1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (73.08) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawase, T; Van Breemen, C | 1 |
| Barreau, P; Basset, M; Cost, H; Geny, B; Le Peuch, C | 1 |
| Churcher, Y; Gomperts, BD | 1 |
| Aghajanian, GK | 1 |
| Aiyar, J; Chandy, KG; Grissmer, S | 1 |
| Imanaga, I; Inoue, M | 1 |
| Jonas, JC; Li, G; Palmer, M; Weller, U; Wollheim, CB | 1 |
| Benzing, CF; Kono, T; Robinson, FW; Sumida, Y; Yano, Y | 1 |
| Babior, BM; el-Benna, J; Park, JW; Ruedi, JM | 1 |
| Imada-Shirakata, Y; Kotera, T; Okuma, M; Ueda, S | 1 |
| Chen, PS; Rees, H; Sluka, KA; Tsuruoka, M; Willis, WD | 1 |
| Imanaga, I; Inoue, M; Sakamoto, Y; Yano, A | 1 |
| Hidaka, H; Iida, Y; Matsukawa, Y; Miyazaki, JI; Niki, I; Nimura, Y; Onoda, K; Sakaguchi, H; Senda, T | 1 |
| Grillner, S; Parker, D; Svensson, E | 1 |
| Jones, SW; Kammermeier, PJ | 1 |
| Alberi, S; Dreifuss, JJ; Raggenbass, M | 1 |
| Behar, J; Biancani, P; Chen, Q; Harnett, K; Xiao, Z; Yu, P | 1 |
| Akopov, SE; Pearce, WJ; Zhang, L | 1 |
| Ito, M; Nakano, T; Narumiya, S; Nishikawa, M; Sasaki, Y; Shiku, H; Suzuki, Y; Wada, H; Yamamoto, M | 1 |
| Nagumo, H; Okamoto, H; Ono, Y; Sasaki, Y; Seto, M; Takuwa, Y | 1 |
| Tse, A; Tse, FW | 1 |
| Amano, M; Fukata, Y; Kaibuchi, K; Shimokawa, H | 1 |
| Fujishima, M; Hirano, K; Ibayashi, S; Kanaide, H; Nakamura, K; Nishimura, J | 1 |
| Kravtsov, GM; Pang, SF; Poon, AM | 1 |
| Eto, Y; Kandabashi, T; Kunihiro, I; Matsumoto, Y; Miyata, K; Morishige, K; Nakayama, K; Obara, K; Shimokawa, H; Takahashi, S; Takeshita, A | 1 |
| Kanaide, H; Naito, S; Nishimura, J; Seki, N; Takahashi, R; Tomoda, T; Yunoki, T | 1 |
26 other study(ies) available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Aluminum fluoride induces a reversible Ca2+ sensitization in alpha-toxin-permeabilized vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum; Aluminum Compounds; Animals; Bacterial Toxins; Calcium; Egtazic Acid; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hemolysin Proteins; In Vitro Techniques; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Rabbits; Vasoconstriction | 1992 |
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Membrane; Clone Cells; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Isoquinolines; Leukemia, Myeloid; Lipid Metabolism; Piperazines; Protein Kinase C; Staurosporine; Streptolysins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
ATP-dependent and ATP-independent pathways of exocytosis revealed by interchanging glutamate and chloride as the major anion in permeabilized mast cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Anions; beta-N-Acetylhexosaminidases; Calcium; Cations; Chlorides; Exocytosis; Glutamates; Glutamic Acid; Glyceryl Ethers; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Male; Mast Cells; Molecular Sequence Data; Peptide Fragments; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Secretory Rate; Signal Transduction | 1990 |
Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Electric Conductivity; Facial Nerve; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Isoquinolines; Male; Motor Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Serotonin; Thionucleotides | 1990 |
Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcineurin; Calmodulin-Binding Proteins; Charybdotoxin; Cloning, Molecular; Electric Stimulation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Membrane Potentials; Mice; Oocytes; Pertussis Toxin; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Potassium Channels; Protein Kinase C; Receptors, Serotonin; Recombinant Proteins; RNA, Complementary; Scorpion Venoms; Second Messenger Systems; Serotonin; Staurosporine; Transcription, Genetic; Virulence Factors, Bordetella; Xenopus laevis | 1993 |
Phosphatase is responsible for run down, and probably G protein-mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Alkaline Phosphatase; Aluminum Compounds; Animals; Chromaffin System; Down-Regulation; Electrophysiology; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Guinea Pigs; Isoquinolines; Marine Toxins; Membrane Potentials; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Potassium Channel Blockers; Potassium Channels; Protein Phosphatase 1; Sulfonamides | 1995 |
Dynamics of Ca2+ and guanosine 5'-[gamma-thio]triphosphate action on insulin secretion from alpha-toxin-permeabilized HIT-T15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Insulin; Insulin Secretion; Isoquinolines; Kinetics; Piperazines; Staphylococcus aureus; Type C Phospholipases | 1994 |
Primary sites of actions of staurosporine and H-7 in the cascade of insulin action to glucose transport in rat adipocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Binding Sites; Biological Transport; Cells, Cultured; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Isoquinolines; Male; Monosaccharide Transport Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Staurosporine | 1993 |
Cell-free activation of the respiratory burst oxidase by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Catalase; Cattle; Cell-Free System; Cytosol; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Isoquinolines; Maleimides; NADH, NADPH Oxidoreductases; NADP; NADPH Oxidases; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Rats; Respiratory Burst; Superoxide Dismutase | 1995 |
Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Calcium; Cells, Cultured; Chlorides; Colon; Egtazic Acid; Electrolytes; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Intestinal Mucosa; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin | 1997 |
Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Animals; Capsaicin; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haplorhini; Hot Temperature; Injections, Intradermal; Isoquinolines; Microdialysis; Nerve Fibers; Neural Pathways; Physical Stimulation; Piperidines; Protein Kinase Inhibitors; Spinal Cord; Sulfonamides; Thalamus; Thionucleotides | 1997 |
Cyanide suppression of inwardly rectifying K+ channels in guinea pig chromaffin cells involves dephosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenal Medulla; Animals; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Kinetics; Marine Toxins; Membrane Potentials; Oxazoles; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Potassium Channels; Potassium Channels, Inwardly Rectifying; Ribonucleotides; Sodium Cyanide; Uridine Triphosphate | 1997 |
Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Azepines; Bacterial Proteins; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cells, Cultured; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Myosin Heavy Chains; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Rats; Rats, Wistar; Streptolysins | 1997 |
Substance P modulates sensory action potentials in the lamprey via a protein kinase C-mediated reduction of a 4-aminopyridine-sensitive potassium conductance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Adenylate Cyclase Toxin; Alkaloids; Animals; Benzophenanthridines; Cadmium Chloride; Electric Stimulation; Enzyme Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lampreys; Male; Neurons; Notochord; Peptides; Pertussis Toxin; Phenanthridines; Phorbol 12,13-Dibutyrate; Potassium Channels; Protein Kinase C; Protein Kinases; Spinal Cord; Substance P; Tetraethylammonium; Thionucleotides; Virulence Factors, Bordetella; Wasp Venoms | 1997 |
Facilitation of L-type calcium current in thalamic neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Electrophysiology; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Okadaic Acid; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Staurosporine; Thalamic Nuclei; Thionucleotides; Time Factors | 1998 |
The oxytocin-induced inward current in vagal neurons of the rat is mediated by G protein activation but not by an increase in the intracellular calcium concentration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain Stem; Buffers; Calcium; Colforsin; Cyclic AMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; N-Methylaspartate; Neurons; Oxytocin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Thionucleotides; Vagus Nerve | 1997 |
Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calmodulin; Cats; Cell Membrane; Cholecystokinin; Diglycerides; Egtazic Acid; Female; Gallbladder; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phospholipase C beta; Potassium Chloride; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Regulation of Ca2+ sensitization by PKC and rho proteins in ovine cerebral arteries: effects of artery size and age.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Calcium; Cerebral Arteries; Enzyme Activation; Enzyme Inhibitors; Escin; Exotoxins; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Pregnancy; Protein Kinase C; rhoA GTP-Binding Protein; Serotonin; Sheep | 1998 |
Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Blood Platelets; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Myosin-Light-Chain Phosphatase; Myosins; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein | 1999 |
Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blood Proteins; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; Swine | 2000 |
Stimulation of Ca(2+)-independent exocytosis in rat pituitary gonadotrophs by G-protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum Compounds; Animals; Calcium; Calcium-Transporting ATPases; Cyclic AMP; Cytoplasmic Granules; Cytosol; Egtazic Acid; Enzyme Inhibitors; Exocytosis; Fluorides; Fluorometry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Male; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Anterior; Protein Kinase C; Rats; Staurosporine | 2000 |
Purification and in vitro activity of Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Baculoviridae; Catalytic Domain; Cattle; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Staurosporine | 2000 |
Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Basilar Artery; Calcium; Endothelin-1; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Protein Kinase C; Rabbits; Vasodilator Agents | 2001 |
Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apamin; Binding, Competitive; Cecum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Melatonin; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels; Protein-Tyrosine Kinases; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2002 |
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium; Capillary Permeability; Coronary Vasospasm; Coronary Vessels; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Monomeric GTP-Binding Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; rho-Associated Kinases; Swine | 2003 |
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Prostate; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Type C Phospholipases | 2007 |