Compounds > 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

1-(5-isoquinolinesulfonyl)-2-methylpiperazine and h 89

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with h 89 in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's49 (63.64)18.2507
2000's22 (28.57)29.6817
2010's6 (7.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hidaka, H; Kobayashi, R; Watanabe, M1
Hidaka, H; Kobayashi, R1
Hidaka, H; Tokumitsu, H; Watanabe, M1
Allen, JM; Balbi, D1
Findik, D; Hidaka, H; Lavin, M; Song, Q1
Kondoh, S; Mue, S; Ohuchi, K; Tanabe, J; Watanabe, M1
Hirai, H; Ikeuchi, Y; Okada, Y1
Chang, JP; Jobin, RM; Neumann, CM; Van Goor, F; Wong, AO1
Onozuka, M; Watanabe, K1
Bers, DM; Hove-Madsen, L; Mattiazzi, A1
Bers, DM; Yuan, W1
Kimura, I; Kimura, M; Nojima, H1
Kubota, C; Murata, Y; Shinagawa, T; Shinohara, O1
Boniece, IR; Maiese, K; Skurat, K; Wagner, JA1
Fujihara, M; Ito, N; Muroi, M; Muroi, Y; Suzuki, T1
Muroi, M; Suzuki, T1
Hidaka, H; Miyamoto, K; Nakamura, S; Nomura, M; Sanae, F; Yamamoto, H1
DelValle, J; Osburn, J; Wang, L; Wilson, EJ1
Bosche, MC; Levine, RA; Nandi, J; Rotker, JD; Strapko, A1
Rothstein, TL; Wang, Z; Xie, H1
Benz, D; Möller, K; Perrin, D; Söling, HD1
Bossemeyer, D; Engh, RA; Girod, A; Huber, R; Kinzel, V1
Furukawa, S; Shono, T; Taniai, K; Yamakawa, M1
Ikeuchi, Y; Nishizaki, T; Okada, Y1
Fujimoto, S; Satake, N; Shibata, S1
Ruskoaho, H; Taskinen, P; Toth, M1
Burke, JP; Hablitz, JJ1
Gault, LM; Siegel, RE1
Bavister, BD; Rose-Hellekant, TA1
Marunaka, Y; Niisato, N1
Miyamoto, K; Nomura, M; Sugiura, N; Yamamoto, H1
Chen, PS; Rees, H; Sluka, KA; Tsuruoka, M; Willis, WD1
Hirata, C; Kizaki, H; Onishi, Y; Sakurai, Y; Tanimoto, Y; Yamada, T1
Puschner, B; Schacht, J1
Delay, RJ; Dionne, VE; Dubin, AE1
Kumatoriya, K; Nomura, T; Yamauchi, T; Yoshimura, Y1
Bertaglia, A; Cervo, L; Mukherjee, S; Samanin, R1
Nishizaki, T; Nomura, T1
Marunaka, Y; Niisato, N; Shintani, Y1
Kamitori, K; Kohsaka, S; Machide, M; Nakamura, Y1
Huh, SO; Kim, YH; Lee, JK; Lee, KJ; Song, DK; Suh, HW; Won, JS1
Chik, CL; Ho, AK; Karpinski, E; Li, B1
Krnjević, K; Liu, PL; McArdle, JJ; Ren, J; Ye, JH1
Isohama, Y; Kai, H; Miyata, T; Okumura, M; Shinozawa, S1
Konishi, S; Mitoma, H1
Bajorath, J; Godden, JW; Stahura, F1
Ito, Y; Marunaka, Y; Niisato, N1
Asahi, M; Fujino, M; Ohnishi, K; Ohnishi, T; Takahashi, A; Wang, X1
Choi, MR; Huh, SO; Kim, YH; Lee, JK; Song, DK; Suh, HW1
Callahan, LA; DiMarco, A; Nethery, D; Stofan, D; Supinski, G1
Kubo, Y; Miyashita, T1
Dietz, R; Gschwend, S; Orzechowski, HD; Paul, M; Stula, M; Vetter, R; von Harsdorf, R1
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
Ferrier, GR; Zhu, J1
Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M1
Baldelli, P; Carabelli, V; Carbone, E; Hernández-Guijo, JM1
Choi, MR; Suh, HW; Won, JS1
Courjaret, R; Lapied, B1
Douglas, RM; Gu, XQ; Haddad, GG; Yao, H1
Hörsch, D; Trümper, A; Trümper, K1
Kaneishi, K; Kato, M; Kobayashi, H; Sakuma, Y1
Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V1
Carlson, RR; Dudman, JT; Konradi, C; Macías, W1
Banerjee, U; Calvin, HI; Fu, SC; Guo, L; Li, W; Wu, K1
Linsdell, P; McDonald, TF; Missan, S1
Tang, X; Zhang, C1
Blishchenko, EY; Ivanov, VT; Karelin, AA; Khachin, DP; Leontiev, KV; Sazonova, OV; Tolmazova, AG1
Li, DL; Li, YJ; Sun, WP; Xiao, FC; Zhang, LB; Zhou, SS; Zhou, YM1
Nishikawa, T; Omura, M; Suematsu, S1
Bai, HB; Cui, YR; Fang, X; Guan, CX; Khunkhun, R; Zhang, M1
Horiuchi, N; Maeda, T1
Cao, AL; Liu, HY; Zeng, WD; Zhang, CQ1
Boeck, CR; de Araújo Herculano, B; Martins, WC; Tasca, CI; Vandresen-Filho, S1
Brar, BK; Helgeland, E; Jonassen, AK; Mjøs, OD; Wergeland, A1
Aguiar, AS; Bettio, LE; Budni, J; Cunha, MP; Machado, DG; Martins, DF; Oliveira, Á; Pazini, FL; Rodrigues, AL; Santos, AR1
Holloway, AC; Nurse, CA; Salman, S1
Konishi, S; Ono, Y; Saitow, F1

Reviews

1 review(s) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and h 89

ArticleYear
[Molecular pharmacology of intracellular calcium signaling].
    Seikagaku. The Journal of Japanese Biochemical Society, 1990, Volume: 62, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Cyclic AMP; Humans; Isoquinolines; Muscle Contraction; Muscle, Smooth; Myosins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Second Messenger Systems; Sulfonamides

1990

Other Studies

76 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and h 89

ArticleYear
Properties and use of H-series compounds as protein kinase inhibitors.
    Methods in enzymology, 1991, Volume: 201

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Isoquinolines; Kinetics; PC12 Cells; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides

1991
Search for the functional substrate proteins of protein kinases and their selective inhibitors.
    Advances in second messenger and phosphoprotein research, 1990, Volume: 24

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Gland Neoplasms; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Cell Differentiation; Isoquinolines; Neoplasm Proteins; Pheochromocytoma; Phosphorylation; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Rats; Second Messenger Systems; Substrate Specificity; Sulfonamides; Tumor Cells, Cultured

1990
Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells.
    Brain research. Molecular brain research, 1994, Volume: 23, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic

1994
Protein kinase A inhibitors enhance radiation-induced apoptosis.
    Journal of cellular biochemistry, 1995, Volume: 57, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Burkitt Lymphoma; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Tumor Cells, Cultured

1995
Possible roles of protein kinases in neutrophil chemotactic factor production by leucocytes in allergic inflammation in rats.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Cells, Cultured; Chemotactic Factors; Culture Media, Conditioned; Cycloheximide; Depression, Chemical; Dexamethasone; Genistein; Hypersensitivity; Indole Alkaloids; Inflammation; Isoelectric Focusing; Isoflavones; Isoquinolines; Leukocytes; Male; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sulfonamides

1994
The contribution of PKA to the excitatory mechanism of adenosine in guinea pig superior colliculus slices.
    Neuroscience letters, 1994, Nov-21, Volume: 182, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Bucladesine; Culture Media; Cyclic AMP-Dependent Protein Kinases; Guinea Pigs; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sulfonamides; Superior Colliculi; Synaptic Transmission

1994
Interactions of cyclic adenosine 3',5'-monophosphate, protein kinase-C, and calcium in dopamine- and gonadotropin-releasing hormone-stimulated growth hormone release in the goldfish.
    Endocrinology, 1994, Volume: 135, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine; Female; Goldfish; Gonadotropin-Releasing Hormone; Growth Hormone; Isoquinolines; Male; Piperazines; Pituitary Gland; Protein Kinase C; Sulfonamides; Verapamil

1994
Glutamate elicits an outward K+ current which is normally suppressed by a Ca2+/calmodulin-dependent protein kinase II.
    Brain research, 1994, Aug-22, Volume: 654, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alkaloids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Cholera Toxin; Dose-Response Relationship, Drug; Ganglia, Invertebrate; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kynurenic Acid; Membrane Potentials; Neurons; Pertussis Toxin; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Snails; Staurosporine; Sulfonamides; Time Factors; Virulence Factors, Bordetella

1994
Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Biological Transport; Calcium; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Isoquinolines; Myocardium; Piperazines; Protein Kinase Inhibitors; Rabbits; Sarcoplasmic Reticulum; Sulfonamides

1994
Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase.
    The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electric Conductivity; Ferrets; Heart; Heart Ventricles; Isoquinolines; Myocardium; Peptide Fragments; Piperazines; Rabbits; Staurosporine; Sulfonamides

1994
The evidence of accelerative interaction between cAMP-dependent protein kinase and external calcium for the desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscle cells.
    Neuroscience letters, 1994, Feb-14, Volume: 167, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Hydroxybenzoates; Isoquinolines; Mice; Muscles; Piperazines; Receptors, Nicotinic; Staurosporine; Sulfonamides; Time Factors

1994
Protein kinase C inhibitors enhance differentiation of rat adipocyte precursor cells in serum-free culture.
    Biochemical medicine and metabolic biology, 1994, Volume: 51, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Glycerolphosphate Dehydrogenase; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate

1994
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia.
    Journal of neuroscience research, 1993, Sep-01, Volume: 36, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Cell Death; Cell Hypoxia; Cells, Cultured; Dibutyryl Cyclic GMP; Hippocampus; Isoquinolines; Nerve Tissue Proteins; Nitric Oxide; Phorbol Esters; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Staurosporine; Sulfonamides

1993
Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774).
    The Journal of biological chemistry, 1993, Jul-15, Volume: 268, Issue:20

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cell Line; Cyclic AMP; Female; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oligodeoxyribonucleotides; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-jun; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate

1993
Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line, J774.
    Cellular signalling, 1993, Volume: 5, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Bucladesine; Cholera Toxin; Colforsin; Consensus Sequence; Cyclic AMP; Dinoprostone; Female; Gene Expression Regulation, Neoplastic; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Phosphorylation; Piperazines; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factor RelB; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

1993
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
    Cancer letters, 1993, Aug-31, Volume: 72, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cyclic AMP-Dependent Protein Kinases; Isoquinolines; Liver Neoplasms, Experimental; Piperazines; Protein Kinase C; Rats; Sulfonamides; Tumor Cells, Cultured

1993
Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C.
    Gastroenterology, 1996, Volume: 110, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminopyrine; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Gastric Acid; Inositol 1,4,5-Trisphosphate; Isoquinolines; Parasympathomimetics; Parietal Cells, Gastric; Piperazines; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Sulfonamides

1996
Effects of cyclic adenosine monophosphate-dependent protein kinase and calcium-dependent protein kinase modulators on stimulated gastric acid secretion in the perfused rat stomach.
    Pharmacology, 1995, Volume: 51, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gastric Acid; Histamine; Injections, Intravenous; Isoquinolines; Male; Naphthalenes; Pentagastrin; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate

1995
Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes.
    Cellular immunology, 1996, May-01, Volume: 169, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Anti-Idiotypic; Antigens, CD; B-Lymphocytes; B7-2 Antigen; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Immunoglobulins; Ionomycin; Isoquinolines; Lymphoma, B-Cell; Membrane Glycoproteins; Mice; Molecular Sequence Data; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Antigen, B-Cell; Signal Transduction; Staurosporine; Sulfonamides

1996
The role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells.
    The Biochemical journal, 1996, Feb-15, Volume: 314 ( Pt 1)

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amylases; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Immunoblotting; Isoproterenol; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Binding; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate

1996
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
    The Journal of biological chemistry, 1996, Oct-18, Volume: 271, Issue:42

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites; Casein Kinase II; Casein Kinases; Cattle; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glycine; Isoquinolines; Myosin-Light-Chain Kinase; Protein Conformation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Sulfonamides

1996
Elicitors triggering the simultaneous gene expression of antibacterial proteins of the silkworm, Bombyx mori.
    Biochemical and biophysical research communications, 1996, Sep-24, Volume: 226, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Infective Agents; Bombyx; Cell Adhesion; Enzyme Inhibitors; Gene Expression; Genes, Insect; Hemocytes; Insect Hormones; Insect Proteins; Isoquinolines; Larva; Lipid A; Lipopolysaccharides; Peptidoglycan; Protein Biosynthesis; Signal Transduction; Sugar Acids; Sulfonamides

1996
Repetitive applications of ATP potentiate potassium current by Ca2+/calmodulin kinase in cultured rat hippocampal neurons.
    Neuroscience letters, 1996, Jan-19, Volume: 203, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Hippocampus; Indoles; Ion Channel Gating; Isoquinolines; Maleimides; Neurons; Patch-Clamp Techniques; Potassium; Protein Kinase C; Rats; Signal Transduction; Sulfonamides

1996
The potentiation of nitroglycerin-induced relaxation by PKG inhibition in rat aortic rings.
    General pharmacology, 1996, Volume: 27, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Nitroglycerin; Potassium Channels; Protein Kinase C; Purinones; Rats; Rats, Wistar; Staurosporine; Sulfonamides; Vasodilator Agents

1996
Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart.
    The Journal of endocrinology, 1996, Volume: 150, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Heart Rate; Isoquinolines; Male; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Relaxin; Staurosporine; Stimulation, Chemical; Sulfonamides

1996
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
    Neuroscience, 1996, Volume: 75, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides

1996
Expression of the GABAA receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Apr-01, Volume: 17, Issue:7

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Chelating Agents; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Macromolecular Substances; Membrane Potentials; Neurons; Nifedipine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sulfonamides; Tetrodotoxin; Time Factors; Transcription, Genetic

1997
Precocious oocyte maturation is induced by an inhibitor of cAMP-dependent protein kinase in the intact golden hamster.
    Molecular reproduction and development, 1996, Volume: 44, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Female; Indoles; Isoquinolines; Maleimides; Mesocricetus; Oocytes; Phorbol Esters; Protein Kinase C; Signal Transduction; Sulfonamides

1996
Regulation of Cl- transport by IBMX in renal A6 epithelium.
    Pflugers Archiv : European journal of physiology, 1997, Volume: 434, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channel Blockers; Cell Line; Chloride Channels; Chlorides; Cyclic AMP; Cytosol; Enzyme Inhibitors; Epithelium; Ion Transport; Isoquinolines; Kidney; Kinetics; Nitrobenzoates; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Sulfonamides; Xenopus laevis

1997
Leukocyte function-associated antigen 1-dependent adhesion of rat hepatoma AH66F cells and inhibition by protein kinase C inhibitors.
    Biochemical pharmacology, 1997, May-09, Volume: 53, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies, Monoclonal; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Female; Intercellular Adhesion Molecule-1; Isoquinolines; Liver Neoplasms, Experimental; Lymphocyte Function-Associated Antigen-1; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tumor Cells, Cultured

1997
Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate.
    Experimental brain research, 1997, Volume: 115, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Animals; Capsaicin; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haplorhini; Hot Temperature; Injections, Intradermal; Isoquinolines; Microdialysis; Nerve Fibers; Neural Pathways; Physical Stimulation; Piperidines; Protein Kinase Inhibitors; Spinal Cord; Sulfonamides; Thalamus; Thionucleotides

1997
Preincubation of thymocytes with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) induces apoptosis in non-stimulated thymocytes.
    Biochemistry and molecular biology international, 1997, Volume: 42, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Isoenzymes; Isoquinolines; Lactams, Macrocyclic; Male; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA; Sulfonamides; T-Lymphocytes; Thymus Gland

1997
Calmodulin-dependent protein kinases mediate calcium-induced slow motility of mammalian outer hair cells.
    Hearing research, 1997, Volume: 110, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Hair Cells, Auditory, Outer; Ionomycin; Ionophores; Isoquinolines; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Staurosporine; Sulfonamides

1997
A cyclic nucleotide-dependent chloride conductance in olfactory receptor neurons.
    The Journal of membrane biology, 1997, Sep-01, Volume: 159, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium; Chloride Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Membrane Potentials; Necturus; Olfactory Receptor Neurons; Patch-Clamp Techniques; Photolysis; Sulfonamides

1997
Overexpression of alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II in neuroblastoma cells -- H-7 promotes neurite outgrowth.
    Brain research, 1997, Aug-22, Volume: 766, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Immunoblotting; Isoenzymes; Isoquinolines; Mice; Molecular Sequence Data; Neurites; Neuroblastoma; Phosphorylation; Substrate Specificity; Sulfonamides; Transfection; Tumor Cells, Cultured

1997
Protein kinases A and C are involved in the mechanisms underlying consolidation of cocaine place conditioning.
    Brain research, 1997, Nov-14, Volume: 775, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Cocaine; Conditioning, Operant; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Injections, Intraventricular; Isoquinolines; Male; Motor Activity; Narcotics; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides

1997
Methamphetamine modulates ACh-evoked currents in Xenopus occytes expressing the rat alpha7 receptors.
    Neuroscience letters, 1997, Dec-19, Volume: 239, Issue:2-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoquinolines; Maleimides; Methamphetamine; Oocytes; Protein Kinase C; Rats; Receptors, Nicotinic; RNA, Messenger; Sulfonamides; Xenopus

1997
Protein phosphatase 2B-dependent pathway of insulin action on single Cl- channel conductance in renal epithelium.
    The Journal of membrane biology, 1998, Feb-01, Volume: 161, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcineurin; Calcineurin Inhibitors; Calmodulin; Cell Line; Chloride Channels; Cyclosporine; Cytosol; Electric Conductivity; Enzyme Inhibitors; Epithelial Cells; Insulin; Isoquinolines; Kidney; Phenols; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides

1998
Selective activation of phospholipase C gamma1 and distinct protein kinase C subspecies in intracellular signaling by hepatocyte growth factor/scatter factor in primary cultured rat neocortical cells.
    Journal of neurochemistry, 1998, Volume: 71, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fetus; Flavonoids; Hepatocyte Growth Factor; Isoenzymes; Isoquinolines; Naphthalenes; Neocortex; Neurons; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-met; Rats; Rats, Wistar; Signal Transduction; Subcellular Fractions; Substrate Specificity; Sulfonamides; Type C Phospholipases

1998
Prostaglandin E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture.
    Brain research. Molecular brain research, 1998, Oct-01, Volume: 60, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dinoprostone; Enkephalins; Enzyme Inhibitors; Flavonoids; Imidazoles; Isoquinolines; Kinetics; Nimodipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic

1998
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation.
    Journal of neurochemistry, 1999, Volume: 72, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics

1999
Cocaine decreases the glycine-induced Cl- current of acutely dissociated rat hippocampal neurons.
    European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Anesthetics, Local; Animals; Benzophenanthridines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Cocaine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Glycine Agents; Hippocampus; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Strychnine; Sulfonamides; Tetrodotoxin

1999
Effects of eosinophil granule major basic protein on phosphatidylcholine secretion in rat type II pneumocytes.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Proteins; Calcium; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Eosinophil Granule Proteins; Guinea Pigs; Inflammation Mediators; Isoquinolines; Lung; Phosphatidylcholines; Protein Kinase Inhibitors; Rats; Ribonucleases; Sulfonamides

1999
Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses.
    Neuroscience, 1999, Volume: 88, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cerebellum; Colforsin; Cyclic AMP; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Methiothepin; Neuronal Plasticity; Norepinephrine; Propranolol; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA; Serotonin; Sulfonamides; Synapses; Synaptic Transmission; Tetrodotoxin; Thionucleotides

1999
Evaluation of docking strategies for virtual screening of compound databases: cAMP-dependent serine/threonine kinase as an example.
    Journal of molecular graphics & modelling, 1998, Volume: 16, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Computer Graphics; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Databases, Factual; Enzyme Inhibitors; Evaluation Studies as Topic; Humans; Isoquinolines; Molecular Structure; Protein Conformation; Sulfonamides

1998
Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms.
    Life sciences, 1999, Volume: 65, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Indoles; Isoquinolines; Myristic Acid; Pulmonary Alveoli; Pyrroles; Rats; Rats, Wistar; Sodium; Sodium Channels; Structure-Activity Relationship; Sulfonamides; Terbutaline

1999
Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells.
    The British journal of dermatology, 1999, Volume: 141, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Gamma Rays; Humans; Isoquinolines; Polymorphism, Single-Stranded Conformational; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
    Neuroscience letters, 1999, Nov-26, Volume: 276, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Calmodulin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; Isoquinolines; Nimodipine; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured

1999
Effects of protein kinase A inhibition on rat diaphragm force generation.
    Respiration physiology, 2000, Volume: 120, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP-Dependent Protein Kinases; Diaphragm; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Kinetics; Male; Muscle Contraction; Muscle Fatigue; Rats; Rats, Sprague-Dawley; Sulfonamides

2000
Extracellular Ca2+ sensitivity of mGluR1alpha induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
    Receptors & channels, 2000, Volume: 7, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Cell Size; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Dyes; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Isoquinolines; MAP Kinase Signaling System; Protein Kinase C; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases

2000
Influence of sustained mechanical stress on Egr-1 mRNA expression in cultured human endothelial cells.
    Molecular and cellular biochemistry, 2000, Volume: 210, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Blotting, Northern; Cell Line; Cells, Cultured; Chelating Agents; Colchicine; DNA-Binding Proteins; Early Growth Response Protein 1; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Gadolinium; Humans; Immediate-Early Proteins; Isoquinolines; Microscopy, Fluorescence; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; Stress, Mechanical; Sulfonamides; Transcription Factors; Umbilical Veins

2000
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
Regulation of a voltage-sensitive release mechanism by Ca(2+)-calmodulin-dependent kinase in cardiac myocytes.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cadmium; Caffeine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Isoquinolines; Male; Myocardial Contraction; Myocardium; Patch-Clamp Techniques; Phosphorylation; Signal Transduction; Sulfonamides; Tetracaine

2000
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
    Journal of neurochemistry, 2001, Volume: 76, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate

2001
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
    The Journal of physiology, 2001, Apr-01, Volume: 532, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Autocrine Communication; Calcium; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; GABA Antagonists; Isoquinolines; Kinetics; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Kinase Inhibitors; Sulfonamides; Suramin

2001
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
    Brain research, 2001, Jun-08, Volume: 903, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1

2001
Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).
    Molecular pharmacology, 2001, Volume: 60, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adenylyl Imidodiphosphate; Animals; Bungarotoxins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Imidazoles; Insecta; Insecticides; Isoquinolines; Median Nerve; Neonicotinoids; Neurons; Niacin; Nitro Compounds; Okadaic Acid; Permeability; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Nicotinic; Signal Transduction; Sulfonamides

2001
Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acids; Alkaloids; Animals; Benzophenanthridines; Cell Hypoxia; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Guanidines; Hippocampus; Hydrogen-Ion Concentration; Hypoxia, Brain; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Neurologic Mutants; Neurons; Oxygen; Phenanthridines; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Sulfonamides; Sulfones

2001
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
    The Journal of endocrinology, 2002, Volume: 174, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin

2002
3',5'-cyclic adenosine monophosphate augments intracellular Ca2+ concentration and gonadotropin-releasing hormone (GnRH) release in immortalized GnRH neurons in an Na+ -dependent manner.
    Endocrinology, 2002, Volume: 143, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Calcium; Cell Line, Transformed; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Isoquinolines; Neurons; Protein Kinase C; Sodium; Sulfonamides; Tetrodotoxin

2002
Regulation of glutamatergic neurotransmission in the striatum by presynaptic adenylyl cyclase-dependent processes.
    Neurochemistry international, 2003, Volume: 42, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Calcium; Calmodulin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Feedback; Female; Glutamic Acid; Imidazoles; Imines; Isoenzymes; Isoproterenol; Isoquinolines; Kainic Acid; Male; Mice; N-Methylaspartate; Nerve Tissue Proteins; Propranolol; Receptors, Adrenergic, beta; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Presynaptic; Second Messenger Systems; Sulfonamides; Synaptic Transmission; Trifluoperazine

2003
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
    Brain research. Molecular brain research, 2003, Jul-23, Volume: 115, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection

2003
Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A.
    Current eye research, 2003, Volume: 27, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Crystallin A Chain; Animals; Animals, Newborn; Buthionine Sulfoximine; Calcium; Cataract; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Female; Isoquinolines; Lens Cortex, Crystalline; Male; Mice; Organ Culture Techniques; Phosphorylation; Potassium; Pregnancy; Protein Kinase C; Sodium; Spectrophotometry, Atomic; Sulfonamides

2003
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.
    Biochimica et biophysica acta, 2006, Volume: 1758, Issue:10

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cytochalasin D; Cytoskeleton; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoquinolines; KCNQ1 Potassium Channel; Maleimides; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins

2006
Activation of protein kinases A and C promoted proliferation of chicken primordial germ cells.
    Animal reproduction science, 2007, Volume: 101, Issue:3-4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Proliferation; Chick Embryo; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Germ Cells; Isoquinolines; Phorbol Esters; Protein Kinase C; Sulfonamides

2007
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.
    The FEBS journal, 2007, Volume: 274, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Proliferation; Chelating Agents; Chlorocebus aethiops; Endorphins; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Isoquinolines; MAP Kinase Signaling System; Mice; Nifedipine; Protein Kinase Inhibitors; Sulfonamides; Verapamil

2007
Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.
    Experimental physiology, 2007, Volume: 92, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiogenesis Inhibitors; Animals; Chloride Channels; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Genistein; Isoquinolines; Myocytes, Cardiac; Niflumic Acid; Nitrobenzoates; Patch-Clamp Techniques; Phenols; Potassium Channels; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Vanadates

2007
Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells.
    Endocrine journal, 2007, Volume: 54, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenocorticotropic Hormone; Animals; Bucladesine; Calcium; Calcium Signaling; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydrocortisone; Isoquinolines; Naphthalenes; Phospholipase A2 Inhibitors; Phospholipases A2; Primaquine; Protein Kinase C; Protein Kinase Inhibitors; Quinacrine; Second Messenger Systems; Sulfonamides; Zona Fasciculata

2007
Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.
    Peptides, 2007, Volume: 28, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bronchi; Cadherins; Calmodulin; Cell Line; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Immunochemistry; Isoquinolines; Ki-67 Antigen; Models, Biological; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Vasoactive Intestinal Peptide; Wound Healing

2007
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
    Journal of biochemistry, 2009, Volume: 145, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin

2009
Follicle-stimulating hormone promotes proliferation of cultured chicken ovarian germ cells through protein kinases A and C activation.
    Journal of Zhejiang University. Science. B, 2010, Volume: 11, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Proliferation; Cells, Cultured; Chickens; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Follicle Stimulating Hormone; Isoquinolines; Ovum; Protein Kinase C; Receptors, FSH; Sulfonamides; Tetradecanoylphorbol Acetate

2010
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
    Behavioural brain research, 2011, May-16, Volume: 219, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Psychological; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Injections, Intraventricular; Isoquinolines; Male; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Sulfonamides; Wortmannin

2011
Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling.
    Regulatory peptides, 2012, Feb-10, Volume: 174, Issue:1-3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Cell Death; Corticotropin-Releasing Hormone; Cyclic AMP-Dependent Protein Kinases; Heart; Isoquinolines; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Protein Kinase C; Receptors, Corticotropin-Releasing Hormone; Signal Transduction; Structure-Activity Relationship; Sulfonamides

2012
The antidepressant-like effect of physical activity on a voluntary running wheel.
    Medicine and science in sports and exercise, 2013, Volume: 45, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Hindlimb Suspension; Isoquinolines; Male; Mice; Physical Conditioning, Animal; Protein Kinase Inhibitors; Sulfonamides

2013
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
    American journal of physiology. Cell physiology, 2014, Aug-01, Volume: 307, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenal Medulla; Analgesics, Opioid; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinases; Carbonic Anhydrase I; Carbonic Anhydrase II; Cell Hypoxia; Cell Line; Chromaffin Cells; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Female; Hypercapnia; Indoles; Isoquinolines; KATP Channels; Maleimides; Morphine; Naloxone; Narcotic Antagonists; Norepinephrine; Oligopeptides; Potassium Channels, Inwardly Rectifying; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides

2014
Differential Modulation of GABAA Receptors Underlies Postsynaptic Depolarization- and Purinoceptor-Mediated Enhancement of Cerebellar Inhibitory Transmission: A Non-Stationary Fluctuation Analysis Study.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cerebellum; Female; Isoquinolines; Male; Patch-Clamp Techniques; Protein Kinase Inhibitors; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Purinergic; Signal Transduction; Sulfonamides; Synapses; Synaptic Potentials

2016