptides; Piperazines; Protein Kinase C; Protein Kinases; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Thionucleotides | 1996 |
Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Cell Survival; Cyclosporine; DNA Replication; Enzyme Inhibitors; Extracellular Space; Fibroblast Growth Factors; Isoquinolines; Lysophospholipids; Mice; Phosphoprotein Phosphatases; Piperazines; Signal Transduction; Tacrolimus | 1996 |
Calcium-and phorbol ester-dependent calponin phosphorylation in homogenates of swine carotid artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Calponins; Carotid Arteries; Electrophoresis; Enzyme Inhibitors; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Staurosporine; Swine | 1996 |
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Feedback; Female; Kidney Tubules, Collecting; Male; Ouabain; Patch-Clamp Techniques; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
The histamine H1 receptor in GT1-7 neuronal cells is regulated by calcium influx and KN-62, a putative inhibitor of calcium/calmodulin protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Receptors, Histamine H1; Signal Transduction; Tumor Cells, Cultured | 1996 |
Repetitive applications of ATP potentiate potassium current by Ca2+/calmodulin kinase in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Hippocampus; Indoles; Ion Channel Gating; Isoquinolines; Maleimides; Neurons; Patch-Clamp Techniques; Potassium; Protein Kinase C; Rats; Signal Transduction; Sulfonamides | 1996 |
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Small Cell; Enzyme Inhibitors; Humans; Isoquinolines; Lung Neoplasms; Piperazines; Receptors, Muscarinic; Tumor Cells, Cultured | 1995 |
Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Heart Rate; Isoquinolines; Male; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Relaxin; Staurosporine; Stimulation, Chemical; Sulfonamides | 1996 |
Tonic protein kinase C-mediated vasoconstriction is unmasked when nitric oxide synthase is inhibited in cerebral microvessels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Indoles; Kinetics; Male; Maleimides; Microcirculation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Protein Kinase C; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction | 1996 |
Distinct synaptic loci of Ca2+/calmodulin-dependent protein kinase II necessary for long-term potentiation and depression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Long-Term Potentiation; Male; Neuronal Plasticity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses | 1996 |
Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cerebellum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Kinetics; Marine Toxins; Membrane Potentials; Nerve Fibers; Oxazoles; Purkinje Cells; Rats; Receptors, GABA-A; Signal Transduction; Staurosporine | 1996 |
Fibroblast growth factor receptor function is required for the orderly projection of ganglion cell axons in the developing mammalian retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Axons; Cell Adhesion Molecules; Cyclohexanones; Eye Proteins; Fetal Proteins; Mammals; Mice; Rats; Receptors, Fibroblast Growth Factor; Retina; Retinal Ganglion Cells; Signal Transduction | 1996 |
Molecular mechanisms underlying the regulation of proenkephalin gene expression in cultured spinal cord cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mollusk Venoms; Nimodipine; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate | 1996 |
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Carrier Proteins; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Hematopoietic Stem Cells; Humans; Interleukin-2; Isoflavones; Janus Kinase 3; Lymphocytes; Mice; Phosphorylation; Phytohemagglutinins; Polyenes; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-2; RNA, Messenger; Serine; Signal Transduction; Sirolimus; Stimulation, Chemical; Tacrolimus; Transcription Factors; Transfection | 1996 |
Cellular events involved in the sensitization of etoposide-resistant cells by inhibitors of calcium-calmodulin-dependent processes. Role for effects on apoptosis, DNA cleavable complex, and phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Apoptosis; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; DNA Topoisomerases, Type II; Drug Resistance; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Topoisomerase II Inhibitors; Trifluoperazine | 1996 |
Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Calcium; Cell Line; Cyclic AMP; Dinoprostone; Hematopoietic Stem Cells; Humans; Iloprost; Ionomycin; Megakaryocytes; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Receptors, Prostaglandin; Receptors, Thrombin; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1996 |
The CaM-kinase II inhibitor KN-62 blocks NMDA but not kainate stimulation of NO synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Mice; Mice, Inbred Strains; N-Methylaspartate; Nitric Oxide Synthase | 1996 |
Temporal activation of Ca2+-calmodulin-sensitive protein kinase type II is obligate for adipogenesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Adipose Tissue; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Indoles; Mice; Pyrroles; Sulfonamides | 1997 |
Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carnitine O-Palmitoyltransferase; Enzyme Activation; Enzyme Inhibitors; L-Lactate Dehydrogenase; Liver; Male; Okadaic Acid; Phosphorylation; Rats; Rats, Wistar | 1997 |
Expression of the GABAA receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Chelating Agents; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Macromolecular Substances; Membrane Potentials; Neurons; Nifedipine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sulfonamides; Tetrodotoxin; Time Factors; Transcription, Genetic | 1997 |
Inhibitory avoidance learning alters the amygdala calcium/calmodulin-dependent protein kinase II activity in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Avoidance Learning; Calcium-Calmodulin-Dependent Protein Kinases; Electroshock; Enzyme Inhibitors; Male; Rats; Rats, Sprague-Dawley | 1997 |
Regulation of phospholipid biosynthesis by Ca(2+)-calmodulin-dependent protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acid; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Indoles; Jurkat Cells; Myosin-Light-Chain Kinase; Naphthalenes; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phospholipids | 1997 |
Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Kinetics; Macromolecular Substances; Maleimides; Mutagenesis, Site-Directed; Oleic Acid; Oocytes; Point Mutation; Protein Kinase C; Receptors, Nicotinic; Recombinant Proteins; Serine; Torpedo; Xenopus laevis | 1997 |
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium; Cytosol; Enzyme Inhibitors; Humans; Kinetics; Lymphocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7 | 1997 |
Regulation of quantal transmitter secretion by ATP and protein kinases at developing neuromuscular synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Adenosine Triphosphate; Animals; Cells, Cultured; Coculture Techniques; Embryo, Nonmammalian; Enzyme Inhibitors; Evoked Potentials; Kinetics; Muscle, Skeletal; Neuromuscular Junction; Neurons; Protein Kinases; Quantum Theory; Suramin; Synapses; Synaptic Transmission; Theophylline; Triazines; Xenopus laevis | 1997 |
Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpipe
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Inhibitors; Humans; Neuroblastoma; Piperidines; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Tumor Cells, Cultured | 1997 |
The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Biomarkers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Circadian Rhythm; Drug Evaluation, Preclinical; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Suprachiasmatic Nucleus; Trifluoperazine | 1997 |
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Male; Peptide Mapping; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission | 1997 |
Role of calcium-calmodulin-dependent protein kinase II in modulation of sensorimotor synapses in Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Aplysia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Evoked Potentials; Membrane Potentials; Neurons, Afferent; Serotonin; Synapses | 1997 |
Preincubation of thymocytes with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) induces apoptosis in non-stimulated thymocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoenzymes; Isoquinolines; Lactams, Macrocyclic; Male; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA; Sulfonamides; T-Lymphocytes; Thymus Gland | 1997 |
Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mous
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; beta-Endorphin; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Imidazoles; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; omega-Conotoxin GVIA; Peptides; Spinal Cord | 1997 |
Calmodulin-dependent protein kinases mediate calcium-induced slow motility of mammalian outer hair cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Auditory, Outer; Ionomycin; Ionophores; Isoquinolines; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Staurosporine; Sulfonamides | 1997 |
Further evidence of Ca(2+)-dependent, exocytotic-like serotonin release induced by D-fenfluramine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Exocytosis; Fenfluramine; Hippocampus; In Vitro Techniques; Male; Polymyxin B; Potassium Chloride; Rats; Rats, Inbred Strains; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptosomes | 1997 |
Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining beta-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arousal; beta-Endorphin; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cosyntropin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fear; Hippocampus; Indoles; Injections, Intraperitoneal; Lypressin; Male; Mental Recall; Neural Pathways; Pyrroles; Rats; Rats, Wistar; Retention, Psychology | 1997 |
Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Azepines; Bacterial Proteins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cells, Cultured; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Myosin Heavy Chains; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Rats; Rats, Wistar; Streptolysins | 1997 |
Overexpression of alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II in neuroblastoma cells -- H-7 promotes neurite outgrowth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Immunoblotting; Isoenzymes; Isoquinolines; Mice; Molecular Sequence Data; Neurites; Neuroblastoma; Phosphorylation; Substrate Specificity; Sulfonamides; Transfection; Tumor Cells, Cultured | 1997 |
Effects of intrathecal injection of nimodipine, omega-conotoxin GVIA, calmidazolium, and KN-62 on the antinociception induced by cold water swimming stress in the mouse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesia; Animals; Calcium Channel Blockers; Cold Temperature; Enzyme Inhibitors; Imidazoles; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Mollusk Venoms; Nimodipine; omega-Conotoxin GVIA; Pain Measurement; Peptides; Stress, Physiological; Swimming | 1997 |
ATP, a partial agonist for the P2Z receptor of human lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Affinity Labels; Barium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethidium; Flow Cytometry; Humans; In Vitro Techniques; Ion Channels; Leukemia, Lymphocytic, Chronic, B-Cell; Linear Models; Lymphocytes; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Structure-Activity Relationship; Thionucleotides | 1997 |
The Ca2+/calmodulin-dependent kinase type IV is involved in the CD5-mediated signaling pathway in human T lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; CD5 Antigens; Enzyme Inhibitors; Gene Expression; Humans; In Vitro Techniques; Interleukin-2; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; T-Lymphocytes; Transcription Factor AP-1; Transcriptional Activation | 1997 |
Effect of KN-62, a selective inhibitor of calmodulin-dependent kinase II, on mouse oocyte activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Fertilization in Vitro; Fluorescent Dyes; Ionophores; Male; Mice; Mice, Inbred ICR; Oocytes; Protein Kinase Inhibitors | 1997 |
Calcium/calmodulin-dependent protein kinase II controls alpha5beta1 integrin-mediated inside-out signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcineurin Inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; CHO Cells; Cricetinae; Enzyme Induction; Enzyme Inhibitors; Fibronectins; Peptides; Protein Binding; Protein Conformation; Receptors, Fibronectin; Signal Transduction | 1998 |
Differences in regulation of Ca(2+)-activated Cl- channels in colonic and parotid secretory cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Cells, Cultured; Chloride Channels; Colon; Enzyme Inhibitors; Humans; Intestinal Mucosa; Kinetics; Male; Parotid Gland; Patch-Clamp Techniques; Peptide Fragments; Polymerase Chain Reaction; Rats; Rats, Wistar | 1998 |
Effect of Ca2+/calmodulin-dependent protein kinase II inhibitors on the neurogenic cerebroarterial relaxation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Arteries; Coronary Vessels; Cyclic GMP; Dinoprost; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Norepinephrine; Oxytocics; Phosphorylation; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Tetrodotoxin; Vasoconstrictor Agents | 1997 |
Accumulation of cholesterol and GM2 ganglioside in cells cultured in the presence of progesterone: an implication for the basic defect in Niemann-Pick disease type C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Cells, Cultured; Cholesterol; Fibroblasts; Fluorescent Antibody Technique; G(M2) Ganglioside; Humans; Imipramine; Niemann-Pick Diseases; Progesterone; Rats | 1998 |
Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Okadaic Acid; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sodium; Sodium Channels; Synaptosomes; Tetrodotoxin; Veratridine | 1998 |
A release mechanism for stored ATP in ocular ciliary epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Chloride Channels; Ciliary Body; Enzyme Inhibitors; Ocular Physiological Phenomena; Pigment Epithelium of Eye; Rabbits; Signal Transduction | 1998 |
Calcium/calmodulin-dependent protein kinase II involvement in release of gonadotropin-releasing hormone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Male; Potassium; Rats; Rats, Sprague-Dawley; Sulfonamides | 1998 |
Modulation of glutamate sensitivities by inhibitors of a protein kinase and a protein phosphatase in cultured rat Purkinje cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Iontophoresis; Marine Toxins; Nerve Tissue Proteins; Oxazoles; Protein Tyrosine Phosphatases; Purkinje Cells; Rats; Receptors, AMPA; Sulfonamides | 1998 |
ETA receptor mediated inhibition of intracellular pH regulation in cultured bovine corneal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arsenicals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclosporine; Diuretics; Egtazic Acid; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epithelium, Corneal; Hydrogen-Ion Concentration; Immunosuppressive Agents; Intracellular Fluid; Naphthalenes; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Endothelin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1998 |
Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Chimera; Enzyme Inhibitors; Ethidium; Fluorescent Dyes; Humans; Ion Transport; Isoquinolines; Leukocytes; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 1998 |
Inhibition of lung surfactant secretion by KN-62, a specific inhibitor of the calcium- and calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ionophores; Male; Phosphatidylcholines; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Terbutaline; Tetradecanoylphorbol Acetate | 1998 |
Purification and characterization of a Ca2+/calmodulin-dependent protein kinase II from hog gastric mucosa using a protein-protein affinity chromatographic technique.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cations, Divalent; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Inhibitors; Gastric Mucosa; Kinetics; Magnesium; Manganese; Molecular Weight; Substrate Specificity; Swine | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
Mechanisms of isoflurane-increased submaximum Ca2+-activated force in rabbit skinned femoral arterial strips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Inhalation; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Femoral Artery; In Vitro Techniques; Isoflurane; Male; Myosin Light Chains; Phosphorylation; Protein Kinase C; Rabbits; Vasoconstriction | 1998 |
Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; DNA Damage; Drug Resistance, Neoplasm; Egtazic Acid; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Topoisomerase II Inhibitors | 1998 |
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic | 1998 |
The okadaic acid induced ACAT activation is prevented by a specific inhibitor of the Ca2+/calmodulin protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Kinetics; Liver; Maleimides; Naphthalenes; Okadaic Acid; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase | 1998 |
Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Phosphorylase Kinase; Phosphorylation; Rats; Recombinant Proteins; Serine; Substrate Specificity; tau Proteins | 1998 |
Serotonin induces an increase in D-myo-inositol (1,4,5)-trisphosphate 3-kinase activity in rat brainstem slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzylamines; Brain Stem; Calcium-Calmodulin-Dependent Protein Kinases; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Indophenol; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Sulfonamides | 1998 |
Fibroblast growth factor receptor signaling in Xenopus retinal axon extension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Brain-Derived Neurotrophic Factor; Cadherins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Size; Cells, Cultured; Cyclohexanones; Fibroblast Growth Factor 2; Growth Cones; Isoenzymes; Lipoprotein Lipase; Neurites; Phospholipase C gamma; Receptors, Fibroblast Growth Factor; Retina; Second Messenger Systems; Transfection; Type C Phospholipases; Xenopus laevis | 1998 |
Stimulators of the cAMP cascade reverse amnesia induced by intra-amygdala but not intrahippocampal KN-62 administration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Avoidance Learning; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hippocampus; Injections; Male; Mental Recall; Rats; Rats, Wistar; Reaction Time; Retention, Psychology | 1999 |
Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cricetinae; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Gene Expression; Genes, fos; Glutamic Acid; Kainic Acid; Male; Mesocricetus; N-Methylaspartate; Phosphorylation; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 1999 |
Regulation of vascular smooth muscle migration by mitogen-activated protein kinase and calcium/calmodulin-dependent protein kinase II signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoprotein Phosphatases; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Signal Transduction | 1998 |
Activation of the P2Z/P2X7 receptor in human lymphocytes produces a delayed permeability lesion: involvement of phospholipase D.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cell Membrane Permeability; Choline; Coloring Agents; Humans; Isotonic Solutions; Lymphocytes; Magnesium; Models, Biological; Phospholipase D; Propidium; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Time Factors | 1999 |
Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, enhances L-type Ca2+ current and [Ca2+]i transient in cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Growth Inhibitors; Guinea Pigs; Heart; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 1999 |
Cocaine decreases the glycine-induced Cl- current of acutely dissociated rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anesthetics, Local; Animals; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Glycine Agents; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Strychnine; Sulfonamides; Tetrodotoxin | 1999 |
The amygdala is involved in the modulation of long-term memory, but not in working or short-term memory.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Avoidance Learning; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; Male; Memory, Short-Term; Muscarinic Antagonists; Norepinephrine; Picrotoxin; Rats; Rats, Wistar; Scopolamine; Time Factors | 1999 |
1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Hypoxia; Cell Membrane; Deoxyglucose; Glucose; Glucose Transporter Type 4; Glycogen; In Vitro Techniques; Insulin; Insulin Antagonists; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 1999 |
Calcium-dependent mechanisms involved in presynaptic long-term depression at the hippocampal mossy fibre-CA3 synapse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Chelating Agents; Cyclopropanes; Egtazic Acid; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Magnesium; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Neural Inhibition; Neuronal Plasticity; Phosphorylation; Presynaptic Terminals; Receptors, Metabotropic Glutamate | 1999 |
Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Axonal Transport; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Neurites; Neurons, Afferent; Phenanthridines; Protein Kinase C | 1999 |
A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoates; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Depression, Chemical; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Methoxyhydroxyphenylglycol; Neuronal Plasticity; Rats; Rats, Wistar; Signal Transduction; Synaptic Transmission | 1999 |
Novel regulation of the A-type K+ current in murine proximal colon by calcium-calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Colon; Enzyme Inhibitors; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Kinetics; Mice; Mice, Inbred BALB C; Muscle, Smooth; Patch-Clamp Techniques; Potassium; Sulfonamides | 1999 |
alpha1-adrenergic receptor activation of c-fos expression in transfected rat-1 fibroblasts: role of Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium; Calmodulin; Doxazosin; Egtazic Acid; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Genes, fos; Imidazoles; Kinetics; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Sulfonamides; Transcription, Genetic; Trifluoperazine | 1999 |
Ca2+/calmodulin-dependent protein kinase II inhibitors potentiate superoxide production in polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Drug Interactions; Enzyme Inhibitors; In Vitro Techniques; Male; Mice; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sulfonamides; Superoxides; Tumor Necrosis Factor-alpha | 1999 |
5-Hydroxytryptamine2A receptor stimulation induces activator protein-1 and cyclic AMP-responsive element binding with cyclic AMP-responsive element-binding protein and Jun D as common components in cerebellar neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphetamines; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Kinetics; Neurons; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Receptor Agonists; Transcription Factor AP-1; Transcription, Genetic; Up-Regulation | 1999 |
Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Tolerance; Enzyme Inhibitors; Hippocampus; Male; Morphine Dependence; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Sulfonamides | 1999 |
Effect of calcium on the uptake of glutamate by synaptosomes: possible involvement of two different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cerebral Cortex; Chelating Agents; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Synaptosomes; Tetrodotoxin; Trifluoperazine | 1999 |
Defective regulation of Ca2+/calmodulin-dependent protein kinase II in gamma-irradiated ataxia telangiectasia fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Ataxia Telangiectasia; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Induction; Fibroblasts; Gamma Rays; Humans; Mitogens | 1999 |
Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Arachidonic Acid; Benzodiazepines; Benzothiadiazines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Genistein; GTP-Binding Proteins; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, AMPA; Signal Transduction; Virulence Factors, Bordetella; Wortmannin | 1999 |
Regulation of glycine transport in cultured Müller cells by Ca2+/calmodulin-dependent enzymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Transport Systems, Neutral; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carrier Proteins; Cell Line; Chick Embryo; Enzyme Inhibitors; Glycine Plasma Membrane Transport Proteins; Imidazoles; Kinetics; Sulfonamides; Trifluoperazine | 1999 |
Involvement of calmodulin and protein kinase C in the regulation of K+ transport by carbachol across the rat distal colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbachol; Cholinergic Agonists; Colon; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Transport; Potassium; Protein Kinase C; Rats; Rats, Wistar; Rubidium Radioisotopes; Staurosporine | 1999 |
Inhibitors of calmodulin-dependent protein kinase are nonspecific blockers of voltage-dependent K+ channels in vascular myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Kinetics; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium; Rabbits; Sulfonamides | 1999 |
Xenon induces metaphase arrest in rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anaphase; Anesthetics, Inhalation; Animals; Astrocytes; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromosome Segregation; Helium; Ionomycin; Isoflurane; Metaphase; Mitosis; Mitotic Index; Nitrogen; Rats; Time Factors; Xenon | 1999 |
Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cell Line; Enzyme Inhibitors; Humans; Interleukin-1; L-Lactate Dehydrogenase; Lipopolysaccharides; Monocytes; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 1999 |
Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Amnesia, Retrograde; Animals; Avoidance Learning; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Environment; Enzyme Inhibitors; Hippocampus; Indoles; Injections; Male; Psychomotor Performance; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
Polycations induce calcium signaling in glomerular podocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Benzoquinones; Calcium Signaling; Cells, Cultured; DEAE-Dextran; Heparin; Kidney Glomerulus; Lactams, Macrocyclic; Marine Toxins; Mice; Muramidase; Oxazoles; Protamines; Quinones; Rifabutin; Staurosporine; Thapsigargin | 1999 |
Ca2+/calmodulin-dependent protein kinase II isoenzymes gamma and delta are both present in H+/K+-ATPase-containing rabbit gastric tubulovesicles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; H(+)-K(+)-Exchanging ATPase; Immunochemistry; In Vitro Techniques; Isoenzymes; Parietal Cells, Gastric; Phosphorylation; Precipitin Tests; Rabbits; Substrate Specificity | 1999 |
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CD28 Antigens; Cell Adhesion Molecules; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Fluid; Ionophores; Jurkat Cells; Lymphocyte Activation; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation | 1999 |
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Calmodulin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; Isoquinolines; Nimodipine; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured | 1999 |
Role of calcium/calmodulin-dependent protein kinases in expression of Fos protein in the nucleus tractus solitarii after sustained hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Hypertension; Male; Medulla Oblongata; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; RNA, Messenger; Solitary Nucleus | 2000 |
Functional characterization of the P2X(4) receptor orthologues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Axons; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Recombinant Proteins; Suramin | 2000 |
Short- and long-term memory are differentially affected by metabolic inhibitors given into hippocampus and entorhinal cortex.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Animals; Avoidance Learning; Carbazoles; Entorhinal Cortex; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Hippocampus; Indoles; Inhibition, Psychological; Male; Memory; Memory, Short-Term; Phenols; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Sodium Chloride; Staurosporine | 2000 |
Interactions of calcium/calmodulin-dependent protein kinases (CaMK) and extracellular-regulated kinase (ERK) in monocyte adherence and TNFalpha production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Enzyme Inhibitors; Humans; Lipopolysaccharides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Peptides; Tumor Necrosis Factor-alpha | 2000 |
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines | 2000 |
Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Humans; Macrophages; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Structure-Activity Relationship | 2000 |
Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nitrates; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Tyrphostins | 2000 |
Intra-hippocampal KN-62 hinders the memory of habituation acquired alone, but not simultaneously with a water-finding task.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Habituation, Psychophysiologic; Hippocampus; Male; Maze Learning; Memory; Microinjections; Rats; Rats, Wistar | 1999 |
N-methyl-D-aspartate enhancement of the glycine response in the rat sacral dorsal commissural neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Spinal Cord | 2000 |
Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcimycin; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Gene Expression Regulation; Heart; Ionomycin; Kinetics; Models, Cardiovascular; Myocardium; Myosin Heavy Chains; Promoter Regions, Genetic; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Antibodies, Blocking; Benzoxazoles; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Fluorescent Dyes; Humans; Imidazoles; In Vitro Techniques; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Receptors, Purinergic P2X7; Stimulation, Chemical | 2000 |
A novel protein kinase from Brassica juncea stimulated by a protozoan calcium binding protein. Purification and partial characterization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brassica; Calcium; Calcium Signaling; Calcium-Binding Proteins; Calmodulin; Chelating Agents; Egtazic Acid; Entamoeba histolytica; Histones; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Peptides; Phosphorylation; Phosphoserine; Plant Proteins; Protein Kinases; Protein Processing, Post-Translational; Protozoan Proteins; Recombinant Fusion Proteins; Staurosporine; Sulfonamides | 2000 |
Membrane depolarization-mediated survival of sympathetic neurons occurs through both phosphatidylinositol 3-kinase- and CaM kinase II-dependent pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Chromones; Drug Synergism; Enzyme Inhibitors; Ganglia, Sympathetic; Membrane Potentials; Morpholines; Nerve Growth Factor; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats | 2000 |
A possible role for Ca(2+)/calmodulin-dependent protein kinase IV during pancreatic acinar stimulus-secretion coupling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Immunoblotting; Indole Alkaloids; Male; Myosin-Light-Chain Kinase; Pancreas; Phosphotransferases; Rats; Rats, Sprague-Dawley; Sincalide; Sulfonamides | 2000 |
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclosporine; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Okadaic Acid; Piperidines; Pyrilamine; Ranitidine; Receptors, Histamine H1; Sulfonamides; Tacrolimus; Tumor Cells, Cultured | 2000 |
Developmental regulation of neuronal KCa channels by TGFbeta 1: transcriptional and posttranscriptional effects mediated by Erk MAP kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Ganglia, Parasympathetic; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Mitogen-Activated Protein Kinases; Neurons; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta | 2000 |
Na(+) channel regulation by calmodulin kinase II in rat cerebellar granule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ion Transport; Patch-Clamp Techniques; Peptide Fragments; Rats; Sodium; Sodium Channels | 2000 |
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Choline O-Acetyltransferase; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Mice; Neoplasm Proteins; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Processing, Post-Translational; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2001 |
Regulation of Ca(2+)-activated K(+) channels by multifunctional Ca(2+)/calmodulin-dependent protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Feedback; Glomerular Mesangium; Humans; Large-Conductance Calcium-Activated Potassium Channels; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated | 2000 |
Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Conditioning, Psychological; Enzyme Inhibitors; Hippocampus; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2000 |
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Involvement of distinct signaling pathways in activin-induced increases in FSH secretion and enlargement of FSH cell population in the rat pituitary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Activins; Animals; Antibody Specificity; Bromodeoxyuridine; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Growth Substances; Humans; Inhibins; Nicardipine; Pituitary Gland, Anterior; Rats; Signal Transduction | 2000 |
Mechanism for increase in expression of cerebral diazepam binding inhibitor mRNA by nicotine: involvement of L-type voltage-dependent calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Local; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dibucaine; Enzyme Inhibitors; Gene Expression; Hexamethonium; Lidocaine; Membrane Potentials; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; omega-Agatoxin IVA; omega-Conotoxin GVIA; Platelet Aggregation Inhibitors; Procainamide; RNA, Messenger; Sulfonamides; Tetrodotoxin; Tritium | 2000 |
Regulation of a voltage-sensitive release mechanism by Ca(2+)-calmodulin-dependent kinase in cardiac myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cadmium; Caffeine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Isoquinolines; Male; Myocardial Contraction; Myocardium; Patch-Clamp Techniques; Phosphorylation; Signal Transduction; Sulfonamides; Tetracaine | 2000 |
Dependence of insulin secretion from permeabilized pancreatic beta-cells on the activation of Ca(2+)/calmodulin-dependent protein kinase II. A re-evaluation of inhibitor studies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Rats; Rats, Wistar; Sulfonamides | 2000 |
P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium; Chelating Agents; Complement C5a; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guanosine Triphosphate; Humans; Intracellular Fluid; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Reactive Oxygen Species; Receptors, Purinergic P2; Uridine Triphosphate | 2000 |
Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Calcimycin; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Extracellular Space; Female; Imidazoles; Intracellular Fluid; Ionophores; Isradipine; Potassium; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Staurosporine; Zona Glomerulosa | 2001 |
A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Aminopyrine; Animals; Bucladesine; Calcium; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbon Radioisotopes; Cyclic AMP; Cytochalasin D; Cytoskeleton; Drug Interactions; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Parietal Cells, Gastric; Protein Kinase C; Rabbits; Receptors, Cytoplasmic and Nuclear; Stomach | 2001 |
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents, Phytogenic; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; DNA; DNA Damage; DNA Topoisomerases, Type II; Drug Synergism; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans | 2001 |
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation | 2001 |
Complexities of measuring antagonist potency at P2X(7) receptor orthologs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amiloride; Animals; Benzoxazoles; Buffers; Cations, Divalent; Cell Adhesion; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Ethidium; Fluorescent Dyes; Humans; Kinetics; Mice; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rosaniline Dyes; Serum Albumin, Bovine; Sodium Chloride; Species Specificity; Temperature | 2001 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcitriol; Calcium; Calmodulin; Chick Embryo; Egtazic Acid; Enzyme Activation; Fluphenazine; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Naphthalenes; Neomycin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases; Verapamil | 2001 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
KN-62 provides neuroprotection against glutamate-induced excitotoxicity in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Cerebral Cortex; Female; Glutamic Acid; Neurons; Neuroprotective Agents; Phosphorylation; Rats; Rats, Sprague-Dawley | 1999 |
CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Association Learning; Avoidance Learning; Behavior, Animal; Brachial Plexus; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Conditioning, Psychological; Enzyme Inhibitors; Inhibition, Psychological; Male; Random Allocation; Rats; Rats, Long-Evans; Taste | 2001 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Inhibitors; HL-60 Cells; Humans; Immunophilins; Immunosuppressive Agents; K562 Cells; Leukemia, Myeloid; Neoplasm Proteins; Protein Serine-Threonine Kinases; Sirolimus; Sulfonamides; Tacrolimus; Tacrolimus Binding Proteins; Tumor Cells, Cultured; U937 Cells | 2001 |
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1 | 2001 |
Histamine production by cultured microglial cells of the mouse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Histamine; Histidine Decarboxylase; Lipopolysaccharides; Mice; Microglia; RNA, Messenger | 2001 |
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adenylyl Imidodiphosphate; Animals; Bungarotoxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Imidazoles; Insecta; Insecticides; Isoquinolines; Median Nerve; Neonicotinoids; Neurons; Niacin; Nitro Compounds; Okadaic Acid; Permeability; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Nicotinic; Signal Transduction; Sulfonamides | 2001 |
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cytoskeleton; Edetic Acid; Egtazic Acid; Enzyme Inhibitors; Estrenes; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glutamic Acid; Indoles; Kinetics; Maleimides; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Transfection; Type C Phospholipases | 2001 |
Functional characterization of P2Y and P2X receptors in human eosinophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Calcium; Cells, Cultured; Chelating Agents; Chemotaxis; Egtazic Acid; Enzyme Inhibitors; Eosinophils; Humans; Intracellular Fluid; Macrophage-1 Antigen; Nucleotides; Pertussis Toxin; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Respiratory Burst; Up-Regulation; Virulence Factors, Bordetella | 2001 |
P2Y(11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; RNA, Messenger | 2001 |
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Calcium Channel Blockers; Dose-Response Relationship, Drug; Hemicholinium 3; Hippocampus; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Memory; Memory Disorders; Neurotransmitter Uptake Inhibitors; Nicardipine; Peptide Fragments; Pirenzepine; Rats; Rats, Wistar; Receptors, Vasopressin; Scopolamine | 2001 |
Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Size; Enzyme Inhibitors; Erythroid Precursor Cells; Humans; Hypotonic Solutions; K562 Cells; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Taurine; Trifluoperazine | 2001 |
CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminopyrine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Membrane; Cell Polarity; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Gastric Acid; H(+)-K(+)-Exchanging ATPase; Male; Parietal Cells, Gastric; Protein Transport; Rabbits; Rats; Rats, Wistar; Secretory Vesicles | 2002 |
Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cells, Cultured; Electrophysiology; Humans; Macrophages; Monocytes; Patch-Clamp Techniques; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rosaniline Dyes | 2002 |
Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cyclic Nucleotide-Regulated Protein Kinases; Dopamine; Enzyme Inhibitors; Female; Hypothalamus; Neurons; Prolactin; Rats; Rats, Sprague-Dawley; Sheep; Sulfonamides; Tyrosine 3-Monooxygenase | 2001 |
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Membrane Permeability; Cells, Cultured; Humans; Indicators and Reagents; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Monocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Spectrophotometry, Infrared; Structure-Activity Relationship; Tetrahydroisoquinolines; Tyrosine | 2002 |
CaMKII regulates amphetamine-induced ERK1/2 phosphorylation in striatal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphetamine; Amphetamine-Related Disorders; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; ets-Domain Protein Elk-1; Immunohistochemistry; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neostriatum; Neurons; Phosphorylation; Proto-Oncogene Proteins; Rats; Rats, Wistar; Transcription Factors; Up-Regulation | 2002 |
Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Keratinocytes; Mitogen-Activated Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-myc; Signal Transduction | 2002 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Bradykinin; Brain Chemistry; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; COS Cells; Enzyme Inhibitors; Molecular Sequence Data; p21-Activated Kinases; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Sequence Alignment; Serine; Synapsins | 2002 |
Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell-Free System; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Mast Cells; Peptide Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Rats; Serotonin; Tryptophan Hydroxylase | 2002 |
Postsynaptic kinase signaling underlies inhibitory synaptic plasticity in the lateral superior olive.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gerbillinae; Long-Term Synaptic Depression; Neuronal Plasticity; Olivary Nucleus; Organ Culture Techniques; Patch-Clamp Techniques; Peptide Fragments; Peptides; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Thionucleotides | 2002 |
KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Bacterial; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Chlamydophila Infections; Chlamydophila pneumoniae; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Receptor Cross-Talk; Signal Transduction | 2002 |
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 5-Aminolevulinate Synthetase; Animals; Blotting, Northern; Calcium; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cholesterol; Constitutive Androstane Receptor; Cytoplasm; Dose-Response Relationship, Drug; Estrogens; Gene Expression Regulation; Liver; Male; Mice; Mice, Transgenic; Models, Biological; Oligonucleotide Array Sequence Analysis; Oxygenases; Phosphoenolpyruvate Carboxykinase (ATP); Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Squalene Monooxygenase; Transcription Factors; Transcription, Genetic; Two-Hybrid System Techniques | 2003 |
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Death; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Enzyme Inhibitors; Fetus; Kinetics; Membrane Potentials; Neurons; NG-Nitroarginine Methyl Ester; Nifedipine; Nitriles; Pyrethrins; Rats; Sulfonamides; Tacrolimus; Trifluoperazine; Veratridine | 2003 |
Formation of AP-1 transcription factors during learning in Helix.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Casein Kinase II; CCAAT-Enhancer-Binding Proteins; Central Nervous System; DNA-Binding Proteins; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Exoribonucleases; Flavonoids; Genistein; Helix, Snails; Ionophores; Learning; Phorbol Esters; Protein Serine-Threonine Kinases; Serotonin; Transcription Factor AP-1 | 2003 |
Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Cholinergic Antagonists; Maze Learning; Memory; Microdialysis; Nicardipine; Nootropic Agents; Oligopeptides; Pirenzepine; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Vasopressin; Scopolamine | 2003 |
Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Insulin; Ionomycin; Male; Muscle, Smooth, Vascular; Mutation; Phosphorylation; Rats; Rats, Sprague-Dawley; Threonine | 2003 |
Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Axons; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Imidazoles; Membrane Potentials; Neurons; Peptide Fragments; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Rats; Sequence Deletion; Signal Transduction; Spiral Ganglion | 2003 |
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Arylsulfonates; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ethidium; Humans; Interleukin-1; Macrophages; Monocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Structure-Activity Relationship; Tyrosine | 2003 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
Regulation of ERK phosphorylation by ethanol in fetal cortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cerebral Cortex; Ethanol; Fetus; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation | 2003 |
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 2003 |
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; GTPase-Activating Proteins; Hippocampus; Male; MAP Kinase Signaling System; Phosphorylation; ras Proteins; Rats; Rats, Sprague-Dawley; Reaction Time; Serine; Synapses; Up-Regulation | 2003 |
Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Animals; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Hypertrophy, Left Ventricular; Infusion Pumps, Implantable; Isoproterenol; Male; Muscle Proteins; Myocardial Contraction; Myocardium; Nuclear Proteins; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Repressor Proteins; RNA, Messenger; Thionucleotides | 2003 |
A role for calcium/calmodulin kinase in insulin stimulated glucose transport.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Monosaccharide Transport Proteins; Muscle, Skeletal; Nifedipine; Phosphorylation; Rats; Rats, Sprague-Dawley | 2004 |
Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Glyburide; Humans; Interleukin-18; Leukocytes, Mononuclear; Lipopolysaccharides | 2003 |
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Densitometry; Dopamine Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia-Ischemia, Brain; Male; Nifedipine; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine; Synaptosomes; Time Factors; Trifluoperazine | 2004 |
Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylate Kinase; Animals; Benzylamines; Biological Transport; Caffeine; Calcium; Enzyme Inhibitors; Glucose; Insulin; Kinetics; Male; Muscle Contraction; Muscle, Skeletal; Rats; Rats, Wistar; Sulfonamides | 2004 |
Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Apoptosis; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Insulin; Insulin Secretion; Islets of Langerhans; Palmitates; Phorbol Esters; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Signal Transduction | 2004 |
Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Disks Large Homolog 4 Protein; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2004 |
Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Circadian Rhythm; Cricetinae; Enzyme Inhibitors; Injections, Intraventricular; Light; Mesocricetus; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphorylation; Photoperiod; Sulfonamides; Suprachiasmatic Nucleus | 2004 |
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Animals; Benzylamines; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Glycerol; Hydroxycholesterols; Indoles; Lignans; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthalenes; Oleic Acid; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vacuoles | 2004 |
Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Afferent Pathways; Amygdala; Animals; Auditory Pathways; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Conditioning, Classical; Enzyme Inhibitors; Fear; Long-Term Potentiation; Male; Memory; Neuronal Plasticity; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Thalamus | 2004 |
A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Antimicrobial Cationic Peptides; Apyrase; Binding Sites; Caspase 1; Cathelicidins; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Humans; Interleukin-1; Lipopolysaccharides; Monocytes; Protein Processing, Post-Translational; Purinergic P2 Receptor Antagonists; Receptors, Formyl Peptide; Receptors, Lipoxin; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2004 |
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine | 2004 |
Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Apoptosis; Apyrase; Autocrine Communication; Cell Shape; Cytidine Triphosphate; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Fibroblasts; Fibronectins; Gene Expression Regulation; Humans; Interleukin-6; Membrane Potentials; Paracrine Communication; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Uridine Diphosphate; Uridine Triphosphate | 2004 |
KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Extracts; Cell Line; Enzyme Inhibitors; Monocytes; Muramidase; Phosphorylation; RNA Precursors; RNA Splicing; RNA, Messenger | 2004 |
Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cations; Cattle; Dose-Response Relationship, Drug; Erythrocytes; Humans; Ions; Microscopy, Confocal; Microscopy, Fluorescence; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rubidium; Sodium; Time Factors; Uridine Triphosphate | 2004 |
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Gallopamil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Indoles; Magnesium; Memantine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nifedipine; Protein Kinase C; Pyridines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Staurosporine; Sulfonamides; Tetrodotoxin | 2004 |
The antibiotic polymyxin B modulates P2X7 receptor function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Calcium; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Ethidium; Humans; Intracellular Fluid; K562 Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Macrophages; Mice; Molecular Sequence Data; Oxidation-Reduction; Polymyxin B; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Transfection | 2004 |
Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Chickens; Dose-Response Relationship, Drug; Male; Models, Biological; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Niacinamide; Oxygen; Peptides; Phenylephrine; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Time Factors | 2004 |
AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; AMP-Activated Protein Kinases; Animals; Calcium; Cell Line, Tumor; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Insulinoma; Islets of Langerhans; Kinetics; Mice; Multienzyme Complexes; Protein Serine-Threonine Kinases | 2004 |
Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Benzenesulfonates; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Kinetics; Magnesium; Oocytes; Patch-Clamp Techniques; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X7; Suramin; Time Factors; Xenopus laevis | 2004 |
Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Bacterial; Bacterial Proteins; Cells, Cultured; Chlamydophila pneumoniae; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, Cell Surface; Rolipram; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Up-Regulation | 2004 |
Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anisomycin; Bicuculline; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Emetine; Excitatory Amino Acid Antagonists; Learning; Long-Term Potentiation; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channels; Propanolamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 2005 |
Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Active Transport, Cell Nucleus; Adenoviridae; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Fluorescence Recovery After Photobleaching; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Histone Deacetylases; Kinetics; MEF2 Transcription Factors; Mice; Mice, Inbred Strains; Microscopy, Confocal; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Myogenic Regulatory Factors; Recombinant Fusion Proteins; Staurosporine; Time Factors; Transcription Factors | 2005 |
Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Autoreceptors; Biopterins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylephrine; Piperazines; Pyridines; Raphe Nuclei; Rats; Serotonin; Serotonin Antagonists; Time Factors; Tryptophan; Tryptophan Hydroxylase | 2005 |
Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Brain; Chromones; Down-Regulation; Enzyme Inhibitors; Ischemic Preconditioning; Ketamine; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinase Kinase 11; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Time Factors | 2005 |
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; I-kappa B Kinase; Indoles; Keratinocytes; Maleimides; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotides; Phosphodiesterase Inhibitors; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; Receptor, PAR-2; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases | 2005 |
Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Gonadotropin-Releasing Hormone; JNK Mitogen-Activated Protein Kinases; Luciferases; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins c-raf; Signal Transduction; Sulfonamides | 2005 |
Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Patch-Clamp Techniques; Peptide Fragments; Peptides; Statistics, Nonparametric; Time Factors; Vestibular Nuclei | 2005 |
Human melanomas express functional P2 X(7) receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 7; Caspases; Cell Line, Tumor; Enzyme Inhibitors; Fluorescent Dyes; Humans; Melanoma; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2005 |
Effects of 17beta-estradiol on chemically induced long-term depression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Fulvestrant; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 2005 |
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Butadienes; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Chickens; Cricetinae; Cytoskeleton; Dantrolene; Flavonoids; Growth Cones; MAP Kinase Signaling System; Mesocricetus; Nerve Growth Factors; Neurons; Nifedipine; Nitriles; Peptides; Protein Kinase Inhibitors; Recombinant Fusion Proteins; Ryanodine Receptor Calcium Release Channel; Transfection; Tumor Suppressor Proteins | 2005 |
Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Benzylamines; Biological Transport, Active; Boron Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Line; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Peptides; Sulfonamides | 2005 |
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Nicotine; Nicotinic Agonists; Nimodipine; Pain Measurement; Reaction Time; Spinal Cord; Verapamil | 2005 |
Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Biological Transport; Epidermal Cells; Ethidium; Humans; Keratinocytes; Langerhans Cells; Monocytes; Polymorphism, Genetic; Receptors, IgE; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Skin | 2005 |
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Ischemia; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; GluK2 Kainate Receptor; Hippocampus; Male; Nifedipine; Phosphorylation; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Reperfusion | 2005 |
N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Phosphatase; Apoptosis; Bone and Bones; Bone Diseases, Metabolic; Caspase 3; Caspases; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Isoenzymes; Models, Chemical; NF-kappa B; Osteoblasts; Osteoclasts; Piperazines; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Tartrate-Resistant Acid Phosphatase; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basic Helix-Loop-Helix Transcription Factors; Calbindin 1; Calbindins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Cholecalciferol; Gene Expression Regulation; Hippocampus; Nerve Tissue Proteins; Neurites; Rats; Rats, Sprague-Dawley; RNA Interference; S100 Calcium Binding Protein G; Stem Cells | 2006 |
Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Drug Interactions; Endocytosis; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Okadaic Acid; Protein Transport; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Time Factors; Transfection | 2006 |
Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Cesium; Cilia; Epithelial Cells; In Vitro Techniques; Ion Channels; Ivermectin; Male; Membrane Potentials; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Sodium; Trachea | 2006 |
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bone Marrow Cells; Boron Compounds; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Erythroblasts; Female; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Mice; Mice, Inbred C57BL; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; RNA, Messenger | 2006 |
Modulation by LL-37 of the responses of salivary glands to purinergic agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Antimicrobial Cationic Peptides; Calcium; Cathelicidins; Cations, Divalent; Cell Membrane; Enzyme Inhibitors; Group IV Phospholipases A2; Magnesium; Male; Membrane Fluidity; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Phospholipases A; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2X7; Salivary Glands; Submandibular Gland | 2006 |
Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cocaine; Dose-Response Relationship, Drug; Heart Ventricles; Hypertrophy; Male; Membrane Potentials; Myocytes, Cardiac; Myosin Heavy Chains; Patch-Clamp Techniques; Peptides; Phenylephrine; Phosphorus Radioisotopes; Phosphorylation; Rats; Rats, Sprague-Dawley; Sarcolemma | 2006 |
KN-62 analogues as potent differentiating agents of HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; CD11b Antigen; Cell Differentiation; Cell Proliferation; Enzyme Inhibitors; HL-60 Cells; Humans; Molecular Structure | 2007 |
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Boron Compounds; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Guinea Pigs; Ileum; Indoles; Male; Maleimides; Norepinephrine; Phenethylamines; Pyrrolidinones; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Signal Transduction; Submucous Plexus; Synaptic Transmission; Tetrodotoxin; Theophylline; Triazines; Triazoles | 2007 |
The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cognition; CREB-Binding Protein; Down-Regulation; Enzyme Inhibitors; Exercise Therapy; Hippocampus; Learning; Male; Maze Learning; Memory; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Up-Regulation | 2007 |
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Proliferation; Chelating Agents; Chlorocebus aethiops; Endorphins; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Isoquinolines; MAP Kinase Signaling System; Mice; Nifedipine; Protein Kinase Inhibitors; Sulfonamides; Verapamil | 2007 |
Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apoptosis; Calcium; Caspase 3; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Enzyme Activation; Extracellular Fluid; Flow Cytometry; Humans; Intracellular Membranes; Mesangial Cells; Microscopy, Phase-Contrast; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Time Factors | 2007 |
Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calmodulin-Binding Proteins; Cations; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Ion Channels; Membrane Potentials; Membrane Transport Modulators; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Tetraethylammonium; Time Factors | 2007 |
Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Dexamethasone; Gene Deletion; Gene Expression Regulation; Glucocorticoids; Homeodomain Proteins; Nifedipine; Paired Box Transcription Factors; Pro-Opiomelanocortin; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; T-Box Domain Proteins; Transfection | 2007 |
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Bone Resorption; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cathepsin K; Cathepsins; Cell Differentiation; Cell Line; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Macrophages; Mice; Mice, Inbred C57BL; Osteoclasts; Phosphorylation; Protein Kinase Inhibitors; RANK Ligand; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Time Factors; Transcription, Genetic; Transfection | 2007 |
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium Signaling; Cells, Cultured; Cyclosporine; Electric Stimulation; Gene Expression Regulation; Hexokinase; Ionomycin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Kinases; Rats; Rats, Wistar; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2007 |
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; beta-Alanine; Calcium; Cell Line; Cell Membrane; Cell Membrane Permeability; Ethidium; Fluorescent Dyes; Glycine; Humans; Isoquinolines; Naphthalenes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfones; Tyrosine | 2007 |
Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Dendrites; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hepatocyte Growth Factor; Hippocampus; Immunohistochemistry; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 2007 |
A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; B-Lymphocytes; Barium; Biological Transport; Calcium; Chlorides; Enzyme Inhibitors; Ethidium; Flow Cytometry; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Monocytes; Potassium; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reproducibility of Results; Sodium; T-Lymphocytes; Temperature | 2007 |
Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Biological Transport; Calcium; Carbachol; Ethidium; Interleukin-1beta; Mice; Mice, Knockout; Phospholipases A2; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Saliva; Submandibular Gland | 2007 |
Functional expression of ionotropic purinergic receptors on mouse taste bud cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Signaling; Fluorescent Dyes; Immunohistochemistry; In Vitro Techniques; Isoquinolines; Membrane Potentials; Mice; Microscopy, Fluorescence; Patch-Clamp Techniques; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X7; Receptors, Purinergic P2Y1; Reverse Transcriptase Polymerase Chain Reaction; Taste; Taste Buds; Thionucleotides; Time Factors; Uridine Triphosphate | 2007 |
Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Nicotine; Pain Measurement; Spinal Cord; Sulfonamides | 2007 |
Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Cell Line; Dopamine; Dose-Response Relationship, Drug; Mice; Mice, Transgenic; Necrosis; Neurons; Receptors, Purinergic P2; Receptors, Purinergic P2X7; RNA, Small Interfering; Time Factors | 2007 |
Role for calcium in the development of ovarial patency in Heliothis virescens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Boron Compounds; Calcium; Dose-Response Relationship, Drug; Female; Juvenile Hormones; Moths; omega-Conotoxins; Ovary; Protein Kinase Inhibitors; Ryanodine; Thapsigargin | 2008 |
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Cloning, Molecular; Guinea Pigs; Humans; Mice; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rosaniline Dyes; Species Specificity; Suramin | 2008 |
Negative and positive allosteric modulators of the P2X(7) receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Allosteric Regulation; Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Ethidium; Glycine; Humans; Molecular Structure; Piperazines; Protein Conformation; Pyridoxal Phosphate; Quinolines; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Recombinant Proteins; Species Specificity; Time Factors; Transfection; Vanadates | 2008 |
A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aequorin; Arabidopsis; Arabidopsis Proteins; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cytosol; Gene Expression Regulation, Plant; Genetic Complementation Test; Homeostasis; Saccharomyces cerevisiae; Salts; Signal Transduction; Sodium | 2008 |
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Butadienes; Carbazoles; Conotoxins; Egtazic Acid; GATA2 Transcription Factor; Humans; Imidazoles; Indoles; Keratinocytes; Nerve Tissue Proteins; Nicotine; Nitriles; Phenols; Polyenes; Polyunsaturated Alkamides; Pyridines; Receptors, Nicotinic; RNA, Small Interfering; Signal Transduction; Smoking; Tobacco Smoke Pollution; Tyrphostins; Up-Regulation | 2008 |
Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]i is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Kidney Tubules, Proximal; Membrane Potentials; Opossums; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying | 2008 |
Silencing-induced metaplasticity in hippocampal cultured neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Analysis of Variance; Animals; Calcium Channel Blockers; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Mice; Mice, Inbred C57BL; Neural Inhibition; Neuronal Plasticity; Neurons; Nifedipine; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Valine | 2008 |
[Effects of chronic hypoxia on the expression of calmodulin and calcicum/calmodulin-dependent protein kinase II and the calcium activity in myocardial cells in young rats].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Chronic Disease; Hypoxia; Male; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Carbenoxolone; Cell Line; Cell Membrane Permeability; Connexins; Dose-Response Relationship, Drug; Flufenamic Acid; Gap Junctions; Humans; Macrophages; Mefloquine; Membrane Potentials; Mice; Nerve Tissue Proteins; Oocytes; Phosphorylation; Receptors, Purinergic P2; Receptors, Purinergic P2X7; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Xenopus | 2008 |
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Dose-Response Relationship, Drug; Glycine; Humans; Imidazoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperazines; Plasmids; Polymorphism, Single Nucleotide; Protein Binding; Protein Structure, Tertiary; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridines; Pyridoxal Phosphate; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Sequence Alignment; Species Specificity; Transfection | 2008 |
The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Antimicrobial Cationic Peptides; Calcium; Calcium Signaling; Cathelicidins; Cell Proliferation; Enzyme Inhibitors; Ethidium; Fibroblasts; Gene Expression Regulation; Humans; Mice; NIH 3T3 Cells; Protein Structure, Secondary; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Structure-Activity Relationship | 2008 |
Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Apyrase; Astrocytes; Benzenesulfonates; Benzoxazoles; Cell Line; Cells, Cultured; Gene Knockdown Techniques; Humans; Ligands; Mice; Phenolsulfonphthalein; Propidium; Purinergic P2 Receptor Antagonists; Quinolinium Compounds; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X7; RNA, Small Interfering; Suramin | 2009 |
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 14-3-3 Proteins; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cricetinae; Glucose Transporter Type 4; Insulin; Mice; Myosin Type I; Myosins; Phosphorylation; Protein Transport | 2008 |
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Dendritic Spines; Disks Large Homolog 4 Protein; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamates; Green Fluorescent Proteins; Hippocampus; Indoles; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Membrane Proteins; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phosphorylation; Piperazines; Point Mutation; Protein Structure, Tertiary; Protein Transport; Rats; Rats, Sprague-Dawley; Serine; Time Factors | 2008 |
Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Berberine Alkaloids; Cell Differentiation; Cell Line; Chemistry, Pharmaceutical; Drug Design; Ethidium; Humans; Interleukin-1beta; Lipopolysaccharides; Models, Chemical; Purinergic P2 Receptor Antagonists; Quinolizines; Receptors, Purinergic P2X7; Structure-Activity Relationship | 2009 |
Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Enzyme Inhibitors; Exocytosis; Hippocampus; Myosin Heavy Chains; Myosin Type V; Neurons; Protein Structure, Tertiary; Rats; Rats, Wistar; Recombinant Fusion Proteins; Secretory Vesicles | 2009 |
The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apoptosis; Benzoxazoles; Biological Transport; Calcium; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leukemia; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinolinium Compounds; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Spectrometry, Fluorescence; Time Factors | 2009 |
Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Claudin-1; DNA Primers; Electric Impedance; Epithelium, Corneal; Humans; Membrane Proteins; Neurokinin-1 Receptor Antagonists; Occludin; Phosphoproteins; Physalaemin; Substance P; Tight Junctions; Up-Regulation; Zonula Occludens-1 Protein | 2009 |
Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Embryonic Development; Female; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Male; Mice; Mice, Inbred ICR; Oxazoles; Sulfonamides | 2009 |
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred ICR; Neural Inhibition; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Protein Kinase Inhibitors; Receptors, GABA-A; Thalamic Nuclei | 2010 |
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Genetically Modified; Blotting, Western; Calcium; Cells, Cultured; Charcot-Marie-Tooth Disease; Demyelinating Diseases; Enzyme Inhibitors; Gene Expression Regulation; Immunohistochemistry; Membrane Potential, Mitochondrial; Microscopy; Myelin Proteins; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Schwann Cells | 2009 |
A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Energy Metabolism; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Models, Biological; Nimodipine; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley | 2009 |
A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Count; Enzyme Inhibitors; Exploratory Behavior; Immunohistochemistry; Infusion Pumps; Male; Memory; Neurons; Peptides; Phosphorylation; Rats; Recognition, Psychology; Time Factors | 2009 |
Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Dithiothreitol; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutathione; Glutathione Disulfide; Heart Ventricles; Hydrogen Peroxide; Hypoxia; Indoles; Male; Maleimides; Myocytes, Cardiac; Oxidation-Reduction; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfonamides; Time Factors | 2009 |
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cyclosporine; Humans; Indoles; Kidney Tubules, Proximal; Maleimides; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C | 2009 |
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Apyrase; Cell Proliferation; Cell Survival; Enzyme Activation; Focal Adhesion Kinase 1; High-Energy Shock Waves; Humans; Interleukin-2; Jurkat Cells; Lymphocyte Activation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; RNA Interference; Signal Transduction; Suramin; T-Lymphocytes | 2010 |
Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Agents; Coumarins; Cytochalasin D; Enzyme Inhibitors; Furocoumarins; Glutamic Acid; Hippocampus; Ionomycin; Male; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Synapsins; Synaptic Vesicles | 2010 |
Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Association Learning; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Critical Period, Psychological; Enzyme Activation; Lymnaea; Memory; Receptors, N-Methyl-D-Aspartate; Time Factors | 2010 |
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Hydrogen-Ion Concentration; Macrolides; Male; Membrane Microdomains; Organelles; Protein Kinase C; Protein Subunits; Proteomics; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; RNA Interference; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staurosporine; Vacuolar Proton-Translocating ATPases | 2010 |
TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Antigens, CD; Apyrase; B7-2 Antigen; Cells, Cultured; Humans; Interferon-gamma; Lipopolysaccharide Receptors; Lipopolysaccharides; Monocytes; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Transforming Growth Factor beta1; Up-Regulation | 2010 |
Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line, Tumor; Lymph Nodes; Lymphatic Metastasis; Lymphocytes; Lymphoma; Mice; Mice, Inbred DBA; Molecular Targeted Therapy; Neoplasm Transplantation; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA, Small Interfering | 2010 |
Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Aqueous Humor; Cattle; Cell Line; Ciliary Body; Connexins; Dithiothreitol; Enzyme Inhibitors; Epithelial Cells; HEK293 Cells; Heptanol; Humans; Macrolides; Nerve Tissue Proteins; Probenecid; Receptors, Purinergic P2X7 | 2010 |
Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Enzyme Inhibitors; Humans; Imidazoles; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Synaptotagmin I | 2011 |
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Animals; Benzophenanthridines; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Imidazoles; Indoles; Maleimides; Mice; Muscle, Skeletal; Nifedipine; Potassium Channels, Voltage-Gated; Protein Kinase C; Synapses | 2010 |
LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Gene Expression Regulation, Enzymologic; Hippocampus; Long-Term Potentiation; Membrane Proteins; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Up-Regulation | 2011 |
Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cell Cycle; Cell Line, Tumor; Feedback, Physiological; Gene Expression Profiling; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Systems Biology; Transcription Factors | 2010 |
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Psychological; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Intraventricular; Isoquinolines; Male; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Sulfonamides; Wortmannin | 2011 |
TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Gene Knockdown Techniques; Interleukin-6; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mice; NF-kappa B; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Stress, Mechanical; Sulfonamides | 2011 |
Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Humans; I-kappa B Proteins; Imidazoles; Macrophages; NF-kappaB-Inducing Kinase; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides | 2011 |
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Benzoxazoles; HEK293 Cells; Humans; Macaca mulatta; Membrane Potentials; Molecular Sequence Data; Patch-Clamp Techniques; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Pyridines; Quinolinium Compounds; Receptors, Purinergic P2X7; Single-Cell Analysis; Tetrazoles; Thiazoles | 2011 |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; Animals; Avoidance Learning; Benzazepines; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dobutamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Memory, Long-Term; Memory, Short-Term; Neuronal Plasticity; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, N-Methyl-D-Aspartate | 2011 |
Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adult; Calcium Signaling; Female; Homeostasis; Humans; Intracellular Fluid; Leukocytes, Mononuclear; Male; Middle Aged; Receptors, Purinergic P2X7; Renal Insufficiency, Chronic | 2012 |
4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Apoptosis; Calcium; Calcium Channels; Caspase 3; Caspase 9; Humans; Leukemia, Myeloid, Acute; Membrane Potential, Mitochondrial; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA Interference; RNA, Small Interfering; Tumor Cells, Cultured | 2011 |
Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adipocytes; Aged; Blotting, Western; Calcium Signaling; Case-Control Studies; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Inflammasomes; Inflammation; Inflammation Mediators; Interleukin-6; Intra-Abdominal Fat; Italy; Metabolic Syndrome; Middle Aged; Plasminogen Activator Inhibitor 1; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Real-Time Polymerase Chain Reaction; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Subcutaneous Fat; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Increased expression of calcium/calmodulin-dependent protein kinase type II subunit δ after rat traumatic brain injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Brain Injuries; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caspase 3; Disease Models, Animal; Enzyme Inhibitors; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Recovery of Function; Up-Regulation | 2012 |
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chelating Agents; Chlorocebus aethiops; CREB-Binding Protein; Cystatins; Dendrites; Egtazic Acid; Embryo, Mammalian; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Growth Cones; Hippocampus; Male; Microscopy, Confocal; Neurites; Neurons; Nifedipine; Potassium Chloride; Pseudopodia; Rats; RNA, Messenger; RNA, Small Interfering; Transfection; Up-Regulation; Valine | 2011 |
Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Apyrase; Carbenoxolone; Cell Communication; Cell Line, Tumor; Connexins; Gap Junctions; Humans; Membrane Potentials; Mice; Nerve Tissue Proteins; Neuroblastoma; Patch-Clamp Techniques; Purinergic P2X Receptor Antagonists; Signal Transduction; Suramin | 2012 |
Extracellular ATP induces P2X7-dependent nicotinamide phosphoribosyltransferase release in LPS-activated human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cellular Microenvironment; Cytokines; Extracellular Space; Humans; Immunity, Innate; Inflammation; Lipopolysaccharides; Monocytes; Nicotinamide Phosphoribosyltransferase; Receptors, Purinergic P2X7; Signal Transduction | 2012 |
Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Calcineurin; Calcineurin Inhibitors; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Humans; Interleukin-10; MADS Domain Proteins; MEF2 Transcription Factors; Myogenic Regulatory Factors; Promoter Regions, Genetic; Protein Kinase Inhibitors; RNA, Messenger; T-Lymphocytes; Up-Regulation | 2012 |
NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Animals; Enzyme Inhibitors; Female; Free Radical Scavengers; Histone Deacetylases; Hydrogen Peroxide; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Fibers, Fast-Twitch; NADPH Oxidase 2; NADPH Oxidases; Protein Kinases; Reactive Oxygen Species; Recombinant Fusion Proteins | 2012 |
The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chlorides; Clathrin; Endocytosis; G-Protein-Coupled Receptor Kinases; GTP-Binding Protein alpha Subunits, Gq-G11; Histamine; Histamine H1 Antagonists; Humans; Receptors, Histamine H1; Tumor Cells, Cultured; Zinc Compounds | 2012 |
Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate/P2X7 receptor activation in human periodontal ligament cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Benzenesulfonates; Calcium Channel Blockers; Calcium Signaling; Cell Culture Techniques; Cell Survival; Cells, Cultured; Coloring Agents; Dactinomycin; Homeostasis; Humans; Interleukin-1beta; Luminescent Measurements; Periodontal Ligament; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; RNA, Small Interfering; Signal Transduction; Stress, Mechanical; Suramin; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2013 |
IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Adenosine Triphosphate; Anti-Bacterial Agents; Calcimycin; Calcium Ionophores; Cell-Derived Microparticles; Humans; Interleukin-18; Lipopolysaccharides; Macrophages; Polymyxin B; Protein Precursors; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Pyridines; Quinolines; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Sulfonamides; Tetrazoles; Toll-Like Receptor 4 | 2012 |
The antidepressant-like effect of physical activity on a voluntary running wheel.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Hindlimb Suspension; Isoquinolines; Male; Mice; Physical Conditioning, Animal; Protein Kinase Inhibitors; Sulfonamides | 2013 |
Dentin phosphophoryn activates Smad protein signaling through Ca2+-calmodulin-dependent protein kinase II in undifferentiated mesenchymal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Differentiation; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cattle; Cell Differentiation; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Extracellular Matrix Proteins; Humans; Mesenchymal Stem Cells; Mice; NFATC Transcription Factors; Osteoblasts; Osteogenesis; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Sialoglycoproteins; Smad Proteins, Receptor-Regulated; Smad1 Protein; Transcription Factors | 2013 |
Multidirectional effects of calmodulin kinase II on transmitter release in mature and newly formed mouse motor synapses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Mice; Motor Endplate; Neurotransmitter Agents; Nitrendipine; Okadaic Acid; Phosphoric Monoester Hydrolases; Sulfonamides; Synapses; Synaptic Transmission | 2013 |
Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animal Fins; Animals; Caspase 1; Caspase Inhibitors; Conserved Sequence; Down-Regulation; Embryo, Nonmammalian; Humans; Inflammation; Interleukin-1beta; Leukocytes; NF-kappa B; Rosaniline Dyes; Signal Transduction; Up-Regulation; Zebrafish | 2014 |
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2014 |
Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cells, Cultured; Enzyme Inhibitors; Female; Kinetics; Male; Membrane Potentials; Neurons; Nociceptin; Opioid Peptides; Parietal Lobe; Patch-Clamp Techniques; Potassium Channels; Rats, Wistar; Sulfonamides | 2014 |
Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Cerebellum; Fura-2; Glutamic Acid; Mice; Mice, Inbred C57BL; Neurons; Purinergic P2X Receptor Antagonists; Pyridines; Receptors, Purinergic P2X7; Tetrazoles | 2014 |
Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arthritis, Experimental; Carrageenan; Cattle; Collagen Type II; Drug Discovery; Edema; Enzyme-Linked Immunosorbent Assay; HEK293 Cells; Humans; Hydantoins; Immunoblotting; Inflammation; Interleukin-1beta; Long-Term Potentiation; Macrophages; Male; Mice, Inbred DBA; Molecular Structure; Monocytes; Neuralgia; Purinergic P2X Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Structure-Activity Relationship; Sulfonic Acids; Tissue Distribution | 2015 |
L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Stem; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Female; Male; Nifedipine; Receptors, Serotonin, 5-HT3; Serotonin; Shrews; Vomiting | 2015 |
Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cholinergic Neurons; Colon; Enzyme Inhibitors; In Vitro Techniques; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Myosin-Light-Chain Kinase; Naphthalimides; Peptide Fragments; Pyridines; Rats, Sprague-Dawley; Receptor, Muscarinic M3; rho-Associated Kinases | 2014 |
Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disks Large Homolog 4 Protein; Fas Ligand Protein; Intracellular Signaling Peptides and Proteins; Ischemic Preconditioning; JNK Mitogen-Activated Protein Kinases; Male; Membrane Proteins; Neurons; Nitric Oxide Synthase Type I; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2016 |
Differential Modulation of GABAA Receptors Underlies Postsynaptic Depolarization- and Purinoceptor-Mediated Enhancement of Cerebellar Inhibitory Transmission: A Non-Stationary Fluctuation Analysis Study.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cerebellum; Female; Isoquinolines; Male; Patch-Clamp Techniques; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Purinergic; Signal Transduction; Sulfonamides; Synapses; Synaptic Potentials | 2016 |
The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine/chemokine production in infected human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cells, Cultured; Chemokines; Cytokines; Dengue; Dengue Virus; Humans; Monocytes; Nitric Oxide; Receptors, Purinergic P2X7; Viral Load | 2016 |
CaMKII mediates stimulus specificity in early odor preference learning in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP; Enzyme Inhibitors; Female; Learning; Male; Memory; Odorants; Olfactory Bulb; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Thionucleotides; Time Factors | 2016 |
Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Conditioning, Operant; Cues; Enzyme Inhibitors; Extinction, Psychological; HEK293 Cells; Humans; Male; Memory; Phosphorylation; Proteomics; Rats; Rats, Sprague-Dawley; Self Administration; Serine; Signal Transduction; Sulfonamides | 2016 |
CaMKII inhibition promotes neuronal apoptosis by transcriptionally upregulating Bim expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Apoptosis; Bcl-2-Like Protein 11; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; HEK293 Cells; Humans; Neurons; Peptides; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Transfection; Up-Regulation | 2016 |
Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Agrin; Animals; Benzoquinones; Bungarotoxins; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cell Line; Gene Expression; Lactams, Macrocyclic; Laminin; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Protein Aggregates; Receptors, Cholinergic; Sodium Channel Blockers; Sodium Channels; Staining and Labeling; Tetrodotoxin; Verapamil | 2017 |
An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Activating Transcription Factor 3; Allergens; Animal Testing Alternatives; Biological Assay; Cell Survival; Cells, Cultured; Dinitrochlorobenzene; Glutamate-Cysteine Ligase; Haptens; HSP40 Heat-Shock Proteins; Humans; Hypersensitivity; Interleukin-8; Keratinocytes; L-Lactate Dehydrogenase; Local Lymph Node Assay; NF-E2-Related Factor 2; Purinergic P2X Receptor Antagonists; RNA, Small Interfering | 2017 |
Inhibition of the lateral habenular CaMKⅡ abolishes naloxone-precipitated conditioned place aversion in morphine-dependent mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Avoidance Learning; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Classical; Habenula; Male; Mice, Inbred C57BL; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Substance Withdrawal Syndrome | 2017 |
The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Biomarkers; Calcium; Cell Adhesion; Cell Differentiation; Cell Surface Extensions; Extracellular Space; Gene Knockdown Techniques; Human Embryonic Stem Cells; Humans; Ion Channel Gating; Models, Biological; Purinergic P2X Receptor Antagonists; rac GTP-Binding Proteins; Receptors, Purinergic P2X7; rho GTP-Binding Proteins; Thiazoles; Time-Lapse Imaging | 2017 |
CaMKII inhibition mitigates ischemia/reperfusion-elicited calpain activation and the damage to membrane skeleton proteins in isolated rat hearts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calpain; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Heart; In Vitro Techniques; Male; Membrane Proteins; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sulfonamides; Treatment Outcome | 2017 |
Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Evoked Potentials; Glycine; Hippocampus; Leucine; Mice; Mice, Inbred ICR; Morpholines; Patch-Clamp Techniques; Protein Kinase C; Pyramidal Cells; Pyrroles; Receptors, Glycine; Signal Transduction; Strychnine; Sulfonamides; TRPV Cation Channels | 2018 |
Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; ADP Ribose Transferases; Animals; Apoptosis; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Ion Transport; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAD; Receptors, Purinergic P2X7; T-Lymphocyte Subsets | 2018 |
γ-[Glu]
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cell Proliferation; Cell Survival; Cholecystokinin; Dipeptides; Egtazic Acid; Gastrointestinal Hormones; Glucagon-Like Peptide 1; Humans; Naphthalenes; Peptides; Receptors, Calcium-Sensing | 2019 |
Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Allosteric Site; Amides; Binding Sites; Humans; Imidazoles; Indoles; Models, Molecular; Molecular Docking Simulation; Point Mutation; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Rosaniline Dyes; Thiazoles | 2019 |
Adaptation in 5-HT
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Enzyme Inhibitors; Ethanol; Excitatory Postsynaptic Potentials; Glutamic Acid; Habenula; Neurons; Nociception; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT2; RNA, Messenger; Serotonin 5-HT2 Receptor Antagonists; Substance Withdrawal Syndrome | 2019 |
PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Disks Large Homolog 4 Protein; Down-Regulation; Hippocampus; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Phosphorylation; Post-Synaptic Density; Primary Cell Culture; Rats; Serine; Synaptic Potentials | 2020 |
CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; bcl-2-Associated X Protein; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caspase 12; Cations, Divalent; Cell Line; Cell Movement; Cell Proliferation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Gene Expression Regulation; Heat-Shock Proteins; Hepatic Stellate Cells; Humans; Signal Transduction; Transforming Growth Factor beta1; Uridine Triphosphate | 2021 |